EP4419254A1 - Tube destiné à un procédé avancé d'obtention de fibrine riche en plaquettes - Google Patents
Tube destiné à un procédé avancé d'obtention de fibrine riche en plaquettesInfo
- Publication number
- EP4419254A1 EP4419254A1 EP21807308.8A EP21807308A EP4419254A1 EP 4419254 A1 EP4419254 A1 EP 4419254A1 EP 21807308 A EP21807308 A EP 21807308A EP 4419254 A1 EP4419254 A1 EP 4419254A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- tube
- tubular body
- blood
- centrifugal tube
- centrifugation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 33
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 title claims description 31
- 102000009123 Fibrin Human genes 0.000 title claims description 29
- 108010073385 Fibrin Proteins 0.000 title claims description 29
- 229950003499 fibrin Drugs 0.000 title claims description 26
- 238000005119 centrifugation Methods 0.000 claims abstract description 48
- 210000004369 blood Anatomy 0.000 claims abstract description 36
- 239000008280 blood Substances 0.000 claims abstract description 36
- 230000006378 damage Effects 0.000 claims abstract description 35
- 230000015271 coagulation Effects 0.000 claims abstract description 24
- 238000005345 coagulation Methods 0.000 claims abstract description 24
- 230000008569 process Effects 0.000 claims abstract description 11
- 210000001772 blood platelet Anatomy 0.000 claims description 42
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 7
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 210000003743 erythrocyte Anatomy 0.000 claims description 4
- 244000005700 microbiome Species 0.000 claims description 4
- -1 polyethylene terephthalate Polymers 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 abstract description 6
- 239000000126 substance Substances 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 9
- 239000012190 activator Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000000499 gel Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000001994 activation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000001172 regenerating effect Effects 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 108090000190 Thrombin Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229960004072 thrombin Drugs 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000012953 feeding on blood of other organism Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000948 non-nucleated cell Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
Abstract
L'invention comprend les éléments suivants : un corps tubulaire (11) longitudinalement disposé avec une embouchure (113), un capuchon de tube (12) relié au corps tubulaire (11), une entrée d'aiguille (121) au sommet du corps de capuchon de tube (12), un élément d'étanchéité (122) sur le corps du capuchon de tube (12), au moins un élément de destruction (13) sur la surface interne du corps tubulaire (11) et s'étendant au moins partiellement vers le centre du tube afin de raccourcir le processus de coagulation en décomposant les plaquettes dans le sang pendant la centrifugation, un corps de tuyau (111) longitudinal dans le corps tubulaire (11), une base de corps (112) au fond dudit corps de tuyau (111) disposée de préférence dans une structure incurvée, le corps de tuyau (111) et la base de corps (112) étant intégrés.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/TR2021/051070 WO2023069027A1 (fr) | 2021-10-19 | 2021-10-19 | Tube destiné à un procédé avancé d'obtention de fibrine riche en plaquettes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4419254A1 true EP4419254A1 (fr) | 2024-08-28 |
Family
ID=78621964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP21807308.8A Pending EP4419254A1 (fr) | 2021-10-19 | 2021-10-19 | Tube destiné à un procédé avancé d'obtention de fibrine riche en plaquettes |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP4419254A1 (fr) |
| WO (1) | WO2023069027A1 (fr) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201004072D0 (en) | 2010-03-11 | 2010-04-28 | Turzi Antoine | Process, tube and device for the preparation of wound healant composition |
| TR201109999A2 (tr) | 2011-10-10 | 2012-07-23 | Akman Serhan | Trombositten zengin fibrin yapımı için tüp. |
| CN104704106B (zh) | 2013-04-11 | 2016-08-24 | 早安生物株式会社 | 提取自血小板的血液分离容器 |
| KR101279652B1 (ko) | 2013-04-11 | 2013-07-05 | (주) 굿모닝 바이오 | 응고 촉매체를 구비한 자가 혈소판 농축물질 분리장치, 이를 이용한 자가 혈소판 농축물질 분리 및 응고방법 |
| EP3129146B1 (fr) * | 2014-04-09 | 2020-01-01 | Greiner Bio-One GmbH | Unité de réception destinés à recevoir un liquide corporel |
| DK3148698T3 (da) * | 2014-06-01 | 2019-07-15 | Debiopharm Int Sa | Prøveindsamlings- og bearbejdnings-indretning |
-
2021
- 2021-10-19 EP EP21807308.8A patent/EP4419254A1/fr active Pending
- 2021-10-19 WO PCT/TR2021/051070 patent/WO2023069027A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023069027A1 (fr) | 2023-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4892133B2 (ja) | 血小板富有血漿及び／又は血小板濃縮物を製造する方法 | |
| US12011463B2 (en) | Multilayered blood product | |
| US6649072B2 (en) | Method for producing autologous platelet-rich plasma | |
| EP2769745B1 (fr) | Séparateur de composants sanguins et procédé de préparation d'un sérum | |
| US20140311988A1 (en) | Method and apparatus for producing platelet rich plasma and/or platelet concentrate | |
| EP2421578B1 (fr) | Ensemble, dispositif, trousse et procédé pour préparer du plasma riche en plaquettes (prp) | |
| EP2766122B1 (fr) | Tube servant à produire de la fibrine riche en plaquettes | |
| US20080190857A1 (en) | System and Methods of Producing Membranes | |
| JP2017051665A (ja) | 血液から少なくとも１種類の合成物を調製する方法、及び該方法を実施する際に使用するための抽出装置 | |
| CA3153723A1 (fr) | Dispositif de type centrifugeuse et procede d'utilisation | |
| US20160100912A1 (en) | Methods, inserts, and systems useful for endodontic treatment | |
| WO2023069027A1 (fr) | Tube destiné à un procédé avancé d'obtention de fibrine riche en plaquettes | |
| KR20170006820A (ko) | 혈소판 농축 방법 및 이를 위한 농축기구 | |
| US20220118153A1 (en) | Layered blood product for stopping/reducing bleeding in an open surgical wound | |
| KR101416481B1 (ko) | 고농도의 혈소판을 포함하는 혈소판농축섬유소의 추출 및 절단방법 | |
| US20210132036A1 (en) | Systems, Methods and Apparatus for Separating Components of a Sample | |
| ES2364733B1 (es) | Metodo para la preparacion de al menos un compuesto a partir de sangre, y dispositivo de extraccion para ser utilizado en la ejecucion de dicho metodo | |
| KR20230061187A (ko) | 혈소판 농축 혈장 추출용 혈액분리장치 | |
| TR201815514A2 (tr) | Trombosi̇t zengi̇n plazma elde etmek üzere bi̇r yöntem | |
| WO2017033734A1 (fr) | Dispositif de séparation de composant sanguin et procédé de séparation de composant sanguin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20240516 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |