EP4043882A8 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xviii - Google Patents

Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xviii Download PDF

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Publication number
EP4043882A8
EP4043882A8 EP21211005.0A EP21211005A EP4043882A8 EP 4043882 A8 EP4043882 A8 EP 4043882A8 EP 21211005 A EP21211005 A EP 21211005A EP 4043882 A8 EP4043882 A8 EP 4043882A8
Authority
EP
European Patent Office
Prior art keywords
sequences
detection
mrsa
methicillin
identification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21211005.0A
Other languages
German (de)
French (fr)
Other versions
EP4043882A1 (en
Inventor
Ann Huletsky
Richard Giroux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson Infusion Therapy Systems Inc
Original Assignee
Becton Dickinson Infusion Therapy Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37911412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP4043882(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Becton Dickinson Infusion Therapy Systems Inc filed Critical Becton Dickinson Infusion Therapy Systems Inc
Publication of EP4043882A1 publication Critical patent/EP4043882A1/en
Publication of EP4043882A8 publication Critical patent/EP4043882A8/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

ABSTRACT OF THE DISCLOSURE
Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for diagnostic purposes and/or epidemiological typing.
EP21211005.0A 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xviii Pending EP4043882A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/248,438 US7838221B2 (en) 2005-10-11 2005-10-11 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
PCT/US2006/039996 WO2007044873A2 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej types xi to xx
EP10016031.6A EP2325643B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XV
EP06825875A EP1934613B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xi

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP06825875A Division EP1934613B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xi
EP10016031.6A Division EP2325643B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XV

Publications (2)

Publication Number Publication Date
EP4043882A1 EP4043882A1 (en) 2022-08-17
EP4043882A8 true EP4043882A8 (en) 2022-10-12

Family

ID=37911412

Family Applications (8)

Application Number Title Priority Date Filing Date
EP10016072.0A Active EP2325644B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xii
EP10016074.6A Active EP2322930B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xiv
EP10016019.1A Active EP2325646B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XVII
EP10016031.6A Revoked EP2325643B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XV
EP10016020.9A Revoked EP2325647B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xx
EP21211005.0A Pending EP4043882A1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xviii
EP06825875A Revoked EP1934613B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xi
EP10016073.8A Active EP2325645B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xiii

Family Applications Before (5)

Application Number Title Priority Date Filing Date
EP10016072.0A Active EP2325644B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xii
EP10016074.6A Active EP2322930B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xiv
EP10016019.1A Active EP2325646B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XVII
EP10016031.6A Revoked EP2325643B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (MRSA) of MREJ type XV
EP10016020.9A Revoked EP2325647B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xx

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP06825875A Revoked EP1934613B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej type xi
EP10016073.8A Active EP2325645B1 (en) 2005-10-11 2006-10-10 Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ type xiii

Country Status (11)

