ES2041216B1 - Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina. - Google Patents

Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.

Info

Publication number
ES2041216B1
ES2041216B1 ES09200414A ES9200414A ES2041216B1 ES 2041216 B1 ES2041216 B1 ES 2041216B1 ES 09200414 A ES09200414 A ES 09200414A ES 9200414 A ES9200414 A ES 9200414A ES 2041216 B1 ES2041216 B1 ES 2041216B1
Authority
ES
Spain
Prior art keywords
procedure
preparation
diosmine
diosmin
hydrogensulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09200414A
Other languages
English (en)
Other versions
ES2041216A1 (es
Inventor
Venero Aurelio Orjales
Pestana Ramon Mosquera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09200414A priority Critical patent/ES2041216B1/es
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority to DE69326176T priority patent/DE69326176T2/de
Priority to DK93500023T priority patent/DK0558435T3/da
Priority to AT93500023T priority patent/ATE184014T1/de
Priority to EP93500023A priority patent/EP0558435B1/en
Priority to ZA931300A priority patent/ZA931300B/xx
Priority to AU33787/93A priority patent/AU661553B2/en
Priority to FI930812A priority patent/FI930812A/fi
Priority to CA002090301A priority patent/CA2090301C/en
Priority to KR1019930002682A priority patent/KR100272646B1/ko
Priority to US08/022,571 priority patent/US5296469A/en
Priority to MX9301042A priority patent/MX9301042A/es
Priority to JP5036957A priority patent/JPH069677A/ja
Priority to NO930670A priority patent/NO179709C/no
Priority to TW082102160A priority patent/TW305845B/zh
Publication of ES2041216A1 publication Critical patent/ES2041216A1/es
Application granted granted Critical
Publication of ES2041216B1 publication Critical patent/ES2041216B1/es
Priority to GR990403065T priority patent/GR3031972T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

PROCEDIMIENTO DE PREPARACION DE UN NUEVO DERIVADO SULFATADO DE DIOSMINA. SE DESCRIBE EL PROCEDIMIENTO DE PREPARACION DEL COMPLEJO ALUMINICO DE HEPTAKIS (HIDROGENO SULFATO) DE DIOSMINA, CARACTERIZADO PORQUE SE HACEN REACCIONAR UN MOL DE DIOSMINA CON SIETE MOLES DE UN AGENTE SULFATANTE EN TOTAL AUSENCIA DE HUMEDAD, Y, DESPUES DE AISLAR EL HEPTAKIS (HIDROGENO SULFATO) DE DIOSMINA RESULTANTE COMO SAL SODICA, SE TRATA ESTA CON UNA SOLUCION ACUOSA DE HIDROXICLORURO DE ALUMINIO. EL PRODUCTO ES DE UTILIDAD EN EL TRATAMIENTO DE LOS PROCESOS ULCEROSOS.
ES09200414A 1992-02-25 1992-02-25 Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina. Expired - Fee Related ES2041216B1 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES09200414A ES2041216B1 (es) 1992-02-25 1992-02-25 Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.
DK93500023T DK0558435T3 (da) 1992-02-25 1993-02-24 Sulfaterede diosminderivater
AT93500023T ATE184014T1 (de) 1992-02-25 1993-02-24 Sulfatierte diosminderivate
EP93500023A EP0558435B1 (en) 1992-02-25 1993-02-24 Sulfated diosmin derivative
ZA931300A ZA931300B (en) 1992-02-25 1993-02-24 New sulfated diosmin derivative
AU33787/93A AU661553B2 (en) 1992-02-25 1993-02-24 New sulfated diosmin derivative
FI930812A FI930812A (fi) 1992-02-25 1993-02-24 Ny sulfatiserad diosminderivat
CA002090301A CA2090301C (en) 1992-02-25 1993-02-24 New sulfated diosmin derivative
DE69326176T DE69326176T2 (de) 1992-02-25 1993-02-24 Sulfatierte Diosminderivate
KR1019930002682A KR100272646B1 (ko) 1992-02-25 1993-02-25 황산화 디오스민 유도체
US08/022,571 US5296469A (en) 1992-02-25 1993-02-25 New sulfated diosmin derivative
MX9301042A MX9301042A (es) 1992-02-25 1993-02-25 Nuevo derivado sulfatado de diosmina.
JP5036957A JPH069677A (ja) 1992-02-25 1993-02-25 新規硫酸化ジオスミン誘導体
NO930670A NO179709C (no) 1992-02-25 1993-02-25 Diosminheptakis(hydrogensulfat)-aluminiumkompleks
TW082102160A TW305845B (es) 1992-02-25 1993-03-23
GR990403065T GR3031972T3 (en) 1992-02-25 1999-11-29 Sulfated diosmin derivative.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09200414A ES2041216B1 (es) 1992-02-25 1992-02-25 Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.

