EP4648689A1

EP4648689A1 - Guidewires configured for clot and occlusion material compositional analysis

Info

Publication number: EP4648689A1
Application number: EP23704028.2A
Authority: EP
Inventors: Marvin Clyde C. VERGARA
Original assignee: Bard Peripheral Vascular Inc
Current assignee: Bard Peripheral Vascular Inc
Priority date: 2023-01-09
Filing date: 2023-01-09
Publication date: 2025-11-19
Also published as: WO2024151300A1

Abstract

A guidewire includes an emitter optical fiber that extends through an optical fiber lumen. The emitter optical fiber is configured to deliver radiation. A collector optical fiber extends through the optical fiber lumen. The collector optical fiber is configured to collect radiation for use in diffuse reflectance spectroscopy to analyze a clot material composition. An emitter lens is positioned in the optical fiber lumen and covering a first portion of the distal terminal end of the optical fiber lumen. The emitter lens is configured to direct radiation from the emitter optical fiber toward the area of the body lumen path. A collector lens is positioned in the optical fiber lumen and covers a second portion of the distal terminal end of the optical fiber lumen. The collector lens is configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

Description

GUIDEWIRES CONFIGURED FOR CEOT AND OCCLUSION MATERIAL COMPOSITIONAL ANALYSIS

TECHNICAL FIELD

[0001] The present specification generally relates to catheter systems, guidewires and methods for analyzing clot and occlusion materials and, more specifically, to guidewires that can be used to perform spectroscopy analysis of clot and occlusion compositions.

BACKGROUND

[0002] Strokes are typically broken down in to two main classifications, ischemic and hemorrhagic. Ischemic strokes occur as a blood vessel in the brain becomes blocked resulting in impaired blood flow, oxygen, and nutrient supply. Ischemic strokes can be broken down in to further groups, thrombotic and embolic strokes. Thrombotic strokes result from blood clots that develop in blood vessels in the brain. Embolic strokes result from blood clots or plaque that develop somewhere else in the body and travels to the brain. Recent advances in technology in the thrombectomy space has shown success in removing or dissolving these occlusions or clots before they can reach the brain or cut off a large amount of blood flow, oxygen, and nutrients. A highly important step prior to removing the clot or occlusion is understanding the clot material composition in order to appropriately proceed with the proper treatment. Current technologies in the angiography space, with advancements in CT and MR (magnetic resonance) angiography, has helped physicians identify and understand locations of clots. But these technologies are still limited and may not provide any further assessment of clot composition.

SUMMARY

[0003] According to a first embodiment, a guidewire for a catheter system includes a guidewire body suitable for insertion into an occluded body lumen. The guidewire body has an optical fiber lumen extending therethrough. An emitter optical fiber extends through the optical fiber lumen. The emitter optical fiber is configured to deliver radiation to a distal terminal end of the optical fiber lumen. A collector optical fiber extends through the optical fiber lumen. The collector optical fiber is configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition. An emitter lens is positioned in the optical fiber lumen and covering a first portion of the distal terminal end of the optical fiber lumen. The emitter lens is configured to direct radiation from the emitter optical fiber toward the area of the body lumen path. A collector lens positioned in the optical fiber lumen and covering a second portion of the distal terminal end of the optical fiber lumen, the collector lens configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

[0004] According to another embodiment, a method of forming a guidewire for use in delivering and collecting radiation to and from an area of a body lumen path for diffuse reflectance spectroscopy is provided. The method includes placing an emitter optical fiber within an optical fiber lumen of a guidewire body. The emitter optical fiber is configured to deliver radiation to a distal terminal end of the optical fiber lumen. A collector optical fiber is placed within the optical fiber lumen of the guidewire body. The collector optical fiber is configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition. An emitter lens is placed in the optical fiber lumen and covers a first portion of the distal terminal end. The emitter lens is configured to direct radiation from the emitter optical fiber toward the area of the body lumen path. A collector lens is placed in the optical fiber lumen and covers a second portion of the distal terminal end. The collector lens is configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

[0005] These and additional features provided by the embodiments described herein will be more fully understood in view of the following detailed description, in conjunction with the drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

[0006] The embodiments set forth in the drawings are illustrative and exemplary in nature and not intended to limit the subject matter defined by the claims. The following detailed description of the illustrative embodiments can be understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which:

