EP4384160A4 - HETEROCYCLICAL COMPOUNDS AND METHODS FOR USE - Google Patents

HETEROCYCLICAL COMPOUNDS AND METHODS FOR USE

Info

Publication number
EP4384160A4
EP4384160A4 EP22856568.5A EP22856568A EP4384160A4 EP 4384160 A4 EP4384160 A4 EP 4384160A4 EP 22856568 A EP22856568 A EP 22856568A EP 4384160 A4 EP4384160 A4 EP 4384160A4
Authority
EP
European Patent Office
Prior art keywords
methods
heterocyclical
compounds
heterocyclical compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22856568.5A
Other languages
German (de)
French (fr)
Other versions
EP4384160A1 (en
Inventor
Michael M Yamano
Yunxiao Li
Primali Navaratne
Jose Medina
Ning Chen
Liping Pettus
Rene Rahimoff
Xiaofen Li
John Stellwagen
Francesco Manoni
Kexue Li
Brian Alan Lanman
Ryan Paul Wurz
Wei Zhao
Huan Rui
Josephine Eshon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of EP4384160A1 publication Critical patent/EP4384160A1/en
Publication of EP4384160A4 publication Critical patent/EP4384160A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP22856568.5A 2021-08-10 2022-08-10 HETEROCYCLICAL COMPOUNDS AND METHODS FOR USE Pending EP4384160A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163231543P 2021-08-10 2021-08-10
US202163289579P 2021-12-14 2021-12-14
PCT/US2022/039971 WO2023018812A1 (en) 2021-08-10 2022-08-10 Heterocyclic compounds and methods of use

Publications (2)

Publication Number Publication Date
EP4384160A1 EP4384160A1 (en) 2024-06-19
EP4384160A4 true EP4384160A4 (en) 2025-10-29

Family

ID=85201014

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22856568.5A Pending EP4384160A4 (en) 2021-08-10 2022-08-10 HETEROCYCLICAL COMPOUNDS AND METHODS FOR USE

Country Status (7)

Country Link
EP (1) EP4384160A4 (en)
JP (1) JP2024532734A (en)
AU (1) AU2022325771A1 (en)
CA (1) CA3228310A1 (en)
MX (1) MX2024001893A (en)
TW (1) TW202330529A (en)
WO (1) WO2023018812A1 (en)

