EP3209278A1 - Poudre pour nettoyage de dents par jet pulvérulent - Google Patents

Poudre pour nettoyage de dents par jet pulvérulent

Info

Publication number
EP3209278A1
EP3209278A1 EP15784025.7A EP15784025A EP3209278A1 EP 3209278 A1 EP3209278 A1 EP 3209278A1 EP 15784025 A EP15784025 A EP 15784025A EP 3209278 A1 EP3209278 A1 EP 3209278A1
Authority
EP
European Patent Office
Prior art keywords
powder
jet
disaccharide
dental
μηη
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP15784025.7A
Other languages
German (de)
English (en)
Inventor
Jennifer HARTL
Uwe MUNDIL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orochemie GmbH and Co KG
Original Assignee
Orochemie GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3209278(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orochemie GmbH and Co KG filed Critical Orochemie GmbH and Co KG
Publication of EP3209278A1 publication Critical patent/EP3209278A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof

Definitions

  • the present invention relates to the use of particulate substrates as Abrasiv- and / or polishing body for the preparation of a dental jet powder for supra and / or subgingival powder jet cleaning.
  • Pulverstrahlgenesis today represents a common and widely used method for professional cleaning of tooth or tooth root surfaces. Discoloration, hard and soft coverings can thus quickly, gently and efficiently remove and replace or supplement the mechanical scraping with hand instruments or ultrasonic treatments ,
  • sodium bicarbonate powder blasting abrasive abrasive powders are an excellent means of efficiently cleaning tooth surfaces
  • the use of sodium bicarbonate powders in the subgingival region is problematic due to their high abrasiveness to dentin and cementum.
  • WO 97/04741 A1 discloses the use of xylitol and calcium carbonate in powders having an average particle size of less than 20 ⁇ .
  • EP 1 468 659 A2 discloses the use of calcium triphosphate as an abrasive in powder blasting.
  • the object of the present invention is therefore to provide a new jet powder, with which an optimized abrasive effect can be achieved, namely supra- as well as subgingival, while overcoming the disadvantages of the prior art in terms of patient acceptance.
  • this object is achieved by using at least one disaccharide as Abrasiv- and / or polishing body for the preparation of a dental jet powder for the supra- and / or subgingival powder jet cleaning of tooth surfaces.
  • composition for use as a dental jet powder comprising (i) 70 to 99.9% by weight of one or more disaccharides as a first abrasive and / or polishing body, and (ii) 0 , 1 to 30.0% by weight of a flow aid, wherein the sum of all proportions 100 wt .-% results.
  • a composition which has at least one disaccharide.
  • the disaccharide is selected from trehalose and / or palatinose or mixtures thereof.
  • the disaccharides, in particular trehalose and / or palatinose, or powders thereof, have u.a.
  • the surprising advantage that they have a better solubility, and can be achieved with them a gentler treatment of the tooth surfaces than with comparative powders, at the same time the compatibility is increased.
  • the disaccharides are more acceptable in taste than, for example, sodium bicarbonate.
  • Disaccharides in the present context and in the relevant field are understood to mean, on a regular basis, double sugars which are covalently linked by linking two monosaccharides (monosaccharides) via a glycosidic bond Disaccharides in common is their sweet taste. In particular, acariotic disaccharides are preferred in the present case.
  • the disaccharides used according to the invention may be composed of alpha- or beta-linked monosaccharides, as well as different stereoisomers.
  • the monosaccharides which may be in alpha or beta form, and which constitute the building blocks for the disaccharides, are usually glucose, fructose, galactose, linked together in different combinations and via different bonds (alpha or beta glycosidic) are.
  • Cellobiose, gentiobiose, isomaltulose (palatinose), isomaltose, lactose, lactulose, laminaribiose, maltose, maltulose, meliobiose, rhamnose, neotrehalose, nigerose, rutinose sambuiose, saccharodes, trehalose are known, for example.
  • acariogenic disaccharides are preferred, in particular palatinose and trehalose.
  • Trehalose is a disaccharide consisting of two ⁇ , ⁇ '-1, 1-glycosidically linked glucose molecules.
  • the systematic name of trehalose is 1-a-glucopyranosyl-1-a-glucopyranoside, in the shorthand: Glc ⁇ (1-> 1) a Glc.
  • Palatinose also referred to in the literature and in the field as Isoma- Itulose, has the systematic name of 6-O- ⁇ -D-glucopyranosyl-fructose, and like trehalose is akariogen and therefore tooth-friendly. Both sugars do not cause digestive problems or other tolerance problems.
  • Both sugars have a low glycemic index, are food grade, and excellent in flavor.
  • the disaccharides according to the invention are present as a powder with a certain average particle size.
  • the powders are made by grinding, sieving, Air classification, classifying or other processes known in the art process steps in the desired particle size distribution produced.
  • factors such as the hardness and mass of the particles are essentially decisive in addition to the particle velocity to be influenced by the corresponding device.
  • large particles with a lower density have approximately the same abrasivity as smaller particles with greater density.
  • disaccharides in particular of disaccharides having a density of less than or equal to 2.0 g / cm 3 in powder form, leads to a jet powder with which the disadvantages of the jet powder known in the prior art are overcome can.
  • the disaccharide powders have not led to a clumping in the blasting machine in laboratory tests, and therefore offer an excellent alternative to the jet powders previously used in the prior art, the production of which is often associated with high costs.
  • the disaccharide can be used sub- or supragingival.