[0007] FIG. 1 schematically depicts a clot analysis system including guidewire configured to emit and collect light energy, according to one or more embodiments shown and described herein; [0008] FIG. 2 schematically depicts a distal end portion of a guidewire with lens array, according to one or more embodiments shown and described herein;

[0009] FIG. 3 schematically depicts a side section view of the guidewire of FIG. 2, according to one or more embodiments shown and described herein;

[0010] FIG. 4 schematically depicts a distal end portion of a guidewire with lens array, according to one or more embodiments shown and described herein;

[0011] FIG. 5 schematically depicts a side section view of the guidewire of FIG. 4, according to one or more embodiments shown and described herein;

[0012] FIG. 6 schematically depicts a distal end portion of a guidewire with lens array, according to one or more embodiments shown and described herein; and

[0013] FIG. 7 schematically depicts a side section view along line 7-7 of FIG. 6, according to one or more embodiments shown and described herein;

DETAILED DESCRIPTION

[0014] Embodiments described herein are generally directed to guidewires for clot analysis systems that are configured for use in analyzing clot and occlusion materials. The guidewires include a guidewire body suitable for insertion into an occluded body lumen. The guidewire body includes an optical fiber lumen extending therethrough. Located within the optical fiber lumen are an emitter optical fiber and a collector optical fiber. The emitter optical fiber is configured to deliver radiation to a distal terminal end of the optical fiber lumen. The collector optical fiber is configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition. An emitter lens is positioned in the optical fiber lumen and covers a first portion of the distal terminal end of the optical fiber lumen. The emitter lens is configured to direct radiation from the emitter optical fiber toward the area of the body lumen path. A collector lens is positioned in the optical fiber lumen and covers a second portion of the distal terminal end of the optical fiber lumen. The collector lens is configured to deliver radiation from the area of the body lumen path to the collector optical fiber. [0015] The ability to diagnose clot and occlusion types is an important step in determining treatment. Clot and occlusion types include those that include fibrin, red blood cells (RBC) and mixtures thereof. As used herein, the terms “clot” and “occlusion” are used interchangeably. Further, the ability to identify surrounding tissue, such as a vessel wall, can also be helpful in diagnosing and removing clots. The guidewires described herein are medical devices that carry one or more optical fibers that are used to deliver radiation from a radiation source and collect the radiation that is scattered by the tissue. The collected radiation is then delivered to a spectrometer for a diffuse spectroscopy (DRS) analysis. The DRS analysis can provide data, such as wavelength versus intensity data of the collected radiation that can be used to identify clot types automatically using selection parameters, e.g., of intensity at selected wavelengths, or manually.

[0016] Referring to FIG. 1, a clot analysis system 10 includes a disposable subassembly 12 and a non-disposable subassembly 14. The disposable subassembly 12 includes a guidewire 16 that includes a guidewire body 18 that is suitable for insertion into and through a body lumen 20 proximate an occlusion 22. The guidewire body 18 includes an optical fiber lumen 24 extending therethrough that provides a pathway for optical fibers 26 and 28, the optical fiber 26 being an emitter optical fiber and the optical fiber 28 being a collector optical fiber. The emitter optical fiber 26 is configured to deliver radiation to a distal terminal end 30 of the optical fiber lumen 24. The collector optical fiber 28 is configured to collect radiation from an area of a body lumen path 32 for use in diffuse reflectance spectroscopy to analyze a clot material composition of occlusion 22. The guidewire 16 may be configured to be transferred through the anatomy itself or using a delivery catheter or another suitable medical device, for example, for providing both analysis and treatment functions.

[0017] Any suitable optical fibers may be used including various cores, claddings, and jackets. In some embodiments, multimode optical fibers may be used having numerical apertures between approximately 0.06 and 0.41. Emitter optical fibers with core diameters from about 10 to about 100 microns and collector optical fibers with core diameters from about 50 to about 200 microns may be used.

