EP4676332A1 - Ph sensor for stoma dejecta - Google Patents

Ph sensor for stoma dejecta

Info

Publication number
EP4676332A1
EP4676332A1 EP24717439.4A EP24717439A EP4676332A1 EP 4676332 A1 EP4676332 A1 EP 4676332A1 EP 24717439 A EP24717439 A EP 24717439A EP 4676332 A1 EP4676332 A1 EP 4676332A1
Authority
EP
European Patent Office
Prior art keywords
dejecta
stoma
sensor device
mfc
anode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24717439.4A
Other languages
German (de)
French (fr)
Inventor
Mallory BRODNIK
Riley FORST
Luke TEASLEY
Mustafa Guler
Terry Johnson
Adrian P. Defante
Abram D. Janis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hollister Inc
Original Assignee
Hollister Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hollister Inc filed Critical Hollister Inc
Publication of EP4676332A1 publication Critical patent/EP4676332A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/44—Devices worn by the patient for reception of urine, faeces, catamenial or other discharge; Colostomy devices
    • A61F5/445—Colostomy, ileostomy or urethrostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M8/00—Fuel cells; Manufacture thereof
    • H01M8/16—Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts

Definitions

  • the present disclosure relates to pH sensors, and more particularly to pH sensors for stoma dejecta.
  • Human dejecta contains various bio-physio-chemical markers that can provide insight into the health condition of a person.
  • Studies have shown links between pH of fecal matter and diseases. For example, a significantly increased correlation between mortality and bacteremia percentages has been shown in patients with an overly acidic or basic fecal matter.
  • the pH of a healthy human’s feces is typically about 6.6 and sits slightly acidic as a result of the fermentation of sugars and the production of fatty acids in the human digestive system.
  • beneficial bacteria tend to prefer slightly acidic gut microbiomes whereas harmful bacteria prefer a more basic environment.
  • the proton exchange that occurs in many biochemical reactions conducted by bacteria serve as a method with which they alter and control the pH of their environment.
  • the population of harmful bacteria grows as the population of beneficial bacteria decreases.
  • the gastrointestinal pH and its effect on the bacterial population can impact absorption of vitamins, electrolytes, and activities of digestive enzymes.
  • Ostomy surgery such as urostomy, colostomy, and ileostomy
  • a stoma is created in patient’s abdomen and connected to the urinary or digestive system to allow body waste to egress therethrough.
  • Ostomates typically wear an ostomy pouch for collecting body waste (also referred to herein as stoma dejecta) attached to the peristomal skin via an ostomy skin barrier appliance.
  • Stoma dejecta does not travel through the full gastrointestinal tract, and thus, levels of biomarkers in stoma dejecta can be different than those of a healthy person’s dejecta.
  • the sensor device may also include an ion detecting device configured to detect ions in stoma dejecta.
  • the MFC-based biosensor that detects H + ions may be replaced with another ion-selective MFC-based biosensor.
  • the pH indicator may be a universal pH indicator configured to change color along the full range of pH from about 1 to about 14.
  • the universal pH indicator may be formed from a mixture of Methyl Red, Phenolphthalein, Ethanol, Bromothymol Blue, and NaOH.
  • the pH indicator may be configured to change color along a range of pH from about 4 to about 10.
  • an ostomy appliance may comprise a pouch configured to collect stoma dejecta, a skin barrier appliance configured to attach the pouch to user’s skin, and the sensor device of any of the foregoing embodiments.
  • the sensor device may be arranged in the pouch.
  • the sensor device may be attached to an inner surface of the pouch.
  • the sensor device 16 may be configured to measure electric current generated in the MFC when electrochemically active microorganisms (EAMs) in the MFC catalyze degradation of organic compounds, and correlate the electric current measurements to a pH level or a change in pH level of stoma dejecta.
  • EAMs electrochemically active microorganisms
  • the electrons may be captured by the anode 104 and travel to the cathode 108 through an external circuit 112. Protons may migrate to the cathode chamber 106 through the PEM 110 to keep a charge balance. In the cathode chamber 106, oxygen (O2) may act as electron acceptor to form water (H2O) byproduct.
  • O2 oxygen
  • H2O water
  • the sensor device 16 may be configured to allow stoma dejecta to flow into the anode chamber 102 and measure electric current generated in the MFC 100 and correlate the electric current measurements to a pH level or a change in pH level of stoma dejecta.
  • the sensor device 16 may include an MFC-based biosensor configured to measure pH or detect a change in pH of stoma dejecta collected in the ostomy pouch 12.
  • FIG. 3 is a schematic illustration of a MFC-based biosensor 200 according to an embodiment.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Energy (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Sustainable Development (AREA)
  • Manufacturing & Machinery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nursing (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A sensor device for measuring pH of stoma dejecta includes a microbial fuel cell (MFC). The sensor device measures electric current generated in the MFC and analyzes the electric current measurements to determine pH of stoma dejecta or a change in pH of stoma dejecta.

