EP3003300A1 - A solution for eyelid margin hygiene and a device for its application - Google Patents
A solution for eyelid margin hygiene and a device for its applicationInfo
- Publication number
- EP3003300A1 EP3003300A1 EP14738603.1A EP14738603A EP3003300A1 EP 3003300 A1 EP3003300 A1 EP 3003300A1 EP 14738603 A EP14738603 A EP 14738603A EP 3003300 A1 EP3003300 A1 EP 3003300A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- solution
- eyelid
- hygiene
- kit according
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000744 eyelid Anatomy 0.000 title claims abstract description 35
- 229920000742 Cotton Polymers 0.000 claims description 9
- 229940119170 jojoba wax Drugs 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 7
- WRYLYDPHFGVWKC-UHFFFAOYSA-N 4-terpineol Chemical compound CC(C)C1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 4
- WRYLYDPHFGVWKC-SNVBAGLBSA-N 4-Terpineol Natural products CC(C)[C@]1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-SNVBAGLBSA-N 0.000 claims description 3
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- MQTOSJVFKKJCRP-HHZDEWPHSA-N Azythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@H]([C@@]([C@H](O)[C@H](C)N(C)C[C@@H](C)C[C@](C)(O)[C@@H](O[C@@H]2[C@H]([C@@H](C[C@H](C)O2)N(C)C)O)[C@@H]1C)(C)O)CC)[C@@H]1C[C@](C)(OC)[C@H](O)[C@@H](C)O1 MQTOSJVFKKJCRP-HHZDEWPHSA-N 0.000 claims description 2
- 241000978725 Mimosa tenuiflora Species 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 239000005844 Thymol Substances 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 2
- 229940081510 piroctone olamine Drugs 0.000 claims description 2
- 229960002180 tetracycline Drugs 0.000 claims description 2
- 229930101283 tetracycline Natural products 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 229960000790 thymol Drugs 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- CUCUKLJLRRAKFN-UHFFFAOYSA-N 7-Hydroxy-(S)-usnate Chemical compound CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O CUCUKLJLRRAKFN-UHFFFAOYSA-N 0.000 claims 1
- 241000221096 Simmondsia chinensis Species 0.000 claims 1
- 229940004858 usnic acid Drugs 0.000 claims 1
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 claims 1
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usninic acid Natural products CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 18
- 206010065062 Meibomian gland dysfunction Diseases 0.000 description 7
- 208000010217 blepharitis Diseases 0.000 description 7
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 4
- 206010013774 Dry eye Diseases 0.000 description 4
- 239000003889 eye drop Substances 0.000 description 4
- 229940012356 eye drops Drugs 0.000 description 4
- 208000008025 hordeolum Diseases 0.000 description 4
- 210000004175 meibomian gland Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 244000044822 Simmondsia californica Species 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 210000000720 eyelash Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- -1 thinners Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 241001608562 Chalazion Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004164 Wax ester Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000012977 invasive surgical procedure Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000011092 plastic-coated paper Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007391 self-medication Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 229940021506 stye Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
- A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1018—Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1036—Applicators comprising a pad, tissue, sponge, or the like containing a cosmetic substance, e.g. impregnated with liquid or containing a soluble solid substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Definitions
- the present invention relates to products for eyelid hygiene and particularly for eyelid margin hygiene.
- Figure 1 shows a detail of the device according to the invention.
- the solution may be contained in a multiple-dose drip-counter container (and in this case it is preferable for the solution to contain appropriate preserving agents, as explained above), or in single-dose phials (ophtioles) made of polyethylene, normally containing a volume in the range of 0.35 to 1 ml, and preferably 0.5 ml, prepackaged and containing a volume of solution corresponding, for instance, to 0.15 - 0.5 ml, and preferably 0.25 ml, and in this case it will be unnecessary to add any preserving agents.
Abstract
A solution for eyelid margin hygiene, and a kit comprising said solution with applicators for applying it to the eyelid margins are described.
Description
A SOLUTION FOR EYELID MARGIN HYGIENE AND A DEVICE FOR ITS APPLICATION
Field of the invention
The present invention relates to products for eyelid hygiene and particularly for eyelid margin hygiene.
State of the art
The generic term eyelid hygiene is commonly used to mean all those norms, activities and practices designed to cleanse and/or disinfect the skin of the eyelid, the eyelashes, and the eyelid margins. The most common indications for which ophthalmologists recommend performing eyelid hygiene procedures are eyelid dermatitis, anterior blepharitis, posterior blepharitis, Meibomian gland dysfunction (MGD), recurrent styes and chalazia, and post-operative eyelid cleansing.
