EP3852773A4 - Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof - Google Patents

Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof Download PDF

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Publication number
EP3852773A4
EP3852773A4 EP19861568.4A EP19861568A EP3852773A4 EP 3852773 A4 EP3852773 A4 EP 3852773A4 EP 19861568 A EP19861568 A EP 19861568A EP 3852773 A4 EP3852773 A4 EP 3852773A4
Authority
EP
European Patent Office
Prior art keywords
manufacture
compositions derived
cellular compositions
graft tolerance
deceased donors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19861568.4A
Other languages
German (de)
French (fr)
Other versions
EP3852773A1 (en
Inventor
Michael Zdanowski
Colby SUIRE
D. Scott BATTY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medeor Therapeutics Inc
Original Assignee
Medeor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeor Therapeutics Inc filed Critical Medeor Therapeutics Inc
Publication of EP3852773A1 publication Critical patent/EP3852773A1/en
Publication of EP3852773A4 publication Critical patent/EP3852773A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0669—Bone marrow stromal cells; Whole bone marrow

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP19861568.4A 2018-09-18 2019-09-18 Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof Pending EP3852773A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862732827P 2018-09-18 2018-09-18
US201862732832P 2018-09-18 2018-09-18
US201862732823P 2018-09-18 2018-09-18
US201862732830P 2018-09-18 2018-09-18
PCT/US2019/051711 WO2020061180A1 (en) 2018-09-18 2019-09-18 Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof

Publications (2)

Publication Number Publication Date
EP3852773A1 EP3852773A1 (en) 2021-07-28
EP3852773A4 true EP3852773A4 (en) 2022-06-29

Family

ID=69887779

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19861568.4A Pending EP3852773A4 (en) 2018-09-18 2019-09-18 Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof

Country Status (6)

Country Link
EP (1) EP3852773A4 (en)
JP (1) JP2022502483A (en)
CN (1) CN113164517A (en)
AU (1) AU2019344937A1 (en)
CA (1) CA3112320A1 (en)
WO (1) WO2020061180A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
EP3980036A4 (en) * 2019-06-06 2023-01-25 Medeor Therapeutics, Inc. Methods of making cellular products by post-mortem mobilization and harvesting of hematopoietic cells
WO2022020210A1 (en) 2020-07-18 2022-01-27 Ossium Health, Inc. Permeation of whole vertebral bodies with a cryoprotectant using vacuum assisted diffusion
CA3195653A1 (en) 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN117279650A (en) 2020-12-18 2023-12-22 奥瑟姆健康公司 Cell therapy method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2648354C2 (en) * 2011-12-22 2018-03-23 Иеда Рисеч Энд Девелопмент Ко. Лтд. Combination therapy for stable and long term engraftment using specific protocols for t/b-cell depletion
EP3804735A1 (en) * 2013-02-26 2021-04-14 The Board of Trustees of the Leland Stanford Junior University Combined organ and hematopoietic cells for transplantation tolerance of grafts
US10881692B2 (en) * 2018-04-05 2021-01-05 Medeor Therapeutics, Inc. Compositions for establishing mixed chimerism and methods of manufacture thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LINK H ET AL: "Combined transplantation of allogeneic bone marrow and CD34+ blood cells", BLOOD, 1 October 1995 (1995-10-01), pages 2500 - 2508, XP055889577, Retrieved from the Internet <URL:https://ashpublications.org/blood/article-pdf/86/7/2500/622137/2500.pdf> [retrieved on 20220209], DOI: 10.1182/blood.V86.7.2500.bloodjournal8672500 *
See also references of WO2020061180A1 *
ZUBER JULIEN ET AL: "Mechanisms of Mixed Chimerism-Based Transplant Tolerance", TRENDS IN IMMUNOLOGY, vol. 38, no. 11, 1 November 2017 (2017-11-01), pages 829 - 843, XP085273403, ISSN: 1471-4906, DOI: 10.1016/J.IT.2017.07.008 *

Also Published As

Publication number Publication date
JP2022502483A (en) 2022-01-11
AU2019344937A1 (en) 2021-04-08
CA3112320A1 (en) 2020-03-26
CN113164517A (en) 2021-07-23
WO2020061180A1 (en) 2020-03-26
EP3852773A1 (en) 2021-07-28

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A4 Supplementary search report drawn up and despatched

Effective date: 20220601

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0789 20100101ALI20220525BHEP

Ipc: C12N 5/071 20100101ALI20220525BHEP

Ipc: A61P 37/06 20060101ALI20220525BHEP

Ipc: A61K 41/00 20200101ALI20220525BHEP

Ipc: A61K 35/28 20150101AFI20220525BHEP