ES2032887T3 - Metodo para preparar emulsiones acuosas fluoroquimicas, estables y concentradas. - Google Patents

Metodo para preparar emulsiones acuosas fluoroquimicas, estables y concentradas.

Info

Publication number
ES2032887T3
ES2032887T3 ES198888104014T ES88104014T ES2032887T3 ES 2032887 T3 ES2032887 T3 ES 2032887T3 ES 198888104014 T ES198888104014 T ES 198888104014T ES 88104014 T ES88104014 T ES 88104014T ES 2032887 T3 ES2032887 T3 ES 2032887T3
Authority
ES
Spain
Prior art keywords
emulsion
stable
concentrated water
water emulsions
surgical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888104014T
Other languages
English (en)
Spanish (es)
Inventor
Frank Kenneth Schweighardt
Charles Randall Kayhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Products and Chemicals Inc
Original Assignee
Air Products and Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Products and Chemicals Inc filed Critical Air Products and Chemicals Inc
Application granted granted Critical
Publication of ES2032887T3 publication Critical patent/ES2032887T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Public Health (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)
ES198888104014T 1987-03-20 1988-03-14 Metodo para preparar emulsiones acuosas fluoroquimicas, estables y concentradas. Expired - Lifetime ES2032887T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/028,521 US4895876A (en) 1987-03-20 1987-03-20 Concentrated stable fluorochemical aqueous emulsions containing triglycerides

Publications (1)

Publication Number Publication Date
ES2032887T3 true ES2032887T3 (es) 1993-03-01

Family

ID=21843917

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888104014T Expired - Lifetime ES2032887T3 (es) 1987-03-20 1988-03-14 Metodo para preparar emulsiones acuosas fluoroquimicas, estables y concentradas.

Country Status (10)

Country Link
US (1) US4895876A (de)
EP (1) EP0282949B1 (de)
JP (1) JPS63264521A (de)
KR (1) KR900006830B1 (de)
BR (1) BR8801157A (de)
CA (1) CA1312011C (de)
DE (1) DE3871195D1 (de)
ES (1) ES2032887T3 (de)
MX (1) MX169411B (de)
ZA (1) ZA881953B (de)

Families Citing this family (55)

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US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US5514720A (en) * 1986-07-09 1996-05-07 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US4781676A (en) * 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
JPH0372423A (ja) * 1989-05-26 1991-03-27 Green Cross Corp:The パーフルオロカーボン化合物含有乳化製剤
EP0440925A1 (de) * 1989-12-13 1991-08-14 The Green Cross Corporation Aufbewahrungsflüssigkeit und Aufbewahrungsverfahren für innere Organe
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
AU648100B2 (en) * 1990-09-03 1994-04-14 Unilever Plc Hair treatment composition
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
WO1993002653A1 (en) * 1991-08-08 1993-02-18 Segel Leigh D Fluorocarbon blood substitute
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
WO1993005819A1 (en) * 1991-09-17 1993-04-01 Sonus Pharmaceuticals, Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
AU667847B2 (en) * 1991-11-14 1996-04-18 Alliance Pharmaceutical Corporation Method and apparatus for partial liquid ventilation using fluorocarbons
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
GB9204509D0 (en) * 1992-03-02 1992-04-15 Unilever Plc Hair care composition
US5628930A (en) * 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5595687A (en) 1992-10-30 1997-01-21 Thomas Jefferson University Emulsion stability
US5420359A (en) * 1992-12-11 1995-05-30 Minnesota Mining And Manufacturing Company Chlorofluoroether compositions and preparation thereof
DE69427185T2 (de) * 1993-01-25 2001-12-06 Sonus Pharmaceutical, Inc. Phase-Stift Kolloide zur Verwendung als Ultraschallkontrastmittel
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5635538A (en) * 1993-03-16 1997-06-03 Alliance Pharmaceutical Corp. Fluorocarbon emulsions with reduced pulmonary gas-trapping properties
US5969004A (en) * 1993-10-15 1999-10-19 The Gillette Company Aqueous inks
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5726209A (en) * 1995-06-07 1998-03-10 Alliance Pharmaceutical Corp. Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir
US6521211B1 (en) * 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ES2305368T3 (es) * 2002-05-10 2008-11-01 THE PROCTER & GAMBLE COMPANY Tisu estampado en relieve que tiene fibras superficiales sueltas y metodo para su produccion.
GB0319500D0 (en) * 2003-08-19 2003-09-17 Resolution Chemicals Ltd Particle-size reduction apparatus,and use thereof
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20070149617A1 (en) 2005-11-14 2007-06-28 Deckelbaum Richard J Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
WO2007134304A1 (en) * 2006-05-15 2007-11-22 Virginia Commonwealth University Methods and compositions for controlled and sustained production and delivery of peroxides
US8410181B2 (en) 2006-09-19 2013-04-02 The Trustees Of Columbia University In The City Of New York Omega-3 diglyceride emulsions
US8618056B2 (en) 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
CA2729597C (en) * 2008-07-18 2018-01-16 Oxygen Biotherapeutics, Inc. Method of treating traumatic brain injury
US20100144597A1 (en) * 2008-12-10 2010-06-10 Ward Kevin R Novel combinatorial approaches to enhancing oxygen transport to tissues
US20100267842A1 (en) * 2009-04-15 2010-10-21 Richard Kiral Emulsions of Perfluorocarbons
SG183878A1 (en) * 2010-03-19 2012-10-30 Oxygen Biotherapeutics Inc Perfluorocarbon eye cream formulations
CN103491976B (zh) * 2011-01-14 2015-04-01 卡思伯特·O·辛普金斯 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物
US20120196270A1 (en) * 2011-02-02 2012-08-02 Sangart, Inc. Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex
EP2978307B1 (de) * 2013-03-28 2018-12-26 The Trustees of Columbia University in the City of New York Reperfusion mit omega-3-glyceriden zur förderung eines spenderorganschutzes für transplantationen
WO2024046999A1 (de) 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Lecithin-modifizierte nanoskalierte sauerstoffträger (lenox)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331209B2 (de) * 1973-10-05 1978-09-01
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
JPS5331208A (en) * 1976-09-02 1978-03-24 Matsushita Electric Ind Co Ltd Lubricator for closed compressor and the like
JPS5924132B2 (ja) * 1980-12-02 1984-06-07 株式会社 林原生物化学研究所 栄養補給用乳剤の製法
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4497829A (en) * 1982-07-27 1985-02-05 The University Of Pennsylvania Process for preparing perfluorochemical emulsion artificial blood
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
JPS6033367A (ja) * 1983-08-04 1985-02-20 Nec Corp アルミニウムのドライエッチング方法
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
SE8505048L (sv) * 1985-10-25 1987-04-26 Nutritional Int Res Inst Nutritionsemulsion med syretransporterande egenskaper
EP0231091B1 (de) * 1986-01-24 1993-03-31 Children's Hospital Medical Center Stabile Emulsionen von stark fluorierten, organischen Verbindungen
US4781676A (en) * 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions

Also Published As

Publication number Publication date
DE3871195D1 (de) 1992-06-25
US4895876A (en) 1990-01-23
MX169411B (es) 1993-07-02
JPS63264521A (ja) 1988-11-01
KR900006830B1 (ko) 1990-09-22
EP0282949A3 (en) 1989-08-09
KR880010755A (ko) 1988-10-24
EP0282949A2 (de) 1988-09-21
EP0282949B1 (de) 1992-05-20
BR8801157A (pt) 1988-10-18
ZA881953B (en) 1989-11-29
CA1312011C (en) 1992-12-29

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