EP2926166A2 - Vorrichtung zur überwachung eines elektronenstrahls über bremsstrahlungsbildgebung - Google Patents
Vorrichtung zur überwachung eines elektronenstrahls über bremsstrahlungsbildgebungInfo
- Publication number
- EP2926166A2 EP2926166A2 EP13805800.3A EP13805800A EP2926166A2 EP 2926166 A2 EP2926166 A2 EP 2926166A2 EP 13805800 A EP13805800 A EP 13805800A EP 2926166 A2 EP2926166 A2 EP 2926166A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- electron beam
- electron
- packaging container
- beam emitter
- sensor device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
- B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/02—Irradiation devices having no beam-forming means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/245—Detection characterised by the variable being measured
- H01J2237/24507—Intensity, dose or other characteristics of particle beams or electromagnetic radiation
Definitions
- the present invention relates to a device and method for irradiating objects with electron beams.
- An increasingly common packaging type is the "carton bottle” manufactured in a filling machine in that packaging blanks of the above-described packaging laminate are formed and sealed as a sleeve. Said sleeve is closed in one end in that a top of thermoplastic material is injection moulded directly on the sleeve end portion.
- the sheets of packaging laminate may be cut from a magazine reel of packaging laminate.
- the packaging container When the top is finished the packaging container is ready to be filled with product through the still open bottom, and then sealed and finally folded. Before the filling operation the packaging container undergoes treatment. If distribution and storage is to be made in chilled temperature the packaging container is disinfected, whereas if distribution and storage is to be made in ambient temperature, the packaging container needs to be sterilized.
- a conventional way of sterilizing a ready-to-fill packaging container is to use hydrogen peroxide, preferably in gas phase.
- Another way to sterilize such packaging containers is to irradiate it by means of a low voltage electron beam emitted from an electron beam emitter.
- An example of linear irradiation by electron beam of ready-to-fill packaging containers is disclosed in the international patent publication WO 2005/002973.
- the electron beam emitter is cylindrical with an electron exit window positioned at one of the distal ends.
- the packaging container is lifted to surround the electron beam emitter during the sterilization cycle.
- Other examples of irradiation of packaging containers, in these cases PET bottles are described in for example WO 2011/011079 and EP 2 371 397, the latter describing a rotary system. In these systems emitters are used having a diameter small enough to be passed through a neck portion of the bottles.
- dosimetry tests These tests are made regularly, generally daily, throughout the lifetime of the electron beam emitter.
- dosimetry tests involve adding a dosimeter means, i.e. a patch reacting on radiation exposure, to a packaging container to measure if a correct absorbed dose is obtained during radiation.
- measurements of voltage and current are made in the electron beam emitter. The current over the filament is measured by comparing the current fed to the filament and current leaving the filament. In this way it is possible to determine the amount of electrons emitted from the filament.
- the voltage i.e. the electric potential, between the electron exit window and the filament is measured.
- the measured value of voltage and current is then used as a set value during production of packaging containers. The current and voltage are continuously monitored during production, and as long as the value is not lower than the set value it is assumed that the packaging containers receive the correct dose.
- An object of the invention is to provide an irradiation device for irradiating objects with electron beams.
- the irradiation device comprises at least one electron beam emitter having an electron exit window through which said electron beam is emitted, at least one sensor device for measuring at least a first dose control parameter of the electron beam.
- the sensor device comprises a sensing area in form of a plate adapted to be at least temporarily exposed to said electron beam, said plate being further adapted to generate x-rays when hit by electrons of said electron beam, and at least one x-ray imaging sensor adapted to detect the generated x-rays.
- said electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window passes within the sensing area of the sensor device.
- said first dose control parameter is dose rate (kGy/s).
- the sensor device is connected to a dose processing module for processing the information from the at least one x-ray imaging sensor.
- the first dose control parameter is processed, in the dose processing module, together with second dose control parameters comprising current and voltage fed to the electron beam emitter and position of the electron beam emitter in relation to the sensor device.
- the dose processing module is adapted to provide a signal if the measured first dose control parameter is not within an acceptable, pre-set dose control parameter range.
- the dose processing module is adapted to generate a dose mapping image of the dose control parameter of the electron beam.
- the sensing area of the sensor device at least covers the extension of the entire electron beam in a plane of the sensing area and the first control parameter is detected once during the passage of the electron beam over the sensor device.