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WO2019195609A2 (en) 2018-04-04 2019-10-10 Arvinas Operations, Inc. Modulators of proteolysis and associated methods of use
EP4067343A4 (en) 2019-11-29 2024-01-03 Taiho Pharmaceutical Co., Ltd. Novel phenol compound or salt thereof
EP4436571A4 (en) * 2021-11-24 2025-10-15 Merck Sharp & Dohme Llc Small-molecule inhibitors of KRAS mutant proteins
JP2025510572A (en) 2022-03-08 2025-04-15 レボリューション メディシンズ インコーポレイテッド Methods for treating immunorefractory lung cancer
CA3247639A1 (en) 2022-05-06 2023-11-09 PAQ Therapeutics Inc. Kras g12d proteolysis targeting chimeras
WO2023213269A1 (en) * 2022-05-06 2023-11-09 Zai Lab (Shanghai) Co., Ltd. Amide-substituted heterocyclic compounds as kras g12d modulators and uses thereof
CR20240508A (en) 2022-05-19 2024-12-20 Genentech Inc Aza-tetracyclic oxazepine compounds and uses thereof
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
EP4540244A1 (en) * 2022-06-15 2025-04-23 Mirati Therapeutics, Inc. Prodrugs of pan-kras inhibitors
EP4549439A1 (en) * 2022-07-01 2025-05-07 Suzhou Zelgen Biopharmaceutical Co., Ltd. Substituted pyrimidine-fused ring inhibitor, method for preparing same, and use thereof
WO2024008068A1 (en) * 2022-07-04 2024-01-11 Jacobio Pharmaceuticals Co., Ltd. K-ras mutant protein inhibitors
WO2024012519A1 (en) * 2022-07-13 2024-01-18 北京华森英诺生物科技有限公司 Pan-kras inhibitor
WO2024041606A1 (en) * 2022-08-24 2024-02-29 泰励生物科技（上海）有限公司 Compound with anti-kras mutant tumor activity
TW202430179A (en) 2022-11-21 2024-08-01 美商樹線生物科學公司 Spirocyclic dihydropyranopyrimidine kras inhibitors
US12448399B2 (en) 2023-01-26 2025-10-21 Arvinas Operations, Inc. Cereblon-based KRAS degrading PROTACs and uses related thereto
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
CR20250420A (en) 2023-04-07 2025-11-20 Revolution Medicines Inc MACROCYCLIC RAS INHIBITORS
AR132338A1 (en) 2023-04-07 2025-06-18 Revolution Medicines Inc RAS INHIBITORS
CN121100123A (en) 2023-04-14 2025-12-09 锐新医药公司 Crystalline forms of Ras inhibitors
CN121464140A (en) 2023-04-14 2026-02-03 锐新医药公司 Crystalline forms of RAS inhibitors, compositions containing the same, and methods of use thereof
TW202508595A (en) 2023-05-04 2025-03-01 美商銳新醫藥公司 Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025038936A1 (en) 2023-08-17 2025-02-20 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
TW202528315A (en) 2023-09-21 2025-07-16 美商樹線生物科學公司 Spirocyclic dihydropyranopyridine kras inhibitors
CN121941690A (en) 2023-10-03 2026-04-28 Paq医疗公司 KRAS protein hydrolysis targeting chimera
TW202529804A (en) 2023-10-06 2025-08-01 美商安進公司 Combination therapy for cancer treatment
US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
AU2024361909A1 (en) 2023-10-20 2026-03-26 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202602882A (en) * 2024-03-14 2026-01-16 美商安進公司 Macrocyclic compounds as modulators of kras and uses thereof
WO2025194054A1 (en) * 2024-03-14 2025-09-18 Amgen Inc. Spirocyclic compounds as modulators of kras and uses thereof
WO2025228384A1 (en) * 2024-04-30 2025-11-06 Hutchmed Limited Antibody-drug conjugates and use thereof
TW202547461A (en) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ras inhibitors
WO2025245127A1 (en) 2024-05-21 2025-11-27 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022132200A1 (en) * 2020-12-15 2022-06-23 Mirati Therapeutics, Inc. Azaquinazoline pan-kras inhibitors
WO2022228568A1 (en) * 2021-04-30 2022-11-03 劲方医药科技(上海)有限公司 Pyridino- or pyrimido-cyclic compound, preparation method therefor and medical use thereof
WO2022248885A2 (en) * 2021-05-28 2022-12-01 Redx Pharma Plc. Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103588792B (en) * 2013-03-04 2016-03-23 中国科学院上海药物研究所 Pyridopyrimidine or pyrimidopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof
EP3908283A4 (en) * 2019-01-10 2022-10-12 Mirati Therapeutics, Inc. Kras g12c inhibitors
MX2022002465A (en) * 2019-08-29 2022-05-19 Mirati Therapeutics Inc KRAS G12D INHIBITORS.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022132200A1 (en) * 2020-12-15 2022-06-23 Mirati Therapeutics, Inc. Azaquinazoline pan-kras inhibitors
WO2022228568A1 (en) * 2021-04-30 2022-11-03 劲方医药科技(上海)有限公司 Pyridino- or pyrimido-cyclic compound, preparation method therefor and medical use thereof
WO2022248885A2 (en) * 2021-05-28 2022-12-01 Redx Pharma Plc. Compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2023018812A1 *

Also Published As

Publication number Publication date
JP2024532734A (en) 2024-09-10
EP4384160A1 (en) 2024-06-19
TW202330529A (en) 2023-08-01
AU2022325771A1 (en) 2024-02-15
MX2024001893A (en) 2024-02-29
CA3228310A1 (en) 2023-02-16
WO2023018812A1 (en) 2023-02-16

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