EP3884044A4 - MANUFACTURE OF VIRUSES - Google Patents

MANUFACTURE OF VIRUSES Download PDF

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Publication number
EP3884044A4
EP3884044A4 EP19887930.6A EP19887930A EP3884044A4 EP 3884044 A4 EP3884044 A4 EP 3884044A4 EP 19887930 A EP19887930 A EP 19887930A EP 3884044 A4 EP3884044 A4 EP 3884044A4
Authority
EP
European Patent Office
Prior art keywords
viruses
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19887930.6A
Other languages
German (de)
French (fr)
Other versions
EP3884044A1 (en
Inventor
Paul Andrew Wright
Katy WACK
Mingrui Zhang
Jackie Vasseur
Susan Nicole HOLLEY
August Allen RENSHAW
Guangyu Zhu
Michelle Catherine VENDEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalivir Immunotherapeutics Inc
Original Assignee
Western Oncolytics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Western Oncolytics Ltd filed Critical Western Oncolytics Ltd
Publication of EP3884044A1 publication Critical patent/EP3884044A1/en
Publication of EP3884044A4 publication Critical patent/EP3884044A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24151—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP19887930.6A 2018-11-21 2019-11-21 MANUFACTURE OF VIRUSES Withdrawn EP3884044A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862770577P 2018-11-21 2018-11-21
PCT/US2019/062643 WO2020106975A1 (en) 2018-11-21 2019-11-21 Manufacture of virus

Publications (2)

Publication Number Publication Date
EP3884044A1 EP3884044A1 (en) 2021-09-29
EP3884044A4 true EP3884044A4 (en) 2022-08-31

Family

ID=70774620

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19887930.6A Withdrawn EP3884044A4 (en) 2018-11-21 2019-11-21 MANUFACTURE OF VIRUSES

Country Status (8)

Country Link
US (1) US20210277363A1 (en)
EP (1) EP3884044A4 (en)
JP (1) JP7625519B2 (en)
KR (1) KR20210093965A (en)
CN (1) CN113330111A (en)
AU (1) AU2019384164A1 (en)
CA (1) CA3120129A1 (en)
WO (1) WO2020106975A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4222250A1 (en) * 2020-10-02 2023-08-09 Genelux Corporation Bioreactor production of virus from adherent cells
CN121219392A (en) * 2023-05-31 2025-12-26 康宁股份有限公司 Methods for improving cell collection efficiency in fixed-bed bioreactors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0981601B1 (en) 1997-01-31 2006-09-06 Schering Corporation Methods for cultivating cells and propagating viruses
EP2287288B1 (en) * 2002-07-09 2012-11-07 Baxter International Inc. Animal protein free media for cultivation of cells
US20070207461A1 (en) * 2004-02-23 2007-09-06 Crucell Holland B.V. Virus Purification Methods
US8541559B2 (en) * 2006-06-12 2013-09-24 Cytos Biotechnology Ag Process for producing aggregated oligonucleotides
EP2615167A1 (en) * 2006-09-15 2013-07-17 MedImmune, LLC Method for eliminating DNA contaminants from viral preparations
JP2010526546A (en) 2007-05-14 2010-08-05 バヴァリアン・ノルディック・アクティーゼルスカブ Purification of vaccinia virus and recombinant vaccinia virus vaccines
US8003363B2 (en) * 2007-05-14 2011-08-23 Bavarian Nordic A/S Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines
US8785173B2 (en) * 2008-09-24 2014-07-22 Medimmune, Llc Methods for purification of viruses
EP2739293B1 (en) * 2011-08-05 2020-06-10 SillaJen Biotherapeutics, Inc. Methods and compositions for production of vaccina virus
US10851350B1 (en) * 2017-06-27 2020-12-01 Genelux Corporation Bioreactor production of virus from adherent cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Benzonase(R) endonuclease", EMD MILLIPORE, 1 September 2018 (2018-09-01), pages 1 - 40, XP055719716, Retrieved from the Internet <URL:https://www.emdmillipore.com/Web-US-Site/en_CA/-/USD/ShowDocument-Pronet?id=201312.078> [retrieved on 20200803] *
GUO ZONG SHENG ET AL: "Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus", MOLECULAR THERAPY- METHODS & CLINICAL DEVELOPMENT, vol. 7, 1 December 2017 (2017-12-01), GB, pages 112 - 122, XP055945551, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2017.09.007 *
HUGHES LAURA ET AL: "A rapidOrthopoxviruspurification protocol suitable for high-containment laboratories", JOURNAL OF VIROLOGICAL METHODS, ELSEVIER BV, NL, vol. 243, 26 January 2017 (2017-01-26), pages 68 - 73, XP029939443, ISSN: 0166-0934, DOI: 10.1016/J.JVIROMET.2017.01.018 *
MOLEIRINHO MAFALDA G ET AL: "Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis", vol. 18, 9 November 2018 (2018-11-09), pages 1 - 9, XP009509939, ISSN: 1566-5232, Retrieved from the Internet <URL:http://www.eurekaselect.com/167211/article> DOI: 10.2174/1566523218666181109141257 *
See also references of WO2020106975A1 *

Also Published As

Publication number Publication date
JP7625519B2 (en) 2025-02-03
CA3120129A1 (en) 2020-05-28
EP3884044A1 (en) 2021-09-29
CN113330111A (en) 2021-08-31
US20210277363A1 (en) 2021-09-09
KR20210093965A (en) 2021-07-28
JP2022508156A (en) 2022-01-19
WO2020106975A1 (en) 2020-05-28
AU2019384164A1 (en) 2021-06-03

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