- the electron beam emitter and the sensor device are arranged such, in relation to each other, that when the electron beam emitter passes over the sensor device a plane, corresponding to the surface of the electron exit window, is moved in a direction parallel to the first plane of the sensor device.
- the dose processing module is in communication with an emitter control module and an irradiation control module, and the second dose control parameters are adapted to be sent to the dose processing module from said emitter control module and said irradiation control module.
- the emitter control module is connected to means for measuring the current over a filament of the electron beam emitter and the voltage between the electron exit window and said filament.
- the at least one x-ray imaging sensor comprises a scintillator connected to an array of photomultipliers or photodiodes.
- the at least one x-ray imaging sensor is a CCD sensor or a CMOS sensor.
- the plate is made of a metallic material.
- the electron exit window of the electron beam emitter is adapted to at least temporarily face said plate, and the plate is arranged as a barrier between the electron exit window and the at least one x-ray imaging sensor, such that the electrons hit the plate.
- the electron beam emitter and the sensor device are adapted to perform a relative movement, in relation to each other, such that the electron exit window and the plate of the sensor device face each other.
- the at least one x-ray imaging sensor is encapsulated in a box, said box having said plate as a lid.
- the sensing area is large enough to catch the entire cross section of the electron beam.
- the thickness of the plate is large enough to prevent electrons of the electron beam to pass through it.
- the sensor device and the electron beam emitter are arranged such in relation to each other that when the electron beam emitter passes the sensor device a distance in the range of 1-10 mm is formed between the plane of the electron exit window surface and the first plane of the sensor device.
- a second sensing area is arranged in a second plane, said second plane being parallel to the first plane and spaced from the first plane in a direction substantially perpendicular to the plane of the electron exit window, and away from said plane of the electron exit window.
- the irradiation device is provided in a filling machine for use in sterilization of objects in the form of packaging containers, and comprises a first position being a packaging container infeed point, and a second position being a packaging container outfeed point.
- the electron beam emitter is adapted to perform a first movement from the first position to the second position, and during said first movement the electron beam emitter is adapted to be at least
- said electron beam emitter is adapted to perform a second movement from the second position to the first position, and during said second movement the electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window is adapted to be at least temporarily located within the sensing area of the sensor device.
- the electron beam emitter is temporarily in line with the sensor device such that the at least one dose control parameter of the electron beam can be measured.
- said electron beam emitter is being arranged on a rotatable carrier, and wherein the carrier is adapted to let the electron beam emitter pass the packaging container infeed point and the packaging container outfeed point.
- the irradiation device comprises packaging container conveying means being adapted to convey the packaging container from said packaging container infeed point to said packaging container outfeed synchronously with the rotation of the carrier and aligned with the electron beam emitter.
- the packaging container conveying means being further adapted to displace the packaging container in relation to the electron beam emitter between a non-engaged position in which the packaging container and the electron beam emitter are not engaged with each other and an engaged position in which the packaging container and the electron beam emitter are fully engaged with each other.
- the irradiation device comprises more than one electron beam emitter.
- the invention also relates to a method for irradiating objects with electron beams.
- the method comprises the steps of emitting an electron beam through an electron exit window of an electron beam emitter, measuring at least s first dose control parameter of the electron beam by a sensor device, said step of measuring comprising forcing the electrons of the electron beam to hit a plate, which plate is adapted to generate x-rays when hit by the electrons, and detecting the generated x-rays by at least one x-ray imaging sensor.
- the method is used for irradiating, with electron beams, objects in the form of packaging containers, in a filling machine.
- the method comprises the steps of providing a first position being a packaging container infeed point, providing a second position being a packaging container outfeed point, performing a first movement of the said electron beam emitter from the first position to the second position, and during said first movement, at least temporarily engaging the electron beam emitter with a packaging container for irradiating said packaging container, and performing a second movement of said electron beam emitter from the second position to the first position, and during said second movement the electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window is adapted to be at least temporarily located within the sensing area of the sensor device.
- the method comprises the steps of providing a connection between the sensor device and a dose processing module, processing the information from the at least one x-ray imaging sensor in the dose processing module, said dose processing module being adapted to provide a signal if the measured dose control parameter is not within an acceptable, pre-set dose control parameter range.
- Fig. 1 is a packaging container and an exemplary electron beam emitter in a fully engaged sterilization position
- Fig. 2a is a first embodiment of the invention
- Fig. 2b is a second embodiment being a modification of the first embodiment
- Fig. 3a is a perspective view of an irradiation device according to a third embodiment of the invention.