[0018] Located at the distal terminal end 30 of the guidewire body 18 is a lens array 33. The lens array 33 includes an emitter lens 34 and a collector lens 36. The emitter lens 34 is positioned in the optical fiber lumen 24 and covers a first portion 38 of the distal terminal end 30 of the optical fiber lumen 24. The emitter lens 34 is configured to direct radiation from the emitter optical fiber 26 toward the area of the body lumen path 32. The collector lens 28 is positioned in the optical fiber lumen 24 and covers a second portion 40 of the distal terminal end 30 of the optical fiber lumen 24. The collector lens 36 is configured to collect and deliver radiation from the area of the body lumen path 32 to the collector optical fiber 28. The emitter lens 34 and the collector lens 36 can be selected to improve both the delivery of light to the area of the body lumen path 32 and the collection of the scattered light from the area of the body lumen path 32 using two different lens structures.

[0019] Any suitable lenses may be used for the emitter lens 34 and the collector lens 36. Additional lenses may also be used in order to direct, focus and collect light energy. For example, the collector lens 36 and/or emitter lens 34 may include a collimator for aligning the light rays. Converging lenses may be used to focus light energy at a particular location. Diverging lenses may be used to spread light energy. The lenses 34 and 36 may be provided with coatings that may be formed of same or different compositions. The coatings may be configured to separate the emitting and collecting functions in order to reduce interference.

[0020] The emitter optical fiber 26 is coupled to a light source 41. The light source 41 may be part of a spectroscopy system 42 that includes the light source 41 and one or more spectrometers 44. The light source 41 may be configured to provide energy in a wavelength range from about 200 to about 2500 nanometers, such as in the visible wavelength range of from about 380 to about 750 nanometers, the ultraviolet wavelength range of from about 100 to about 400 nanometers and or the near-infrared wavelength range of from about 800 to about 2500 nanometers. The wavelength can be selected depending, at least in part, on the type of tissues being analyzed. For example, at certain wavelengths RBC clots, fibrin clots, mixtures of RBC and fibrin clots, blood and vessel wall may exhibit different light scatter intensities detectable in a spectroscopy analysis.

[0021] The collector optical fiber 28 is coupled to the spectrometer 44. While not shown, where a single optical fiber is used for both emitting and collecting the light energy, a splitter (represented by element 46) may be provided to split a light beam into multiple light beams so as to both emit light from the light source 41 and to provide collected light to the spectrometer 44. The spectrometer 44, for example, may be provided as part of or connected to a computing device 48 (e.g., a computer, tablet, smartphone, etc.) that includes software saved in memory that is configured to provide measurement output (e.g., on display 50). An exemplary spectrometer and associated software package is commercially available from Ocean Insight, Orlando FL.

[0022] FIGS. 2-7 illustrate guidewire embodiments with different lens array configurations. Referring first to FIGS. 2 and 3, an embodiment of a guidewire 100 includes a guidewire body 102 that includes an optical fiber lumen 104 extending therethrough (FIG. 3). The guidewire 100 includes an emitter optical fiber 106 and multiple collector optical fibers 108 that extend through the optical fiber lumen 104. The emitter optical fiber 106 is optically coupled to an emitter lens 110 and the director optical fibers 108 are optically connected to a collector lens 112. Any suitable methods may be used to optically couple the fibers 106 and 108 to the lenses 110 and 112, such as using an optical adhesive. Further, each optical fiber 106, 108 may extend through its own respective dedicated sub-lumen 114 extending through the guidewire body 102. As noted above, the lenses 110 and 112 may be configured to reshape light exiting the emitter optical fiber 106 and entering the collector optical fiber 108 in order to improve the emitting and collecting functions of the optical fibers 106 and 108 compared to if the lens array 115 is absent.

[0023] In the illustrated embodiment of FIG. 2 showing a distal terminal end portion 116 of the guidewire 100, the collector lens 112 is concentric with the emitter lens 110. A support structure 118, in this case a support cylinder, is provided, which can aid in supporting the lens array 115 in the concentric arrangement at the end portion 116. The emitter lens 110 covers a central first portion 120 of the end portion 116 while the collector lens 112 covers an outer perimeter second portion 122 of the end portion 116. Because the emitter lens 110 and collector lens 112 are concentric, the lenses 110 and 112 have different shapes and may cover different area measurements. While adjacent side edges 124 and 126 are illustrated as contiguous, they may be separated by a divider wall or other structure. Further, both of the emitter lens 110 and the collector lens 112 may be located entirely within the optical fiber lumen 104. In other embodiments, one or both of the lenses 110 and 112 may be located at least partially outside the optical fiber lumen 104.

