EP3517535A4 - Composé hétérocyclique substitué par un alcynyle, son procédé de préparation et son utilisation médicale - Google Patents
Composé hétérocyclique substitué par un alcynyle, son procédé de préparation et son utilisation médicale Download PDFInfo
- Publication number
- EP3517535A4 EP3517535A4 EP17849992.7A EP17849992A EP3517535A4 EP 3517535 A4 EP3517535 A4 EP 3517535A4 EP 17849992 A EP17849992 A EP 17849992A EP 3517535 A4 EP3517535 A4 EP 3517535A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- alkynyl
- preparation
- heterocyclic compound
- substituted heterocyclic
- method therefor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610833890.3A CN107840842A (zh) | 2016-09-19 | 2016-09-19 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
PCT/CN2017/072570 WO2018049781A1 (fr) | 2016-09-19 | 2017-01-25 | Composé hétérocyclique substitué par un alcynyle, son procédé de préparation et son utilisation médicale |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3517535A1 EP3517535A1 (fr) | 2019-07-31 |
EP3517535A4 true EP3517535A4 (fr) | 2020-02-26 |
EP3517535B1 EP3517535B1 (fr) | 2022-06-29 |
Family
ID=61618562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17849992.7A Active EP3517535B1 (fr) | 2016-09-19 | 2017-01-25 | Composé hétérocyclique substitué par un alcynyle, son procédé de préparation et son utilisation médicale |
Country Status (12)
Country | Link |
---|---|
US (3) | US10710981B2 (fr) |
EP (1) | EP3517535B1 (fr) |
JP (1) | JP6906811B2 (fr) |
KR (1) | KR20190052113A (fr) |
CN (2) | CN107840842A (fr) |
AU (1) | AU2017327954B2 (fr) |
CA (1) | CA3036594C (fr) |
ES (1) | ES2925212T3 (fr) |
MX (1) | MX2019003143A (fr) |
RU (1) | RU2729069C1 (fr) |
SG (1) | SG10202102822RA (fr) |
WO (1) | WO2018049781A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020120673A1 (fr) * | 2018-12-13 | 2020-06-18 | Intervet International B.V. | Procédé de préparation de 1-[(3r,4s)-4-cyanotétrahydropyran-3-yl]-3-[(2-fluoro-6-méthoxy-4-pyridyl)amino]pyrazole-4-carboxamide |
CN113474337A (zh) | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3,5-二甲氧基苯基)氨基)喹喔啉衍生物 |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
AU2020412067A1 (en) * | 2019-12-26 | 2022-08-11 | Beijing Innocare Pharma Tech Co., Ltd. | Crystalline forms of (S) -1- (1-acryloylpyrrolidin-3-yl) -3- ( (3, 5-dimethoxyphenyl) ethynyl) -5- (methylamino) -1H-pyrazole-4-carboxamide |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
WO2021247971A1 (fr) * | 2020-06-05 | 2021-12-09 | Kinnate Biopharma Inc. | Inhibiteurs des kinases du récepteur du facteur de croissance des fibroblastes |
US11345681B1 (en) * | 2020-06-05 | 2022-05-31 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
JP2024503661A (ja) * | 2021-01-12 | 2024-01-26 | ベイジン・イノケア・ファーマ・テク・カンパニー・リミテッド | (s)-1-(1-アクリロイルピロリジン-3-イル)-3-((3,5-ジメトキシフェニル)エチニル)-5-(メチルアミノ)-1h-ピラゾール-4-カルボキサミドの製造方法 |
CN115433190A (zh) * | 2021-06-02 | 2022-12-06 | 药雅科技(上海)有限公司 | 不可逆杂环化合物fgfr抑制剂的制备方法和用途 |
CN114853739B (zh) * | 2021-02-03 | 2023-09-22 | 药雅科技(上海)有限公司 | 一种炔代吡嗪类fgfr抑制剂及其制备方法和用途 |
CN115043832B (zh) * | 2021-03-08 | 2023-08-22 | 药雅科技(上海)有限公司 | 一种fgfr抑制剂炔代杂环类化合物及其制备方法和用途 |
MX2024005341A (es) * | 2021-11-03 | 2024-05-20 | Beijing Innocare Pharma Tech Co Ltd | Dispersion solida amorfa que comprende (s)-1-(1-acriloilpirrolidin -3-il)-3-((3,5-dimetoxifenil)etinil)-5-(metilamino)-1h-pirazol-4- carboxamida. |
CN118354772A (zh) * | 2021-11-16 | 2024-07-16 | 北京诺诚健华医药科技有限公司 | 治疗头颈癌的方法 |
WO2023107980A1 (fr) * | 2021-12-08 | 2023-06-15 | Kinnate Biopharma Inc. | Formes à l'état solide d'un inhibiteur de fgfr |
CA3240059A1 (fr) * | 2021-12-08 | 2023-06-15 | Kinnate Biopharma Inc. | Traitement du cancer avec un inhibiteur de la kinase fgfr |
WO2023107870A1 (fr) * | 2021-12-08 | 2023-06-15 | Kinnate Biopharma Inc. | Inhibiteurs des kinases du récepteur du facteur de croissance des fibroblastes |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008075068A2 (fr) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Nouveaux composés |