- Fig 3b is a view from above of the irradiation device of Fig. 3a
- Fig 5 is plan views of two examples of electron beam shape and intensity
- Fig 6 is an illustration showing general electron energy distribution curves
- Fig 7 is a sensor device according to a fourth embodiment of the invention.
- Fig. 8 is a view of an electron beam emitter and a cross sectional view
- Fig. 9 is a view of a dose processing module and a sensor device connected to each other but separated by an irradiation shield (which is partly shown).
- Fig. 10 is a view of a sensor device according to the invention and a part of an electron beam emitter.
- the irradiation device of the invention may be used for many purposes, one being sterilization of objects such as for example packaging containers, plastic pre-forms, plastic bottles, plastic bags and medical devices.
- objects such as for example packaging containers, plastic pre-forms, plastic bottles, plastic bags and medical devices.
- FIG. 1 an exemplary electron beam emitter 10 and the concept of electron beam sterilization will be briefly described.
- the object being sterilized is a ready-to-fill packaging container 12.
- the electron beam emitter 10 comprises an electron generator 14 for emitting a substantially circular electron beam 16.
- the electron generator 14 is enclosed in a hermetically sealed vacuum chamber 18.
- Said vacuum chamber 18 is provided with an electron exit window 20.
- the electron generator 14 comprises a cathode housing 22 and a filament 24.
- the electron generator 14 also comprises a control grid 26.
- an electron beam 16 is generated by heating the filament 24.
- the electrical resistance of the filament 24 causes the filament to be heated to a temperature in the order of 2000°C. This heating causes the filament 24 to emit a cloud of electrons.
- the electrons are accelerated towards the electron exit window 20 by means of a high-voltage potential between the cathode housing 22 and the exit window 20 (being the anode). Further, the electrons pass through the electron exit window 20 and continue towards the target area, i.e. in this case the inside of the packaging container 12.
- the high-voltage potential is created by for example connecting the cathode housing 22 and the filament 24 to a power supply 28 and by connecting the vacuum chamber to ground 30.
- the filament also needs a second connection 29.
- the electron beam emitter 10 is generally denoted low voltage electron beam emitter if the voltage is below 300 kV.
- operating voltages in the order of 50-150kV is conventionally used.
- the accelerating voltage is in the order 95kV. This voltage results in a kinetic (motive) energy of 95keV in respect of each electron.
- an electrical potential also to the control grid 26 the emission of electrons may be further controlled. If a separate and variable electrical potential is applied to the control grid 26 it makes it possible to use the control grid 26 for active shaping of the generated electron beam.
- the control grid 26 may be electrically connected to a separate power supply 32.
- the filament 24 can be made of tungsten.
- the emitter 10 is, as mentioned, further provided with an electron exit window 20.
- the window 20 is made of a metallic foil, such as for example titanium, and have a thickness in the order of 4-12 ⁇ .
- a supporting net (not shown) formed of aluminum or copper supports the foil from inside the vacuum chamber 18. The electrons are exiting the vacuum chamber 18 through the exit window 20.
- the vacuum chamber 18 is made up of two cylindrical bodies 18a, 18b with substantially cylindrical symmetry. An end of the first cylindrical body 18a is provided with the electron exit window 20. The diameter of said first body 18a is small enough to be inserted into the ready-to-fill packaging container 12, the cross section of said first body is dimensioned such that it can be guided through an opening
- the second body 18b is provided with the electron beam generatorl4, and the diameter of said second body 18b is larger than the first body 18a.
- the diameter of the emitted electron beam 16, while still inside the emitter 10, is smaller than the diameter of the first body 18a.
- the opening 34 of the packaging container is an open bottom end, which after filling will be sealed and folded to form a substantially flat bottom surface. It should however be understood that the opening may in other embodiments be arranged in the top of the packaging container, constituting a neck or spout portion of the packaging container. Such neck or spout portion will, after filling, be sealed by for instance a screw cap.
- FIG. 2a a first embodiment of the invention is shown, illustrating the general or conceptual idea of the invention.
- a packaging container is to be sterilized by an electron beam from an electron beam emitter in an irradiation device of a filling machine.
- the irradiation device there is arranged at least one sensor device for measuring at least one dose control parameter of the electron beam.
- the electron beam emitter has an electron exit window and is adapted to be movable from a first position
- the positions 35, 37 are illustrated by circles in the figure, and the movement of the electron beam emitter is illustrated by arrows.