[0024] FIG. 4 illustrates an embodiment of a guidewire 130 that includes separated emitter and collector lenses 132 and 134. As above with FIG. 2, the guidewire 130 includes a support structure 136 that can be a support cylinder that is located inside guidewire body 135. The emitter lens 132 covers a first portion 138 of end portion 140 while the collector lens 134 covers a second portion 142 of end portion 144. In this example, the lenses 132 and 134 may be the same shape and may cover substantially the same area measurements. The emitter and collector lenses 132 and 134 may be separated by a divider 146 formed by a wall that extends between the emitter and collector lenses 132 and 134. As shown by FIG. 5, the divider 146 may extend through optical fiber lumen 148 and optically and physically separate emitter and collector optical fibers 150 and 152.

[0025] In the illustrated example, the divider 146 may be formed as part of the support structure 136 such that they are formed from a single, monolithic piece of material. In other embodiments, the divider 146 may be formed separately from the support structure 136 and then connected thereto through any suitable process. The divider 146 may extend through the entire length of the optical fiber lumen 148 or may extend only partially through the optical fiber lumen 148. It should be noted that a divider between emitter lenses and collector lenses may be provided with any of the embodiments described herein.

[0026] Referring to FIG. 6, another embodiment of a guidewire 160 with lens array 162 is illustrated with another divider 164. In this embodiment, the lens array 162 includes multiple emitter lenses 166 and collector lenses 168. The lens placement alternates between emitter lenses 166 and collector lenses 168 around the divider 164 and around a circumferential direction of guidewire body 170.

[0027] The emitter and collector lenses 166 and 168 are illustrated as being triangular in shape having a relatively wider outer edge 172 and 174 at support structure 176 and a relatively narrow inner edge 178 and 180 at the divider 164 with tapered side edges 182 and 184 extending between the outer edges 172 and 174 and inner edges 178 and 180. The triangular shapes of the emitter and collector lenses 166 and 168 are truncated by the presence of the divider 164. While triangular shapes of the emitter and collector lenses 166 and 168 are illustrated, the emitter and collector lenses can be any suitable shape and placement depending, at least in part, on the procedure and anatomical constraints. Adjacent emitter and collector lenses 166 and 168 may be contiguous along their side edges 182 and 184. While adjacent side edges 182 and 184 are illustrated as contiguous, they may be separated by a divider wall or other structure.

[0028] Referring briefly to FIG. 7, a cross-sectional view along line 7-7 of the guidewire of FIG. 6 is illustrated. In this embodiment, each emitter optical fiber 190 and collector optical fiber 192 may be located within its own sub-lumen 194. Adjacent sub-lumens 194 may be separated by divider walls 196 and the divider 164. In some embodiments as shown, the divider 164 and divider walls 196 may be part of the support structure 176, such as by forming as an extrusion. In other embodiments, the divider 164 and/or divider walls 196 may be formed separately and then connected to the support structure 176.

[0029] The above-described clot analysis systems with guidewires integrate a spectroscopy analysis using the guidewires as light energy emitters and also collectors. Placement of the optical fibers within the guidewires maintains a reduced cross-sectional profile that can be used for patients. The use of the distal face of the guidewire to emit and collect light helps to direct light at a clot effectively for the spectroscopy analysis. The use of multiple optical fibers can provide flexibility with sizing. Adding the emitting and collection functions to the guidewires can provide flexibility in terms of workflow to that other procedures can occur while gaining information regarding clot composition for further procedural recommendations and steps. Use of the spectroscopy analysis can reduce complications from mismatched treatments due to a lack of information of disease states and clot formation.

