Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/062—Oil-in-water emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
  • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

• the present invention relates to a toothpaste free of TiO 2 and exhibiting a whiteness and gloss in all respects similar to conventional toothpastes containing such an ingredient.
• Toothpaste generally refers to formulations which are used to clean the surfaces of the oral cavity. Toothpaste is an oral composition which is not intentionally swallowed for the purpose of systemic delivery of therapeutic agents, but which is applied to the oral cavity, used to treat the oral cavity, and then expectorated.
• Toothpaste is typically used in conjunction with a cleaning instrument such as a toothbrush, typically by applying it to the bristles of the toothbrush and then brushing accessible surfaces of the oral cavity. Toothpaste usually comes in the form of a paste or gel.
• a toothpaste is made up of ingredients that contribute to oral health and ingredients that give it and allow it to maintain a proper texture.
• a toothpaste comprises a foaming agent whose role is to dislodge food particles, bacteria and dental plaque and to eliminate stains on the teeth.
• abrasive mineral fillers such as silica derivatives, for example, which help to whiten teeth by cleaning, polishing them and removing stains. smooth surface, while protecting the enamel.
• Silica contributes to the removal of surface stains thanks to the mechanical action of the toothbrush.
• abrasive fillers are conventionally found silica, precipitated particulate silicas, calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, sodium and potassium pyrophosphate , for example.
• the composition of a toothpaste mainly comprises water which acts as a moisturizer and solubilizer of the ingredients; humectants such as polyols, binders and thickeners such as hydrocolloids, polysaccharides or gums. These humectants and thickeners help to make brushing pleasant by balancing the consistency and viscosity of the toothpaste.
• a toothpaste also comprises various ingredients conferring advantageous organoleptic properties of taste or color, such as flavors and colorings.
• a toothpaste also has particular rheological characteristics.
• a viscoplastic fluid i.e. a threshold fluid.
• a threshold fluid Such fluids are media that hold both solid and fluid: they refuse to flow if they are not pushed hard enough, that is, if the applied stress remains below a threshold. This is due to the fact that, at rest, there exists in these media a rigid three-dimensional structure which is destroyed when the stress becomes greater than the critical stress, the threshold.
• a characteristic that is often sought after for a toothpaste is its whiteness, its shine, and even its opacity, in connection with the association it makes with the whiteness of the teeth, which is often sought after.
• This aspect of whiteness and shine may concern the whole body of the toothpaste or at least part of it. This occurs in the case of the inclusion of colored particles in a white toothpaste or in the case of a striped toothpaste, where a colored paste is combined with a white paste, which makes it possible to obtain the stripes during the extrusion of the toothpaste from the tube by virtue of the pressure applied to said tube.
• Optical attributes such as whiteness, color, brilliance or even opacity are conventionally measurable and measured using colorimeters or spectrophotometers, such as, for example, those marketed by the company Konica Minolta.
• Such equipment has dedicated the evaluation of food products, beverages, cosmetics or even paints and the ad hoc software makes it possible to obtain values of luminosity, opacity, fluorescence, color, brightness, brightness of whiteness or more color and this in a reproducible and objective manner.
• titanium dioxide is an ingredient commonly used as a colorant in cosmetic products in general. It gives toothpaste whiteness, shine and shine.
• Titanium dioxide (T1O2) (Cl 77891; E171) is an inorganic compound used in many applications, in particular in nanometric form for its ultraviolet absorption properties and its photocatalytic power, but also in micrometric form for its coloring functions and opacifying. Its characteristics are very interesting in industrial sectors such as paint, cosmetics, plastics, confectionery, textile coatings and drugs for example.
• Titanium dioxide is also a very present material in toothpaste for its opacifying effect and for its ability to impart a white color to toothpaste. In addition, its quality / price ratio is very reasonable. However, the question of titanium dioxide as to its toxicity is still uncertain for scientists. Its regulation and classification are therefore currently widely debated.
• the present invention provides a solution for replacing TiO2 in toothpastes in order to achieve a whiteness comparable to that of toothpaste produced with this controversial ingredient.
• the invention therefore relates to an oral composition in the form of a toothpaste comprising: - An oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier,
• a foaming agent and optionally an abrasive filler are optionally used.
