EP4322830A1 - Dispositif et procédé d'imagerie de cibles mobiles - Google Patents
Dispositif et procédé d'imagerie de cibles mobilesInfo
- Publication number
- EP4322830A1 EP4322830A1 EP22717401.8A EP22717401A EP4322830A1 EP 4322830 A1 EP4322830 A1 EP 4322830A1 EP 22717401 A EP22717401 A EP 22717401A EP 4322830 A1 EP4322830 A1 EP 4322830A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- optical
- module
- moving target
- imaging device
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/2407—Optical details
- G02B23/2461—Illumination
- G02B23/2469—Illumination using optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/361—Optical details, e.g. image relay to the camera or image sensor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/26—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
- G02B6/06—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres the relative position of the fibres being the same at both ends, e.g. for transporting images
Definitions
- the present invention generally relates to the field of imaging and in particular to a device and a method for imaging moving targets.
- Functional cerebral imaging generally consists of measuring a signal resulting from neuronal activity in a living being. There are a multitude of functional brain imaging techniques that differ from each other by the nature of the signals measured and by the methodology implemented to acquire such signals.
- Certain functional brain imaging techniques known to be non-invasive and suitable for experimentation in humans, are based on the reading of signals related to vascular or metabolic events that arise from neuronal activation. Such techniques include magnetic resonance imaging, magnetoencephalography, and positron emission tomography. These techniques only offer an indirect readout of neuronal activity and are therefore very limited in terms of temporal resolution. In addition, they require heavy and bulky equipment which considerably limits the subjects' repertoire of actions and movements, making them ill-suited to the study of complex behavioral tasks.
- optical functional imaging techniques requires the use of numerous optical components making it possible to collect small variations in the quantity of light. Such optical components are often heavy and bulky, so the coupling of optical recordings with the performance of more or less complex behavioral tasks in mice is one of the main methodological challenges encountered by neuroscientists today.
- Another known solution consists in transporting the optical signals from a zone of interest of a moving target to a conventional static imaging system, via a flexible interface consisting of a set of fiber optics.
- the fiber interface imposes constraints on the movement of the moving target, particularly in terms of rotation, thus limiting the behavioral repertoire that it is possible to study.
- the mechanical stresses related to the rotations of the moving target can lead to rapid deterioration of the interface which is made up of fragile optical fibers.
- the present invention provides a device for imaging a moving target moving on a given plane of movement.
- the imaging device includes:
- the first unit comprising a location module configured to determine one or more movement parameters of the moving target; and an optical contact module configured to collect optical signals generated in an area of interest of the moving target, the optical contact module comprising a free end in contact with the area of interest, a captive end having a first geometric shape given plane and a plurality of optical fibers connecting the two ends; a second unit comprising an optical processing module associated with an optical axis and with an active area having a second geometric shape given plane, the optical processing module being configured to process the collected optical signals; a rotating module configured to rotate the captive end around the optical axis by means of a motor provided in the imaging device; and a calculation module configured to determine, as a function of the one or more movement parameters, control instructions intended for the motor.
- the optical processing module can be configured to acquire, during acquisition time windows, a plurality of optical images, each of the optical images being representative of a plurality of optical signals collected via the plurality of optical fibers and simultaneously acquired from the area of interest.
- the calculation module can be configured to determine the command setpoints so as to block the pivoting of the captive end during the acquisition time windows, according to an optimal pivoting angle between the first and second geometric shape.
- the optimum pivot angle may correspond to a maximum overlap between the first and the second geometric shape.
- the calculation module can be configured to determine, outside the acquisition time windows, the control instructions so as to compensate for the torsion undergone by the plurality of optical fibers and induced by rotational movements of the moving target.
- the calculation module can be configured to determine the control instructions so as to compensate for the torsion undergone by the plurality of optical fibers and induced by rotational movements of the moving target, during and in outside the acquisition time windows.
- the second unit may further comprise a save module configured to save each of the acquired optical images associated with a corresponding pivot angle between the first and the second geometric shape.
- the optical processing module can also be configured to transmit, during transmission time windows, a plurality of optical excitation signals to the area of interest.
