EP3692164A4 - Methylation markers for diagnosing cancer - Google Patents

Methylation markers for diagnosing cancer Download PDF

Info

Publication number
EP3692164A4
EP3692164A4 EP18863856.3A EP18863856A EP3692164A4 EP 3692164 A4 EP3692164 A4 EP 3692164A4 EP 18863856 A EP18863856 A EP 18863856A EP 3692164 A4 EP3692164 A4 EP 3692164A4
Authority
EP
European Patent Office
Prior art keywords
diagnosing cancer
methylation markers
methylation
markers
diagnosing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18863856.3A
Other languages
German (de)
French (fr)
Other versions
EP3692164A1 (en
Inventor
Kang Zhang
Rui Hou
Lianghong ZHENG
Gen LI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Youhealth Oncotech Ltd
University of California
Original Assignee
Youhealth Oncotech Ltd
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Youhealth Oncotech Ltd, University of California filed Critical Youhealth Oncotech Ltd
Publication of EP3692164A1 publication Critical patent/EP3692164A1/en
Publication of EP3692164A4 publication Critical patent/EP3692164A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP18863856.3A 2017-10-06 2018-10-05 Methylation markers for diagnosing cancer Pending EP3692164A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762569459P 2017-10-06 2017-10-06
US201862673593P 2018-05-18 2018-05-18
PCT/US2018/054660 WO2019071161A1 (en) 2017-10-06 2018-10-05 Methylation markers for diagnosing cancer

Publications (2)

Publication Number Publication Date
EP3692164A1 EP3692164A1 (en) 2020-08-12
EP3692164A4 true EP3692164A4 (en) 2021-09-29

Family

ID=65994841

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18863856.3A Pending EP3692164A4 (en) 2017-10-06 2018-10-05 Methylation markers for diagnosing cancer

Country Status (5)

Country Link
US (1) US20200277677A1 (en)
EP (1) EP3692164A4 (en)
CN (1) CN111742062B (en)
BR (1) BR112020006912A2 (en)
WO (1) WO2019071161A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
WO2018009703A1 (en) * 2016-07-06 2018-01-11 Youhealth Biotech, Limited Breast and ovarian cancer methylation markers and uses thereof
CN110197474B (en) * 2018-03-27 2023-08-25 腾讯科技（深圳）有限公司 Image processing method and device and training method of neural network model
CN110724743B (en) * 2019-11-15 2021-02-26 广州市基准医疗有限责任公司 Methylated biomarker related to colorectal cancer diagnosis in human blood and application thereof
CN110747274B (en) * 2019-11-18 2023-12-22 中山大学肿瘤防治中心 Gene methylation panel and kit for diagnosing and predicting colorectal cancer curative effect and prognosis
CN111009290B (en) * 2019-12-12 2023-10-31 中国人民解放军总医院 Training method of plateau adaptability detection model, adaptability recognition method and device
EP4081655A1 (en) 2019-12-24 2022-11-02 Vib Vzw Disease detection in liquid biopsies
KR20230017169A (en) * 2020-03-31 2023-02-03 프리놈 홀딩스, 인크. Method and system for colorectal cancer detection through nucleic acid methylation analysis
CN112391466A (en) * 2020-05-19 2021-02-23 广州市基准医疗有限责任公司 Methylation biomarker for detecting breast cancer or combination and application thereof
CN112430657B (en) * 2020-10-27 2022-09-09 哈尔滨医科大学 Methylation marker related to colorectal cancer and kit for detecting colorectal cancer
CN112501293B (en) * 2020-11-17 2022-06-14 圣湘生物科技股份有限公司 Reagent combination for detecting liver cancer, kit and application thereof
CN112899359B (en) * 2021-01-27 2023-06-23 广州市基准医疗有限责任公司 Methylation marker for benign and malignant lung nodule detection or combination and application thereof
WO2022226231A1 (en) * 2021-04-21 2022-10-27 Helio Health Inc. Liver cancer methylation and protein markers and their uses
CN117344010B (en) * 2022-06-29 2024-04-26 广州市基准医疗有限责任公司 DNA methylation biomarker for diagnosing gastric cancer, kit and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2497834A2 (en) * 2009-11-05 2012-09-12 Genomictree, Inc. Method for detecting the methylation of colon-cancer-specific methylation marker genes for colon cancer diagnosis
US20140255418A1 (en) * 2011-10-17 2014-09-11 King Abdullah University Science and Technology Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer
WO2015021263A2 (en) * 2013-08-08 2015-02-12 Temple University-Of The Commonwealth System Of Higher Education Methylation biomarkers for colorectal cancer
WO2015091979A2 (en) * 2013-12-20 2015-06-25 Ait Austrian Institute Of Technology Gmbh Gene methylation based colorectal cancer diagnosis
US20160210403A1 (en) * 2015-01-18 2016-07-21 The Regents Of The University Of California Method and system for determining cancer status