Publications (2)

Publication Number Publication Date
ES2041216A1 ES2041216A1 (es) 1993-11-01
ES2041216B1 true ES2041216B1 (es) 1994-06-16

Family

ID=8276183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09200414A Expired - Fee Related ES2041216B1 (es) 1992-02-25 1992-02-25 Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.

Country Status (16)

Country Link
US (1) US5296469A (es)
EP (1) EP0558435B1 (es)
JP (1) JPH069677A (es)
KR (1) KR100272646B1 (es)
AT (1) ATE184014T1 (es)
AU (1) AU661553B2 (es)
CA (1) CA2090301C (es)
DE (1) DE69326176T2 (es)
DK (1) DK0558435T3 (es)
ES (1) ES2041216B1 (es)
FI (1) FI930812A (es)
GR (1) GR3031972T3 (es)
MX (1) MX9301042A (es)
NO (1) NO179709C (es)
TW (1) TW305845B (es)
ZA (1) ZA931300B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1975297A (en) * 1996-02-21 1997-09-10 Glycomed Incorporated Sialyl lewisx mimetics containing flavanoid backbones
ES2158774B1 (es) * 1999-04-12 2002-03-16 Faes Fabrica Espanola De Produ Nuevo procedimiento para la preparacion industrial de dosmalfato en povo.
US7034054B2 (en) * 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
WO2010076879A1 (ja) * 2009-01-03 2010-07-08 静岡県公立大学法人 硫酸化ｃ-配糖体及びその単離方法並びに合成方法
CN112188894B (zh) 2019-05-05 2023-12-08 广州新创忆药物临床研究有限公司 一种调节人体体重失衡的化合物、其组合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58513A (en) * 1978-12-04 1982-11-30 American Cyanamid Co Rutin poly(h-)sulfate salts and the preparation thereof
US4334058A (en) * 1979-07-31 1982-06-08 American Cyanamid Company Rutin poly(H--)sulfate salts and related compounds
US4414207A (en) * 1980-08-25 1983-11-08 American Cyanamid Company Rutin poly(H-)sulfate salts and related compounds
ES8707969A1 (es) * 1986-05-09 1987-10-01 Espanola Prod Quimicos Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas
IT1245371B (it) * 1991-03-28 1994-09-20 Geymonat Spa Derivati di flavoni, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
CA2090301C (en) 2000-04-11
NO930670L (no) 1993-08-26
ATE184014T1 (de) 1999-09-15
AU3378793A (en) 1993-08-26
ES2041216A1 (es) 1993-11-01
CA2090301A1 (en) 1993-08-26
FI930812A (fi) 1993-08-26
DE69326176D1 (de) 1999-10-07
NO930670D0 (no) 1993-02-25
DE69326176T2 (de) 2000-04-20
KR930017916A (ko) 1993-09-20
EP0558435B1 (en) 1999-09-01
TW305845B (es) 1997-05-21
NO179709B (no) 1996-08-26
KR100272646B1 (ko) 2000-11-15
GR3031972T3 (en) 2000-03-31
ZA931300B (en) 1993-12-20
FI930812A0 (fi) 1993-02-24
EP0558435A1 (en) 1993-09-01
JPH069677A (ja) 1994-01-18
US5296469A (en) 1994-03-22
MX9301042A (es) 1993-12-01
AU661553B2 (en) 1995-07-27
NO179709C (no) 1996-12-04
DK0558435T3 (da) 2000-03-27

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Effective date: 20010416

FD2A Announcement of lapse in spain

Effective date: 20110803