• the invention relates to an oral composition in the form of a toothpaste comprising:
• an oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater than or equal to 10 and
• foaming agent preferably having an HLB of between 3 and 8, particularly greater than 3 and less than 8;
• the oral composition in the form of toothpaste also has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the composition according to the invention comprises a foaming agent as well as an abrasive filler.
• composition according to the invention is advantageously characterized in that it has a viscosity, at 25 ° C., of between 3500 mPa.s and 30,000 mPa.s, or even between 4000 mPa.s and 30,000 mPa.s, in particular between 5,000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• composition according to the invention is characterized in that it does not contain TiO 2 while exhibiting the attributes and colorimetric characteristics of color, whiteness, or even possibly opacity, similar to that of a toothpaste comprising it.
• the composition according to the invention is characterized in that the aqueous phase represents, in% by weight, from 30 to 80%, particularly from 40 to 75%, more particularly from 45 to 70%, more particularly still from 50 to 70% , more particularly also between 50 and 65%, of the composition.
• the composition according to the invention is characterized in that the fatty phase represents, in% by weight of the composition, from 1 to 40%, particularly from 2 to 40%, particularly from 2 to 35%, more particularly from 4 to 30%, or even from 4 to 25%, and more particularly still from 5 to 23%.
• the fatty phase represents, in% by weight of the composition, approximately 20 to 25%.
• the composition according to the invention is characterized in that it does not contain TiO 2, that the fatty phase represents, in% by weight, from 1 to 40%, particularly from 2 to 35%, more particularly from 4 to 30%, or even from 4 to 25%, and more particularly still 5 and 23%, of the composition; that the fatty phase comprises a vegetable oil that is liquid or solid at room temperature and that the emulsifier is chosen from nonionic alkylglycosides, esters, fatty alcohols and mixtures thereof.
• the esters are chosen from esters of fatty acids and of glycerol or of esters of fatty acids and polyglycerol.
• a suitable ester can be chosen from esters of sugars and fatty acids or esters of glycerol and fatty acids.
• the sugar can be chosen from glucose, sucrose, fructose for example.
• it is sucrose.
• the esterified fatty acid can be a fatty acid comprising from 8 to 20 carbon atoms, in particular, from 10 to 20 carbon atoms, or even from 12 to 20 carbon atoms.
• a suitable ester can be, for example, the sucrose cocoate contained in the commercial product sold under the name Tegosoft® LSE65K or the sucrose stearate contained in the commercial product sold under the name Sisterna® SP70C, for example, as well as mixtures thereof.
• a suitable ester may be polyglyceryl-3 diisostearate or polyglyceryl-6 laurate, contained for example in the commercial product Fluidifeel® easy.
• the composition is characterized in that the aqueous phase comprises water and a humectant and optionally a thickener.
• the composition according to the invention is characterized in that the water represents, in% by weight, from 20 to 60%, or even from 25 to 60%, particularly from 30 to 55%, more particularly still from 33 to 50%, of the composition.
• the composition according to the invention is characterized in that the humectant represents, in% by weight, from 10 to 30%, particularly from 15 to 25%, particularly between 15 and 20%, more particularly about 18%, of the composition.
• the composition according to the invention in a particular embodiment, is also characterized in that the fatty phase comprises a fatty substance which is liquid or solid at ambient temperature, that is to say approximately 20 ° C. and atmospheric pressure.
• composition according to the invention is characterized in that the fatty phase comprises a liquid or solid vegetable oil at room temperature.
• composition according to the invention is characterized in that the optional abrasive filler represents, in% by weight, from 0 to 40%, particularly from 5 to 40%, more particularly from 10 to 30%, more particularly still from 12 to 25%, particularly still about 13 to 20% of the composition.
• an object of the present invention to target the use of an oil-in-water emulsion as defined in one of the embodiments of the composition according to the invention, in the manufacture of an oral composition.
• the bleached oral composition also has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100 .
• the bleached oral composition has a viscosity, at 25 ° C, of between 3500 mPa.s and 30,000 mPa.s, in particular between 4000 mPa.s and 30,000 mPa.s, in particular between 5000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• the bleached oral composition has a viscosity, at 25 ° C, of between 3500 mPa.s and 30,000 mPa.s, or even between 4000 mPa.s and 30,000 mPa.s, in particular between 5000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• the invention also relates to a method for obtaining an oral composition according to one of the embodiments described above, comprising:
• an oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater or equal to 10, said emulsion comprising a foaming agent exhibiting an HLB of between 3 and 8, particularly greater than 3 and less than 8, and
• the oral composition is a toothpaste.