- said electron beam emitter is adapted to be at least temporarily engaged with a packaging container for irradiating said packaging container.
- the electron beam emitter is at least temporarily positioned with the electron exit window substantially in line with a sensor device 56, for allowing the sensor device 56 to measure at least one dose control parameter of the electron beam of said electron beam emitter.
- the electron beam emitter is adapted to be transported simultaneously with the packaging container from the first position 35 to the second position 37, and the electron beam emitter sterilizes the packaging container during that transport.
- the electron beam emitter is then further transported from the second position 37 to the first position 35, and during that transport the electron beam emitter passes the sensor device 56.
- the electron beam emitter is in operation, i.e. emitting an electron beam, throughout the entire transport, i.e. from the first position 35 to the second position 37 and back to the first position 35.
- the electron beam device is of the type described in relation to Fig. 1, but could alternatively be of another type suitable for sterilizing packaging containers of the bottle-type.
- the first position 35 corresponds to a packaging container infeed point 42 (see Fig. 3b). At the infeed point the packaging container is starting to be moved relative the electron beam emitter in a vertical direction so that the electron beam emitter is started to be received in the opening (reference numeral 34 in Fig. 1) of the packaging container for sterilizing the packaging container.
- the second position 37 corresponds to a packaging container outfeed point 44 (see Fig. 3b). At the outfeed point 44 the packaging container has been or is about to be released from its engagement with the electron beam emitter, i.e. the packaging container is moved relative the electron beam emitter in the vertical direction, away from a position in which the electron beam emitter is received in the opening of the packaging container.
- the transport of electron beam emitter and packaging container from the first position 35 to the second position 37 is a packaging container sterilization cycle
- the transport of the electron beam emitter from the second position 37 to the first position 35 is an electron beam dose measurement cycle.
- dose measurement cycles are performed in between subsequent packaging container sterilization cycles.
- Fig. 2b is showing a second, general embodiment being a slight variant of the first embodiment.
- the first position is a similar position as the first position 35 described above, but here denoted 35' .
- the second position is a similar position as the second position 37 described above, but here denoted 37' .
- the difference between the embodiments is that the packaging sterilization cycle involves a considerably longer transport distance and/or time than the dose measurement cycle.
- Fig. 3a and 3b show a third embodiment of the invention, being a more detailed embodiment compared to the first two.
- the figures show an irradiation device 36 in which several above described electron beam emitters 10 are arranged.
- six emitters 10 are provided to a rotatable carrier 38.
- the rotatable carrier 38 is, in this embodiment, shaped as a wheel and is rotatable round a centre shaft 40.
- the direction of the rotation is illustrated by the arrow R and the rotatable movement is continuous.
- the emitters 10 are fixed to the carrier 38 so that they are being carried along when the carrier 38 rotates.
- the transportation of the packaging containers is made in a direction transversely to the longitudinal extension of the emitters 10.
- the irradiation device 36 further comprises packaging container conveying means, not shown, being adapted to convey the packaging container 10 from the infeed point 42 to the outfeed point 44 synchronously with the carrier revolution movement and in alignment with the electron beam emitter 10.
- the packaging container 12 is moved synchronously with the electron beam emitter 10 and a longitudinal centre axis of the packaging container 12 is aligned with a longitudinal centre axis of the electron beam emitter 10, see the dashed-dotted line a in Fig. 1.
- the packaging container conveying means is being further adapted to vertically displace the packaging container 12 in relation to the electron beam emitter 10.
- the electron beam emitter 10 is arranged stationary in the carrier 38 and cannot move towards the packaging container 12.
- the packaging container conveying means can displace the packaging container 12 between a non-engaged position in which the packaging container 12 and the electron beam emitter 10 are not engaged with each other and a engaged position in which the packaging container 12 and the electron beam emitter 10 are fully engaged with each other.
- the packaging container 12 is positioned in the non-engaged position, i.e. not in engagement with the electron beam emitter 10.
- the infeed and outfeed points 42, 44 are similar to the first and second positions 35, 37 of the earlier described embodiments.
- the packaging containers 12 are supplied to the irradiation device 36 from an infeed wheel 46.
- Each packaging container 12 is aligned with a corresponding electron beam emitter 10.
- the packaging container 12 conveying means displaces the packaging container 12 towards the electron beam emitter 10 so that the electron beam emitter 10 is received in the opening 34 of the packaging container 12 for sterilizing the packaging container 10.