- the second unit may further comprise a relay module comprising a rotating element and a static element, the relay module being configured to receive, via a first wired connection connected to the rotating element, the one or several movement parameters from the location module, and to transmit, via a second wired connection connected to the static element, the one or more movement parameters received to the calculation module.
- the first unit may further include a wireless transmitting module configured to transmit the one or more motion parameters
- the second unit may further include a wireless receiving module configured to receive the one or more movement parameters
- the one or more motion parameters may include an angle defining the orientation of the moving target with respect to a predefined direction and collinear with the plane of motion.
- the location module may comprise an inertial unit comprising a magnetometer.
- an imaging device comprising an optical contact module, the optical contact module comprising a free end in contact with an area of interest of the moving target, a captive end and a plurality of optical fibers connecting the two ends, and an optical processing module associated with an optical axis and an active area, the method comprises the steps consisting of:
- the step of determining control setpoints can be implemented in such a way as to block the pivoting of the captive end around the optical axis, during the acquisition time windows.
- FIG. 1 represents a moving target imaging device, according to one embodiment of the invention
- FIG. 2 represents an optical contact module, according to one embodiment of the invention
- FIG. 3-B illustrate the pivoting of the captive end relative to the active zone, according to embodiments of the invention
- FIG. 4 represents a method for imaging moving targets, according to one embodiment of the invention.
- FIG. 1 represents an imaging device 100 of a moving target 200 moving on a given plane of movement, according to one embodiment of the invention.
- the imaging device 100 can be used in neuroscience applications to study a subject's nervous system.
- the subject can be any living being.
- the imaging device 100 can be used to study the neural basis of behavior in a small animal (such as a mouse, for example), when the animal behaves freely, i.e. say without being subject to any external constraint likely to affect his behavior.
- the imaging device 100 according to the invention is advantageously compatible with various optical imaging techniques used in neurosciences, such as for example and by way of non-limiting examples, photon/multi-photon fiber imaging, confocal microscopy, uniform or patterned optogenetic stimulation, etc. More generally, the imaging device 100, according to embodiments of the invention, can be used to perform imaging of any moving target 200 whose behavior cannot be predicted and can include rotational movements.
- the moving target 200 can move on a movement plane provided with a measurement mark in which the instantaneous position of the moving target 200 can be defined by two coordinates according to the coordinate system used, the coordinate system possibly be the Cartesian coordinate system or the polar coordinate system, for example.
- the plane of movement can be fixed in the terrestrial frame of reference and its orientation in such a frame of reference can be known beforehand with accuracy.
- the moving target 200 can evolve in a three-dimensional (3D) evolution space equipped with a measurement reference in which the instantaneous position of the moving target 200 can be marked by three coordinates, the Cartesian, cylindrical or spherical can be used.
- the moving target 200 can move freely on the plane of movement without being subjected to any external constraint likely to affect its behavior.
- the moving target 200 can be subjected to external constraints which can consist in modifying the characteristics of the environment in which the moving target 200 evolves.
- characteristics of the target's environment may include, but are not limited to, physical obstructions, electromagnetic field strength and orientation, light level, and/or chemical properties.
- the movement of the moving target 200 as described by a trajectory and a speed of movement, cannot be predicted and can be random, i.e. the trajectory traveled by the target 200 can be arbitrary and its speed of movement can vary over time.
- the moving target 200 can be a laboratory mouse moving on a given plane of movement.
- the imaging device 100 of FIG. 1 can be configured to image an area of interest of the mouse using a suitable optical imaging technique.
- the area of interest may be the laboratory mouse cerebral cortex and the optical imaging technique may be two-photon excitation imaging that exploits the process of fluorescence to image living tissue.
- the imaging device 100 comprises a first unit 10 arranged rigidly on the moving target 200.
- the first unit 10 comprises a location module 12 configured to determine one or more movement parameters of the moving target 200 such as the instantaneous position of the moving target 200 in the movement plane. Such movement parameters can make it possible to determine accurately and in real time the trajectory and the speed of movement of the moving target 200.
- the location module 12 may not be in direct contact with the moving target 200.
- the first unit 10 further comprises an optical contact module 11 comprising a plurality of optical fibers 110 and two ends: a first end, called the free end 111 (EL), and a second end, called the captive end 112 (EC ), the two free and captive ends being connected via the plurality of optical fibers 110.
