EP3484620A4 - Élimination des bulles dans un dispositif microfluidique - Google Patents

Élimination des bulles dans un dispositif microfluidique Download PDF

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Publication number
EP3484620A4
EP3484620A4 EP17828357.8A EP17828357A EP3484620A4 EP 3484620 A4 EP3484620 A4 EP 3484620A4 EP 17828357 A EP17828357 A EP 17828357A EP 3484620 A4 EP3484620 A4 EP 3484620A4
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EP
European Patent Office
Prior art keywords
microfluidic device
removing bubbles
bubbles
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17828357.8A
Other languages
German (de)
English (en)
Other versions
EP3484620A1 (fr
EP3484620B1 (fr
Inventor
Daniel Levner
Josiah Daniel SLIZ
Christopher David HINOJOSA
Joshua GOMES
Kyung Jin Jang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emulate Inc
Original Assignee
Emulate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emulate Inc filed Critical Emulate Inc
Priority to EP23219278.1A priority Critical patent/EP4325111A3/fr
Publication of EP3484620A1 publication Critical patent/EP3484620A1/fr
Publication of EP3484620A4 publication Critical patent/EP3484620A4/fr
Application granted granted Critical
Publication of EP3484620B1 publication Critical patent/EP3484620B1/fr
Active legal-status Critical Current
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Developers In Electrophotography (AREA)
EP17828357.8A 2016-07-12 2017-07-12 Élimination des bulles dans un dispositif microfluidique Active EP3484620B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23219278.1A EP4325111A3 (fr) 2016-07-12 2017-07-12 Élimination de bulles dans un dispositif microfluidique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662361266P 2016-07-12 2016-07-12
PCT/US2017/041656 WO2018013646A1 (fr) 2016-07-12 2017-07-12 Élimination des bulles dans un dispositif microfluidique

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP23219278.1A Division-Into EP4325111A3 (fr) 2016-07-12 2017-07-12 Élimination de bulles dans un dispositif microfluidique
EP23219278.1A Division EP4325111A3 (fr) 2016-07-12 2017-07-12 Élimination de bulles dans un dispositif microfluidique

Publications (3)

Publication Number Publication Date
EP3484620A1 EP3484620A1 (fr) 2019-05-22
EP3484620A4 true EP3484620A4 (fr) 2020-02-19
EP3484620B1 EP3484620B1 (fr) 2024-03-27

Family

ID=59676741

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17828357.8A Active EP3484620B1 (fr) 2016-07-12 2017-07-12 Élimination des bulles dans un dispositif microfluidique
EP23219278.1A Pending EP4325111A3 (fr) 2016-07-12 2017-07-12 Élimination de bulles dans un dispositif microfluidique

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP23219278.1A Pending EP4325111A3 (fr) 2016-07-12 2017-07-12 Élimination de bulles dans un dispositif microfluidique

Country Status (10)

Country Link
US (7) US10661275B2 (fr)
EP (2) EP3484620B1 (fr)
JP (4) JP7398955B2 (fr)
KR (4) KR102308594B1 (fr)
AU (1) AU2017296322A1 (fr)
CA (2) CA3130928A1 (fr)
GB (2) GB2569000B (fr)
HK (1) HK1255368A1 (fr)
SG (1) SG11201900081QA (fr)
WO (1) WO2018013646A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4026616A1 (fr) * 2015-08-26 2022-07-13 Emulate, Inc. Ensemble collecteur de perfusion
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
KR102308594B1 (ko) * 2016-07-12 2021-10-05 에뮬레이트, 인크. 마이크로유체 장치에서의 버블 제거
USD860471S1 (en) * 2016-07-12 2019-09-17 EMULATE, Inc. Perfusion module lid
JP6872182B2 (ja) * 2016-11-17 2021-05-19 コンビナティ インコーポレイテッド 核酸分析および定量化のための方法ならびにシステム
JP2021512619A (ja) * 2018-02-07 2021-05-20 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ハイスループットマイクロ流体デバイス
US11946029B2 (en) * 2018-02-16 2024-04-02 Astrego Diagnostics Ab Microfluidic device
EP3847234A2 (fr) 2018-09-04 2021-07-14 The Charles Stark Draper Laboratory, Inc. Procédé et dispositif d'électrotransfection à haute intensité de champ de microvésicules et de cellules
FR3094012B1 (fr) * 2019-03-20 2022-08-12 Cherry Biotech Sas Procédé d'enrichissement en gaz et simultanément de déplacement d’un fluide et dispositif pour le contrôle de l'environnement cellulaire sur une plaque de culture cellulaire multipuits correspondant.
JP7500225B2 (ja) 2020-02-28 2024-06-17 キヤノン株式会社 液体吐出装置および液体補給容器
US11898197B2 (en) 2020-07-30 2024-02-13 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US11904314B2 (en) 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US11660598B2 (en) 2020-08-07 2023-05-30 Overture Life, Inc. Microfluidic devices and methods for delivering solutions to biological material
WO2022140342A1 (fr) * 2020-12-23 2022-06-30 Parallel Fluidics Inc. Plateforme microfluidique modulaire