  • gums are inflamed and not treated for a long time, it may be a periodontitis, so an inflammation of the periodontium develop. This is regularly accompanied by a bone loss and a gum decline. The gum retraction, in turn, exposes the necks of the teeth and increases sensitivity. These exposed dental necks, as well as the usually subgingival areas, especially the tooth roots, must be treated with powders of lower abrasivity than are supra-gingival areas so as not to injure the more sensitive tooth tissue present here.
  • the average particle size of the jet powder according to the invention is smaller than when using the powder for the supragingival beam cleaning.
  • the interaction between the density of the disaccharides used and their particle size play an outstanding role, and it has been found that a density of the disaccharides used for the powders of less than or equal to 2.0 g / cm 3 in conjunction with a certain particle size of the disaccharides or the jet powder, which is tailored to the particular application, leads to optimal cleaning results.
  • the mean particle size is less than or equal to 50 ⁇ (D50), and less than or equal to 80 ⁇ (D50) for the supragingival region.
  • the jet powder further comprises at least one of the following ingredients: a flow aid, a flavoring agent, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, lactobacilli or fragments thereof, and / or bacteriocides, or Mixtures of one or more of them.
  • the above-mentioned further ingredients are selected in terms of their particle size with respect to the jet powder composition so that the average particle size of the jet powder remains in the above-mentioned preferred ranges, ie, for example, in subgingival applications with a mean Particle size (D50) of less than 50 ⁇ , and in supragingigvalen applications of less than 80 ⁇ (D50).
  • D50 mean Particle size
  • Riesel Anlagenn are known in the field of jet powder, and are release agents that are added to crystalline substances in order to avoid the clumping of the substances, which can be used better and by machine. Even with jet powders, it may be necessary to use one or more flow aids to prevent clogging of the nozzle of the blasting device in a clumping of the powder substances.
  • the flow aid is selected from silicon dioxide, calcium carbonate, aluminum silicates, and / or aluminum hydroxide.
  • the alditol is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lacitol, tritol, or mixtures of one or more thereof.
  • Alditols are non-cyclic polyols which are structurally derived as reduction products of carbohydrates, and therefore represent sugar alcohols. They have long been used in jet powders as sugar substitutes for improving the taste, since alditols are not cariogenic. In addition, alditols were also used as Abrasiv- or polishing body in jet powders, the average particle size used usually depends on whether the jet powder is to be used sub- or supragingival. For subgingival applications, an average particle size of less than or equal to about 50 ⁇ (D50) is generally used, for supragingival applications an average particle size of less than or equal to about 80 ⁇ (D50).
  • glycine As a crystalline amino acid, for example, glycine can be used.
  • flavorings to be used according to the invention are, for example, natural or nature-identical odorants and / or flavorings. This is generally understood to mean flavors with which products which are taken orally or ingested give a special smell or taste.
  • Natural flavoring odoriferous and flavoring substances are substances or mixtures of substances which are obtained from natural sources, for example plants or parts of plants, and, if appropriate, purified. Alternatively, the flavoring agents to be used may also be produced synthetically.
  • Triclosan, chlorhexidine, copper, zinc and tin (II) salts, such as zinc citrate, zinc sulfate, zinc glycinate, sodium zinc citrate and tin (II) pyrophosphate can be used as bactericides or, in general, antimicrobial substances.
  • Metronidazole, quaternary ammonium compounds; Bisguanides, such as chlorhexidine digluconate, hexetidine, cetylpyridinium chloride, octenidine, alexidine are used.
  • Suitable bleaching agents are in particular or generally peroxide compounds, potassium, ammonium, sodium and lithium persulfates and perborate mono- and tetrahydrate, sodium pyrophosphate peroxide.
  • natural or derived from natural substances or microorganisms substances or parts thereof can be used in the use / composition according to the invention, such as, for example, lactobacilli or fragments thereof, which may be killed.
  • the jet powder for the different fields of application may have differently adapted average particle sizes.
  • the use is provided when the disaccharide in the jet powder in a proportion of between 70 to 99.9 wt .-%, in particular from 95% to 99.9 wt .-%, is included ,
  • the composition may also contain further ingredients such as flavoring agents, flow aids, etc., so that the percentage of disaccharide can vary depending on the desired application.
  • the at least one disaccharide is used as an abrasive and / or polishing body in a dental jet powder for the therapy and / or prophylaxis of dental or dental diseases.
  • the present invention also relates to a composition for use as a dental jet powder, the composition comprising: 70 to 99.9% by weight of one or more, preferably acariogenic, disaccharides as a first abrasive and / or polishing article , and 0.1 to 30.0 wt .-% of a flow aid, wherein the sum of all proportions 100 wt .-% results.
  • compositions can be used for different purposes, taking into account in particular the general condition of the teeth and tooth surfaces.
  • the disaccharide can be present, for example, in anhydrous form or as dihydrate.
  • composition is preferably an anhydrous powder, wherein "anhydrous” is to be understood here as meaning that the composition has no further addition of water, except for possibly hydrated ingredients.
  • the disaccharide is trehalose and / or palatinose and / or if the disaccharide in the composition Setting a mean particle size (D50) of between 10 ⁇ and 80 ⁇ has.
  • the trehalose to be used may preferably be a trehalose selected from the following CAS (chemical abstract services) numbers: 99-20-7 ( ⁇ , ⁇ -D-trehalose), 585-91-1 (a, ⁇ -D-trehalose), 6138-23-4 ( ⁇ , ⁇ -D-trehalose dihydrate), 499-23-0 ( ⁇ , ⁇ -D-trehalose), 25018-27-3 (trehalose octaacetate).
