EP3876979A4 - COMPOSITIONS OF T LYMPHOCYTES WITH ENHANCED PHENOTYPIC PROPERTIES - Google Patents

COMPOSITIONS OF T LYMPHOCYTES WITH ENHANCED PHENOTYPIC PROPERTIES Download PDF

Info

Publication number
EP3876979A4
EP3876979A4 EP19883163.8A EP19883163A EP3876979A4 EP 3876979 A4 EP3876979 A4 EP 3876979A4 EP 19883163 A EP19883163 A EP 19883163A EP 3876979 A4 EP3876979 A4 EP 3876979A4
Authority
EP
European Patent Office
Prior art keywords
lymphocytes
compositions
phenotypic properties
enhanced phenotypic
enhanced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19883163.8A
Other languages
German (de)
French (fr)
Other versions
EP3876979A1 (en
Inventor
Mathias Oelke
Kristi JONES
Sojung Kim
Lauren SUAREZ
Ken Carter
Scott CARMER
Dan BEDNARIK
Vineetha EDAVANA
Emily Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellkure Inc
Original Assignee
Neximmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neximmune Inc filed Critical Neximmune Inc
Publication of EP3876979A1 publication Critical patent/EP3876979A1/en
Publication of EP3876979A4 publication Critical patent/EP3876979A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4238—Regulators of development
    • A61K40/4239—Cell cycle regulated proteins, e.g. cyclin, CDC, CDK or INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/427—PRAME
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A61K40/4272—Melan-A/MART
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP19883163.8A 2018-11-08 2019-11-08 COMPOSITIONS OF T LYMPHOCYTES WITH ENHANCED PHENOTYPIC PROPERTIES Pending EP3876979A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862757467P 2018-11-08 2018-11-08
US201962821031P 2019-03-20 2019-03-20
US201962867499P 2019-06-27 2019-06-27
PCT/US2019/060477 WO2020097466A1 (en) 2018-11-08 2019-11-08 T cell compositions with improved phenotypic properties

Publications (2)

Publication Number Publication Date
EP3876979A1 EP3876979A1 (en) 2021-09-15
EP3876979A4 true EP3876979A4 (en) 2022-08-24

Family

ID=70612526

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19883163.8A Pending EP3876979A4 (en) 2018-11-08 2019-11-08 COMPOSITIONS OF T LYMPHOCYTES WITH ENHANCED PHENOTYPIC PROPERTIES

Country Status (12)

Country Link
US (2) US20200188435A1 (en)
EP (1) EP3876979A4 (en)
JP (1) JP2022512948A (en)
KR (1) KR20210095157A (en)
CN (2) CN113226359B (en)
AU (1) AU2019375997A1 (en)
BR (1) BR112021008963A2 (en)
CA (1) CA3118757A1 (en)
IL (1) IL282914A (en)
MX (1) MX2021005372A (en)
SG (1) SG11202104611YA (en)
WO (1) WO2020097466A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
CN113880953A (en) * 2020-07-01 2022-01-04 华夏英泰（北京）生物技术有限公司 T cell antigen receptor, polymer compound thereof, preparation method and application thereof
WO2022233956A1 (en) 2021-05-05 2022-11-10 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding prame
JP7692633B2 (en) * 2021-05-07 2025-06-16 康人 徳元 Method for producing memory T cells
CN113388612A (en) * 2021-06-18 2021-09-14 重庆天科雅生物科技有限公司 Primer designed for TCR with epitope point of IYVLVMLVL and application thereof
WO2024148216A2 (en) * 2023-01-05 2024-07-11 Neximmune, Inc. Combination therapy with t cell engager

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015189356A1 (en) * 2014-06-11 2015-12-17 Polybiocept Ab Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
WO2017161092A1 (en) * 2016-03-16 2017-09-21 Neximmune, Inc. Production of antigen-specific t-cells