When eyelid hygiene has the purpose of cleansing the orifices of the Meibomian glands, as in the case of posterior blepharitis, MGD, internal styes and chalazia, it is fundamentally important for this to be done as precisely and effectively as possible at eyelid margin level. In patients with these conditions and dysfunctions, the orifices of the Meibomian glands are obstructed due to an accumulation of epithelial cells (hyperkeratinization) and the presence of thickened Meibomian sebum.
The products and devices for eyelid hygiene currently available on the market mainly consist of medicated cotton gauze or nonwoven fabric pads packaged singly under sterile conditions. Some products are available in the form of a liquid, gel or foam and sold for use as eyelid cleansers with or without the aid of cotton gauze pads.
As an alternative to the above-mentioned products and devices, the ophthalmologist will often recommend that patients dip the tip of a cotton wool bud in various fluid substances (warm water, baby shampoo, chamomile, antibiotic eye drops, artificial tears) and use it to cleanse the eyelid margins in an effort to keep the glandular orifices clean (see, for instance, Sue Stevens "How to clean eyelids" Community Eye Health Journal Vol. 24, No. 75, 31 October 2011 ).
Both the premedicated cotton pads and the cleansing products are very useful and easy to use when patients need to cleanse the eyelid skin and eyelashes. Patients
complain of having severe difficulty, however, when the same products are prescribed for hygiene of the eyelid margin. The dimensions of the cotton pads, their consistency and manageability do not enable a sufficiently precise and effective cleansing of the eyelid margins.
In addition, the above-mentioned alternative practices often expose patients to the classic risks of DIY: the cotton wool buds are never sterile and may be a source of eyelid and eye contamination; the substances used are not always indicated for ophthalmological use; patients rarely have a thorough understanding of the correct procedure to perform and this can expose them to pointless or even hazardous manoeuvres.
The patent application US 2011/0124725 describes a treatment for dry eye involving eye drops or ointments for instilling in the eye, or the treatment of Meibomian gland obstruction/dysfunction. According to said patent application, jojoba oil is used as a carrier of local anaesthetics to prepare patients for the performance of an invasive surgical procedure (intraductal probing) of the Meibomian glands. The text makes no reference to eyelid hygiene or the treatment of (posterior or anterior) blepharitis, chalazion or stye, which form the therapeutic objects of the present patent application, nor to the possible use of jojoba oil in combination with cotton wool buds as a non-invasive self-medication product based on the principles of cleansing both mechanically and by affinity.
The consequence of all the above is that eyelid hygiene performed using the products currently available on the market is not effective for the treatment of disorders such as MGD, posterior blepharitis, seborrhoeic blepharitis, recurrent styes and chalazia. Hence the evident interest in products and devices suitable for cleansing the eyelid margins that are easy to use and designed for said purpose. Brief description of the figures
Figure 1 shows a detail of the device according to the invention.
Summary of the invention
A solution for eyelid margin hygiene, and a kit comprising said solution with applicators for applying it to the eyelid margins are described.
Detailed description of the invention
The present invention enables the above-described problems to be overcome by means of a solution for eyelid margin hygiene and a kit comprising said solution and an applicator for applying it to the eyelid margins.
The solution according to the invention consists of jojoba oil, extracted preferably by cold pressing from Simmondsia chinensis seeds, possibly in combination with: natural or synthetic antibacterial, anti-inflammatory and/or antioxidant agents, thinners, and preserving agents.
The antibacterial agent for use according to the invention may be chosen, for instance, from among: terpinen-4-ol, thymol, Mimosa tenuiflora liposoluble extract, piroctone olamine, azythromycin, tetracycline, and their derivatives.
When included, these products are normally in quantities in the range of 0.01 to
0.05%, and preferably 0.03% (w/V calculated on the total volume of the solution).
An example of anti-inflammatory agent for use according to the invention is o bisabolol; when added, it is normally in quantities in the range of 0.01 to 1 %, and preferably 0.5% (w/V calculated on the total volume of the solution).
The antioxidant for use according to the invention may be chosen, for instance, from among: vitamin E (0.1 to 0.5%), butylhydroxyanisole (BHA) and butylhydroxytoluene (BHT) (0.01 to 0.05%).
Suitable thinners for use according to the invention include vegetable oils (e.g. castor oil), mineral oils (e.g. vaseline oil), or synthetic oils (e.g. dicaprylyl carbonate); the thinners are naturally added in the quantities needed to achieve the required final density.
Finally, the preserving agents are those commonly used in solutions for ophthalmological use, such as combinations of parabens, in the quantities commonly used for this purpose.
According to the invention, however, it is preferable to avoid the use of preserving agents, which are not considered essential, partly because the solution is preferably marketed in sterile single doses, as explained in more detail below. A solution according to the invention may thus consist of 100% jojoba oil, extracted from Simmondsia chinensis seeds by cold pressing, or it may, for instance, comprise the following formulation: jojoba oil 99.97% and terpinen-4-ol 0.03%.