Description

pH SENSOR FOR STOMA DEJECTA
BACKGROUND
[0001] The present disclosure relates to pH sensors, and more particularly to pH sensors for stoma dejecta.
[0002] Human dejecta contains various bio-physio-chemical markers that can provide insight into the health condition of a person. Studies have shown links between pH of fecal matter and diseases. For example, a significantly increased correlation between mortality and bacteremia percentages has been shown in patients with an overly acidic or basic fecal matter. The pH of a healthy human’s feces is typically about 6.6 and sits slightly acidic as a result of the fermentation of sugars and the production of fatty acids in the human digestive system.
[0003] Research regarding pH of feces and gastrointestinal tract has also illuminated a relationship between colorectal cancer and fecal pH. It has been shown that higher levels of colonic pH can promote carcinogen creation from bile acids, which leads to initiating and progressing of colorectal cancer. Population studies have shown that patients without colon cancer exhibit a fecal pH of 6.6 ± 0.44 whereas patients with colon cancer have a fecal pH of 8.0 ± 0.44.
[0004] Further, it is well documented that beneficial bacteria tend to prefer slightly acidic gut microbiomes whereas harmful bacteria prefer a more basic environment. The proton exchange that occurs in many biochemical reactions conducted by bacteria serve as a method with which they alter and control the pH of their environment. As such, the population of harmful bacteria grows as the population of beneficial bacteria decreases. Further, the gastrointestinal pH and its effect on the bacterial population can impact absorption of vitamins, electrolytes, and activities of digestive enzymes.
[0005] Ostomy surgery, such as urostomy, colostomy, and ileostomy, is a medical procedure where an opening known as a stoma is created in patient’s abdomen and connected to the urinary or digestive system to allow body waste to egress therethrough. Ostomates typically wear an ostomy pouch for collecting body waste (also referred to herein as stoma dejecta) attached to the peristomal skin via an ostomy skin barrier appliance. Stoma dejecta does not travel through the full gastrointestinal tract, and thus, levels of biomarkers in stoma dejecta can be different than those of a healthy person’s dejecta. However, current studies about gastrointestinal pH have been mostly limited to people with the full gastrointestinal track anatomy. Similarly, studies of urine pH have been mostly limited to subjects with bladders. The knowledge of the pH and/or ionic composition in urine from urostomy patients and other stoma dejecta can provide valuable information and biomarkers that can be used to monitor the health of ostomates and improve treatments and/or to assess and monitor disease progressions.
[0006] Thus, there is a need for a device for measuring pH of stoma dejecta for data collection in stoma dejecta research and for monitoring of the health of ostomates.
BRIEF SUMMARY
[0007] In one aspect, a sensor device for measuring pH of stoma dejecta includes a microbial fuel cell (MFC). The sensor device may be configured to measure electric current generated in the MFC and analyze the electric current measurements to determine pH of stoma dejecta or a change in pH of stoma dejecta.
[0008] In an embodiment, the MFC may comprise an anode chamber including an anode, a cathode chamber including a cathode, and a proton exchange membrane (PEM) separating the two chambers and configured to allow protons to migrate from the anode chamber to the cathode chamber. In such an embodiment, the sensor device may be configured to allow stoma dejecta containing electrochemically active microorganisms (EAMs) and organic compounds to flow into the anode chamber. The anode may be configured to capture electrons generated when the EAMs oxidize the organic compounds.
[0009] In an embodiment, the MFC may be an MFC-based biosensor. The MFC-based biosensor may comprise an anodic chamber including an anode and a biofilm comprising EAMs arranged in contact with the anode. The anode may be configured to capture electrons generated when the EAMs in the biofilm oxidize the organic compounds in the anodic chamber. The sensor device may be configured to allow stoma dejecta to flow into the anodic chamber. In some embodiments, the MFC-based biosensor may be configured such that an electron flow rate from the biofilm to the anode is influenced by pH of the stoma dejecta that comes in contact with the biofilm. For example, the MFC-based biosensor may be configured such that the electron flow rate increases as the pH of stoma dejecta increases. In another example, the MFC-based biosensor may be configured such that the electron flow rate decreases as the pH of stoma dejecta increases. [0010] In an embodiment, the MFC-based biosensor may comprise an anodic chamber including an anode and stoma dejecta in contact with the anode. The anode may be configured to capture electrons generated when the EAMs in the stoma dejecta oxidize the organic compounds in the anodic chamber.