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
JP3680219B2 (en) * 1994-06-28 2005-08-10 独立行政法人理化学研究所 Induction culture method of cancer cytotoxic T lymphocytes
NZ331688A (en) 1996-03-28 2000-02-28 Univ Johns Hopkins Soluble divalent and multivalent heterodimeric analogs of proteins
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US6140113A (en) 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
US7973137B1 (en) 1996-03-28 2011-07-05 Johns Hopkins University Cell compositions comprising molecular complexes that modify immune responses
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US20050169898A1 (en) 1997-04-15 2005-08-04 Jianlin Gong Cell fusions and methods of making and using the same
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
KR20030032922A (en) 2000-02-24 2003-04-26 싸이트 테라피스 인코포레이티드 Simultaneous stimulation and concentration of cells
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20020131960A1 (en) 2000-06-02 2002-09-19 Michel Sadelain Artificial antigen presenting cells and methods of use thereof
WO2003057171A2 (en) 2002-01-03 2003-07-17 The Trustees Of The University Of Pennsylvania Activation and expansion of t-cells using an engineered multivalent signaling platform
DE60334474D1 (en) 2002-07-12 2010-11-18 Univ Johns Hopkins REAGENTS AND METHODS OF INTERVENTION IN UNIQUE CLONOTYPE LYMPHOCYTE RECEPTORS
TW200502391A (en) 2003-05-08 2005-01-16 Xcyte Therapies Inc Generation and isolation of antigen-specific t cells
PT1956080E (en) 2005-08-08 2011-12-30 San Raffaele Centro Fond USE OF IL-7 AND IL-15 FOR THE GENETIC MODIFICATION OF MEMORY LYMPOCYTES
WO2009094273A2 (en) 2008-01-15 2009-07-30 Yale University Compositions and methods for adoptive and active immunotherapy
WO2010065544A2 (en) 2008-12-01 2010-06-10 The Johns Hopkins University Diagnostic and treatment methods for cancer based on immune inhibitors
WO2010099205A1 (en) 2009-02-24 2010-09-02 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (pml)
US8075895B2 (en) * 2009-09-22 2011-12-13 Janssen Pharmaceutica N.V. Identification of antigenic peptides from multiple myeloma cells
EP2569633B1 (en) 2010-05-14 2016-02-10 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
EP2404618A1 (en) 2010-07-07 2012-01-11 Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen Immunomodulatory protein constructs with a helical polymeric backbone.
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
US10758487B2 (en) 2011-12-09 2020-09-01 The Johns Hopkins University Artificial antigen presenting cells having a defined and dynamic shape
KR101749195B1 (en) 2011-12-12 2017-06-20 셀 메디카 리미티드 Process of expanding t cells
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
US10463750B2 (en) 2013-02-15 2019-11-05 The Johns Hopkins University Antigen-Specific T cell redirectors
KR102164405B1 (en) 2013-03-14 2020-10-12 더 존스 홉킨스 유니버시티 Nanoscale artificial antigen presenting cells
US11807675B2 (en) 2013-10-03 2023-11-07 The University Of Maryland, Baltimore Nanoparticle based artificial antigen presenting cell mediated activation of NKT cells
WO2015127190A1 (en) * 2014-02-21 2015-08-27 Argos Therapeutics, Inc. Tscm cells and methods for use
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CN106062185A (en) 2014-04-24 2016-10-26 美天旎生物技术有限公司 Method for automated generation of genetically modified t cells
HUE049514T2 (en) 2014-04-25 2020-09-28 Bluebird Bio Inc Improved procedures for developing adoptive cell therapies
CA3017170C (en) 2014-09-17 2021-03-23 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
AU2016341529B2 (en) 2015-10-22 2023-03-30 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
IL258935B2 (en) 2015-10-28 2024-08-01 Life Tech As Selective expansion of different T-cell subpopulations by altering cell surface signals and signal ratio
BR112018008442A2 (en) * 2015-11-05 2018-11-06 Juno Therapeutics Inc chimeric receptors containing traf inducer domains and related compositions and methods
EP3384012A1 (en) * 2015-12-04 2018-10-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of amplifying a population of antigen-specific memory cd4+ t cells using artificial presenting cells expressing hla class ii molecules
IT201700041430A1 (en) * 2017-04-13 2018-10-13 Sarong Spa Method and apparatus for making capsules with a filter
BR112020005552A2 (en) * 2017-09-20 2020-10-27 Neximmune, Inc. cell compositions comprising antigen-specific t cells for adoptive therapy
EP3704229B1 (en) * 2017-11-01 2023-12-20 Juno Therapeutics, Inc. Process for producing a t cell composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015189356A1 (en) * 2014-06-11 2015-12-17 Polybiocept Ab Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
WO2017161092A1 (en) * 2016-03-16 2017-09-21 Neximmune, Inc. Production of antigen-specific t-cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CIERI NICOLETTA ET AL: "IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 121, no. 4, 24 January 2013 (2013-01-24), pages 573 - 584, XP086511136, ISSN: 0006-4971, [retrieved on 20201119], DOI: 10.1182/BLOOD-2012-05-431718 *
KARLO PERICA ET AL: "Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy", ACS NANO, vol. 9, no. 7, 28 July 2015 (2015-07-28), US, pages 6861 - 6871, XP055423519, ISSN: 1936-0851, DOI: 10.1021/acsnano.5b02829 *
See also references of WO2020097466A1 *

