EP2977438A4 - Microchip, method for dna analysis, and system for dna analysis - Google Patents
Microchip, method for dna analysis, and system for dna analysisInfo
- Publication number
- EP2977438A4 EP2977438A4 EP14769006.9A EP14769006A EP2977438A4 EP 2977438 A4 EP2977438 A4 EP 2977438A4 EP 14769006 A EP14769006 A EP 14769006A EP 2977438 A4 EP2977438 A4 EP 2977438A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- dna analysis
- microchip
- dna
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013059106 | 2013-03-21 | ||
PCT/JP2014/055721 WO2014148265A1 (en) | 2013-03-21 | 2014-03-06 | Microchip, method for dna analysis, and system for dna analysis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2977438A1 EP2977438A1 (en) | 2016-01-27 |
EP2977438A4 true EP2977438A4 (en) | 2016-12-14 |
Family
ID=51579953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14769006.9A Withdrawn EP2977438A4 (en) | 2013-03-21 | 2014-03-06 | Microchip, method for dna analysis, and system for dna analysis |
Country Status (4)
Country | Link |
---|---|
US (1) | US10195607B2 (en) |
EP (1) | EP2977438A4 (en) |
JP (1) | JP6137301B2 (en) |
WO (1) | WO2014148265A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018181360A1 (en) | 2017-03-28 | 2018-10-04 | 日本電気株式会社 | Microchip control system |
KR20200113236A (en) * | 2018-01-24 | 2020-10-06 | 퍼킨엘머 헬스 사이언시즈, 아이엔씨. | Purification of nucleic acids on microfluidic chips by separation |
CN108733983A (en) * | 2018-05-29 | 2018-11-02 | 永康市翌阳科技有限公司 | A kind of information storing device |
CN108920906A (en) * | 2018-05-29 | 2018-11-30 | 永康市翌阳科技有限公司 | A kind of information storing device of green non-pollution |
JP2022502644A (en) * | 2018-09-28 | 2022-01-11 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | Positive temperature coefficient heating of laboratory diagnostic equipment |
CN116157500A (en) * | 2020-07-08 | 2023-05-23 | 卢马克特公司 | Sampling device and system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020068357A1 (en) * | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method |
US20090294287A1 (en) * | 2005-05-24 | 2009-12-03 | Ebara Corporation | Microchip electrophoresis method and device |
US20120055798A1 (en) * | 2010-03-09 | 2012-03-08 | Netbio, Inc. | Unitary Biochip Providing Sample-in to Results-out Processing and Methods of Manufacture |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07322881A (en) | 1994-05-31 | 1995-12-12 | S R L:Kk | Oligonucleotide, diagnostic reagent for hepatitis c comprising the same and method for diagnosing hepatitis c using the same |
US6554985B2 (en) | 1998-11-10 | 2003-04-29 | Curagen Corporation | Methods and formulations for the separation of biological macromolecules |
JP4362987B2 (en) | 2001-04-09 | 2009-11-11 | 株式会社島津製作所 | Sample introduction method in microchip electrophoresis |
TW200702660A (en) | 2003-11-21 | 2007-01-16 | Ebara Corp | Microfluidic treatment method and device |
CN101622543B (en) | 2007-03-05 | 2013-08-14 | 日本电气株式会社 | Flow control mechanism for microchip |
JP5641184B2 (en) | 2007-09-10 | 2014-12-17 | 日本電気株式会社 | Microchip sample processing equipment |
WO2009035062A1 (en) | 2007-09-10 | 2009-03-19 | Nec Corporation | Sample packing device |
JP5556178B2 (en) | 2007-09-21 | 2014-07-23 | 日本電気株式会社 | Temperature control method and system |
