EP3475753A4 - Automated adjustment of light sheet geometry in a microscope - Google Patents

Automated adjustment of light sheet geometry in a microscope Download PDF

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Publication number
EP3475753A4
EP3475753A4 EP17816281.4A EP17816281A EP3475753A4 EP 3475753 A4 EP3475753 A4 EP 3475753A4 EP 17816281 A EP17816281 A EP 17816281A EP 3475753 A4 EP3475753 A4 EP 3475753A4
Authority
EP
European Patent Office
Prior art keywords
microscope
light sheet
automated adjustment
sheet geometry
geometry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17816281.4A
Other languages
German (de)
French (fr)
Other versions
EP3475753A1 (en
Inventor
Philipp Johannes Keller
Raghav Kumar Chhetri
Loïc Alain ROYER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Howard Hughes Medical Institute
Original Assignee
Howard Hughes Medical Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howard Hughes Medical Institute filed Critical Howard Hughes Medical Institute
Publication of EP3475753A1 publication Critical patent/EP3475753A1/en
Publication of EP3475753A4 publication Critical patent/EP3475753A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/32—Micromanipulators structurally combined with microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0025—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for optical correction, e.g. distorsion, aberration

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP17816281.4A 2016-06-24 2017-06-23 Automated adjustment of light sheet geometry in a microscope Pending EP3475753A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662354384P 2016-06-24 2016-06-24
US201762447154P 2017-01-17 2017-01-17
PCT/US2017/038970 WO2017223426A1 (en) 2016-06-24 2017-06-23 Automated adjustment of light sheet geometry in a microscope

Publications (2)

Publication Number Publication Date
EP3475753A1 EP3475753A1 (en) 2019-05-01
EP3475753A4 true EP3475753A4 (en) 2020-04-15

Family

ID=60783949

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17816281.4A Pending EP3475753A4 (en) 2016-06-24 2017-06-23 Automated adjustment of light sheet geometry in a microscope

Country Status (5)

Country Link
US (2) US11320640B2 (en)
EP (1) EP3475753A4 (en)
JP (2) JP6906550B2 (en)
AU (1) AU2017281533B2 (en)
WO (1) WO2017223426A1 (en)

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CN108226120B (en) * 2018-01-23 2020-10-16 哈尔滨工业大学 Device and method for measuring size and energy distribution of sheet laser beam
WO2019236549A1 (en) * 2018-06-08 2019-12-12 The Board Of Trustees Of The Leland Stanford Junior University Near infra-red light sheet microscopy through scattering tissues
CN108956562B (en) * 2018-06-11 2020-05-22 浙江大学 Light section fluorescence microscopic imaging method and device based on repositioning
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US11322343B2 (en) * 2019-07-09 2022-05-03 IonQ, Inc. Optical alignment using reflective dove prisms
KR102073712B1 (en) * 2019-10-29 2020-02-05 한국기초과학지원연구원 Sensorless adaptive optical system, image module and communication module by using the same
WO2021159285A1 (en) * 2020-02-12 2021-08-19 深圳华大智造科技股份有限公司 Optical imaging system and biochemical substance detection system using same
CN111521608A (en) * 2020-04-27 2020-08-11 中国科学院广州生物医药与健康研究院 Super-resolution microscopic imaging method and microscope
EP4211508A4 (en) * 2020-09-14 2024-10-23 Singular Genomics Systems Inc Methods and systems for multidimensional imaging
EP4214562A1 (en) * 2020-09-20 2023-07-26 The Regents Of The University Of California Transverse sheet illumination microscopy (transim)
DE102020128524A1 (en) * 2020-10-29 2022-05-05 Carl Zeiss Microscopy Gmbh Light sheet microscope and method of light sheet microscopy
DE102021114307A1 (en) * 2021-06-02 2022-12-08 Carl Zeiss Microscopy Gmbh DIGITAL CONTRAST POST-PROCESSING OF MICROSCOPY IMAGES
WO2024068447A1 (en) 2022-09-26 2024-04-04 Consiglio Nazionale Delle Ricerche System and method for adjusting the alignment of a light sheet microscope
WO2024113204A1 (en) * 2022-11-30 2024-06-06 Nuohai Life Science (Shanghai) Co., Ltd A tiling light sheet microscope, its imaging method, microscopy system and a detection camera

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WO2014150536A1 (en) * 2013-03-15 2014-09-25 Wayne Leonard Rodenhausen Lightsheet microscopy with rotational-shear interferometry
US20150098126A1 (en) * 2013-10-09 2015-04-09 Howard Hughes Medical Institute Multiview Light-Sheet Microscopy
EP2887117A1 (en) * 2013-12-18 2015-06-24 Carl Zeiss Microscopy GmbH Microscope and method of SPIM microscopy

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WO2010014244A2 (en) * 2008-07-30 2010-02-04 The Regents Of The University Of California, San Francisco Multidirectional selective plane illumination microscopy
WO2014150536A1 (en) * 2013-03-15 2014-09-25 Wayne Leonard Rodenhausen Lightsheet microscopy with rotational-shear interferometry
US20150098126A1 (en) * 2013-10-09 2015-04-09 Howard Hughes Medical Institute Multiview Light-Sheet Microscopy
EP2887117A1 (en) * 2013-12-18 2015-06-24 Carl Zeiss Microscopy GmbH Microscope and method of SPIM microscopy

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Title
MICHAEL WEBER ET AL: "Chapter 11 - Light sheet microscopy", 1 January 2014, QUANTITATIVE IMAGING IN CELL BIOLOGY; [METHODS IN CELL BIOLOGY; ISSN 0091-679X; VOL. 123], ELSEVIER, US, PAGE(S) 193 - 215, ISBN: 978-0-12-420138-5, XP008175309 *
RAPHAEL JORAND ET AL: "Deep and Clear Optical Imaging of Thick Inhomogeneous Samples", PLOS ONE, vol. 7, no. 4, 25 April 2012 (2012-04-25), pages e35795, XP055419329, DOI: 10.1371/journal.pone.0035795 *
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Also Published As

Publication number Publication date
EP3475753A1 (en) 2019-05-01
WO2017223426A1 (en) 2017-12-28
US20220236550A1 (en) 2022-07-28
US11320640B2 (en) 2022-05-03
AU2017281533B2 (en) 2019-06-27
AU2017281533A1 (en) 2018-12-20
JP2019525216A (en) 2019-09-05
JP2021092575A (en) 2021-06-17
US20190219811A1 (en) 2019-07-18
JP6906550B2 (en) 2021-07-21

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