- the free end 111 can be fixed rigidly to an area of interest of the moving target 200.
- the zone of interest can be the cerebral cortex of the mouse.
- the free end 111 of the optical contact module 11 can be configured to emit, by means of the optical fibers 110 used, optical excitation signals towards the area of interest, and/or to collect, by means of the optical fibers 110 used, signals optics, i.e.
- each of the optical fibers 110 forming the optical contact module 11 can present at its free end 111 an accepting cone (numerical aperture) defining the light rays which will be guided, that is to say transmitted, through the optical fiber.
- the optical signals collected by the free end 111 of the optical contact module 11 are recovered at the level of the captive end 112 after propagation through the optical fibers 110 used.
- Figure 2 illustrates an example of optical contact module 11.
- the optical fibers 110 forming the optical contact module 11 can be identical in terms of opto-geometric characteristics and their number can be chosen according to the resolution of the images optics to be acquired by the imaging device 100 and depending on the surface of the area of interest.
- Optical fibers 110 can be long enough to allow moving target 200 to move freely on the plane of motion.
- the ends of the optical fibers 110 can be distributed in a regular manner at each of the two free and captive ends of the optical contact module 11 according to a first given planar geometric shape.
- the first planar geometric shape can be obtained by connecting the ends of the outer optical fibers 110 in one of the two ends of the optical contact module 11 and can be rectangular, circular or other.
- the two free and captive ends of the optical contact module 11 can be compact so as to maintain the distribution of the ends of the optical fibers 110 which must be the same in the free and captive ends of the optical contact module 11.
- the imaging device 100 further comprises a second unit 20 separate from the first unit 10, that is to say that the second unit 20 is not arranged on the target mobile 200 and that it can be fixed relative to the plane of movement on which the mobile target 200 moves.
- the second unit 20 separates from the first unit 10, that is to say that the second unit 20 is not arranged on the target mobile 200 and that it can be fixed relative to the plane of movement on which the mobile target 200 moves.
- the 20 comprises an optical processing module 21 associated with an optical axis 211 and with an active zone 212 having a second given plane geometric shape which may be different from the first plane geometric shape described above, the optical axis 211 being perpendicular to the active zone 212.
- the active zone 212 corresponds for example to the zone where the photographic sensors which represent the photosensitive elements are grouped.
- the optical processing module 21 can be arranged opposite the captive end 112 of the optical contact module 11 so as to optimize the optical coupling between the two elements.
- the optimization of the optical coupling can be obtained by making the optical axis 211 coincide with the center of the captive end 112 and by arranging the active zone 212 and the captive end 112 in a parallel manner, which creates an overlap between the first and the second planar geometric shape while projecting the captive end 112 onto the active zone 212. Such an adjustment can be made only once before the imaging device 100 is put into operation.
- the optical processing module includes
- each constituent element of the optical image can be obtained by detecting an optical signal received by means of one of the optical fibers 110 forming the module of the optical contact.
- the optical processing module 21 can be configured to transmit, during transmission time windows, optical excitation signals to the area of interest by means of the optical contact module 11.
- two optical excitation signals simultaneously emitted by the optical processing module 21 can have identical or different characteristics in terms of intensity, wavelength and state of polarization.
- the second unit 20 comprises a rotating module 22 to which the captive end 112 of the optical contact module 11 is fixed so as to allow the rotation of the captive end 112 around the optical axis 211 of the module.
- optical processing 21 The rotating module 22 can be configured to rotate around the optical axis 211 of the optical processing module 21 by means of a motor 26 provided in the imaging device 100.
- the rotating module 22 can have the shape of a hollow cylinder having as its axis of revolution the optical axis 211 of the optical processing module 21.
- the optical fibers 110 can pass through the interior of the rotating module 22 in height, and the captive end 112 can be placed so as to come to block the rotating module 22.
- a belt 23 and a transmission pulley 24 can be used to ensure the transmission of the rotational movement of the motor 26 to the rotating module 22.
- a pivot angle ment can be defined to quantify the rotation of the captive end 112 relative to the active area 212 of the optical processing module 21.
- the second unit 20 further comprises a calculation module 25 configured to receive the movement parameters of the moving target 200 as determined by the location module 12 arranged on the moving target 200.