Country Link
US (1) US7838221B2 (en)
EP (8) EP2325644B1 (en)
JP (2) JP5214454B2 (en)
AT (1) ATE496143T1 (en)
AU (1) AU2006302044B2 (en)
CA (3) CA3113401A1 (en)
DE (1) DE602006019757D1 (en)
DK (5) DK2325643T3 (en)
ES (7) ES2733864T3 (en)
HK (1) HK1122844A1 (en)
WO (1) WO2007044873A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2348042A1 (en) * 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US11834720B2 (en) * 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
ATE467689T1 (en) * 2006-05-12 2010-05-15 Cepheid RECOGNITION OF THE JOIN OF A DNA RECOMBINATION
EP2118311B1 (en) 2006-12-19 2013-07-03 GeneOhm Sciences, Inc. Detection of staphylococcus aureus and identification of methicillin-resistant staphylococcus aureus
US8535888B2 (en) * 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
AU2008242250B2 (en) 2007-04-19 2014-03-27 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
US7888075B2 (en) * 2007-07-31 2011-02-15 Quest Diagnostics Investments Incorporated Detection of methicillin-resistant and methicillin-sensitive Staphylococcus aureus in biological samples
US20100304366A1 (en) * 2007-11-13 2010-12-02 Wu Ling-Chuan Chen Methods for Determining Virulence and Invasiveness Among Various Staphylococcus Aureus Strains
EP3434785A1 (en) 2007-12-21 2019-01-30 bioMerieux SA Detection of methicillin-resistant staphylococcus aureus
WO2009117310A2 (en) * 2008-03-17 2009-09-24 Cedars-Sinai Medical Center Methods for treatment and prevention of mrsa/mssa
AR077841A1 (en) * 2009-08-11 2011-09-28 Univ Brandeis METHODS KITS AND COMPOSITIONS OF DETECTION OF NUCLEIC ACID AT MULTIPLE TEMPERATURES, WITH A SINGLE PROBE
RU2012124051A (en) * 2009-11-13 2013-12-20 Бекман Каултер, Инк. SYSTEMS AND METHODS FOR DETECTING THE AVAILABILITY OF THE BIOLOGICAL SIGN WITH THE USE OF CLUSTERING
US8715936B2 (en) 2010-01-13 2014-05-06 Medical Diagnostic Laboratories, Llc Method of determining types I, II, III, IV or V or methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample
US20140030712A1 (en) * 2011-02-01 2014-01-30 Baylor College Of Medicine Genomic approach to the identification of biomarkers for antibiotic resistance and susceptibility in clinical isolates of bacterial pathogens
WO2013048583A2 (en) 2011-05-24 2013-04-04 Elitech Holding B.V. Detection of methicillin-resistant staphylococcus aureus
EP3450572A1 (en) * 2011-12-23 2019-03-06 bioMérieux Detection of meca variant strains of methicillin-resistant staphylococcus aureus
WO2013112755A1 (en) 2012-01-24 2013-08-01 The Trustees Of Columbia University In The City Of New York Field optimized assay devices, methods, and systems
IN2014DN09199A (en) * 2012-04-06 2015-07-10 Geneohm Sciences Canada Inc
WO2016025698A1 (en) 2014-08-13 2016-02-18 The Trustees Of Columbia University In The City Of New York Diagnostic devices, systems, and methods
US11098349B2 (en) * 2015-11-04 2021-08-24 The Translational Genomics Research Institute Systems and methods of diagnosing and characterizing infections
CA3155871A1 (en) 2017-07-10 2019-01-17 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
EP3665309B1 (en) * 2017-08-11 2023-02-22 Gen-Probe Incorporated Compositions and methods for detecting staphylococcus aureus
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
JP7470095B2 (en) 2018-07-10 2024-04-17 ジェン-プローブ・インコーポレーテッド Methods and systems for detecting and quantifying nucleic acids - Patents.com
WO2021046336A1 (en) * 2019-09-06 2021-03-11 Teleflex Medical Incorporated Oligonucleotides for real-time determining the identification and antibiotic resistance of pathogenic microorganisms
JP2023508100A (en) 2019-12-27 2023-02-28 エフ. ホフマン-ラ ロシュ エージー. Compositions and methods for detecting methicillin-resistant Staphylococcus aureus
WO2023089186A1 (en) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
EP4289972A1 (en) 2022-06-09 2023-12-13 Congen Biotechnologie GmbH Method for detecting methicillin resistant staphylococcus aureus