• toothpaste In the context of the present invention, we will speak of toothpaste, toothpaste or toothpaste cream in an equivalent manner.
• composition according to the invention is characterized in that it does not contain TiO2.
• no TiO 2 means that this compound is not added and that its possible presence only exists in trace amounts, which corresponds to an amount less than 0.1%, more particularly less than 0.05%, or even less than 0.025%, in% by weight of the composition.
• composition according to the invention is in the form of a toothpaste.
• It can comprise any pharmaceutically or cosmetically acceptable excipient well known to those skilled in the art as suitable for entering into this type of composition.
• composition in the form of toothpaste according to the invention may in particular comprise: vitamins, minerals such as calcium, flavors, sweeteners.
• the composition may include preservatives or thickening agents, as well as mixtures thereof, for example.
• the optional abrasive filler can be mineral or organic.
• An inorganic abrasive filler can be chosen from compounds such as silicas, silicates, sodium bicarbonate or calcium phosphates.
• An organic abrasive filler can be chosen from insoluble vegetable powders.
• an organic abrasive filler can be a cellulose powder, in particular a microcrystalline cellulose powder, a starch powder, in particular a rice powder, rice starch, as well as their mixtures, for example.
• a mineral abrasive filler can also be of animal origin. It could be coral powder, shell powder, oyster shell powder, or their mixtures, for example.
• composition in the form of toothpaste according to the invention may also comprise other active ingredients such as enzymes, remineralizing agents, antibacterial agents, such as chlorhexidine for example, or anti-biofilm agents such as o-cymen. 5ol, a cranberry extract (or Vaccinium niacrocarpon) for example.
• active ingredients such as enzymes, remineralizing agents, antibacterial agents, such as chlorhexidine for example, or anti-biofilm agents such as o-cymen. 5ol, a cranberry extract (or Vaccinium niacrocarpon) for example.
• composition according to the invention can thus comprise at least one remineralizing agent.
• the mineralizing agent is a fluorine salt.
• Such a fluorine salt can in particular be chosen from potassium, sodium and tin fluorides, amino fluorides and quaternary ammonium fluorides.
• the fluorine salt is an amine fluoride of formula (I) below:
• R1 represents a hydrogen atom or a (Ci-C 6 ) alkyl group
• R2 represents a group CH2OH, CC> 2 ((C1-C6) alkyl), CONH (CH 2 ) 2 0H or [Chem 2] and R2 is in position 2 or 3 with respect to the nitrogen atom.
• (Ci-C 6 ) alkyl” group means a saturated, linear or branched hydrocarbon chain comprising 1 to 6, in particular 1 to 4, carbon atoms. By way of example, mention may be made of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl or even hexyl groups.
• R1 is H.
• the present invention further relates to the use of an oil-in-water emulsion as described herein for the manufacture of a toothpaste having a whiteness value L * of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90.
• the present invention further relates to the use of an oil-in-water emulsion as described here for the manufacture of a toothpaste exhibiting a whiteness value L * as explained above.
• the toothpaste has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the toothpaste thus manufactured does not contain TiO 2.
• the value of whiteness L * as well as the value of opacity can be measured by well known colorimetric techniques using a commercial colorimeter.
• the aqueous phase represents, in% by weight, from 30 to 80%, particularly from 40 to 75%, more particularly from 45 to 70%, more more particularly still from 50 to 70%, more particularly also between 50 and 65%, of the composition.
• the fatty phase represents, in% by weight, from 1 to 40%, particularly from 2 to 40%, particularly from 2 to 35%, more particularly from 4 to 30%, or even from 4 to 25%, and more particularly still from 5 to 23%, of the composition.
• the fatty phase represents, in% by weight of the composition, approximately 20 to 25%.
• the aqueous phase comprises water, a humectant and optionally a thickener.
• the humectant can be a polyol.
• a suitable polyol can be advantageously chosen from the group comprising glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, propanel, 3 diol and their mixtures.
• the humectant is glycerol.
• Some polyols act as a humectant and may, by their nature as a saccharide derivative, help impart a sweet taste to the composition.