- the calculation module 25 is configured to determine, as a function of the movement parameters received, control instructions intended for the motor 26 acting on the rotation of the rotating module 22.
- the calculation module 25 can be configured to determine such control instructions so as to reduce the torsion undergone by the optical fibers 110 forming the optical contact module 11 and induced by the movements of rotation of the moving target 200. It should be noted that the level of torsion undergone by the optical fibers 110 can be weak or strong.
- the calculation module 25 can be configured to only compensate for the high levels of torsion undergone by the optical fibers 110 used.
- the calculation module 25 can also be configured to determine, from the movement parameters received from the moving target 200, torsion values T.
- the torsion values determined by the calculation module 25 can be defined angle values to quantify a relative rotation of the captive end 112 with respect to the free end 111.
- a neutral or zero relative rotation of the captive end 112 with respect to the free end 111 may correspond to a first twist value T 0 for which the optical fibers 110 undergo substantially no twist.
- the first torsion value T 0 also called 'torsion neutral level', can be defined for example according to the following equation (1):
- a threshold relative rotation of the captive end 112 with respect to the free end 111 can correspond to a second value of torsion T threshold for which the optical fibers 110 undergo a threshold torsion T threshold impacting the behavior of the moving target 200 and/or degrading the quality of the optical signals and/or damaging the optical fibers 110.
- the second twist value T threshold also called the twist threshold level, can be defined for example according to equation (2) next :
- the number N can be positive or negative depending on the direction of the relative rotation of the captive end 112 with respect to the free end 111.
- the number N can be an integer preset in the calculation module 25 and/or an adjustment value accessible and modifiable by a user of the imaging device 100.
- the calculation module 25 can be configured to determine the torsion value T, continuously or discretely, depending on:
- the calculation module 25 can be configured to compare the torsion value T determined with a neutral level of torsion T seuü , continuously or discretely.
- the calculation module 25 is configured to operate according to a first mode of operation, in which control instructions intended for the motor 26 are determined so as to block, during each time window of acquisition , the pivoting of the rotating module 22, that is to say blocking the pivoting of the captive end 112, relative to the active zone 212 of the optical processing module 21.
- the blocking of the pivoting can be carried out at an optimal pivot angle between the captive end 112 and the active area 212 that maximizes their overlap
- Such embodiments are advantageous for short acquisition time windows, typically less than one second, during which the moving target 200 can remain stationary or its movement generates a low level of torsion without consequences on the quality of the optical signals and on the behavior of the moving target 200.
- the images Optical ges acquired during the same acquisition time window are superimposable and can be interpreted without difficulty.
- the calculation module 25 can be configured to determine control instructions intended for the motor 26 so as to compensate for the torsion undergone by the optical fibers 110.
- the calculation module 25 can be configured to determine other additional instructions, also called 'acquisition instructions'.
- the acquisition instructions can be intended for the optical processing module 21 and determined so as to stop the acquisition of the optical images in response to detection by the calculation module 25 of a torsion value T greater than a threshold level of twist T seuü .
- the calculation module 25 can be configured to determine the torsion value T during the acquisition time window, then to compare the torsion value T with a threshold level of torsion T only . Acquisition instructions can thus be generated if a condition relating to the torsion value T and to the torsion threshold level T only is satisfied, in response to the comparison step.
- the condition can be defined for example by the following equation (3):
- the acquisition instructions can thus generate so-called 'waiting moments' of the optical processing module 21 during which new pivoting control instructions intended for the motor 26 can be determined so as to cause the captive end 112 around the optical axis 211, with respect to the active area 212 (for example and without limitation, according to a number N of 360° rotations).
- these new pivoting control setpoints can also be determined according to the optimal pivoting angle between the captive end 112 and the active zone 212 which maximizes their overlap.
- the waiting times can be defined by short durations (ie brief interruption of the acquisitions of the optical images) with respect to the interrupted acquisition time window. Waiting times can depending for example on the pivoting speed of the captive end 112 by the motor 26 and/or on the torsion threshold level T predefined threshold . The waiting times can thus be preset to minimize the durations of interruption of optical image acquisitions as a function, for example, of the durations of the acquisition time windows and/or of the tolerated degradation of the quality of the optical signals.