- the packaging container conveying means is not the focus of this invention and will therefore not be described in detail. It may be arranged on the carrier 38, or on the electron beam emitters 10, or a combination thereof. It may alternatively be arranged separate from the carrier 38 but able to convey the packaging containers 12 synchronous with the carrier rotation. For example it may be arranged on an irradiation shielding device enclosing the carrier 38.
- the packaging conveying means is provided with packaging container gripping means that is adapted to grip the packaging container 12.
- the packaging container 12 When reaching the outfeed point 44 a sterilization cycle, or irradiation cycle, of the packaging container 12 is completed and the packaging container 12 has been retracted from the engaged position back to the non-engaged position. Hence, the packaging container 12 is then ready to be fed out from the irradiation device 36 by means of an outfeed wheel 54 for further transfer to a filling device (not shown).
- the electron beam emitter 10 Upon further rotation of the carrier 38, from the outfeed point 44 and back to the infeed point 42, the electron beam emitter 10 is not engaged with any packaging container 12 but is still maintained in operation, i.e. it still emitting the same electron beam.
- a new sterilization cycle is commenced with a new packaging container 12 supplied from the infeed wheel 46.
- the infeed and outfeed wheels 46, 54 are not the focus of this invention and will therefore not be described in detail.
- the packaging container 12 is transferred from the infeed wheel 46 to the carrier 38 of the irradiation device 36.
- the packaging container 12 is transferred from the carrier 38 to the outfeed wheel 54 for further transport to a filling station.
- the sensor device 56 is stationary arranged in the area between the packaging container outfeed point 44 and the packaging container infeed point 42, i.e. the area in which no packaging containers 12 are present in the irradiation device 36.
- the sensor device 56 is arranged such that the electron beam emitters 10 can pass over a sensor area 58 being a sensor device top surface, and further it is arranged so that when an electron beam emitter 10 is passed above it the electron exit window 20 is temporarily in line with the sensor device 56 for allowing the sensor device 56 to measure the first dose control parameters of the electron beam 16 of said electron beam emitter 10. Since this is a surface type of sensor device a "snap shot" measurement is made in an instant when the sensor device and the electron exit window is aligned with each other, i.e. when an imagined centre axis
- the boundary of the electron beam to be measured should be located within the sensing area 58 of the sensor device 56.
- the electron beam emitter 10 and the sensor device 56 are arranged such, in relation to each other, that when the electron beam emitter 10 passes over the sensor device 56 a plane P 0 , corresponding to the surface of the electron exit window 20, is moved in a direction parallel to a first plane Pi of the sensor device 56. This is shown in Fig.10.
- the two planes P 0 and Pi are shown as dashed lines in the figure.
- the electron beam emitter 10, of which only a portion is shown in Fig. 10 is adapted to move such that the electron beam 16 emitted from the electron exit window 20 is passing within a sensing area 58 of the sensor device 56.
- the sensing area 58 is a plate 74 that will be described later on.
- the distance between the electron exit window plane Po and the first plane Pi is the range of approximately 0,5-15 mm for an electron beam emitter of an operating voltage in the range of 50-150kV. Preferably, a distance in the range of approximately 1 -10 mm is used. The distance is preferably chosen depending on where on the electron beam, i.e. electron cloud, one want to measure.
- the electron beam exits the electron exit window in a quite narrow shape and as the electrons reach further away from the window they are scattering, which makes the electron beam become wider.
- the plane Pi is provided at a level similar to where the boundary of the electron beam has its largest width W.
- the sensor device is positioned such that the plane Pi is very close to the electron exit window 20, i.e.
- the irradiation device 36 has been described in a schematic way. Only parts of the irradiation device 36 being involved in the invention has been described, but it is to be understood that the irradiation device comprises also additional parts such as drive units for driving the carrier 38 and the packaging conveying means, an irradiation shield enclosing the irradiation device 36 for securing that electrons and x-rays are not spread to the environment outside of the device, and aseptic barriers being either flow barriers or physical walls, or a combination of the two, for creating and maintaining satisfactory aseptic zones.
- Fig. 4 illustrates modules being connected to each other and to the sensor device 56.
- the dose processing module 60 is in communication with an emitter control module 64.
- Said emitter control module 64 handles at least a first part of second dose control parameters such as the current and voltage fed to the electron beam emitter, i.e. the current over the filament 24 of the electron beam emitter 10 and the voltage between the electron exit window 20 and said filament 24.
- This information is fed to the dose processing module 60.