• the thickening agent can be chosen from carboxyvinyl polymers, cellulose derivatives, carrageenans, guar gum, xanthan gum, acacia, tragacanth, and mixtures thereof.
• the cellulose derivatives can be chosen from the group comprising hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, carboxymethylhydroxyethylcellulose and their mixtures.
• the water represents, in% by weight, from 20 to 60%, or even from 25 to 60%, particularly from 30 to 55%, more particularly still from 33 to 50%, of the composition.
• the humectant represents, in% by weight, from 10 to 30%, particularly from 15 to 25%, particularly between 15 and 20%, more particularly approximately 18%, of the composition.
• the humectant is glycerol in these amounts mentioned.
• the thickener represents, in% by weight, from 0 to 10%, particularly from 0 to 5%, particularly approximately 1%, of the composition.
• the thickener is a cellulose derivative, and in particular it is carboxymethylcellulose (also called carmellose). It is a very hygroscopic cellulose ether often used in the form of its sodium salt, sodium carboxymethylcellulose.
• the emulsifier represents, in% by weight, from 0.1 to 10%, or even from 0.5 to 8%, particularly again from 1 to 6% and more particularly from 1 .5 to 4 %, of the composition.
• the emulsifier can be chosen from traditional emulsifiers known to pharmacy and cosmetics for the topical formulation of cosmetic or skin care products.
• emulsifier or surfactant
• a discontinuous phase the first liquid
• the second liquid the second liquid
• a continuous phase the second liquid
• the role of the emulsifier as a surfactant is to reduce the surface tension between the two liquid phases, by forming a film around the dispersed droplets.
• a surfactant is an amphiphilic molecule, that is to say having both a polar hydrophilic part and another nonpolar hydrophobic.
• the surfactant has an affinity with the hydrophilic phases and the non-hydrophilic phases (lipophilic for example). It is therefore placed at the interface of these two phases and allows the interfacial tension to drop. This therefore makes it possible to dissolve two initially immiscible phases.
• the surfactant used is called an emulsifier or emulsifier. It will have an affinity with the hydrophilic (aqueous) phase and an affinity with the lipophilic (fatty) phase.
• HLB hydrophilic-lipophilic-balance
• HLB is a great characteristic of an emulsifier. It is measured by a method described by Griffith (Griffin WC, Classification of Surface-Active Agents by HLB, Journal of the Society of Cosmetic Chemists 1 (1949): 311) and makes it possible to quantify the balance existing between the hydrophilic part and the lipophilic part of the emulsifier molecule, equilibrium linked to solubility in water. The scale varies from 0 to 20; the higher the value, the greater the solubility in water.
• amphiphile is lipophilic.
• the amphiphile is hydrophilic. (The closer the value is to 20, the greater the solubility in water.)
• an emulsifier whose HLB is less than 8, or even less than 7, or even less than 6, will be preferred.
• an emulsifier whose HLB is greater than 8, or even greater than 9, or even greater than 10.
• the emulsion is an oil / water emulsion and the emulsifier, or the mixture of emulsifiers, will be chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater than or equal to 10.
• the emulsifier may be chosen from nonionic alkylglycosides, esters, fatty alcohols and mixtures thereof.
• a suitable nonionic alkylglycoside preferably agrosourced, can in particular be chosen from alkyl- (poly) glycosides, and their mixtures, of general formula
• - Alk denotes a hydrophobic aliphatic hydrocarbon fragment, saturated or unsaturated, linear or branched comprising from 3 to 22 carbon atoms
• - Z represents a hydrophilic glycoside group, for example such as glucose, xylose or arabinose, and
• Z represents a glucose group.
• Z represents a xylose group.
• Z represents an arabinose group.
• Alk denotes a saturated or unsaturated, linear or branched, hydrophobic aliphatic hydrocarbon moiety comprising 6 to 22 carbon atoms.
• Alk denotes a hydrophobic aliphatic hydrocarbon fragment, saturated or unsaturated, linear or branched, comprising 8 to 20 carbon atoms.
• Alk denotes a hydrophobic aliphatic hydrocarbon fragment, saturated or unsaturated, linear or branched comprising 10 to 20 carbon atoms.
• Alk denotes a hydrophobic aliphatic hydrocarbon fragment, saturated or unsaturated, linear or branched, comprising 12 to 20 carbon atoms.