- the first mode of operation implemented in relation to an acquisition of optical images can be adapted to emit, during emission time windows, optical excitation signals towards the zone of interest.
- the calculation module 25 can be configured to block the pivoting of the captive end 112 with respect to the active zone 212 of the optical processing module 21.
- the calculation module 25 is configured to operate according to a second mode of operation, in which control instructions intended for the motor 26 are determined so as to compensate for the torsion undergone by the optical fibers 110 and induced by the rotational movements of the moving target 200, during and outside the acquisition time windows.
- the second unit 20 may further comprise a save module (not shown in Figure 1) configured to save, temporarily or permanently, each optical image acquired by the optical processing module 21 in association with the corresponding pivot angle between the captive end 112 and the active area 212.
- digital processing can be implemented in real time or a posteriori by the backup module, for example, for each set of images optics acquired during a same acquisition time window, in order to pivot each optical image according to the corresponding pivoting angle so as to align all the optical images according to the same pivoting angle.
- This notably makes it possible to simplify the interpretation of the information contained in the acquired optical images.
- Such embodiments are particularly advantageous for long acquisition time windows, typically greater than a few seconds, during which the moving target 200 can perform rotational movements.
- the calculation module 25 can also be configured to determine control instructions intended for the motor 26 so as to block the pivoting of the rotating module 22, during the acquisition of each optical image of a same acquisition time window and/or during the acquisition of all optical images of a same time window acquisition. Apart from the acquisition of an optical image or a set of optical images, the torsion undergone by the optical fibers 110 and induced by the rotational movements of the mobile target 200 is compensated continuously, during and in outside the acquisition time windows, according to the second initial mode of operation.
- this variant of the second mode of operation can make it possible to anticipate and correct a priori the phenomena of blurring (or motion blurring) relating to the rotation of the captive end 112 with respect to the active zone 212, for the duration the acquisition of an optical image or of a set of optical images, thus improving the resulting digital processing, implemented in real time or a posteriori by the backup module.
- the second mode of operation described in relation to optical image acquisition can be adapted to transmit, during transmission time windows, optical excitation signals to the area of interest.
- the calculation module 25 can be configured to determine control instructions intended for the motor 26 so as to compensate for the torsion undergone by the optical fibers 110 and induced by the rotational movements of the moving target 200, during and in outside the transmission time windows.
- the save module can then be configured to save the pivot angle at which each plurality of excitation signals is simultaneously emitted.
- the optical processing module 21 can be configured to perform the transmission of excitation signals and the acquisition of optical images in parallel in time.
- the calculation module 25 is configured to determine an operating mode from among the first and the second operating mode as a function of the duration of the acquisition and transmission time windows.
- the optical processing module 21 can be configured to perform the emission of excitation signals and the acquisition of optical images in a time-sequential manner.
- the modulus of Calculator 25 is then configured to determine an operating mode to carry out the acquisition of optical images or the emission of excitation signals according to the duration of the corresponding time window.
- the acquisition of optical images can be performed in a mode of operation different from that of emission of excitation signals.
- the second unit 20 may further comprise a relay module 27 of the "slip ring" type configured to convey, in the form of electrical signals, via a wired connection (i.e. say using very light electrical cables), the movement parameters determined by the location module 12 to the calculation module 25.
- the relay module 27 comprises a freely rotating element and a static element configured to reliably exchange electrical signals.
- the freely rotating element of the relay module 27 is connected to the location module 12 via a first plurality of electrical cables
- the static element of the relay module 27 is connected to the calculation module 25 via a second plurality of electrical cables.
- the rotational movement of the freely rotating element of the module of relay 27 can be produced by motor 26, via a belt 23 for example, in a manner similar to the rotational movement of rotating module 22.
- the routing of the movement parameters determined by the location module 12 to the calculation module 25 can be done via a wireless connection. between the two modules.
- the first unit 10 may further comprise a wireless transmission module configured to transmit, in the form of radio frequency signals, the movement parameters determined by the location module 12.
- the second unit 20 may comprise in further a wireless receiving module configured to receive and to decode the radio frequency signals carrying the motion parameters.
- the wireless reception module can also be configured to transmit the movement parameters received to the calculation module 25.