- a second part of second dose control parameters is handled by an irradiation device control module 64, which is part of a filling machine control module. This second part regards at least the position of the electron beam emitter in relation to the sensor device.
- This information is either fed via the emitter control module to the dose processing module, or directly to the dose processing module. Hence, all of these second control parameters are fed to the dose processing module 60.
- the second dose control parameters are processed together with the first dose control parameter.
- the first dose control parameter is processed with the information of the second dose control parameters. It is important to combine the measurements from the sensor device with information about the position of the electron beam emitter and the voltage and current fed to the emitterat the time when the measurement by the sensor device is made.
- the dose processing module 60 is adapted to provide a feedback signal to the irradiation device control module 64 of the filling machine if the dose rate is not within an acceptable, pre-set dose rate range.
- a filling machine is a machine for manufacturing the packaging containers and that sterilizes, fills and seals them.
- the irradiation device forms the part of the machine performing the sterilization.
- the irradiation device control module 64 may be for instance be part of a PLC
- the feedback from the dose processing module 60 to the irradiation device control module 64 is immediate and in case of an improper dose action can be taken quickly.
- An advantage in this regard is that the dose is measured in between every sterilization cycle, and that therefore presence of improperly sterilized packaging containers may be discovered early on. This reduces the amount of packaging containers that will have to be discarded, compared to prior art daily dosimetry.
- Either a present dose control parameter is compared with a set value, for example a worst case value, or it is checked that a present dose control parameter is within an acceptable value range.
- the sensor device 56 or the dose processing module 60 is of the type able to generate a 2D (two dimensional) image or 2D matrix of the dose control parameters.
- the image comprises information about the dose rate (kGy/s) in each point and hence indirectly also information about the electron beam shape. Dose rate and electron beam shape will be described in more detail further down.
- the sensor device 56 or the dose processing module 60 comprises digital image processing means or matrix processing means able to compare the generated 2D image or 2D matrix with a pre-set image or matrix for the purpose of detecting unacceptable discrepancies.
- said pre-set 2D image may be compared with two pre-set 2D images, each defining the upper and lower boundaries of acceptable values.
- the dose processing module 60 is connected to the emitter control module 64.
- the emitter control module 64 is used for controlling and adjusting for example the voltage and current being fed to the electron beam emitter 10.
- the voltage and current may be adjusted based on input from the sensor device 56 or from stored, pre-set dose control parameters. This is useful in case it is discovered that more electrons need to be emitted to secure that correct sterilization is obtained during the available sterilization time.
- the dose processing module 60 and emitter control module 64 can be further used to calibrate the electron beam emitters 10. Since all electron beam emitters 10 on the carrier 38 are measured by one and the same sensor device 56 the dose control parameters of the emitters 10 can be mutually compared. If for example parameters differ unacceptably between the electron beam emitters, the emitter control module 64 can adjust their voltage and current so that the parameters of the electron beam emitters 10 become equal or at least become within an acceptable range.
- the dose processing module 60, the emitter control module 64 and the irradiation device control module 62 are software modules that can either be comprised in one hardware unit or separated and comprised in two or several hardware units.
- the above described irradiation device control module 62 is connected to a device (not shown) for separating insufficiently irradiated packaging containers from sufficiently irradiated packaging containers based on the feedback signal. If there is a signal from the dose processing module 60 to the irradiation device control module 62 that the packaging container 12 just being fed out was sterilized by an improperly operating emitter 10, the irradiation device control module 62 sends a signal to the separation device to separate out that improperly sterilized packaging container. In that way it is secured that only properly sterilized packaging containers can proceed to filling. Alternatively, the irradiation device control module 62 is connected to a device (not shown) for re-sterilization of the improperly sterilized packaging containers.
- the device captures the faulty packaging containers at the outfeed and feeds them back to the infeed to allow them to have another sterilization cycle. Since the packaging containers may already have received some of the dose, the operating voltage of the emitter may need to be adjusted not to give the re-circulated packaging containers a too high dose. It is also needed to provide a device for accumulation of packaging containers. Since there is a continuous stream of packaging containers being fed into the irradiation device a re-circulating packaging container will obviously cause some problem. It will occupy one of the emitters so that a new packaging container cannot be fed into the irradiation chamber. The device for accumulation can accumulate the new packaging containers being refused entry into the irradiation device. At any appropriate time the device of accumulation can be emptied while the manufacturing of new packaging containers can preferably be stopped.
