EP3024500A4 - Clinical multimodality-tools for pre-and intraoperative insulinoma diagnostics - Google Patents

Clinical multimodality-tools for pre-and intraoperative insulinoma diagnostics Download PDF

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Publication number
EP3024500A4
EP3024500A4 EP14829114.9A EP14829114A EP3024500A4 EP 3024500 A4 EP3024500 A4 EP 3024500A4 EP 14829114 A EP14829114 A EP 14829114A EP 3024500 A4 EP3024500 A4 EP 3024500A4
Authority
EP
European Patent Office
Prior art keywords
multimodality
insulinoma
intraoperative
diagnostics
clinical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14829114.9A
Other languages
German (de)
French (fr)
Other versions
EP3024500A1 (en
Inventor
Thomas Reiner
Christian Brand
Jason Lewis
Wolfgang Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Publication of EP3024500A1 publication Critical patent/EP3024500A1/en
Publication of EP3024500A4 publication Critical patent/EP3024500A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP14829114.9A 2014-07-25 2014-07-25 Clinical multimodality-tools for pre-and intraoperative insulinoma diagnostics Withdrawn EP3024500A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2014/048277 WO2015013665A1 (en) 2013-07-25 2014-07-25 Clinical multimodality-tools for pre-and intraoperative insulinoma diagnostics

Publications (2)

Publication Number Publication Date
EP3024500A1 EP3024500A1 (en) 2016-06-01
EP3024500A4 true EP3024500A4 (en) 2017-04-19

Family

ID=59522788

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14829114.9A Withdrawn EP3024500A4 (en) 2014-07-25 2014-07-25 Clinical multimodality-tools for pre-and intraoperative insulinoma diagnostics

Country Status (2)

Country Link
EP (1) EP3024500A4 (en)
WO (1) WO2015013665A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110206605A1 (en) * 2009-12-10 2011-08-25 Kyoto University Molecular Probe for Imaging of Pancreatic Islets and Use of the Same
WO2012121746A2 (en) * 2011-03-09 2012-09-13 The General Hospital Corporation Imaging beta cell mass

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6924264B1 (en) * 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
US9403875B2 (en) * 2009-01-27 2016-08-02 University Of Southern California Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110206605A1 (en) * 2009-12-10 2011-08-25 Kyoto University Molecular Probe for Imaging of Pancreatic Islets and Use of the Same
WO2012121746A2 (en) * 2011-03-09 2012-09-13 The General Hospital Corporation Imaging beta cell mass

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHRISTIAN BRAND ET AL: "In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent", BIOCONJUGATE CHEMISTRY, vol. 25, no. 7, 23 May 2014 (2014-05-23), pages 1323 - 1330, XP055352994, ISSN: 1043-1802, DOI: 10.1021/bc500178d *
See also references of WO2015013665A1 *
SHUANGLONG LIU ET AL: "Efficient Construction of PET/Fluorescence Probe Based on Sarcophagine Cage: An Opportunity to Integrate Diagnosis with Treatment", MOLECULAR IMAGING AND BIOLOGY, SPRINGER-VERLAG, NE, vol. 14, no. 6, 3 April 2012 (2012-04-03), pages 718 - 724, XP035135415, ISSN: 1860-2002, DOI: 10.1007/S11307-012-0557-Z *
SUSAN M. CLARDY ET AL: "Fluorescent Exendin-4 Derivatives for Pancreatic [beta]-Cell Analysis", BIOCONJUGATE CHEMISTRY, vol. 25, no. 1, 15 January 2014 (2014-01-15), pages 171 - 177, XP055353198, ISSN: 1043-1802, DOI: 10.1021/bc4005014 *
T. REINER ET AL: "Accurate measurement of pancreatic islet -cell mass using a second-generation fluorescent exendin-4 analog", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, vol. 108, no. 31, 18 July 2011 (2011-07-18), US, pages 12815 - 12820, XP055353032, ISSN: 0027-8424, DOI: 10.1073/pnas.1109859108 *
TSUBERY H ET AL: "PROLONGING THE ACTION OF PROTEIN AND PEPTIDE DRUGS BY A NOVEL APPROACH OF REVERSIBLE POLYETHYLENE GLYCOL MODIFICATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 279, no. 37, 10 September 2004 (2004-09-10), pages 38118 - 38124, XP008040599, ISSN: 0021-9258, DOI: 10.1074/JBC.M405155200 *
WU ZHANHONG ET AL: "64Cu Labeled sarcophagine exendin-4 for microPET imaging of glucagon like peptide-1 receptor expression", JOURNAL OF NUCLEAR MEDICINE, 1 May 2013 (2013-05-01), pages 1 - 2, XP055352993, Retrieved from the Internet <URL:http://jnm.snmjournals.org/content/54/supplement_2/1157.short> [retrieved on 20170308] *
ZHANHONG WU ET AL: "64 Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression", THERANOSTICS, vol. 4, no. 8, 1 January 2014 (2014-01-01), AU, pages 770 - 777, XP055353108, ISSN: 1838-7640, DOI: 10.7150/thno.7759 *

Also Published As

Publication number Publication date
WO2015013665A1 (en) 2015-01-29
EP3024500A1 (en) 2016-06-01

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: REINER, THOMAS

Inventor name: LEWIS, JASON

Inventor name: BRAND, CHRISTIAN

Inventor name: WEBER, WOLFGANG

A4 Supplementary search report drawn up and despatched

Effective date: 20170317

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Ipc: A61K 49/14 20060101ALI20170313BHEP

Ipc: A61K 49/12 20060101ALI20170313BHEP

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Ipc: A61K 51/08 20060101ALI20170313BHEP

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