EP3023100A1 (fr) * | 2013-07-18 | 2016-05-25 | Taiho Pharmaceutical Co., Ltd. | Médicament antitumoral pour l'administration intermittente d'inhibiteur de fgfr |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
KR101124245B1 (ko) | 2002-06-27 | 2012-07-02 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
CN1508130A (zh) | 2002-12-18 | 2004-06-30 | 中国科学院大连化学物理研究所 | N-苯基-n’-嘧啶基取代脲类衍生物的合成方法 |
US7150894B2 (en) * | 2003-05-01 | 2006-12-19 | Kraft Foods Holdings, Inc. | Acid whey texture system |
SI1761520T1 (sl) | 2004-06-23 | 2008-10-31 | Lilly Co Eli | Inhibitorji kinaze |
FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
JP2009515998A (ja) | 2005-11-16 | 2009-04-16 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | ピラゾロチアゾールタンパク質キナーゼモジュレータ |
FR2908409B1 (fr) | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
CN101611014B (zh) * | 2006-12-21 | 2012-05-30 | 阿斯利康(瑞典)有限公司 | 用作fgfr抑制剂的酰氨基吡唑类化合物 |
PL2959900T3 (pl) | 2008-06-16 | 2017-11-30 | University Of Tennessee Research Foundation | Związek do leczenia raka |
FR2947546B1 (fr) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
AU2010347233B2 (en) | 2010-03-01 | 2015-06-18 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
WO2013014039A1 (fr) * | 2011-07-28 | 2013-01-31 | Nerviano Medical Sciences S.R.L. | Pyrimidinyl-pyrroles substitués alcynyle agissant comme inhibiteurs de kinase |
WO2013024427A1 (fr) | 2011-08-16 | 2013-02-21 | Glenmark Pharmaceuticals S.A. | Nouveaux dérivés d'urée en tant qu'inhibiteurs de kinase tec et leurs utilisations |
CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
TW201536293A (zh) | 2013-07-18 | 2015-10-01 | Taiho Pharmaceutical Co Ltd | 對fgfr抑制劑具耐受性之癌的治療藥 |
AU2014338549B2 (en) | 2013-10-25 | 2017-05-25 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors |
JP6695353B2 (ja) | 2015-03-25 | 2020-05-20 | ノバルティス アーゲー | Fgfr4阻害剤としてのホルミル化n−複素環式誘導体 |
-
2016
- 2016-09-19 CN CN201610833890.3A patent/CN107840842A/zh not_active Withdrawn
-
2017
- 2017-01-25 WO PCT/CN2017/072570 patent/WO2018049781A1/fr unknown
- 2017-01-25 MX MX2019003143A patent/MX2019003143A/es unknown
- 2017-01-25 KR KR1020197011454A patent/KR20190052113A/ko not_active Application Discontinuation
- 2017-01-25 CA CA3036594A patent/CA3036594C/fr active Active
- 2017-01-25 RU RU2019112046A patent/RU2729069C1/ru active
- 2017-01-25 AU AU2017327954A patent/AU2017327954B2/en active Active
- 2017-01-25 CN CN201780057036.5A patent/CN109843873B/zh active Active
- 2017-01-25 ES ES17849992T patent/ES2925212T3/es active Active
- 2017-01-25 EP EP17849992.7A patent/EP3517535B1/fr active Active
- 2017-01-25 SG SG10202102822RA patent/SG10202102822RA/en unknown
- 2017-01-25 JP JP2019515464A patent/JP6906811B2/ja active Active
-
2019
- 2019-03-14 US US16/353,806 patent/US10710981B2/en active Active
-
2020
- 2020-07-10 US US16/925,738 patent/US11059805B2/en active Active
-
2021
- 2021-07-07 US US17/369,850 patent/US11572353B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008075068A2 (fr) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Nouveaux composés |
EP3023100A1 (fr) * | 2013-07-18 | 2016-05-25 | Taiho Pharmaceutical Co., Ltd. | Médicament antitumoral pour l'administration intermittente d'inhibiteur de fgfr |
Non-Patent Citations (1)
Title |
---|
See also references of WO2018049781A1 * |
Also Published As
Publication number | Publication date |
---|---|
US11572353B2 (en) | 2023-02-07 |
AU2017327954A1 (en) | 2019-05-02 |
AU2017327954B2 (en) | 2022-02-03 |
RU2729069C1 (ru) | 2020-08-04 |
US11059805B2 (en) | 2021-07-13 |
CN109843873B (zh) | 2022-06-17 |
CA3036594A1 (fr) | 2018-03-22 |
US20190210997A1 (en) | 2019-07-11 |
EP3517535A1 (fr) | 2019-07-31 |
JP2019529444A (ja) | 2019-10-17 |
CN107840842A (zh) | 2018-03-27 |
US20210332027A1 (en) | 2021-10-28 |
JP6906811B2 (ja) | 2021-07-21 |
WO2018049781A1 (fr) | 2018-03-22 |
US20200339541A1 (en) | 2020-10-29 |
CN109843873A (zh) | 2019-06-04 |
EP3517535B1 (fr) | 2022-06-29 |
ES2925212T3 (es) | 2022-10-14 |
MX2019003143A (es) | 2019-06-17 |
SG10202102822RA (en) | 2021-05-28 |
KR20190052113A (ko) | 2019-05-15 |
CA3036594C (fr) | 2024-02-13 |
US10710981B2 (en) | 2020-07-14 |
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