• a suitable alkylglycoside can be cetearyl glucoside as for example contained in the commercial product sold under the name Montanov® 68.
• a suitable ester can be chosen from esters of sugars and fatty acids or esters of glycerol and fatty acids or esters of fatty acids and polyglycerol.
• the sugar can be chosen from glucose, sucrose, fructose for example.
• it is sucrose.
• the esterified fatty acid can be a fatty acid comprising from 8 to 20 carbon atoms, in particular, from 10 to 20 carbon atoms, or even from 12 to 20 carbon atoms.
• a suitable ester can be, for example, the sucrose cocoate contained in the commercial product sold under the name Tegosoft® LSE65K or the sucrose stearate contained in the commercial product sold under the name Sisterna® SP70C, for example, as well as mixtures thereof.
• a suitable ester may be polyglyceryl-3 diisostearate or polyglyceryl-6 laurate, contained for example in the commercial product Fluidifeel® easy.
• the fatty alcohol can be chosen from alcohols with a long carbon chain having an even number of carbon atoms of between 8 and 30, particularly between 8 and 24, or even between 8 and 20, as well as mixtures.
• the fatty alcohol can be chosen from stearyl alcohol, cetyl alcohol, cetostearyl alcohol and their mixtures.
• the fatty phase comprises, or consists of - apart from emulsifier - a fatty substance that is liquid or solid at room temperature, that is to say around 20 ° C and atmospheric pressure (i.e. 760 mm Hg).
• emulsifier - a fatty substance that is liquid or solid at room temperature, that is to say around 20 ° C and atmospheric pressure (i.e. 760 mm Hg).
• it is a fatty substance that is liquid at room temperature.
• the fatty phase can be chosen from the group consisting of a vegetable oil that is liquid or solid at room temperature, a synthetic oil, a silicone oil, and mixtures thereof.
• the fatty phase can be chosen from the group of vegetable oils consisting of sunflower oil, coconut oil, plum seed oil, sesame oil, jojoba oil, rapeseed oil (for example contained in the commercial product Lipex Bassol C®) and rice oil, and mixtures thereof.
• sunflower oil sold under the name of refined sunflower oil by Olvéa
• high purity plant alkanes C15-1 C19 alkane
• Emogreen L19 and L15 by Seppic
• coconut oil sold by Aldivia
• refined and winterized sesame oil sold by Olvéa
• the virgin plum seed extract sold under the name Prunus Domestica Seed Extract by Expanscience
• the rapeseed oil sold under the name Lipex Bassol C by the company Unipex or also the rice oil sold by the company Maruzen Chemicals.
• the fatty phase comprises an oil which is liquid at room temperature in an amount, expressed in% by weight of the composition, of between 5 and 30%, particularly between 5 and 25%, more particularly between 10 and 25%, again more particularly between 15 and 25%, even advantageously around 20%.
• the moisturizing effect in the mouth and on the lips is appreciated, as is the film-forming effect obtained on the teeth.
• a fatty phase comprising, or consisting of, an oil which is liquid at ambient temperature, in particular a vegetable oil which is liquid at ambient temperature, that is to say approximately 20 ° C.
• a liquid vegetable oil at room temperature can be advantageously a sunflower oil; the inventors have in fact been able to observe that it confers, on the one hand, good stability to the emulsion and, on the other hand, a good sensation in the mouth during use.
• Such a sunflower oil will be comprised, in% by weight of the composition, from around 5 to 30%, in particular from 5 to 25%, in particular still from 10 to 30%, more particularly still 15 and 30%, and even more particularly around 20%.
• the synthetic oil can thus be chosen from the group comprising synthetic triglycerides, for example caprylic / capric triglyceride.
• the silicone oil can be selected from the group consisting of polysiloxanes, polymethylsiloxanes, polydimethylsiloxanes, and mixtures thereof. In particular, it can be dimethicone.
• the fatty phase is a vegetable oil or a mixture of vegetable oils, in particular liquid at room temperature.
• the composition according to the invention also comprises at least one foaming agent.
• foam the formation of foam, the dispersion of a large volume of gas in a small volume of liquid, requires the presence of foaming agents which adsorb at the water-air interface.
• the foaming agents according to the invention have an HLB of between 3 and 8, particularly greater than 3 and less than 8.