JPWO2009119698A1 (en) | 2008-03-24 | 2011-07-28 | 日本電気株式会社 | Microchip channel control mechanism |
EP2486978A1 (en) * | 2010-10-28 | 2012-08-15 | Roche Diagnostics GmbH | Microfluid test carrier for separating a fluid volume in partial volumes |
-
2014
- 2014-03-06 EP EP14769006.9A patent/EP2977438A4/en not_active Withdrawn
- 2014-03-06 JP JP2015506693A patent/JP6137301B2/en active Active
- 2014-03-06 US US14/778,260 patent/US10195607B2/en active Active
- 2014-03-06 WO PCT/JP2014/055721 patent/WO2014148265A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020068357A1 (en) * | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method |
US20090294287A1 (en) * | 2005-05-24 | 2009-12-03 | Ebara Corporation | Microchip electrophoresis method and device |
US20120055798A1 (en) * | 2010-03-09 | 2012-03-08 | Netbio, Inc. | Unitary Biochip Providing Sample-in to Results-out Processing and Methods of Manufacture |
Non-Patent Citations (7)
Title |
---|
DAMMIKA P MANAGE ET AL: "On-chip HA/SSCP for the detection of hereditary haemochromatosis", MICROFLUIDICS AND NANOFLUIDICS, SPRINGER, BERLIN, DE, vol. 1, no. 4, 9 July 2005 (2005-07-09), pages 364 - 372, XP019359761, ISSN: 1613-4990, DOI: 10.1007/S10404-005-0045-8 * |
GOLNAZ VAHEDI ET AL: "An integrated method for mutation detection using on-chip sample preparation, single-stranded conformation polymorphism, and heteroduplex analysis", ELECTROPHORESIS, vol. 25, no. 14, 1 July 2004 (2004-07-01), DE, pages 2346 - 2356, XP055316213, ISSN: 0173-0835, DOI: 10.1002/elps.200405957 * |
ORITA M ET AL: "Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 5, no. 4, 1 November 1989 (1989-11-01), pages 874 - 879, XP024797317, ISSN: 0888-7543, [retrieved on 19891101], DOI: 10.1016/0888-7543(89)90129-8 * |
P. SUNNUCKS ET AL: "SSCP is not so difficult: the application and utility of single-stranded conformation polymorphism in evolutionary biology and molecular ecology", MOLECULAR ECOLOGY., vol. 9, no. 11, 1 November 2000 (2000-11-01), GB, pages 1699 - 1710, XP055316211, ISSN: 0962-1083, DOI: 10.1046/j.1365-294x.2000.01084.x * |
See also references of WO2014148265A1 * |
SHIN ET AL: "Separation and Size Determination of Circular and Linear Single-Stranded DNAs by Alkaline Agarose Gel Electrophoresis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 226, 1 April 1995 (1995-04-01), pages 202 - 206, XP002110447, ISSN: 0003-2697, DOI: 10.1006/ABIO.1995.1214 * |
TIAN H ET AL: "Single-Strand Conformation Polymorphism Analysis by Capillary and Microchip Electrophoresis: A Fast, Simple Method for Detection of Common Mutations in BRCA1 and BRCA2", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 63, no. 1, 1 January 2000 (2000-01-01), pages 25 - 34, XP004439453, ISSN: 0888-7543, DOI: 10.1006/GENO.1999.6067 * |
Also Published As
Publication number | Publication date |
---|---|
JP6137301B2 (en) | 2017-05-31 |
US20160288119A1 (en) | 2016-10-06 |
US10195607B2 (en) | 2019-02-05 |
EP2977438A1 (en) | 2016-01-27 |
WO2014148265A1 (en) | 2014-09-25 |
JPWO2014148265A1 (en) | 2017-02-16 |
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Ipc: C12M 1/00 20060101AFI20161107BHEP Ipc: B01L 7/00 20060101ALI20161107BHEP Ipc: G01N 27/447 20060101ALI20161107BHEP Ipc: G01N 37/00 20060101ALI20161107BHEP Ipc: B01L 3/00 20060101ALI20161107BHEP |
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