ES2054403T3 - Procedimiento para la produccion de cuerpos de moldeo de dimensionado peque¦o con un elevado contenido en etofibrado y una liberacion controlada de la sustancia activa, su uso y formas de aplicacion de administracion oral derivadas de ello. - Google Patents

Procedimiento para la produccion de cuerpos de moldeo de dimensionado peque¦o con un elevado contenido en etofibrado y una liberacion controlada de la sustancia activa, su uso y formas de aplicacion de administracion oral derivadas de ello.

Info

Publication number
ES2054403T3
ES2054403T3 ES91111147T ES91111147T ES2054403T3 ES 2054403 T3 ES2054403 T3 ES 2054403T3 ES 91111147 T ES91111147 T ES 91111147T ES 91111147 T ES91111147 T ES 91111147T ES 2054403 T3 ES2054403 T3 ES 2054403T3
Authority
ES
Spain
Prior art keywords
activator
high content
etofibration
procedure
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111147T
Other languages
English (en)
Inventor
Eberhard Prof Nurnberg
Erhard Dr Seiller
Eckart Dr Toms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz and Co GmbH and Co KG
Original Assignee
Merz and Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz and Co GmbH and Co KG filed Critical Merz and Co GmbH and Co KG
Application granted granted Critical
Publication of ES2054403T3 publication Critical patent/ES2054403T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO PARA LA FABRICACION DE SOLIDOS MOLDEADOS DIMENSIONADOS CON UN ALTO CONTENIDO EN ETOFIBRA Y UN CONTROLADO ASENTAMIENTO LIBRE DEL ACTIVADOR GRACIAS A LA MEZCLA DE UN ACTIVADOR CON COLOIDES INSOLUBLES EN AGUA, SOLUBLES EN AGUA O HUMEDOS Y FISIOLOGICAMENTE INDIFERENTES, DADO EL CASO UN ADITAMIENTO DE MATERIAL AUXILIAQR DE EXTRUSION Y EL AJUSTE DEL CONTENIDO ACUOSO DE 0 A 50%, UNA EXTRUSION HACIA LOS CUERPOS CILINDRICOS CON UN DIAMETRO DE 0,5 HASTA 3 MM, DADO EL CASO UNA DIVISION DEL EXTRUDADO CON UNA LONGITUD DE 1 HASTA 3 MM, REDONDEADO Y ACTO SEGUIDO SECADO. LOS SOLIDOS MOLDEADOS SE RELLENAN EN CAPSULAS ENDURECIDAS O SE UNEN A PRESION PARA COMPRIMIDOS Y MUESTRAN UN ASENTAMIENTO LIBRE DEL ACTIVADOR CARACTERISTICO Y EQUITATIVO EN UN ESPACIO DE TIEMPO DE 4 A 7 SEGUNDOS SIN UNA ELEVADA CONCENTRACION DE ACTIVADOR EN LA SANGRE GRACIAS A UN EFECTO CONCOMITANTE ESTIPULADO.
ES91111147T 1990-07-07 1991-07-04 Procedimiento para la produccion de cuerpos de moldeo de dimensionado peque¦o con un elevado contenido en etofibrado y una liberacion controlada de la sustancia activa, su uso y formas de aplicacion de administracion oral derivadas de ello. Expired - Lifetime ES2054403T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4021678A DE4021678C2 (de) 1990-07-07 1990-07-07 Verfahren zur Herstellung klein dimensionierter Formkörper mit hohem Etofibrat-Gehalt und kontrollierter Wirkstoff-Freisetzung, deren Verwendung und daraus bestehende oral verabreichbare Applikationsformen

Publications (1)

Publication Number Publication Date
ES2054403T3 true ES2054403T3 (es) 1994-08-01

Family

ID=6409858

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91111146T Expired - Lifetime ES2054402T3 (es) 1990-07-07 1991-07-04 Procedimiento para la preparacion de comprimidos mecanicamente estables y facilmente disgregables a partir de pellets de extrusion con un alto contenido en etofibrado.
ES91111147T Expired - Lifetime ES2054403T3 (es) 1990-07-07 1991-07-04 Procedimiento para la produccion de cuerpos de moldeo de dimensionado peque¦o con un elevado contenido en etofibrado y una liberacion controlada de la sustancia activa, su uso y formas de aplicacion de administracion oral derivadas de ello.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES91111146T Expired - Lifetime ES2054402T3 (es) 1990-07-07 1991-07-04 Procedimiento para la preparacion de comprimidos mecanicamente estables y facilmente disgregables a partir de pellets de extrusion con un alto contenido en etofibrado.