  • CAS chemical abstract services
  • the palatinose (isomaltulose) to be used may be the disaccharide registered under the following CAS number: 13718-94-0.
  • composition according to the invention if, in addition to the disaccharide, the composition additionally contains at least one of the following ingredients: a flow aid, a flavoring agent, a bleaching agent, an analgesic, a crystalline amino acid , an alditol, lactobacilli, and / or bacterial ozides, or mixtures of one or more thereof.
  • the flow aid is selected from at least one of the following: silicon dioxide, calcium carbonate, aluminum silicates, and / or aluminum hydroxide.
  • composition according to the invention in an additional use of an alditol this is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lacitol, tritol, or mixtures of one or more thereof.
  • the respective particle sizes of the other ingredients in particular the alditol or the crystalline amino acid, for example.
  • Glycine to be used on the middle particles - tunes the size of the disaccharide and adjusts accordingly, so that the mean particle size of the jet powder corresponds to the values given above, and the respective use (sub- or supragingival) is adjusted.
  • the composition according to the invention further comprises a flavoring, preferably orange flavor or mint flavor.
  • a flavoring preferably orange flavor or mint flavor.
  • these may be artificial or natural flavorings.
  • the present invention also generally relates to the use of the composition of the invention as a dental jet powder for supra- and subgingival powder jet cleaning of tooth surfaces.
  • jet powder is applied by means of a jet printing device.
  • Jet pressure devices or generally the powder jet technique per se are known in the art.
  • the powder, mixed with water and / or air can be applied to the tooth surfaces with defined pressure by means of this technique or with suitable jet pressure equipment, whereby the discolored discoloration and microbial soft dental plaque can be gently removed.
  • the invention also relates to a system or kit for supra- and subgingival powder jet cleaning of tooth surfaces, comprising a jet pressure device and the composition according to the invention.
  • Fig. 1 is a graph showing the abrasiveness over time for one embodiment of the composition according to the invention ("Supplementary supragingival", lowest curve) compared to two commercially available ones also available for supra-gingival use (product A: top curve, product B: middle curve).
  • trehalose and once palatinose were selected as exemplary embodiments of a disaccharide according to the invention.
  • trehalose or palatinose were provided, wherein the powder of the two disaccharides each had an average particle size (D50) of about 65 ⁇ ; the D90 value was approx. 160 ⁇ in each case.
  • the values D10, D50 and D90 are used to characterize a particle size distribution.
  • the value of D50 is defined as "average particle size” and the values D10 and D90 are used to describe the width of a particle size distribution (D10-D90).
  • compositions were provided, namely once the disaccharide powder with the above average particle size of 65 ⁇ under Addition of a flow aid (Aerosil), and once the disaccharide powder with the above average particle size of 65 ⁇ with the addition of a flow aid (Aerosil) and aroma (mint or orange).
  • Powder trehalose mint
  • the good or better solubility is important for the present purpose of the powder jet cleaning, since no residue should remain in the mouth of the patient, especially in the subgingival cleaning, as they can lead to inflammation or other medical incompatibilities or complications.
  • test parameters were the jet behavior on the surfaces of enamel and root element with respect to damage by detection by means of a scanning electron microscope, and cleaning behavior on colored bovine tooth.
  • compositions used above by way of example, a lower damage to enamel or root elements could be detected in the scanning electron microscope, or at least no damage could be detected at all (data not shown).
  • trehalose and palatinose were again selected as embodiments of a disaccharide according to the invention for a composition according to the invention, which is suitable for subgingival applications this time.
  • blasting experiments with the different embodiments of the blasting powders according to the invention on implant and ceramic models, as well as on human tooth samples, have shown in comparison to four conventional blasting powders and a control (untreated) that the removal of material over the time compared to the conventional powders is improved. (Data not shown).
  • FIG. 1 is a graph showing the average abrasiveness measured on ivory platelets over time for the invention.
  • composition "erf. Zus. supragingival (embodiment: supragigeal jet powder, see above) on one side (lower curve in Fig. 1), and on the other hand for two commercially available comparison products also for supragingival use, one based on sodium bicarbonate (product A: top 1), and the other glycine (product B: middle curve, which overlaps the practical linear curve at 4 minutes).
  • composition of the invention has a lower abrasiveness than two comparison products, and in particular a 25% reduced abrasiveness against the product A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de disaccharides comme corps abrasifs et/ou polissants pour la production d'une poudre dentaire permettant le nettoyage supra-gingival et/ou sub-gingival de surfaces dentaires par jet pulvérulent. En particulier, l'invention concerne également des compositions destinées à être utilisées comme poudre dentaire pour jet pulvérulent, comprenant un ou plusieurs disaccharides comme premier corps abrasif et/ou polissant.
EP15784025.7A 2014-10-22 2015-10-21 Poudre pour nettoyage de dents par jet pulvérulent Pending EP3209278A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014115412.6A DE102014115412A1 (de) 2014-10-22 2014-10-22 Pulver für die dentale Pulverstrahlreinigung
PCT/EP2015/074304 WO2016062742A1 (fr) 2014-10-22 2015-10-21 Poudre pour nettoyage de dents par jet pulvérulent