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
WO2012064172A1 (fr) * 2010-11-08 2012-05-18 Mimos Berhad Canal microfluidique et procédés d'élimination des bulles du fluide dans le canal microfluidique
EP2784151A1 (fr) * 2013-03-28 2014-10-01 ARKRAY, Inc. Dispositif, système et procédé de culture de cellules
WO2016010861A1 (fr) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Systèmes et procédés pour une performance améliorée de systèmes fluidiques et microfluidiques
DE102015001998B3 (de) * 2015-02-20 2016-02-04 Friz Biochem Gesellschaft Für Bioanalytik Mbh Mikrofluidische Kartusche für den Nachweis von Biomolekülen

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960706A (en) 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US20020127740A1 (en) * 2001-03-06 2002-09-12 Ho Winston Z. Quantitative microfluidic biochip and method of use
JP4148778B2 (ja) 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
UA82466C2 (uk) * 2001-07-18 2008-04-25 Бавариан Нордика А/С Спосіб посилення ампліфікації хордопоксвірусу
US6877528B2 (en) 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
US7122153B2 (en) * 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
US6843281B1 (en) * 2003-07-30 2005-01-18 Agilent Techinologies, Inc. Methods and apparatus for introducing liquids into microfluidic chambers
ES2459367T3 (es) * 2004-05-19 2014-05-09 Massachusetts Institute Of Technology Modelos tridimensionales de enfermedades de células/tejidos perfundidos
JP4615925B2 (ja) * 2004-07-28 2011-01-19 セイコーインスツル株式会社 マイクロ流体装置
JP4252545B2 (ja) 2005-03-01 2009-04-08 ローム株式会社 マイクロ流路及びマイクロ流体チップ
US7918244B2 (en) 2005-05-02 2011-04-05 Massachusetts Institute Of Technology Microfluidic bubble logic devices
US20060263873A1 (en) 2005-05-21 2006-11-23 Levine Leanna M Controlled flow microfluidic device and method of fabrication
US7897330B2 (en) 2005-08-11 2011-03-01 AB Sciex, LLC Methods for characterizing enzyme inhibitors
US20070141593A1 (en) * 2005-08-22 2007-06-21 Lee Linda G Apparatus, system, and method using immiscible-fluid-discrete-volumes
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
JPWO2008090681A1 (ja) 2007-01-22 2010-05-13 コニカミノルタエムジー株式会社 マイクロチップ検査装置及びポンプカートリッジ
JP2009121984A (ja) * 2007-11-15 2009-06-04 Fujifilm Corp マイクロ流路内泡除去方法及びマイクロ流路内溶解分散方法
JP4438860B2 (ja) * 2007-12-20 2010-03-24 セイコーエプソン株式会社 生体物質検出カートリッジ、生体物質検出装置、および生体物質検出方法
JP2009236555A (ja) * 2008-03-26 2009-10-15 Shimadzu Corp 流体デバイス及びその製造方法
WO2010053951A1 (fr) 2008-11-05 2010-05-14 Nanopoint, Inc. Système microfluidique actif pour culture in vitro
WO2010092845A1 (fr) 2009-02-13 2010-08-19 コニカミノルタホールディングス株式会社 Structure de passages de micro-écoulement et micropompe
SG177555A1 (en) * 2009-07-06 2012-02-28 Genentech Inc Method of culturing eukaryotic cells
US8372358B2 (en) * 2009-08-21 2013-02-12 The Regents Of The University Of California Microfluidic system and method for using same
JP2011072233A (ja) * 2009-09-30 2011-04-14 Nidek Co Ltd 細胞培養用基材の製造方法
EP2542662B1 (fr) 2010-03-02 2017-12-06 Universite Technologie De Compiegne-UTC Boite multi-reacteurs pour culture cellulaire dynamique
KR20120006591A (ko) * 2010-07-13 2012-01-19 삼성전자주식회사 기포의 발생이 방지된 유체용 센서