- the sensor device 56 may be of any suitable type. It may be comprised of a bundle of sensors, if the sensors for example are of the line type , for example as described in the international publication WO 2007/050007, for each measuring different parameters or needed to together form a 2D image measurement or a matrix measurement.
- the sensor device 56 could also be of the surface type, as shown in Fig. 3a, in which an entire surface 58 is able to measure the electron beam 16. The size of the sensor surface 58 is then preferably chosen so that it is larger than the area of the electron beam 16 (i.e. larger than the electron exit window 20).
- the dose control parameters measured by the sensor device 56 comprise dose rate (kGy/s) and electron beam shape.
- Dose rate is the dose delivery per time unit or dose intensity
- the electron beam shape is the intensity distribution.
- Electron beam load or stress refers to the amount of emitted electrons in each point per time unit, i.e. the intensity; the dose rate (kGy/s). Ideally, the amount of emitted electrons should not need to be "oversized", but just as big as needed in order to obtain the desired dose in the packaging container.
- the electron beam emitter 10 is not delivering an ideal dose distribution it will take longer time, or require more from the electron beam emitter in terms of amount of emitted electrons, to obtain the dose all over the interior surface of the packaging container 12. If the electron beam distribution or intensity is really bad, having spots or areas where no or just a small amount of electrons reach the target, i.e. the packaging container surface, it may even be impossible to reach the dose in all areas of the packaging container. If for example a part of the electron beam for some reason is deflected inside the electron beam emitter 10, with the result that some electrons do not reach through the electron exit window 20 but are instead hitting the inside surface of the emitter or getting stuck in the electron exit window, some areas of the packaging container 12 may not receive any dose. It may also be that only some electrons reach through the electron exit window 20, which would substantially increase the time until a satisfactory dose has been reached.
- the above may be illustrated by Fig. 5.
- the left picture illustrates an exemplary, schematic, exemplary ideal distribution of an electron beam 16 (shown in 2D
- Every electron is shown as a dot.
- the distribution is in this case even and the intensity, i.e. the dose rate, can be regarded as high.
- the right picture illustrates a corresponding exemplary electron beam 16 of a malfunctioning electron beam emitter.
- the beam has an irregular shape and an uneven distribution. Over an area 66 there are no electrons reaching the target, i.e. reaching the packaging container surface, and over another area 68 the intensity or amount of electrons is less than that of electron beam shown on the left side. A packaging container being irradiated with such electron beam emitter will not obtain the required dose, and will need to be discarded.
- an ideal electron beam intensity and distribution may not always look like the one shown in Fig. 5. In fact, in some applications, it is instead desired to have an intensity and distribution not entirely even, but rotational symmetric and with an electron intensity and distribution not being the same along the radius of the window.
- the dose processing module 60 needs to "learn" how the output from the different electron beam emitters looks like.
- the output of the electron beam emitters may not be totally similar, i.e. generally there are acceptable variations in output from one emitter to another. Hence, their outputs are initially measured by the sensor device 56 and stored as reference or baseline. This calibration can be made by simply rotating the carrier 38 one round so that all the electron beam emitters 10 pass the sensor device 56 once. If an electron beam emitter needs to be replaced by a new one, a separate calibration is made for the new electron beam emitter.
- a present dose rate in an area is compared with a set value, for example a worst case value based on the baseline or reference, or it is checked that a present dose rate in an area is within an acceptable range around the baseline or reference.
- a dose control parameter measurement according to the present invention will necessarily not detect electric arcs that may be generated in the electron beam emitter.
- An arc may occur during a time period of less than a second, and cannot be detected by the sensor device unless occurring in the moment the electron beam emitter is passing the sensor device.
- the result may be an unsterile packaging container. Therefore, it is advised to combine the dose control parameter measurement of the present invention with state of the art measurements of voltage and current in the electron beam emitter.
- the current over the filament is measured (comparison of current fed to the filament and current leaving the filament) and the voltage, i.e. the electric potential, between the electron exit window and the filament is measured.
- An arc would result in a short, temporary, detectable fluctuation of the voltage and/or current.
- the measured values of current and voltage are processed by the emitter control module 64 and feedback is sent to the filling machine control module 62.
- a further advantage with the invention if combined with the above mentioned current and voltage measurement, is that it can be utilized for detecting sensor device failure. If the voltage and current monitoring of the electron beam emitters show acceptable values but the feedback signal from the dose processing device 60 suddenly shows discrepancies for all the electron beam emitters, it is likely that the sensor device 56 itself operates faulty. Hence, it can be used for detecting sensor device 56 failure.