Publications (1)

Publication Number Publication Date
EP3209278A1 true EP3209278A1 (fr) 2017-08-30

Family

ID=54337757

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15784025.7A Pending EP3209278A1 (fr) 2014-10-22 2015-10-21 Poudre pour nettoyage de dents par jet pulvérulent

Country Status (6)

Country Link
EP (1) EP3209278A1 (fr)
JP (1) JP6501880B2 (fr)
AU (1) AU2015335036B2 (fr)
DE (1) DE102014115412A1 (fr)
RU (1) RU2717949C2 (fr)
WO (1) WO2016062742A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD825741S1 (en) 2016-12-15 2018-08-14 Water Pik, Inc. Oral irrigator handle
WO2018144771A2 (fr) 2017-02-02 2018-08-09 Water Pik, Inc. Comprimé comprenant un abrasif pour nettoyage dentaire
EP3595578B1 (fr) 2017-03-16 2023-12-20 Water Pik, Inc. Irrigateur buccal pour utilisation avec un agent buccal
DE102017107124A1 (de) * 2017-04-03 2018-10-04 Ferton Holding S.A. Pulver zur Reinigung eines inneren Körperteils und/oder eines Implantats, Verfahren zur Herstellung eines solchen Pulvers und geeignete Verwendungen
USD868243S1 (en) 2018-03-16 2019-11-26 Water Pik, Inc. Oral irrigator tip
EP3824873A1 (fr) * 2019-11-25 2021-05-26 Ferton Holding S.A. Utilisation de rhamnose et d'arabinose pour nettoyage dentaire par jet de poudre
WO2021165332A1 (fr) * 2020-02-17 2021-08-26 Ferton Holding S.A. Cyclodextrines comme poudres de nettoyage dentaire