[0011] In an embodiment, the sensor device may also include a data acquisition member configured to receive electric current signal from the MFC-based biosensor and analyze the electric current signal to determine pH of stoma dejecta or a change in pH of stoma dejecta. The data acquisition member may be configured to transmit stoma dejecta pH data to an external computer for data logging, data analysis and display.
[0012] In any of the foregoing embodiments, the EAMs may be gram-negative bacteria, such as, but not limited to, E. coli, Pseudomonas, Proteus, and Enterobacter . In an embodiment, the EAMs are E. coll and the organic compounds are acetate.
[0013] In some embodiments, the sensor device may also include an ion detecting device configured to detect ions in stoma dejecta. In an embodiment, the MFC-based biosensor that detects H+ ions may be replaced with another ion-selective MFC-based biosensor.
[0014] In another aspect, a sensor device for stoma dejecta may comprise a pH indicator configured to measure pH of stoma dejecta and an ion detecting device configured to detect ions in stoma dejecta.
[0015] In an embodiment, the pH indicator may be a universal pH indicator configured to change color along the full range of pH from about 1 to about 14. The universal pH indicator may be formed from a mixture of Methyl Red, Phenolphthalein, Ethanol, Bromothymol Blue, and NaOH. In another embodiment, the pH indicator may be configured to change color along a range of pH from about 4 to about 10.
[0016] In yet another aspect, an ostomy appliance may comprise a pouch configured to collect stoma dejecta, a skin barrier appliance configured to attach the pouch to user’s skin, and the sensor device of any of the foregoing embodiments. The sensor device may be arranged in the pouch. In an embodiment, the sensor device may be attached to an inner surface of the pouch.
[0017] The foregoing general description and the following detailed description are examples only and are not restrictive of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] The benefits and advantages of the present embodiments will become more readily apparent to those of ordinary skill in the relevant art after reviewing the following detailed description and accompanying drawings, wherein:
[0019] FIG. 1 is a schematic cross-sectional view of an ostomy appliance comprising a sensor device according to an embodiment;
[0020] FIG. 2 is a schematic illustration of a MFC for the sensor device of FIG. 1 according to an embodiment;
[0021] FIG. 3 is a schematic illustration of a MFC-based biosensor for the sensor device of FIG. 1 according to another embodiment; and
[0022] FIG. 4 is a schematic illustration of an ion detector according to an embodiment.
DETAILED DESCRIPTION
[0023] While the present disclosure is susceptible of embodiment in various forms, there is shown in the drawings and will hereinafter be described presently preferred embodiments with the understanding that the present disclosure is to be considered an exemplification and is not intended to limit the disclosure to the specific embodiments illustrated. The words “a” or “an” are to be taken to include both the singular and the plural. Conversely, any reference to plural items shall, where appropriate, include the singular. The words “first,” “second,” “third,” and the like may be used in the present disclosure to describe various information, such information should not be limited to these words. These words are only used to distinguish one category of information from another. The directional words “top,” “bottom,” up,” “down,” front,” “back,” and the like are used for purposes of illustration and as such, are not limiting. Depending on the context, the word “if’ as used herein may be interpreted as “when” or “upon” or “in response to determining.”
[0024] FIG. 1 is a schematic cross-sectional illustration of an ostomy appliance 10 generally comprising an ostomy pouch 12, an ostomy wafer 14, and a sensor device 16 for measuring pH of stoma dejecta according to an embodiment. In the embodiment of FIG. 1, the sensor device 16 may be attached to an inner surface of a pouch wall. In other embodiments, the sensor device 16 may be arranged in the ostomy pouch 12 and unattached. [0025] In an embodiment, the sensor device 16 may include a microbial fuel cell (MFC) and configured to measure pH or detect a change in pH of stoma dejecta collected in the ostomy pouch 12. The sensor device 16 may be configured to measure electric current generated in the MFC when electrochemically active microorganisms (EAMs) in the MFC catalyze degradation of organic compounds, and correlate the electric current measurements to a pH level or a change in pH level of stoma dejecta.
[0026] FIG. 2 is a schematic illustration of a MFC 100 for the sensor device 16 according to an embodiment. The MFC 100 may comprise an anode chamber 102 including an anode 104, a cathode chamber 106 including a cathode 108, and a proton exchange membrane (PEM) 110 separating the two chambers. The PEM 110 may be configured to allow protons (H+) to migrate from the anode chamber 102 to the cathode chamber 106 while preventing oxygen diffusion into the anode chamber 102. In the MFC 100, EAMs in the anode chamber 102 may generate electrons (e‘) and protons (H+) by oxidizing organic compounds. The electrons may be captured by the anode 104 and travel to the cathode 108 through an external circuit 112. Protons may migrate to the cathode chamber 106 through the PEM 110 to keep a charge balance. In the cathode chamber 106, oxygen (O2) may act as electron acceptor to form water (H2O) byproduct.