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
WO1992005281A1 (en) 1990-09-14 1992-04-02 Chugai Seiyaku Kabushiki Kaisha Method of detecting mesitylene-cephem-resistant staphylococcus aureus
JPH0549477A (en) * 1991-08-05 1993-03-02 Wakunaga Pharmaceut Co Ltd Detection of bacteria of the genus staphylococcus
CA2075423A1 (en) 1991-08-13 1993-02-14 Paul Luther Skatrud Rapid method for detection of methicillin resistant staphylococci
DE4338119A1 (en) 1993-11-08 1995-05-11 Bayer Ag Specific gene probes and methods for the quantitative detection of methicillin-resistant staphylococci
US5496706A (en) * 1993-12-17 1996-03-05 Helsinki University Licensing, Ltd. Methods and materials for the detection of Staphylococcus aureus
US6090592A (en) * 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5702895A (en) * 1995-01-19 1997-12-30 Wakunaga Seiyaku Kabushiki Kaisha Method and kit for detecting methicillin-resistant Staphylococcus aureus
JP3957338B2 (en) * 1996-02-23 2007-08-15 株式会社カイノス Diagnostics
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866366A (en) * 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
JPH1156371A (en) 1997-08-22 1999-03-02 Kainosu:Kk Identification method
US6117986A (en) * 1998-06-10 2000-09-12 Intergen Company, L.P. Pyrimidines linked to a quencher
CA2906516C (en) 1999-09-28 2017-03-07 Geneohm Sciences Canada Inc. Nucleic acids and methods for the detection of streptococcus
CA2348042A1 (en) * 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
EP1529847B1 (en) 2003-11-07 2006-04-05 Federal Rep. of Germany repr. by the Ministry of Health & Soc. Security, the latter repr. by the Pres. of the Robert Koch Ins. Method for detecting methicillin resistant Staphylococcus aureus (MRSA)
WO2005089426A2 (en) 2004-03-17 2005-09-29 Medical Discoveries, Inc. Method of treating sepsis
US11834720B2 (en) * 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx

Also Published As

Publication number Publication date
JP2012228262A (en) 2012-11-22
DK2325647T3 (en) 2021-10-04
EP2325646A3 (en) 2011-09-07
EP2325644A3 (en) 2011-09-07
WO2007044873A2 (en) 2007-04-19
AU2006302044B2 (en) 2012-10-18
EP2325643A2 (en) 2011-05-25
US20070082340A1 (en) 2007-04-12
EP2325645B1 (en) 2020-07-29
EP2325646A2 (en) 2011-05-25
JP5706855B2 (en) 2015-04-22
EP2325647A3 (en) 2011-09-07
EP2325644B1 (en) 2020-07-29
CA2963707A1 (en) 2007-04-19
DK2325643T3 (en) 2022-02-21
CA3113401A1 (en) 2007-04-19
ES2904841T3 (en) 2022-04-06
CA2625072C (en) 2017-05-30
ATE496143T1 (en) 2011-02-15
CA2963707C (en) 2021-05-25
ES2891324T3 (en) 2022-01-27
EP4043882A1 (en) 2022-08-17
DK2322930T3 (en) 2021-10-04
EP2322930B1 (en) 2021-07-14
EP2325647B1 (en) 2021-07-14
EP1934613A4 (en) 2009-05-06
HK1122844A1 (en) 2009-05-29
WO2007044873A3 (en) 2008-01-17
AU2006302044A1 (en) 2007-04-19
EP2325644A2 (en) 2011-05-25
EP2325646B1 (en) 2019-01-30
DK2325644T3 (en) 2020-09-28
DK2325645T3 (en) 2020-09-28
ES2824902T3 (en) 2021-05-13
JP2009511056A (en) 2009-03-19
EP2322930A2 (en) 2011-05-18
ES2891323T3 (en) 2022-01-27
DE602006019757D1 (en) 2011-03-03
EP1934613B1 (en) 2011-01-19
ES2358871T3 (en) 2011-05-16
EP2325645A3 (en) 2011-09-07
EP2322930A3 (en) 2011-08-17
EP2325643A3 (en) 2011-09-07
JP5214454B2 (en) 2013-06-19
CA2625072A1 (en) 2007-04-19
US7838221B2 (en) 2010-11-23
EP2325645A2 (en) 2011-05-25
EP2325643B1 (en) 2021-12-01
EP2325647A2 (en) 2011-05-25
ES2733864T3 (en) 2019-12-03
ES2858823T3 (en) 2021-09-30
EP1934613A2 (en) 2008-06-25

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