The jojoba oil used according to the present invention is the product as available commercially, and the compositions containing any of the various additives or other components are prepared according to the known methods normally used in the pharmaceutical sector for the preparation of products of this type.
As shown in Figure 1 , the applicator 10 according to the invention normally consists of a stick 11 that serves as a grip, with at least one of its two ends carrying a bud 12 made of a material suitable for being impregnated with the solution when the product is to be used.
The stick 11 is made of any rigid material suitable for the purpose, such as plastic, wood, metal, etc. (preferably rigid plastic), while the material comprising the one or more bud(s) 12 is cotton, a nonwoven fabric, natural or synthetic bristles, etc.
The buds 12 preferably have a tapered shape, with the end forming a rounded tip that makes it easier to follow the perimeter of the eyelid margin.
The applicators are preferably contained singly or in pairs inside sterile wrappings suitable for the purpose, such as plastic, paper, plastic-coated paper or cellophane sachets, or other material suited to the purpose.
The solution may be contained in a multiple-dose drip-counter container (and in this case it is preferable for the solution to contain appropriate preserving agents, as explained above), or in single-dose phials (ophtioles) made of polyethylene, normally containing a volume in the range of 0.35 to 1 ml, and preferably 0.5 ml, prepackaged and containing a volume of solution corresponding, for instance, to 0.15 - 0.5 ml, and preferably 0.25 ml, and in this case it will be unnecessary to add any preserving agents.
At the time of using the product, having removed the applicator from its sterile container, the user can medicate one of the buds with the solution contained in the single dose or with the required number of drops drawn from the multi-dose drop- counter container, and then apply the solution by rubbing the medicated tip of the applicator along the margins of the eyelids held suitably detached from the eye bulb.
The shape, manageability and stiffness of the applicator enable a straightforward and accurate mechanical cleansing of the orifices of the Meibomian glands, removing cell residues, thickened secretions, bacteria and their toxic metabolites
from the eyelid margins. The high wax ester content in jojoba oil enables a cleansing by affinity of the impaired Meibomian sebum and restores the lipid component of the lacrimal film.
A study was conducted on 9 patients with MGD and chronic blepharitis already receiving treatment for dry eye with eye drops and other products. The patients were treated for 4 weeks with the solution according to the invention and using the above-described applicators.
After the treatment, 89% of the patients reported an improvement or stabilisation of their dry eye symptoms and an improvement in the ocular and palpebral clinical signs. During the course of the study, 55% of the patients reduced or suspended their use of eye drops and other products for dry eye syndrome.
Claims
I . A solution for use in treatments for hygiene of the eyelid margin consisting of jojoba oil, possibly in combination with natural or synthetic antibacterial, antiinflammatory and/or antioxidant agents, thinners and preserving agents.
I. A solution according to claim 1 wherein said jojoba oil is extracted by cold pressing from Simmondsia chinensis seeds.
i. A solution according to claims 1 and 2 wherein said antibacterial agents are chosen from among: terpinen-4-ol, thymol, Mimosa tenuiflora liposoluble extract, piroctone olamine, usnic acid, azythromycin, tetracycline and their derivatives, or mixtures thereof, contained in quantities in the range of 0.01 to 0.05%, and preferably 0.03% (wA calculated on the total volume of the solution).
I. A solution according to claims 1 to 3 wherein said anti-inflammatory agent is o bisabolol in quantities in the range of 0.01 to 1 %, and preferably 0.5% (w/V calculated on the total volume of the solution).
5. A solution according to claims 1 to 4 wherein said antioxidants are chosen from among vitamin E in the range of 0.1 to 0.5%, butylhydroxyanisole (BHA) and butylhydroxytoluene (BHT) between 0.01 and 0.05%.
3. A kit comprising a solution according to claims 1 to 6 and an applicator for applying said solution to the eyelid margins.
J. A kit according to claim 6 wherein the solution, preferably containing appropriate preserving agents, is contained inside a multi-dose drop-counter container, or in single-dose phials, or ophtioles.
3. A kit according to claims 6 and 7 wherein said applicator (10) consists of a stick (1 1 ) that serves as a grip, with at least one of the two ends carrying a bud (12) of material suitable for being impregnated with the solution when the product is to be used.
3. A kit according to claim 8 wherein said stick (1 1 ) is made of a rigid material suited to the purpose, while the bud(s) (12) consist of cotton, a nonwoven fabric, natural or synthetic bristles or the like.