[0030] Embodiments can be described with reference to the following numbered clauses, with certain features laid out in the dependent clauses:

[0031] Clause 1 : A guidewire for a catheter system, comprising: a guidewire body suitable for insertion into an occluded body lumen, the guidewire body having an optical fiber lumen extending therethrough; an emitter optical fiber extending through the optical fiber lumen, the emitter optical fiber configured to deliver radiation to a distal terminal end of the optical fiber lumen; a collector optical fiber extending through the optical fiber lumen, the collector optical fiber configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition; an emitter lens positioned in the optical fiber lumen and covering a first portion of the distal terminal end of the optical fiber lumen, the emitter lens configured to direct radiation from the emitter optical fiber toward the area of the body lumen path; and a collector lens positioned in the optical fiber lumen and covering a second portion of the distal terminal end of the optical fiber lumen, the collector lens configured to deliver radiation from the area of the body lumen path to the collector optical fiber. [0032] Clause 2: The guidewire of clause 1, wherein the emitter lens is a first emitter lens, the guidewire further comprising a second emitter lens positioned in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second emitter lens configured to direct radiation from another emitter optical fiber toward the area of the body lumen path.

[0033] Clause 3: The guidewire lumen of claim 1, wherein the collector lens is a first collector lens, the guidewire comprising a second collector lens positioned in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second collector lens configured to deliver radiation from the area of the body lumen path to another collector optical fiber.

[0034] Clause 4: The guidewire of clause 1 or 2, wherein the emitter lens and the collector lens are entirely within the optical fiber lumen.

[0035] Clause 5: The guidewire of any of clauses 1-4, wherein the emitter lens and the collector lens have contiguous sides.

[0036] Clause 6: The guidewire of any of clauses 1-4 further comprising a divider that separates the emitter lens from the collector lens.

[0037] Clause 7: The guidewire of any of clauses 1-6 further comprising a support cylinder located in the optical fiber lumen, the support cylinder having a support opening that supports the emitter lens and the collector lens.

[0038] Clause 8: The guidewire lumen of any of clauses 1-7, wherein the emitter lens and the collector lens are part of a lens array comprising multiple emitter lenses and multiple collector lenses.

[0039] Clause 9: The guidewire of any of clauses 1-8 comprising multiple emitter optical fibers.

[0040] Clause 10: The guidewire of any of clauses 1-9 comprising multiple collector optical fibers. [0041] Clause 11 : A method of forming a guidewire for use in delivering and collecting radiation to and from an area of a body lumen path for diffuse reflectance spectroscopy, the method comprising: placing an emitter optical fiber within an optical fiber lumen of a guidewire body, the emitter optical fiber configured to deliver radiation to a distal terminal end of the optical fiber lumen; placing a collector optical fiber within the optical fiber lumen of the guidewire body, the collector optical fiber configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition; placing an emitter lens in the optical fiber lumen covering a first portion of the distal terminal end, the emitter lens configured to direct radiation from the emitter optical fiber toward the area of the body lumen path; and placing a collector lens in the optical fiber lumen and covering a second portion of the distal terminal end, the collector lens configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

[0042] Clause 12: The method of clause 11, wherein the emitter lens is a first emitter lens, the method further comprising placing a second emitter lens in the optical fiber lumen and covering a third portion of the distal terminal end, the second emitter lens configured to direct radiation from another emitter optical fiber toward the area of the body lumen path.

[0043] Clause 13: The method lumen of clause 11 or 12, wherein the collector lens is a first collector lens, the method further comprising placing a second collector lens in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second collector lens configured to deliver radiation from the area of the body lumen path to another collector optical fiber.

[0044] Clause 14: The method of any of clauses 11-13, wherein the emitter lens and the collector lens are placed entirely within the optical fiber lumen.

[0045] Clause 15: The method of any of clauses 11-14, wherein the emitter lens and the collector lens are placed to have contiguous sides.

[0046] Clause 16: The method of any of clauses 11-14 further comprising a divider that separates the emitter lens from the collector lens. [0047] Clause 17: The method of any of clauses 11-16 further comprising placing a support cylinder in the optical fiber lumen, the support cylinder having a support opening that supports the emitter lens and the collector lens.

[0048] Clause 18: The method lumen of any of clauses 11-17, wherein the emitter lens and the collector lens are part of a lens array comprising multiple emitter lenses and multiple collector lenses.

[0049] Clause 19: The method of any of clauses 11-18 comprising placing multiple emitter optical fibers in the optical fiber lumen.

[0050] Clause 20: The method of any of clauses 11-19 comprising placing multiple collector optical fibers in the optical fiber lumen.

[0051] It will be apparent to those skilled in the art that various modifications and variations can be made to the embodiments described herein without departing from the spirit and scope of the claimed subject matter. Thus it is intended that the specification cover the modifications and variations of the various embodiments described herein provided such modification and variations come within the scope of the appended claims and their equivalents.