- the location module 12 can be configured to determine and to transmit, via a wired or wireless connection, the movement parameters periodically over time, for example every second. More generally, the time period can be determined based on the behavior of the moving target 200.
- the location module 12 is further configured to compare the current movement parameters, associated with the current instant, with the previous movement parameters, associated with the previous instant, and to transmit the current movement parameters only when they are different with respect to the previous movement parameters.
- the location module 12 is configured not to transmit movement parameters when the moving target 200 is immobile over time, which makes it possible to reduce the calculation load in the calculation module 25.
- the location module 12 may include an inertial unit.
- the inertial unit can be of the micro electromechanical system (MEMS) type of reduced size, typically less than 1 cm 3 .
- MEMS micro electromechanical system
- an inertial unit is capable of determining motion parameters of a moving object relative to the starting point of the moving object.
- movement parameters include instantaneous position, movement speed and orientation (roll, pitch and heading angles).
- the localization module 12 can be configured to determine and to transmit to the calculation module 25 at least the roll angle which governs the rotational movements. of the moving target 200 and which induces twists in the optical fibers 110.
- the location module 12 can be configured to determine and to transmit to the calculation module 25 at least the instantaneous position of the moving target 200.
- the location module 12 may further comprise a magnetometer integrated into the inertial unit and configured to determine the direction pointed by the moving target 200 in the terrestrial reference.
- the implementation of an inertial unit comprising a magnetometer in the location module 12 makes it possible to remedy the measurement errors accumulated in the inertial unit.
- the location module 12 can be configured to transmit, according to regular or irregular transmission instants in time, to the calculation module 25 movement parameters comprising at least one movement parameter determined by the inertial unit which can be the roll angle and/or the instantaneous position, that is to say that the motion parameter determined by the magnetometer may not be transmitted at each instant of transmission.
- the calculation module 25 can be configured to implement a data fusion algorithm which receives input parameters comprising:
- calculation module 25 can be configured to determine control instructions intended for the motor 26 as a function of one or more parameters among the input parameters.
- the second unit 20 may further comprise one or more fixing modules 28 configured to rigidly fix the other modules of the second unit 20.
- FIG. 3-A and 3-B illustrate the rotational movement of the captive end 112 relative to the active area 212 of the optical processing module 21, according to two embodiments of the invention.
- the spacing between the captive end 112 and the active zone 212 of the optical processing module 21 is optimized so that the circle 300 described by the rotation of the captive end 112 is completely included in the active zone 212 of the optical processing module 21.
- Such an embodiment makes it possible, for example, to detect the optical signals coming from the captive end 112, and is particularly advantageous when the module calculation 25 operates according to the second mode of operation described above.
- the spacing between the captive end 112 and the active area 212 of the optical processing module 21 can be optimized by providing at least one optimal pivot angle maximizing the overlap between the captive end 112 and the active area 212 of the optical contact module 11.
- the active area 212 and the captive end 112 have a rectangular shape
- This embodiment makes it possible to effectively exploit the active zone 212 of the optical processing module 21.
- Such an embodiment is particularly advantageous when the calculation module 25 is configured for operation according to the first mode of operation in which the pivoting of the tethered end 112 is blocked during the acquisition or transmission time windows.
- the calculation module 25 is configured to operate according to the first mode of operation. In the presence of several optimal pivoting angles allowing maximum overlap between the captive end 112 and the active area 212 of the optical processing module 21, the calculation module 25 can be configured to choose an optimal pivoting angle to perform the acquisition. optical images and/or the emission of excitation signals, this angle being chosen according to the current position of the captive end 112. close to the current position of captive end 112.
- FIG. 4 represents a method for imaging moving targets implemented by the imaging device 100 described in relation to FIG. 1, according to one embodiment of the invention.
- step 401 one or more movement parameters of the moving target 200 are determined, using a location module 12 comprising, for example, an inertial unit integrating a magnetometer.
- Such motion parameters may include the instantaneous position of moving target 200.
- step 402 control instructions intended for the motor 26 governing the pivoting of the captive end 112 with respect to the active zone 212 of the optical processing module 21 are determined.
- Such command setpoints can be determined as a function of several input parameters including the motion parameters received and mechanical and geometric parameters associated with the motor 26 and the rotating module 22 to which the captive end 112 is attached.