• the foaming agent can come from the family of glutamates such as sodium cocoyl glutamate, by way of example, and contained in the commercial product sold under the name Amisoft® CS11 by Unipex, disodium cocoyl glutamate contained in the commercial product sold under the name Amisoft® ECS22W, sodium lauroyl glutamate contained in the commercial product sold under the name Amisoft® LS11.
• the foaming agent represents, in% by weight, from 0.5 to 8%, particularly from 1 to 6%, more particularly from 1.5 to 4%, of the composition.
• the foaming agent can be supplemented with another compound which stabilizes or thickens the foam which can be chosen from anionic, cationic, nonionic, ester-bonded, amide-bonded and ether-bonded surfactants.
• the choice of such a stabilizing or thickening and foam reinforcing compound depends on the foaming agent itself and on the amounts of water and of the fatty phase and is not critical in itself and can be determined by a person skilled in the art. job.
• the composition according to the invention optionally comprises an abrasive, mineral or organic filler or a mixture.
• the abrasive filler represents, in% by weight, from 0 to 40%, from 5 to 40%, particularly from 10 to 30%, particularly still from 12 to 25%, particularly still approximately 13 to 20% of the composition.
• This abrasive filler can be chosen from the group consisting of silica, precipitated particulate silicas, silicates, calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, pyrophosphates sodium and potassium, sodium trimetaphosphate, sodium hexametaphosphate, hydroxyapatite (particulate) and mixtures thereof.
• the abrasive filler of mineral origin can thus comprise a clay, in particular a white clay, more particularly kaolin.
• the abrasive filler can be organic of plant origin and chosen from the group consisting of rice powder (Oryza sativa), cellulose powder, in particular microcrystalline cellulose powder, rice starch, as well as their mixtures.
• the mineral abrasive filler may also include a filler of animal origin. It could be coral powder, shell powder, oyster shell powder as well as their mixtures, for example.
• composition according to the invention thus comprises an oil-in-water emulsion, a foaming agent, an optional abrasive filler, particularly an inorganic or organic abrasive filler, of plant or animal origin.
• Cosmetically or dermatologically acceptable excipients can also be added. These cosmetically or dermatologically acceptable excipients can be added to the fatty phase and / or to the aqueous phase during the production of the composition according to the invention.
• composition according to the invention is free from TiO2.
• the composition according to the invention has a whiteness identical or at the very least similar to a conventional toothpaste containing TiO 2. Still advantageously, a composition according to the invention can have an opacity value comparable to that of a conventional toothpaste containing TiO 2.
• the whiteness of an oral composition, in particular a toothpaste can be evaluated by measuring the parameters of the colorimetric system L * , a * , b * .
• the L * represents lightness, therefore whiteness, which takes values between 0 (black) and 100 (white).
• the a * represents the value on a green to red axis.
• the b * represents the value on a blue to yellow axis.
• opacity of an oral composition in particular a toothpaste, this can be evaluated like the parameters L, a * , b * defined above via a spectrocolorimeter or spectrophotometer.
• devices marketed by the company KONICA MINOLTA from the CM (Color Measurement) range are particularly suitable, for example the CM-3630 or even the CM-5 which are equipped with image processing software allowing measurements. varied such as brightness, opacity, fluorescence, color, whiteness or for example tint.
• the opacity of the toothpaste cream formulation is its property of not transmitting certain radiation or certain rays.
• opacity refers to the opacity of the product generally determined by measuring the product with a black background and then measuring with a white background.
• the opacity, as well as the L * , a * and b * values can be obtained by using a KONICA MINOLTA CM5 colorimeter for example; as described in the example of the present application and equipped with the ad hoc software.
• the colorimeter can thus be used in "reflection" mode, which makes it possible to automatically determine the opacity at the same time as the colorimetric parameters L * , a * and b * .
• the measurement is performed in Reflection mode in a Petri dish.
• specular reflection The angle at which light reflects is called specular reflection.
• This specular reflection is reflected as in a mirror.
• diffuse reflection Light that is not specular but scattered in all directions is called diffuse reflection.
• the sum of the specular reflection and the diffuse reflection is called the total reflection.
• SCE Standard Component Excluded
• Specular Component Included SCI
• Specular reflection is included in the color measurement in addition to diffuse reflection. This measurement evaluates the overall color of the object, it is independent of the surface condition of the object
• the Reflection mode in a Petri dish associated with the SCE method is used with the device mentioned.