[0027] Suitable EAMs may include, but are not limited to, gram-negative bacteria, such as E. coli, Pseudomonas, Proteus, Enterobacter , which may be found in feces and stoma dejecta. In an embodiment, the MFC 100 may be configured to utilize E. coll as EAMs and acetate as organic compounds, which may also be found in feces and stoma dejecta.
[0028] In an embodiment, the sensor device 16 may be configured to allow stoma dejecta to flow into the anode chamber 102 and measure electric current generated in the MFC 100 and correlate the electric current measurements to a pH level or a change in pH level of stoma dejecta. [0029] In an embodiment, the sensor device 16 may include an MFC-based biosensor configured to measure pH or detect a change in pH of stoma dejecta collected in the ostomy pouch 12. FIG. 3 is a schematic illustration of a MFC-based biosensor 200 according to an embodiment. The MFC-based biosensor 200 may include an anodic chamber 202 comprising an anode 204 and a biofilm 214 containing EAMs arranged in contact with the anode 204. In such an embodiment, the biofilm 214 may function as a bioreceptor and the anode 204 may functionas a transducer. In the MFC-based biosensor 200, organic compounds 216, such as acetate, may be provided to the biofilm 214, wherein EAMs in the biofilm 214 may oxidize the organic compounds 216 and generate electrons (e‘), which are captured by the anode 204. The sensor device 16 may further include a data acquisition member 218 configured to receive electric current signal from the MFCbased biosensor 200 and analyze the electric current signal to determine pH or detect a change in pH of stoma dejecta. The data acquisition member 218 may be configured to transmit data to a computer 220 configured for data logging, data analysis and display.
[0030] In an embodiment, the sensor device 16 may be configured to allow stoma dejecta to flow into the anodic chamber 202. The MFC-based biosensor 200 may be configured such that eletron flow rate from the biofilm 214 to the anode 204 may be influenced by pH of stoma dejecta D that come in contact with the biofilm 214. For example, the electron flow rate may increase as the pH of stoma dejecta increases. In another example, the electron flow rate may decrease as the pH of stoma dejecta increases. In such embodiments, the data acquisition member 218 may be configured to receive electric current signal generated in the MFC-based biosensor 200 and correlate the electric current signal to a pH level or a change in pH level of stoma dejecta.
[0031] In an embodiment, the sensor device 16 may include an MFC-based biosensor configured to measure pH or detect a change in pH of stoma dejecta collected in the ostomy pouch 12. The MFC-based biosensor may be configured similar to the MFC-based biosensor 200 generally comprising an anodic chamber 202 including an anode 204. In this embodiment, the biofilm 214 may be omitted and the anodic chamber may be configured to receive stoma dejecta, wherein the anode may be arranged to be in contact with the stoma dejecta received in the anodic chamber. The anode may be configured to capture eletrons generated when EAMs in the stoma dejecta oxidize organic compounds in the anodic chamber.
[0032] In an embodiment, the sensor device 16 may comprise a universal pH indicator configured to change color along the full pH range (pH 1 - pH 14). In such an embodiment, a user may be provided with a pH color scale for comparing the color of the sensor device 16 after the sensor device 16 has been exposed to stoma dejecta to determine the pH level of stoma dejecta. The universal pH indicator may be formed from a mixture of Methyl Red, Phenolphthalein, 95% Ethanol Solution, Bromothymol Blue, and 0.1 M NaOH.
[0033] In another embodiment, the sensor device 16 may comprise a pH indicator configured to change color only along a range of pH from about 4 to about 10 as detection of extreme pH levels may not be necessary when measuring stoma dejecta.
[0034] In some embodiments, the sensor device 16 may also include an ion detecting device configured to detect ions in stoma dejecta. FIG. 4 is a schematic illustration of an ion detecting device 300 according to an embodiment. The ion detecting device 300 may generally comprise an inlet 302 configure to receive stoma dejecta, an electron beam source 304, a heater 306 configured to vaporize the stoma dejecta, an ion accelerator 308, a magnet 310 configured to deflect ions, wherein lighter ions are deflected more, and an ion detector 312.
[0035] From the foregoing it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present disclosure. It is to be understood that no limitation with respect to the specific embodiments illustrated is intended or should be inferred. The disclosure is intended to cover by the appended claims all such modifications as fall within the scope of the claims.