Also Published As

Publication number Publication date
US20200215115A1 (en) 2020-07-09
BR112021008963A2 (en) 2021-09-14
EP3876979A1 (en) 2021-09-15
US11007222B2 (en) 2021-05-18
CA3118757A1 (en) 2020-05-14
SG11202104611YA (en) 2021-06-29
KR20210095157A (en) 2021-07-30
WO2020097466A1 (en) 2020-05-14
CN118903396A (en) 2024-11-08
MX2021005372A (en) 2021-09-14
CN113226359B (en) 2024-05-24
AU2019375997A1 (en) 2021-06-03
IL282914A (en) 2021-06-30
JP2022512948A (en) 2022-02-07
US20200188435A1 (en) 2020-06-18
CN113226359A (en) 2021-08-06

Similar Documents

Publication Publication Date Title
EP3876979A4 (en) COMPOSITIONS OF T LYMPHOCYTES WITH ENHANCED PHENOTYPIC PROPERTIES
EP3532171A4 (en) CLEANING COMPOSITIONS HAVING CONDITIONERS
EP3561019A4 (en) ADHESIVE COMPOSITION HAVING ANTI-FOG PROPERTIES
EP3452175A4 (en) SOFT CLEANSING COMPOSITIONS WITH MAKE-UP REMOVING PROPERTIES
EP3675804A4 (en) COSMETIC COMPOSITIONS WITH ANTIOXIDANT PROPERTIES
EP3368072A4 (en) COMPOSITIONS AND METHODS FOR ACTIVATION OF DEPENDENT SIGNALING OF "INTERFERON GENE STIMULATOR"
EP3883734A4 (en) ACRYLIC COMPOSITES WITH ENHANCED SURFACE PROPERTIES
EP3371301A4 (en) METHODS AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS
EP3619019A4 (en) ADDITIVE MANUFACTURING SYSTEM WITH ADJUSTABLE MATERIAL PROPERTIES
MA42146A (en) COMPOSITIONS AND PROCESSES FOR ACTIVATION OF "INTERFERON GENE STIMULATOR" DEPENDENT SIGNALING
SG11201707505QA (en) Novel siloxane polymer compositions and their use
EP3443094A4 (en) METHODS OF REDUCING EXPRESSION OF C9ORF72
EP3471539A4 (en) SIGNALING PROCESSING WITH KLRG1
EP2928992A4 (en) COMPOSITIONS OF ADDITIVES AND INDUSTRIAL PROCESSING FLUIDS
EP3389657A4 (en) METHODS OF TREATING HYPERALGESIA
MA50221A (en) LACTASE ENZYMES WITH IMPROVED PROPERTIES
MA50219A (en) LACTASE ENZYMES WITH IMPROVED PROPERTIES
EP3443043A4 (en) PRETREATMENT COMPOSITIONS
EP3429609A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF TYPE VII COLLAGEN DEFICITS
EP3423483A4 (en) VARIANTS OF HUMAN ENZYME KYNURENINASE HAVING IMPROVED PHARMACOLOGICAL PROPERTIES
EP3291980A4 (en) CURRENT COMPACT HANDRAIL HANDS WITH IMPROVED MECHANICAL PROPERTIES
EP3426391A4 (en) COMPOSITIONS AND METHODS FOR ACYLATION OF LACTAMS
EP3353083A4 (en) MOUTHABLE RESERVOIR COATING HAVING BARRIER PROPERTIES
EP3452814A4 (en) EVALUATION OF THE MECHANICAL PROPERTIES OF MAGNETIC RESONANCE FORMATION
EP3518895A4 (en) PHOSPHORYLATED TRIBLOCK COPOLYMERS HAVING PATHOGENIC VIRULENCE SUPPRESSION PROPERTIES

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210604

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40061211

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20220722

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 35/00 20060101ALI20220718BHEP

Ipc: A61K 39/00 20060101AFI20220718BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240311

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CELLKURE, INC.