EP3321284A4 - Monoclonal antibody of human procalcitonin, preparation method therefor, and application thereof - Google Patents

Monoclonal antibody of human procalcitonin, preparation method therefor, and application thereof Download PDF

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Publication number
EP3321284A4
EP3321284A4 EP16820699.3A EP16820699A EP3321284A4 EP 3321284 A4 EP3321284 A4 EP 3321284A4 EP 16820699 A EP16820699 A EP 16820699A EP 3321284 A4 EP3321284 A4 EP 3321284A4
Authority
EP
European Patent Office
Prior art keywords
preparation
application
monoclonal antibody
method therefor
human procalcitonin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16820699.3A
Other languages
German (de)
French (fr)
Other versions
EP3321284B1 (en
EP3321284A1 (en
Inventor
Sen YE
Shizhao HE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Norman Biological Technology Co Ltd
Original Assignee
Nanjing Norman Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Norman Biological Technology Co Ltd filed Critical Nanjing Norman Biological Technology Co Ltd
Priority to EP20167035.3A priority Critical patent/EP3702370A1/en
Publication of EP3321284A1 publication Critical patent/EP3321284A1/en
Publication of EP3321284A4 publication Critical patent/EP3321284A4/en
Application granted granted Critical
Publication of EP3321284B1 publication Critical patent/EP3321284B1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/585—Calcitonins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP16820699.3A 2015-07-09 2016-05-10 Monoclonal antibody of human procalcitonin, preparation method therefor, and application thereof Active EP3321284B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20167035.3A EP3702370A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human-derived procalcitonin, and application thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510400557 2015-07-09
CN201510419304.6A CN105801697A (en) 2015-07-09 2015-07-16 Monoclonal antibody of human-derived procalcitonin, and preparation method and application thereof
PCT/CN2016/081545 WO2017005048A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human procalcitonin, preparation method therefor, and application thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20167035.3A Division-Into EP3702370A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human-derived procalcitonin, and application thereof
EP20167035.3A Division EP3702370A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human-derived procalcitonin, and application thereof

Publications (3)

Publication Number Publication Date
EP3321284A1 EP3321284A1 (en) 2018-05-16
EP3321284A4 true EP3321284A4 (en) 2018-07-11
EP3321284B1 EP3321284B1 (en) 2020-07-08

Family

ID=56466105

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20167035.3A Pending EP3702370A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human-derived procalcitonin, and application thereof
EP16820699.3A Active EP3321284B1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human procalcitonin, preparation method therefor, and application thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20167035.3A Pending EP3702370A1 (en) 2015-07-09 2016-05-10 Monoclonal antibody of human-derived procalcitonin, and application thereof

Country Status (4)

Country Link
US (1) US10882900B2 (en)
EP (2) EP3702370A1 (en)
CN (3) CN111793132A (en)
WO (1) WO2017005048A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109055318A (en) * 2018-07-31 2018-12-21 广东立诊得生物科技有限公司 Hybridoma cell strain A4-6A2 and its Procalcitonin monoclonal antibody and application of generation
CN108998421A (en) * 2018-07-31 2018-12-14 广东立诊得生物科技有限公司 Hybridoma cell strain A4-1B1 and its Procalcitonin monoclonal antibody and application of generation
CN109134653A (en) * 2018-09-10 2019-01-04 宁波奥丞生物科技有限公司 A kind of preparation method of Procalcitonin antibody
CN109652382A (en) * 2018-12-12 2019-04-19 杭州华葵金配生物科技有限公司 A kind of application of Procalcitonin monoclonal antibody hybridoma cell strain and its monoclonal antibody
CN112979804B (en) * 2019-12-18 2022-11-04 东莞市朋志生物科技有限公司 An isolated binding protein comprising a procalcitonin antigen-binding domain
CN114181308B (en) * 2021-12-28 2022-07-19 广州市雷德生物科技有限公司 Procalcitonin antibody and application thereof
CN115873112B (en) * 2022-12-23 2023-07-11 杭州华葵金配生物科技有限公司 Procalcitonin antibody and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1111050A2 (en) * 1999-12-22 2001-06-27 Dade Behring Marburg GmbH Human procalcitonin, its production and use
WO2008104321A1 (en) * 2007-02-28 2008-09-04 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method
WO2010125076A1 (en) * 2009-04-28 2010-11-04 B.R.A.H.M.S Aktiengesellschaft Immunoassay for the detection of procalcitonin
US20130046085A1 (en) * 2011-06-22 2013-02-21 Universidad De Sevilla Antibodies against n-procalcitonin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102702323B (en) * 2011-09-15 2015-04-22 重庆业为基生物科技有限公司 Application of procalcitonin B cell epitope peptide fragment and monoclonal antibody thereof
CN102702324B (en) * 2011-09-15 2015-04-22 重庆业为基生物科技有限公司 Application of human procalcitonin B cell epitope peptide fragment and monoclonal antibody thereof
CN102643332B (en) * 2011-09-15 2014-12-31 重庆业为基生物科技有限公司 Application of B cell epitope peptide of human PCT (Procalcitonin) and monoclonal antibody of B cell epitope peptide
CN104745534B (en) * 2015-03-02 2018-06-22 南方医科大学 A kind of Procalcitonin monoclonal antibody hybridoma 2H4 and monoclonal antibody

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1111050A2 (en) * 1999-12-22 2001-06-27 Dade Behring Marburg GmbH Human procalcitonin, its production and use
WO2008104321A1 (en) * 2007-02-28 2008-09-04 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method
WO2010125076A1 (en) * 2009-04-28 2010-11-04 B.R.A.H.M.S Aktiengesellschaft Immunoassay for the detection of procalcitonin
US20130046085A1 (en) * 2011-06-22 2013-02-21 Universidad De Sevilla Antibodies against n-procalcitonin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KRÄMER PETRA M ET AL: "Development and characterization of new rat monoclonal antibodies for procalcitonin", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, BERLIN, DE, vol. 392, no. 4, 1 October 2008 (2008-10-01), pages 727 - 736, XP002584671, ISSN: 1618-2650, [retrieved on 20080819], DOI: 10.1007/S00216-008-2321-4 *
See also references of WO2017005048A1 *

Also Published As

Publication number Publication date
US10882900B2 (en) 2021-01-05
CN105801697A (en) 2016-07-27
EP3321284B1 (en) 2020-07-08
EP3702370A1 (en) 2020-09-02
CN111793133A (en) 2020-10-20
CN111793132A (en) 2020-10-20
US20190031744A1 (en) 2019-01-31
WO2017005048A1 (en) 2017-01-12
EP3321284A1 (en) 2018-05-16

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