Claims

CLAIMS What is claimed is:
1. A sensor device for measuring pH of stoma dejecta, the sensor device comprising a microbial fuel cell (MFC), wherein the sensor device is configured to measure electric current generated in the MFC and analyze the electric current measurements to determine pH of stoma dejecta or a change in pH of stoma dejecta.
2. The sensor device of claim 1, wherein the MFC comprises an anode chamber including an anode, a cathode chamber including a cathode, and a proton exchange membrane (PEM) separating the two chambers, wherein the PEM is configured to allow protons to migrate from the anode chamber to the cathode chamber.
3. The sensor device of claim 2, wherein the sensor device is configured to allow stoma dejecta to flow into the anode chamber, wherein the stoma dejecta contains electrochemically active microorganisms (EAMs) and organic compounds, wherein the anode is configured to capture electrons generated when the EAMs oxidize the organic compounds.
4. The sensor device of claim 1, wherein the MFC is an MFC-based biosensor comprising an anodic chamber including an anode and a biofilm arranged in contact with the anode, wherein the biofilm comprises EAMs, wherein the anode is configured to capture electrons generated when the EAMs in the biofilm oxidize the organic compounds in the anodic chamber.
5. The sensor device of claim 4, wherein the sensor device is configured to allow stoma dejecta to flow into the anodic chamber, wherein the MFC-based biosensor is configured such that an electron flow rate from the biofilm to the anode is influenced by pH of the stoma dejecta that comes in contact with the biofilm.
6. The sensor device of claim 5, wherein the MFC-based biosensor is configured such that the electron flow rate increases as the pH of stoma dejecta increases.
7. The sensor device of claim 5, wherein the MFC-based biosensor is configured such that the electron flow rate decreases as the pH of stoma dejecta increases.
8. The sensor device of any one of claims 4-7, wherein the sensor device further includes a data acquisition member configured to receive electric current signal from the MFCbased biosensor and analyze the electric current signal to determine pH of stoma dejecta or a change in pH of stoma dejecta.
9. The sensor device of claim 8, wherein the data acquisition member is configured to transmit stoma dejecta pH data to an external computer for data logging, data analysis and display.
10. The sensor device of any one of claims 3-9, wherein the EAMs are gram-negative bacteria.
11. The sensor device of any one of claims 3-9, wherein the EAMs are selected from a group consisting of E. coli, Pseudomonas, Proteus, and Enterobacter.
12. The sensor device of any one of claims 3-9, wherein the EAMs are E. coli and the organic compounds are acetate.
13. The sensor device of any one of claims 1-12, further comprising an ion detecting device configured to detect ions in stoma dejecta.
14. A sensor device for stoma dejecta comprising a pH indicator configured to measure pH of stoma dejecta and an ion detecting device configured to detect ions in stoma dejecta.
15. The sensor device of claim 14, wherein the pH indicator is a universal pH indicator configured to change color along a full range of pH from about 1 to about 14, wherein the universal pH indicator is formed from a mixture of Methyl Red, Phenolphthalein, Ethanol, Bromothymol Blue, and NaOH.
16. The sensor device of claim 14, wherein the pH indicator is configured to change color along a range of pH from about 4 to about 10.
17. The sensor device of any one of claims 14-16, wherein the ion detecting device comprises an inlet configure to receive stoma dejecta, an electron beam source, a heater configured to vaporize the stoma dejecta, an ion accelerator, a magnet configured to deflect ions, and an ion detector.
18. An ostomy appliance comprising: a pouch configured to collect stoma dejecta; a skin barrier appliance configured to attach the pouch to user’s skin; and the sensor device of any one of claims 1-17 arranged in the pouch.
19. The ostomy appliance of claim 18, wherein the sensor device is attached to an inner surface of the pouch.
20. The ostomy appliance of claim 18, wherein the sensor device is arranged in the pouch unattached to the pouch.
EP24717439.4A 2023-03-09 2024-03-07 Ph sensor for stoma dejecta Pending EP4676332A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363489271P 2023-03-09 2023-03-09
US202363489285P 2023-03-09 2023-03-09
PCT/US2024/018813 WO2024186970A1 (en) 2023-03-09 2024-03-07 Ph sensor for stoma dejecta

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CN120549531B (en) * 2025-07-29 2025-10-21 浙江大学医学院附属第一医院(浙江省第一医院) AI vision stoma seepage early warning system

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