10. A kit according to claim 9 wherein said buds (12) have a tapered shape with a rounded tip.
11. A kit according to claims 1 to 10 wherein the applicators are contained singly or in pairs inside sterile wrappings suited to the purpose.
12. The use of a solution according to claims 1 to 5 for eyelid margin hygiene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000128A ITFI20130128A1 (en) | 2013-05-30 | 2013-05-30 | SOLUTION FOR THE HYGIENE OF THE SPREADING MARGINS AND DEVICE FOR ITS APPLICATION. |
PCT/IB2014/061842 WO2014191969A1 (en) | 2013-05-30 | 2014-05-30 | A solution for eyelid margin hygiene and a device for its application |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3003300A1 true EP3003300A1 (en) | 2016-04-13 |
Family
ID=48877348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14738603.1A Withdrawn EP3003300A1 (en) | 2013-05-30 | 2014-05-30 | A solution for eyelid margin hygiene and a device for its application |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3003300A1 (en) |
IT (1) | ITFI20130128A1 (en) |
WO (1) | WO2014191969A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201522144D0 (en) * | 2015-12-15 | 2016-01-27 | Univ Manchester | Compositions and uses and methods relating thereto |
KR102645434B1 (en) * | 2015-12-31 | 2024-03-11 | (주)아모레퍼시픽 | Antimicrobial sponge |
US11478437B2 (en) | 2016-07-05 | 2022-10-25 | Jenivision Inc. | Formulations for hair growth |
GB2580226B (en) * | 2017-06-30 | 2022-08-31 | Jenivision Inc | Formulations for hair growth |
FR3131214A1 (en) * | 2021-12-23 | 2023-06-30 | Laboratoires Thea | TOPICAL COMPOSITION AND ITS APPLICATOR, INTENDED TO RELIEVE CHALAZION |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8455016B2 (en) * | 2004-03-12 | 2013-06-04 | Melbj Holdings, Llc | Treatment for meibomian gland dysfunction or obstruction |
ITFI20120044A1 (en) * | 2012-03-01 | 2013-09-02 | Biodue Spa | FORMULATION FOR OPHTHALMIC USE INCLUDING JOJOBA OIL. |
-
2013
- 2013-05-30 IT IT000128A patent/ITFI20130128A1/en unknown
-
2014
- 2014-05-30 WO PCT/IB2014/061842 patent/WO2014191969A1/en active Application Filing
- 2014-05-30 EP EP14738603.1A patent/EP3003300A1/en not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
None * |
See also references of WO2014191969A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014191969A1 (en) | 2014-12-04 |
ITFI20130128A1 (en) | 2014-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102255726B1 (en) | Compositions and methods for the treatment of meibomian gland dysfunction | |
EP3003300A1 (en) | A solution for eyelid margin hygiene and a device for its application | |
US20050220742A1 (en) | Compositions and methods for maintaining eyelid hygiene | |
US11484516B2 (en) | Agents for increasing meibomian gland lipid secretion | |
CN107982212A (en) | A kind of atropic category medicament slow release eye drops and preparation method thereof | |
JP2019059757A (en) | Aqueous composition for ophthalmological use or otolaryngological use | |
WO2016022066A1 (en) | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting | |
US20190117563A1 (en) | Ocular eyelid scrub composition for the treatment of demodex blepharitis | |
EP2086560A1 (en) | Methods of treating epiphora | |
CN109069415A (en) | The ophthalmic composition of stable storing | |
US20170239307A1 (en) | Composition of doxycycline in liposomes for the prevention, improvement and/or treatment of ocular pathologies | |
WO2013133062A1 (en) | Coating agent for allergic rhinitis | |
US20220387389A1 (en) | Device for internal and external nasal application | |
US20180289541A1 (en) | Novel device for anesthetizing the eye | |
US11564965B2 (en) | Compositions for the treatment of Demodex blepharitis, acne and joint pain | |
US20220016019A1 (en) | Compositions containing plant mucilage | |
RU2397776C2 (en) | Ophthalmologic composition | |
Prakruthi et al. | An Expeditious Recovery from Stye–A Case Study | |
BR102018004898B1 (en) | SHAMPOO FOR EYELASHES | |
Bloch et al. | Corneal alkali burn from local anesthetic cream | |
ES2564560B1 (en) | Composition for the relief, improvement, prevention and / or treatment of dry eye syndrome | |
JP2004161715A (en) | Antiphlogistic sedative solid ointment | |
EP4072601A1 (en) | Disinfecting composition, applicator, and method of disinfecting | |
BR102017022753A2 (en) | Anesthetic and Antiseptic Composition Based on Acmelella Oleracea for Integral Skin | |
UA21727U (en) | Ointment for treating burns and purulent and infected wounds of various etiologies |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20151230 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20180921 |