Claims

1. A guidewire for a catheter system, comprising: a guidewire body suitable for insertion into an occluded body lumen, the guidewire body having an optical fiber lumen extending therethrough; an emitter optical fiber extending through the optical fiber lumen, the emitter optical fiber configured to deliver radiation to a distal terminal end of the optical fiber lumen; a collector optical fiber extending through the optical fiber lumen, the collector optical fiber configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition; an emitter lens positioned in the optical fiber lumen and covering a first portion of the distal terminal end of the optical fiber lumen, the emitter lens configured to direct radiation from the emitter optical fiber toward the area of the body lumen path; and a collector lens positioned in the optical fiber lumen and covering a second portion of the distal terminal end of the optical fiber lumen, the collector lens configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

2. The guidewire of claim 1, wherein the emitter lens is a first emitter lens, the guidewire further comprising a second emitter lens positioned in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second emitter lens configured to direct radiation from another emitter optical fiber toward the area of the body lumen path.

3. The guidewire lumen of claim 1, wherein the collector lens is a first collector lens, the guidewire comprising a second collector lens positioned in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second collector lens configured to deliver radiation from the area of the body lumen path to another collector optical fiber.

4. The guidewire of claim 1, wherein the emitter lens and the collector lens are entirely within the optical fiber lumen.

5. The guidewire of claim 1, wherein the emitter lens and the collector lens have contiguous sides.

6. The guidewire of claim 1 further comprising a divider that separates the emitter lens from the collector lens.

7. The guidewire of claim 1 further comprising a support cylinder located in the optical fiber lumen, the support cylinder having a support opening that supports the emitter lens and the collector lens.

8. The guidewire lumen of claim 1, wherein the emitter lens and the collector lens are part of a lens array comprising multiple emitter lenses and multiple collector lenses.

9. The guidewire of claim 1 comprising multiple emitter optical fibers.

10. The guidewire of claim 1 comprising multiple collector optical fibers.

11. A method of forming a guidewire for use in delivering and collecting radiation to and from an area of a body lumen path for diffuse reflectance spectroscopy, the method comprising: placing an emitter optical fiber within an optical fiber lumen of a guidewire body, the emitter optical fiber configured to deliver radiation to a distal terminal end of the optical fiber lumen; placing a collector optical fiber within the optical fiber lumen of the guidewire body, the collector optical fiber configured to collect radiation from an area of a body lumen path for use in diffuse reflectance spectroscopy to analyze a clot material composition; placing an emitter lens in the optical fiber lumen covering a first portion of the distal terminal end, the emitter lens configured to direct radiation from the emitter optical fiber toward the area of the body lumen path; and placing a collector lens in the optical fiber lumen and covering a second portion of the distal terminal end, the collector lens configured to deliver radiation from the area of the body lumen path to the collector optical fiber.

12. The method of claim 11, wherein the emitter lens is a first emitter lens, the method further comprising placing a second emitter lens in the optical fiber lumen and covering a third portion of the distal terminal end, the second emitter lens configured to direct radiation from another emitter optical fiber toward the area of the body lumen path.

13. The method lumen of claim 11, wherein the collector lens is a first collector lens, the method further comprising placing a second collector lens in the optical fiber lumen and covering a third portion of the distal terminal end of the optical fiber lumen, the second collector lens configured to deliver radiation from the area of the body lumen path to another collector optical fiber.

14. The method of claim 11, wherein the emitter lens and the collector lens are placed entirely within the optical fiber lumen.

15. The method of claim 11, wherein the emitter lens and the collector lens are placed to have contiguous sides.

16. The method of claim 11 further comprising a divider that separates the emitter lens from the collector lens.

17. The method of claim 11 further comprising placing a support cylinder in the optical fiber lumen, the support cylinder having a support opening that supports the emitter lens and the collector lens.

18. The method lumen of claim 11, wherein the emitter lens and the collector lens are part of a lens array comprising multiple emitter lenses and multiple collector lenses.

19. The method of claim 11 comprising placing multiple emitter optical fibers in the optical fiber lumen.

20. The method of claim 11 comprising placing multiple collector optical fibers in the optical fiber lumen.