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9307353B2 (en) * 2013-03-07 2016-04-05 Geofeedia, Inc. System and method for differentially processing a location input for content providers that use different location input formats
CN104531866B (en) * 2014-12-24 2017-02-22 北京丽阳吉诺科技有限公司 Biomarker used for colorectal cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2497834A2 (en) * 2009-11-05 2012-09-12 Genomictree, Inc. Method for detecting the methylation of colon-cancer-specific methylation marker genes for colon cancer diagnosis
US20140255418A1 (en) * 2011-10-17 2014-09-11 King Abdullah University Science and Technology Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer
WO2015021263A2 (en) * 2013-08-08 2015-02-12 Temple University-Of The Commonwealth System Of Higher Education Methylation biomarkers for colorectal cancer
WO2015091979A2 (en) * 2013-12-20 2015-06-25 Ait Austrian Institute Of Technology Gmbh Gene methylation based colorectal cancer diagnosis
US20160210403A1 (en) * 2015-01-18 2016-07-21 The Regents Of The University Of California Method and system for determining cancer status

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RASMUSSEN SIMON LADEFOGED ET AL: "The prognostic efficacy of cell-free DNA hypermethylation in colorectal cancer", ONCOTARGET, vol. 9, no. 6, 23 January 2018 (2018-01-23), United States, pages 7010 - 7022, XP055806493, ISSN: 1949-2553, DOI: 10.18632/oncotarget.24097 *
See also references of WO2019071161A1 *

Also Published As

Publication number Publication date
WO2019071161A1 (en) 2019-04-11
BR112020006912A2 (en) 2020-12-22
EP3692164A1 (en) 2020-08-12
US20200277677A1 (en) 2020-09-03
CN111742062A (en) 2020-10-02
CN111742062B (en) 2023-11-17

Similar Documents

Publication Publication Date Title
EP3692164A4 (en) Methylation markers for diagnosing cancer
EP3717644A4 (en) Detecting breast cancer
EP3828291A4 (en) Methylation modification-based tumor marker stamp-ep1
IL280521A (en) Methylated markers for colorectal cancer
EP3481951A4 (en) Colon cancer methylation markers and uses thereof
EP3605487A4 (en) Marker system
EP3490066A4 (en) Antenna system
EP3828273A4 (en) Methylation modification-based tumor marker stamp-ep2
EP3504346A4 (en) Fecal bacterial markers for colorectal cancer
EP3904515A4 (en) Tumor marker stamp-ep3 based on methylation modification
EP3544605A4 (en) Methods for cancer detection
EP3432422A4 (en) Antenna
EP3245298A4 (en) Biomarkers for colorectal cancer related diseases
EP3618190A4 (en) Antenna
EP3589732A4 (en) Detecting prostate cancer
EP3916092A4 (en) Tumor marker stamp-ep5 based on methylated modification
EP3426159A4 (en) Identifying anatomical structures
EP3661601A4 (en) Methods for increasing fertility
EP3732750A4 (en) Improved antenna system
EP3474373A4 (en) Vehicular antenna
EP3950945A4 (en) Methylation modification-based tumor marker stamp-ep4
EP3904516A4 (en) Methylation modification-based tumor marker stamp-ep6
EP3553888A4 (en) Antenna system
EP3415863A4 (en) Marker
PT3655778T (en) Ctnb1 as a marker for endometrial cancer

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200501

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/686 20180101ALI20210526BHEP

Ipc: C12Q 1/08 20060101ALI20210526BHEP

Ipc: C12Q 1/68 20180101AFI20210526BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20210901

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/686 20180101ALI20210826BHEP

Ipc: C12Q 1/08 20060101ALI20210826BHEP

Ipc: C12Q 1/68 20180101AFI20210826BHEP