EP3272755A4 - Class of tricyclic analogue, preparation method and use thereof - Google Patents

Class of tricyclic analogue, preparation method and use thereof Download PDF

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Publication number
EP3272755A4
EP3272755A4 EP16764175.2A EP16764175A EP3272755A4 EP 3272755 A4 EP3272755 A4 EP 3272755A4 EP 16764175 A EP16764175 A EP 16764175A EP 3272755 A4 EP3272755 A4 EP 3272755A4
Authority
EP
European Patent Office
Prior art keywords
class
preparation
tricyclic
analogue
tricyclic analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16764175.2A
Other languages
German (de)
French (fr)
Other versions
EP3272755A1 (en
Inventor
Fajun Nan
Boliang Li
Yang ZHAN
Xiaowei Zhang
Ying Xiong
Xichan HU
Yangming Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Materia Medica of CAS
Original Assignee
Shanghai Institute of Materia Medica of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute of Materia Medica of CAS filed Critical Shanghai Institute of Materia Medica of CAS
Publication of EP3272755A1 publication Critical patent/EP3272755A1/en
Publication of EP3272755A4 publication Critical patent/EP3272755A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/04—Substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B49/00—Grignard reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP16764175.2A 2015-03-19 2016-03-03 Class of tricyclic analogue, preparation method and use thereof Withdrawn EP3272755A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510121662.9A CN106032383B (en) 2015-03-19 2015-03-19 A kind of tricyclic analog, preparation method and use
PCT/CN2016/075391 WO2016145994A1 (en) 2015-03-19 2016-03-03 Class of tricyclic analogue, preparation method and use thereof

Publications (2)

Publication Number Publication Date
EP3272755A1 EP3272755A1 (en) 2018-01-24
EP3272755A4 true EP3272755A4 (en) 2018-01-24

Family

ID=56918370

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16764175.2A Withdrawn EP3272755A4 (en) 2015-03-19 2016-03-03 Class of tricyclic analogue, preparation method and use thereof

Country Status (6)

Country Link
US (1) US10278962B2 (en)
EP (1) EP3272755A4 (en)
JP (1) JP2018508560A (en)
KR (1) KR101975916B1 (en)
CN (1) CN106032383B (en)
WO (1) WO2016145994A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110950881A (en) * 2018-09-27 2020-04-03 中国科学院上海药物研究所 Tricyclic analogue, preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039010A1 (en) * 1997-03-07 1998-09-11 Kansas State University Research Foundation Tricyclic and tetracyclic pyrones
JP2014144922A (en) * 2013-01-28 2014-08-14 Kitasato Institute Pyripyropene a structure-simplified derivative showing acat2 inhibitory activity
WO2015198966A1 (en) * 2014-06-24 2015-12-30 学校法人北里研究所 Novel pharmaceutical compound having a cholesterol acyltransferase isozyme 2 (acat2) -inhibiting activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935726B1 (en) * 1999-11-12 2011-05-03 Kansas State University Research Foundation Tricyclic pyrones
US6916824B1 (en) * 1999-11-12 2005-07-12 Kansas State University Research Foundation Methods of treating cataracts and diabetic retinopathy with tricyclic pyrones
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
JP5734853B2 (en) * 2008-08-29 2015-06-17 トレヴェンティス コーポレイションＴｒｅｖｅｎｔｉｓ Ｃｏｒｐｏｒａｔｉｏｎ Butyrylcholinesterase ligand as a diagnostic tool and therapy for nervous system diseases
WO2010041568A1 (en) * 2008-10-09 2010-04-15 旭化成ファーマ株式会社 Indazole derivative
WO2011107411A1 (en) * 2010-03-02 2011-09-09 Basf Se Pyranopyranone derivatives as antimicrobial agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039010A1 (en) * 1997-03-07 1998-09-11 Kansas State University Research Foundation Tricyclic and tetracyclic pyrones
JP2014144922A (en) * 2013-01-28 2014-08-14 Kitasato Institute Pyripyropene a structure-simplified derivative showing acat2 inhibitory activity
WO2015198966A1 (en) * 2014-06-24 2015-12-30 学校法人北里研究所 Novel pharmaceutical compound having a cholesterol acyltransferase isozyme 2 (acat2) -inhibiting activity
EP3162805A1 (en) * 2014-06-24 2017-05-03 School Juridical Person Kitasato Institute Novel pharmaceutical compound having a cholesterol acyltransferase isozyme 2 (acat2) -inhibiting activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG J ET AL: "An unexpected retro-aldol-aldol in the AB-ring in the synthesis of (+/-)-arisugacin A", TETRAHEDRON LET, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 18, 29 April 2002 (2002-04-29), pages 3337 - 3340, XP004349380, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)00550-6 *

Also Published As

Publication number Publication date
EP3272755A1 (en) 2018-01-24
WO2016145994A1 (en) 2016-09-22
US20180064696A1 (en) 2018-03-08
KR101975916B1 (en) 2019-05-07
CN106032383A (en) 2016-10-19
JP2018508560A (en) 2018-03-29
KR20170125970A (en) 2017-11-15
US10278962B2 (en) 2019-05-07
CN106032383B (en) 2019-08-13

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