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60204709A (ja) * 1984-03-28 1985-10-16 Lion Corp 口腔用組成物
FI104044B (fi) 1995-07-28 1999-11-15 Neocare Oy Hampaiden hoidossa käytettävä valmiste
JPH10330231A (ja) * 1997-05-29 1998-12-15 Snow Brand Milk Prod Co Ltd 歯垢形成予防及び歯垢分解剤
JP3335107B2 (ja) * 1997-07-22 2002-10-15 有限会社ディー・アン・ディー 歯垢除去材
DE19804065A1 (de) * 1998-02-04 1999-12-23 Matthias Honl Flüssigkeitsabrasivstrahltrennverfahren für biologische Gewebe, Stoffe und Organe wie z. B. Knochen, Knorpel, Zähne und Häute für Biomaterialen wie z. B. Knochenzement (PMMA oder andere Polymere), Verbundwerkstoffe und Metalle sowie für technische Materialien
DE19910559A1 (de) * 1999-03-10 2000-09-14 Espe Dental Ag Subgingivales Pulverstrahlen
JP2004210722A (ja) * 2002-12-27 2004-07-29 Kao Corp 口腔用組成物
WO2004071472A1 (fr) * 2003-02-13 2004-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Preparation dermique a usage externe contenant un sucre derive de la ?,?-trehalose
US20040202980A1 (en) 2003-04-14 2004-10-14 Policicchio Piero A. Dental prophylaxis and air appliance
JP2010053062A (ja) * 2008-08-28 2010-03-11 Sunstar Inc 口腔用組成物
EP2228175B1 (fr) * 2009-03-12 2013-06-19 Ferton Holding SA Utilisation d'un poudre ou d'un mélange de poudre pour la production d'un agent pour le nettoyage par jet pulvérulent de surfaces dentaires
EP2758024B1 (fr) * 2011-09-23 2015-09-09 Tsu, Christopher Louis Poudre pour une utilisation dans un procédé de traitement dentaire
US9358185B2 (en) * 2012-06-18 2016-06-07 3M Innovative Properties Company Powder composition for air polishing the surface of hard dental tissue

Also Published As

Publication number Publication date
JP2017531690A (ja) 2017-10-26
RU2017117496A (ru) 2018-11-23
RU2017117496A3 (fr) 2018-11-23
DE102014115412A1 (de) 2016-05-12
AU2015335036A1 (en) 2017-05-18
JP6501880B2 (ja) 2019-04-17
WO2016062742A1 (fr) 2016-04-28
AU2015335036B2 (en) 2018-11-29
RU2717949C2 (ru) 2020-03-27

Similar Documents

Publication Publication Date Title
EP3209278A1 (fr) Poudre pour nettoyage de dents par jet pulvérulent
DE69631433T2 (de) Zubereitung für die zahnpflege
DE3343200C2 (fr)
EP1162940B1 (fr) Poudres sous forme de jet pour traitement sous-gingival
EP1942913A1 (fr) Utilisation de sels de calcium difficilement solubles dans l'eau et/ou leurs substances composites
DE2510412A1 (de) Arzneimittel gegen gingivitis
DE102016114189A1 (de) Zahnpflegezusammensetzung mit Hydroxylapatit
DE102006009799A1 (de) Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese
KR20130128953A (ko) 잇몸질환 치료용 치약 조성물
WO2007051542A2 (fr) Materiaux composites a base de composes de calcium et de gelatine specifique
WO2019149889A1 (fr) Hydroxyapatite
DE102010063720B4 (de) Silberhaltige Zahnpflegezusammensetzung
WO2008061816A2 (fr) Dispersions homogènes stables au stockage
DE102005052371A1 (de) Verwendung von schwer wasserlöslichen Calciumsalzen und/oder deren Kompositen
WO2008022859A2 (fr) Composition contenant des sels de calcium peu solubles dans l'eau et/ou leurs composites dans une quantité comprise entre 1 et 99 % en poids
DE102017009626A1 (de) Oralzusammensetzung mit Zitrusextrakt und Hydroxylapatit
EP3466403B1 (fr) Utilisation d'un monosaccharide pour le nettoyage de dents subgingival et/ou supragingival
JP2019112376A (ja) 練歯磨剤
WO2007101511A2 (fr) Procédé de nettoyage bucco-dentaire et/ou de reminéralisation
EP3466403A1 (fr) Utilisation d'un monosaccharide pour le nettoyage de dents subgingival et/ou supragingival
WO2007068403A2 (fr) Produits remineralisants
DE102019104840A1 (de) Oralgel-Zusammensetzung mit Hydroxylapatit und Calciumsalz
KR102550067B1 (ko) 폴리크레줄렌 및 불화화합물을 포함하는 구강용 조성물
DE102023103403A1 (de) Mundpflegemittel mit Dimethylglycin
DE102021100811A1 (de) Mundpflegemittel, insbesondere Zahnpasta

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170518

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20200925

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230302

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230502