Country Status (4)

Country Link
EP (2) EP0469328B1 (es)
DE (3) DE4021678C2 (es)
ES (2) ES2054402T3 (es)
PT (2) PT98210B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3034592B2 (ja) * 1990-11-20 2000-04-17 わかもと製薬株式会社 経口用固形製剤及びその製造法
DE4122217C2 (de) * 1991-07-04 1997-02-13 Merz & Co Gmbh & Co Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern
IL109097A0 (en) * 1993-04-03 1994-06-24 Knoll Ag Delayed release micro tablet of beta-phenylpropiophenone derivatives and its production
DE4317127A1 (de) * 1993-05-19 1994-11-24 Merz & Co Gmbh & Co Verwendung von Etofibrat und pharmazeutische Zusammensetzungen, enthaltend Etofibrat, zur Behandlung der diabetischen Angio- und Retinopathie
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
ES2565163T3 (es) * 1996-10-28 2016-03-31 General Mills, Inc. Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado
EP1342548B1 (en) * 1996-10-28 2015-12-23 General Mills, Inc. Embedding and encapsulation of controlled release particles and encapsulated product
DE19809719A1 (de) 1998-03-06 1999-09-09 Roehm Gmbh Wäßrige Dispersion geeignet zur Herstellung von Überzugs- und Bindemitteln für feste orale Arzneiformen
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
AR014765A1 (es) 1998-03-23 2001-03-28 Gen Mills Marketing Inc Composicion de matriz comestible con textura masticable, producto comestible y masticable, composicion comestible, cobertura de alimentos y metodo para la fabricacion de productos comestibles
US6500463B1 (en) 1999-10-01 2002-12-31 General Mills, Inc. Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles
US6436453B1 (en) 2000-06-16 2002-08-20 General Mills, Inc. Production of oil encapsulated minerals and vitamins in a glassy matrix
US6468568B1 (en) 2000-06-16 2002-10-22 General Mills, Inc. Oligosaccharide encapsulated mineral and vitamin ingredients
US6558718B1 (en) 2000-06-19 2003-05-06 General Mills, Inc. Nutrient clusters for food products and methods of preparation
US7431986B2 (en) 2002-07-24 2008-10-07 General Mills, Inc. Encapsulation of sensitive components using pre-emulsification
US7803413B2 (en) 2005-10-31 2010-09-28 General Mills Ip Holdings Ii, Llc. Encapsulation of readily oxidizable components
US10966928B2 (en) 2016-03-25 2021-04-06 Universiteit Gent Oral dosage form
US11065207B2 (en) 2016-03-25 2021-07-20 Universiteit Gent Oral dosage form

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85058A1 (fr) * 1983-10-24 1985-06-19 Pharlyse Comprimes pharmaceutiques a liberation prolongee,leur preparation et leur utilisation
IT1180507B (it) * 1984-06-29 1987-09-23 Roberto Valducci Procedimento per la preparazione di etofibrato o sostanze di pari o simili caratteristiche, in microgunuli-ritardo e prodotto ottenuto con tale procedimento
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
DE3532692A1 (de) * 1985-09-13 1987-03-19 Boehringer Mannheim Gmbh Verfahren zum herstellen von tabletten aus pellets
IT1188212B (it) * 1985-12-20 1988-01-07 Paolo Colombo Sistema per il rilascio a velocita' controllata di sostanze attive

Also Published As

Publication number Publication date
PT98210A (pt) 1992-05-29
EP0468247A1 (de) 1992-01-29
DE59101776D1 (de) 1994-07-07
PT98211B (pt) 1998-12-31
DE59101774D1 (de) 1994-07-07
PT98211A (pt) 1992-05-29
EP0469328A1 (de) 1992-02-05
PT98210B (pt) 1998-12-31
EP0468247B1 (de) 1994-06-01
ES2054402T3 (es) 1994-08-01
DE4021678A1 (de) 1992-01-09
DE4021678C2 (de) 1994-07-07
EP0469328B1 (de) 1994-06-01

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