US8834937B2 (en) * 2010-09-10 2014-09-16 Aichi Gakuin Bone filling material comprising sintered titanium dioxide and dextrin and method for reconstructing bone defects using the same
EP2625531B1 (fr) 2010-10-08 2018-12-12 Biomerieux, Inc Cartes de tests d'échantillons améliorées
US20120245042A1 (en) * 2011-03-14 2012-09-27 The Trustees Of The University Of Pennsylvania Debubbler for microfluidic systems
AU2013267227B2 (en) 2012-05-31 2017-03-02 The University Of North Carolina At Chapel Hill Dissolution guided wetting of structured surfaces
US9962698B2 (en) 2012-09-05 2018-05-08 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
TW201422817A (zh) * 2012-12-14 2014-06-16 Ardic Instr Co 生物感測晶片結構
JP6366226B2 (ja) * 2013-05-24 2018-08-01 株式会社島津製作所 マイクロチップ反応装置
JP2015166707A (ja) 2014-03-04 2015-09-24 キヤノン株式会社 マイクロ流路デバイス
JP6354219B2 (ja) * 2014-03-11 2018-07-11 株式会社Ihi 細胞培養装置
JP2015186474A (ja) 2014-03-13 2015-10-29 アークレイ株式会社 細胞培養方法、細胞培養部材、及び細胞培養装置
US10018620B2 (en) * 2014-04-16 2018-07-10 The Charles Stark Draper Laboratory, Inc. Microfluidic tissue model
WO2015178381A1 (fr) 2014-05-21 2015-11-26 コニカミノルタ株式会社 Procédé de prétraitement pour dispositif d'étalement de cellules, dispositif d'étalement de cellules, et système de prétraitement pour dispositif d'étalement de cellules
EP2985063A1 (fr) 2014-08-15 2016-02-17 Carpegen GmbH Dispositif pour séparer des bulles d'un fluide
CN104225964B (zh) 2014-09-17 2016-09-28 清华大学 微流体气泡排除装置及其制备方法以及微流体器件
EP3307670B1 (fr) * 2015-06-12 2020-12-09 Cytochip Inc. Unités fluidiques et cartouches pour une analyse de multiples analytes
US9873859B2 (en) * 2015-08-20 2018-01-23 H R D Corporation Microorganism growth and products recovery
EP4026616A1 (fr) 2015-08-26 2022-07-13 Emulate, Inc. Ensemble collecteur de perfusion
KR102308594B1 (ko) * 2016-07-12 2021-10-05 에뮬레이트, 인크. 마이크로유체 장치에서의 버블 제거

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
WO2012064172A1 (fr) * 2010-11-08 2012-05-18 Mimos Berhad Canal microfluidique et procédés d'élimination des bulles du fluide dans le canal microfluidique
EP2784151A1 (fr) * 2013-03-28 2014-10-01 ARKRAY, Inc. Dispositif, système et procédé de culture de cellules
WO2016010861A1 (fr) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Systèmes et procédés pour une performance améliorée de systèmes fluidiques et microfluidiques
DE102015001998B3 (de) * 2015-02-20 2016-02-04 Friz Biochem Gesellschaft Für Bioanalytik Mbh Mikrofluidische Kartusche für den Nachweis von Biomolekülen

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SG11201900081QA (en) 2019-02-27
JP7301928B2 (ja) 2023-07-03
KR20240023193A (ko) 2024-02-20
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US20210308675A1 (en) 2021-10-07
US20180015466A1 (en) 2018-01-18
KR20190028468A (ko) 2019-03-18
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US20180016537A1 (en) 2018-01-18
US20180015464A1 (en) 2018-01-18
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US10974242B2 (en) 2021-04-13
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US20180015465A1 (en) 2018-01-18
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