• a composition according to the invention may have the rheological characteristics of a conventional toothpaste, that is to say a viscosity, at 25 ° C., of between 3500 mPa.s and 30,000 mPa.s, or even between 4000 mPa.s and 30,000 mPa.s, in particular between 5,000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• the measurement of the viscosity of the composition according to the invention can be carried out using a Rheomat RM200, at a speed of 27.5s 1 , at a temperature of 25 ° C and using the mobile 3.
• the formulation is packaged in a 150ml jar in order to take the measurement.
• a microscopic analysis of the toothpaste cream composition in emulsion form can be carried out in order to ensure the good formation of the O / W emulsion, that is to say that the fatty phase is well dispersed in the form of droplets. of oil in the aqueous phase.
• an Olympus BX43 type microscope is used in polarized light with a magnification of 20.
• the present invention also relates to the use of an oil-in-water emulsion as defined in the present description, in the manufacture of an oral composition in the form of toothpaste according to the invention, devoid of TiO 2, in order to confer a whiteness value L * of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90.
• the use of the emulsion according to the invention is characterized in that the toothpaste does not include Ti02.
• the present invention also relates to the use of an oil-in-water emulsion as defined in the present description, in the manufacture of an oral composition in the form of toothpaste according to the invention, devoid of TiO 2, in order to give it an opacity value between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• Also provided is a method for whitening an oral composition in the form of toothpaste not comprising TiO 2 comprising combining a foaming agent, and an optional abrasive filler, with an oil-in-water emulsion as described herein. It is possible to add at least one pharmaceutically or cosmetically acceptable excipient.
• the cosmetically or dermatologically acceptable excipient or excipients can be added to the fatty phase and / or to the aqueous phase during the production of the composition according to the invention.
• whitening is meant here the fact of obtaining a toothpaste having an L * value of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90. Also advantageously the expression “whiten” further comprises the fact of obtaining a bleached oral composition which also has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the pharmaceutically or cosmetically acceptable excipient can be selected from the group comprising, or consisting of, a preservative, a flavoring agent, and mixtures thereof, for example.
• the method for whitening a toothpaste according to the invention comprises an additional step of adding at least one additional active ingredient chosen from the group comprising, or consisting of, an antibacterial agent, an anti-biofilm agent, an anti-biofilm agent. - halitosis, a remineralizing agent and mixtures thereof.
• the remineralizing agent is a fluorine salt, advantageously it is nicomethanol hydrofluoride (fluorinol®).
• the inventors have observed that the use of an oil-in-water emulsion with a foaming agent, an optional abrasive filler, and an optional humectant, in the absence of any addition of TiO 2, made it possible to obtain a toothpaste. whose whiteness is in every way comparable to a conventional toothpaste containing this additive.
• the composition according to the invention also exhibits an opacity quite similar to a conventional toothpaste containing TiO2.
• the present invention also relates to a process for obtaining an oral composition in the form of toothpaste according to the invention and as described above, having a whiteness value L * of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90.
• a process for obtaining an oral composition according to the present invention comprises:
• an oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater or equal to 10 and as defined according to one of the embodiments described in the present description and the optional addition of an abrasive filler.
• the oral composition obtained also has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the composition obtained has a viscosity, at 25 ° C., of between 3500 mPa.s and 30,000 mPa.s, or even between 4000 mPa.s and 30,000 mPa.s, in particular between 5000 and 25000 mPa.s, or even again between 10,000 and 22,000 mPa.s.
• the invention relates to an oral composition in the form of a toothpaste comprising:
• an oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater than or equal to 10 and
• the oral composition also has a value opacity between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the composition is characterized in that it further comprises an abrasive filler.
• the composition of the invention is characterized in that it has a viscosity, at 25 ° C, of between 3500 mPa.s and 30,000 mPa.s, or even between 4000 mPa.s and 30,000 mPa .s, in particular between 5,000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• composition of the invention is characterized in that it does not contain TiO 2.
• the composition of the invention is characterized in that the aqueous phase represents, in% by weight, from 30 to 80%, particularly from 40 to 75%, more particularly from 45 to 70%, more more particularly still from 50 to 70%, more particularly also between 50 and 65%, of the composition.
