EP3810627A4 - Synthetic method of bivalirundin - Google Patents

Synthetic method of bivalirundin Download PDF

Info

Publication number
EP3810627A4
EP3810627A4 EP18923472.7A EP18923472A EP3810627A4 EP 3810627 A4 EP3810627 A4 EP 3810627A4 EP 18923472 A EP18923472 A EP 18923472A EP 3810627 A4 EP3810627 A4 EP 3810627A4
Authority
EP
European Patent Office
Prior art keywords
bivalirundin
synthetic method
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18923472.7A
Other languages
German (de)
French (fr)
Other versions
EP3810627A1 (en
Inventor
Ivan Di BONAVENTURA
Runze HE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Space Peptides Pharmaceutical Co Ltd
Original Assignee
Shanghai Space Peptides Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Space Peptides Pharmaceutical Co Ltd filed Critical Shanghai Space Peptides Pharmaceutical Co Ltd
Publication of EP3810627A1 publication Critical patent/EP3810627A1/en
Publication of EP3810627A4 publication Critical patent/EP3810627A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP18923472.7A 2018-06-19 2018-06-19 Synthetic method of bivalirundin Withdrawn EP3810627A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/091752 WO2019241903A1 (en) 2018-06-19 2018-06-19 Synthetic method of bivalirundin

Publications (2)

Publication Number Publication Date
EP3810627A1 EP3810627A1 (en) 2021-04-28
EP3810627A4 true EP3810627A4 (en) 2022-03-09

Family

ID=68982571

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18923472.7A Withdrawn EP3810627A4 (en) 2018-06-19 2018-06-19 Synthetic method of bivalirundin

Country Status (3)

Country Link
EP (1) EP3810627A4 (en)
CN (1) CN112424216A (en)
WO (1) WO2019241903A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033383A2 (en) * 2005-09-14 2007-03-22 Novetide, Ltd. Process for production of bivalirudin
US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions
WO2010117725A2 (en) * 2009-04-06 2010-10-14 Novetide, Ltd. Production of peptides containing poly-gly sequences using fmoc chemistry
US20100292436A1 (en) * 2009-05-15 2010-11-18 Shanghai Ambiopharm, Inc. Method for producing bivalirudin
CN103374054A (en) * 2012-04-28 2013-10-30 上海第一生化药业有限公司 One-step method based solid-phase polypeptide synthesis method
US20140187745A1 (en) * 2011-06-23 2014-07-03 Chengdu Shengnuo Tech Co., Ltd. Method for preparing bivalirudin
CN103242431B (en) * 2013-05-20 2015-05-13 齐鲁制药有限公司 Preparation method of bivalirudin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101033249B (en) * 2006-03-10 2011-05-11 周逸明 Preparation method of synthesizing bivalirudin from solid phase polypeptide
CN102532274B (en) * 2012-02-13 2014-04-23 成都圣诺生物制药有限公司 Method for preparing bivalirudin
CN103319570A (en) * 2013-05-30 2013-09-25 深圳翰宇药业股份有限公司 Preparation method of bivalirudin
US10125163B2 (en) * 2015-10-23 2018-11-13 Cem Corporation Solid phase peptide synthesis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033383A2 (en) * 2005-09-14 2007-03-22 Novetide, Ltd. Process for production of bivalirudin
US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions
WO2010117725A2 (en) * 2009-04-06 2010-10-14 Novetide, Ltd. Production of peptides containing poly-gly sequences using fmoc chemistry
US20100292436A1 (en) * 2009-05-15 2010-11-18 Shanghai Ambiopharm, Inc. Method for producing bivalirudin
US20140187745A1 (en) * 2011-06-23 2014-07-03 Chengdu Shengnuo Tech Co., Ltd. Method for preparing bivalirudin
CN103374054A (en) * 2012-04-28 2013-10-30 上海第一生化药业有限公司 One-step method based solid-phase polypeptide synthesis method
CN103242431B (en) * 2013-05-20 2015-05-13 齐鲁制药有限公司 Preparation method of bivalirudin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019241903A1 *

Also Published As

Publication number Publication date
EP3810627A1 (en) 2021-04-28
WO2019241903A1 (en) 2019-12-26
CN112424216A (en) 2021-02-26

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