EP2992759A4 - Atopic dermatitis model animal and use thereof - Google Patents

Atopic dermatitis model animal and use thereof

Info

Publication number
EP2992759A4
EP2992759A4 EP14791230.7A EP14791230A EP2992759A4 EP 2992759 A4 EP2992759 A4 EP 2992759A4 EP 14791230 A EP14791230 A EP 14791230A EP 2992759 A4 EP2992759 A4 EP 2992759A4
Authority
EP
European Patent Office
Prior art keywords
atopic dermatitis
model animal
dermatitis model
animal
atopic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14791230.7A
Other languages
German (de)
French (fr)
Other versions
EP2992759B1 (en
EP2992759A1 (en
Inventor
Kiyofumi Yamanishi
Hitoshi Mizutani
Yasutomo Imai
Tomohiro Yoshimoto
Kenji Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyogo College of Medicine
Mie University NUC
Original Assignee
Hyogo College of Medicine
Mie University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyogo College of Medicine, Mie University NUC filed Critical Hyogo College of Medicine
Publication of EP2992759A1 publication Critical patent/EP2992759A1/en
Publication of EP2992759A4 publication Critical patent/EP2992759A4/en
Application granted granted Critical
Publication of EP2992759B1 publication Critical patent/EP2992759B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP14791230.7A 2013-05-01 2014-04-30 Atopic dermatitis model animal and use thereof Active EP2992759B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013096637 2013-05-01
PCT/JP2014/061931 WO2014178392A1 (en) 2013-05-01 2014-04-30 Atopic dermatitis model animal and use thereof

Publications (3)

Publication Number Publication Date
EP2992759A1 EP2992759A1 (en) 2016-03-09
EP2992759A4 true EP2992759A4 (en) 2016-12-14
EP2992759B1 EP2992759B1 (en) 2019-07-31

Family

ID=51843517

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14791230.7A Active EP2992759B1 (en) 2013-05-01 2014-04-30 Atopic dermatitis model animal and use thereof

Country Status (4)

Country Link
US (1) US9949465B2 (en)
EP (1) EP2992759B1 (en)
JP (1) JP6362011B2 (en)
WO (1) WO2014178392A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
CN107172879B (en) 2014-11-10 2021-11-05 豪夫迈·罗氏有限公司 Anti-interleukin-33 antibodies and uses thereof
MX2022011156A (en) 2020-03-13 2022-10-13 Genentech Inc Anti-interleukin-33 antibodies and uses thereof.
KR20220163285A (en) * 2021-06-01 2022-12-09 주식회사 에즈큐리스 Screening Method of compound for IL-33 inhibiting and the Pharmaceutical composition comprising the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290939A1 (en) * 2000-06-16 2003-03-12 Nakanishi, Kenji Caspase 1 gene transfer animal
EP1405560A1 (en) * 2001-07-12 2004-04-07 Taiho Pharmaceutical Company Limited Il-18 transgenic animal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290939A1 (en) * 2000-06-16 2003-03-12 Nakanishi, Kenji Caspase 1 gene transfer animal
EP1405560A1 (en) * 2001-07-12 2004-04-07 Taiho Pharmaceutical Company Limited Il-18 transgenic animal

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JITLADA MEEPHANSAN ET AL: "Regulation of IL-33 Expression by IFN-[gamma] and Tumor Necrosis Factor-[alpha] in Normal Human Epidermal Keratinocytes", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, no. 11, 1 November 2012 (2012-11-01), US, pages 2593 - 2600, XP055314105, ISSN: 0022-202X, DOI: 10.1038/jid.2012.185 *
RANKIN ANDREW L ET AL: "IL-33 Induces IL-13-Dependent Cutaneous Fibrosis", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 184, no. 3, 1 February 2010 (2010-02-01), pages 1526 - 1535, XP009167831, ISSN: 0022-1767, DOI: 10.4049/JIMMUNOL.0903306 *
See also references of WO2014178392A1 *

Also Published As

Publication number Publication date
JPWO2014178392A1 (en) 2017-02-23
WO2014178392A1 (en) 2014-11-06
US20160057978A1 (en) 2016-03-03
US9949465B2 (en) 2018-04-24
EP2992759B1 (en) 2019-07-31
EP2992759A1 (en) 2016-03-09
JP6362011B2 (en) 2018-07-25

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