EP3755698A4 - Agents de dégradation d'egfr et procédés d'utilisation de ceux-ci - Google Patents

Agents de dégradation d'egfr et procédés d'utilisation de ceux-ci Download PDF

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Publication number
EP3755698A4
EP3755698A4 EP19757199.5A EP19757199A EP3755698A4 EP 3755698 A4 EP3755698 A4 EP 3755698A4 EP 19757199 A EP19757199 A EP 19757199A EP 3755698 A4 EP3755698 A4 EP 3755698A4
Authority
EP
European Patent Office
Prior art keywords
degraders
egfr
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19757199.5A
Other languages
German (de)
English (en)
Other versions
EP3755698A1 (fr
Inventor
Nathanael S. Gray
Dries DE CLERCQ
Jaebong Jang
Pasi Janne
Ciric TO
Michael Eck
Eunyoung Park
David HEPPNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of EP3755698A1 publication Critical patent/EP3755698A1/fr
Publication of EP3755698A4 publication Critical patent/EP3755698A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19757199.5A 2018-02-20 2019-02-20 Agents de dégradation d'egfr et procédés d'utilisation de ceux-ci Withdrawn EP3755698A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862632830P 2018-02-20 2018-02-20
US201862744089P 2018-10-10 2018-10-10
PCT/US2019/018753 WO2019164932A1 (fr) 2018-02-20 2019-02-20 Agents de dégradation d'egfr et procédés d'utilisation de ceux-ci

Publications (2)

Publication Number Publication Date
EP3755698A1 EP3755698A1 (fr) 2020-12-30
EP3755698A4 true EP3755698A4 (fr) 2021-10-27

Family

ID=67687371

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19757199.5A Withdrawn EP3755698A4 (fr) 2018-02-20 2019-02-20 Agents de dégradation d'egfr et procédés d'utilisation de ceux-ci

Country Status (5)

Country Link
US (1) US20200377477A1 (fr)
EP (1) EP3755698A4 (fr)
AU (1) AU2019225743A1 (fr)
CA (1) CA3088561A1 (fr)
WO (1) WO2019164932A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019225807A1 (en) * 2018-02-20 2020-07-02 Dana-Farber Cancer Institute, Inc. Pharmaceutical combinations of EGFR inhibitors and methods of use thereof
JP2021514397A (ja) * 2018-02-20 2021-06-10 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒ阻害剤の組合せ医薬製剤およびその使用法
JP2024529298A (ja) 2021-07-09 2024-08-06 プレキシウム インコーポレイテッド Ｉｋｚｆ２を調節するアリール化合物及び医薬組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009124399A1 (fr) * 2008-04-11 2009-10-15 Thallion Pharmaceuticals Inc. Inhibition de la migration cellulaire par une dibenzodiazépinone farnésylée
WO2017024317A2 (fr) * 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Procédés pour induire la dégradation de protéine ciblée par des molécules bifonctionnelles
WO2017185023A1 (fr) * 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Dégradation de la kinase 9 cycline-dépendante (cdk9) par conjugaison d'inhibiteurs de cdk9 avec un ligand de type ligase e3 et leurs procédés d'utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061126A2 (fr) * 2004-12-09 2006-06-15 F. Hoffmann-La Roche Ag Derives de dibenzoxazepinone
WO2007056388A2 (fr) * 2005-11-07 2007-05-18 The General Hospital Corporation Compositions et procédés de modulation de l’activité de la poly(adp-ribose) polymérase
RU2016116516A (ru) * 2008-12-08 2018-12-07 Мандифарма Интернэшнл Корпорейшн Лимитед Композиции ингибиторов тирозинкиназных рецепторов белков
WO2016105518A1 (fr) * 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Procédés pour induire la dégradation ciblée de protéines par des molécules bifonctionnelles
US10702527B2 (en) * 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009124399A1 (fr) * 2008-04-11 2009-10-15 Thallion Pharmaceuticals Inc. Inhibition de la migration cellulaire par une dibenzodiazépinone farnésylée
WO2017024317A2 (fr) * 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Procédés pour induire la dégradation de protéine ciblée par des molécules bifonctionnelles
WO2017185023A1 (fr) * 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Dégradation de la kinase 9 cycline-dépendante (cdk9) par conjugaison d'inhibiteurs de cdk9 avec un ligand de type ligase e3 et leurs procédés d'utilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MASTALERZ ET AL: "Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 17, no. 10, 27 April 2007 (2007-04-27), pages 2828 - 2833, XP022049596, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.02.050 *
See also references of WO2019164932A1 *

Also Published As

Publication number Publication date
US20200377477A1 (en) 2020-12-03
EP3755698A1 (fr) 2020-12-30
CA3088561A1 (fr) 2019-08-29
AU2019225743A1 (en) 2020-07-02
WO2019164932A1 (fr) 2019-08-29

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