- step 402 may comprise the determination of control instructions intended for the motor 26 so as to compensate for the torsion undergone by the optical fibers 110 and induced by the rotational movement of the target mobile 200.
- step 403 the pivoting of the captive end 112 around the optical axis 211, that is to say relative to the active area 212, of the optical processing module 21 is implemented , at least outside the acquisition time windows.
- step 404 one or more optical images are acquired by means of the optical processing module 21, during the acquisition time windows.
- step 404 can comprise the saving in a saving module of each of the optical images acquired in association with the corresponding pivot angle between the captive end 112 and the active zone 212 of the optical processing module 21.
- steps 401 to 404 can be repeated regularly or irregularly over time over an observation period which can range from a few seconds to several days.
- step 402 described above may also consist, during acquisition time windows, in determining control instructions intended for the motor 26 so as to block the pivoting of the captive end 112 with respect to the active zone 212 of the optical processing module 21, according to an optimum pivoting angle.
- step 402 may consist in determining control instructions intended for the motor 26 so as to compensate for the twist experienced by the optical fibers 110, similarly during and outside the acquisition time windows.
- step 401 may include determining a twist value T during acquisition time windows, and comparing the twist value T to a twist threshold level T seu .
- step 402 can comprise a determination of the acquisition instructions (according to the value of the torsion value T) intended for the optical processing module 21 so as to stop and/or resume the acquisition of the optical images, during acquisition time windows.
- the embodiments of the invention thus provide a moving target imaging device 100 making it possible to image a zone of interest of a moving target 200 while allowing the moving target 200 to move freely.
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2103848A FR3121999B1 (fr) | 2021-04-14 | 2021-04-14 | Dispositif et procédé d’imagerie de cibles mobiles |
| PCT/EP2022/058652 WO2022218723A1 (fr) | 2021-04-14 | 2022-03-31 | Dispositif et procédé d'imagerie de cibles mobiles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4322830A1 true EP4322830A1 (fr) | 2024-02-21 |
Family
ID=76601338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22717401.8A Pending EP4322830A1 (fr) | 2021-04-14 | 2022-03-31 | Dispositif et procédé d'imagerie de cibles mobiles |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4322830A1 (fr) |
| FR (1) | FR3121999B1 (fr) |
| WO (1) | WO2022218723A1 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007059069A2 (fr) * | 2005-11-11 | 2007-05-24 | Barbour Randall L | Imagerie fonctionnelle pour sujets mobiles |
| US9046659B2 (en) * | 2013-02-12 | 2015-06-02 | Optomak, Inc. | Independent dual path optical rotary joint |
| JP2016118792A (ja) * | 2016-01-07 | 2016-06-30 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 高度なイメージング特性を有する顕微鏡イメージング装置 |
| US10564101B1 (en) * | 2018-11-02 | 2020-02-18 | Optomak, Inc. | Cable movement-isolated multi-channel fluorescence measurement system |
-
2021
- 2021-04-14 FR FR2103848A patent/FR3121999B1/fr active Active
-
2022
- 2022-03-31 EP EP22717401.8A patent/EP4322830A1/fr active Pending
- 2022-03-31 WO PCT/EP2022/058652 patent/WO2022218723A1/fr not_active Ceased
Non-Patent Citations (3)
| Title |
|---|
| ADMIN: "Imaging the Dynamics of Neocortical Population Activity in Behaving and Freely Moving Mammals", 14 September 2016 (2016-09-14), pages 1 - 5, XP093332889, Retrieved from the Internet <URL:https://radiologykey.com/imaging-the-dynamics-of-neocortical-population-activity-in-behaving-and-freely-moving-mammals/> * |
| GUITCHOUNTS GRIGORI ET AL: "Encoding of 3D Head Orienting Movements in the Primary Visual Cortex", NEURON, vol. 108, no. 3, 1 November 2020 (2020-11-01), AMSTERDAM, NL, pages 512 - 525.e4, XP093333037, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2020.07.014 * |
| See also references of WO2022218723A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3121999A1 (fr) | 2022-10-21 |
| FR3121999B1 (fr) | 2025-02-07 |
| WO2022218723A1 (fr) | 2022-10-20 |
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