• the composition of the invention is characterized in that the fatty phase represents, in% by weight, from 1 to 40%, particularly from 2 to 40%, particularly from 2 to 35%, more particularly from 4 to 30%, or even from 4 to 25%, and more particularly still from 5 to 23%, of the composition.
• the fatty phase represents, in% by weight of the composition, approximately 20 to 25%.
• the fatty phase comprises an oil which is liquid at room temperature in an amount, expressed in% by weight of the composition, of between 5 and 30%, or even between 5 and 25%, more particularly between 10 and 25%, again more particularly between 15 and 25%, even advantageously around 20%.
• the composition of the invention is characterized in that the aqueous phase comprises water and a humectant and optionally a thickener.
• the composition of the invention is characterized in that the water represents, in% by weight, from 20 to 60%, or even from 25 to 60%, particularly from 30 to 55%, more particularly still 33 to 50%, of the composition.
• the composition of the invention is characterized in that the humectant represents, in% by weight, from 10 to 30%, particularly from 15 to 25%, particularly between 15 and 20%, more particularly about 18%, of the composition.
• the composition of the invention is characterized in that the fatty phase comprises a fatty substance that is liquid or solid at room temperature, that is to say around 20 ° C and atmospheric pressure.
• the composition of the invention is characterized in that the fatty phase comprises a liquid or solid vegetable oil at room temperature.
• the composition of the invention is characterized in that the abrasive filler represents, in% by weight, from 0 to 40%, from 5 to 40%, particularly from 10 to 30%, particularly still from 12 to 25%, more particularly about 13 to 20% of the composition.
• the invention also relates to the use of an oil-in-water emulsion as defined in one of the preceding embodiments in the manufacture of an oral composition in the form of toothpaste, devoid of TiO 2, in order to confer a whiteness value L * of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90.
• the oral composition thus manufactured also has a opacity value between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100 .
• the composition has a viscosity, at 25 ° C, between 3500 mPa.s and 30,000 mPa.s, or even between 4,000 mPa.s and 30,000 mPa.s, in particular between 5,000 and 25,000 mPa.s, or even between 10,000 and 22,000 mPa.s.
• the invention also relates to a method for whitening an oral composition in the form of toothpaste not comprising TiO 2, consisting in combining a foaming agent, and an optional abrasive filler, with an oil emulsion in water as defined according to one of the preceding embodiments, characterized in that the bleaching of the composition corresponds to obtaining a whiteness value L * of between 60 and 100, between 65 and 100, particularly between 70 and 100, more particularly between 75 and 95, more particularly still between 75 and 90.
• the oral composition obtained also has an opacity value of between 85 and 100, particularly between 90 and 100, more particularly still between 95 and 100.
• the invention also relates to a method for obtaining an oral composition according to one of the preceding embodiments, comprising:
• an oil-in-water emulsion comprising a fatty phase dispersed in an aqueous phase, said emulsion being stabilized by an emulsifier chosen from emulsifiers having an HLB greater than or equal to 8, or even greater than or equal to 9, or even greater or equal to 10, as described in the present description and
• Viscosity measurement (in mPa.s) o Method: - Rheomat RM200
• - opacity measurement use of the Reflection mode in a Petri dish associated with the SCE method used with the device and the software installed.
• the process is carried out cold or hot and the emulsion is carried out using a Rayneri type stirrer.
• aqueous phase and the ingredients which are solubilized therein are mixed intimately.
• the fatty phase (oils and fatty substances) is supplemented with the emulsifier (s) and the liposoluble ingredients and excipients.
• the fatty phase is added with stirring to the aqueous phase.
• fillers eg silicas
• heat-sensitive raw materials eg aromas
• EXAMPLE 1 Emulsion toothpaste containing 5% sunflower oil without TiO 2. Hot process.
• EXAMPLE 6 Emulsion toothpaste at 20% sunflower oil, without TiO2. Cold process.
• Example 7 The formula of this Example 7 is in the form of a conventional toothpaste, pH 6.02 and viscosity after manufacture of 3441 mPa.s.
• This formula is compared to the formula of Example 2 presented above; formula without Ti02 but with an emulsifier and an oil.
• This EXAMPLE 8 was produced without TiO 2 and without the ingredients for making the emulsion, namely the emulsifier (Montanov 68) and sunflower oil.

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