- a further advantage with the invention is that it can be used to predict when it's time to replace the electron beam emitters.
- the images or matrices can be analysed more deeply to find single points in which there is a discrepancy, indicating deposit or dirt on the electron exit window or filament wear.
- the amount of emitted electrons in relation to the current and voltage supplied to the emitter may be monitored over time. This is to be able to detect any slow decrease in the amount of electrons emitted although supplying the same current and voltage. Such may for example be an indication of filament wear.
- the information can be used to calculate an approximate expected lifetime.
- the sensor device 56 comprises a first sensing area 58 and a second sensing area 58' .
- the sensor device 56 is shown in Fig. 7 together with dashed-lined boxes representing a passing electron beam emitter 10.
- the sensing areas 58, 58' are being arranged on two different levels in relation to the plane Po of the electron exit window 20. Hence, the two areas have different distances to the electron exit window 20.
- a larger distance D is formed between the plane Po of the electron exit window 20 and a plane P 2 corresponding to the second sensing area 58', than the distance d formed between the plane Po of the electron exit window 20 and the plane PI of the first sensing area 58.
- the sensor device 56 can be made up by two physically separated sensor units having one sensing area each, as shown in Fig. 7, or the sensor device 56 can be one sensor unit having two sensing areas side by side.
- the distance between the first sensing area 58 and the second sensing area 58' is in the range of 5-20 mm.
- the larger distance D is the sum of the smaller distance d plus a distance in the range of 5-20 mm.
- the distance between the two sensing areas 58, 58' needs to be matched with the acceleration voltage.
- a relatively higher acceleration voltage for instance 150 kV
- the electrons will reach farther than in the case of a relatively lower acceleration voltage, for instance 95 kV.
- the distance between the sensing areas 58, 58' may be made longer than in the case of the lower acceleration voltage.
- a distance of 5-20 mm may be chosen, whereas in the case of the lower acceleration voltage a distance in the order of 5-10 mm is better.
- Fig. 6 shows three graphs being different general electron energy distribution curves A-C.
- the y axis shows the electron energy level (keV) and the x axis shows the electron travelling distance (mm).
- Curve A shows the typical energy distribution for a case in which the initial electron energy is low. A relatively large amount of energy will be absorbed in the electron exit window 20. After passing the electron exit window 20 the electron energy will quickly decrease, which leads to a steep inclination of the energy
- the sensor device 56 comprises a first and a second sensing area 58, 58' being arranged on two different levels in relation to the electron exit window 20 of the electron beam emitter 10.
- the sensor device 56 comprises a plurality of sensing areas arranged on different levels in relation to the electron exit window 20. For example, there may be three sensing areas, on three different levels in relation to the electron exit window. There may be more sensing areas than three. A larger number of sensing areas can give a more exact assessment of the electron energy distribution than a smaller number of sensing areas.
- the sensor device 56 comprises at least one x-ray imaging sensor 70 encapsulated in a box 72 having a lid 74.
- the lid 74 functions as one of the walls of the box, and closes off the box 72.
- the lid 74 is to be regarded as the previous described sensing area 58, and is positioned at the top of the box 72 facing the electron exit window 20 of the electron beam emitter 10.
- the distance between the electron exit window 20 and the sensor device 56 is exaggerated in the figure. In an exemplary application the distance is approximately 0,5-15 mm.
- the area of the lid 74 is preferably of the same size or larger than the area of electron exit window 20.
- the lid 74 is made of a metal plate or metal film, for example made of a plate or film of stainless steel or copper.
- x-rays 76 are generated and partly emitted inside the box 72.
- the x-rays 76 are detected by the at least one x-ray imaging sensor 70.
- the intensity of x-rays detected by the x-ray sensor 70 is proportional to the electron energy deposited in the lid 74 per unit time, assuming that the incident electron energy distribution is constant. Hence, the information from the x-ray imaging sensor 70 can be converted to show an image of for example the dose rate and electron beam shape.
- the x-ray imaging sensor 70 is preferably positioned very close to the plate 74. Preferably the distance between them is less than 1 mm.
- the x-rays are emitted in all directions and in order to obtain a measurement with maintained correspondence between the hitting electrons and the thereby generated x-rays it is necessary to capture the x-rays as close as possible to their plate exit point (into the box 72). Otherwise an x- ray may be measured for example in the middle of the x-ray imaging sensor however originating from for example the left side of the plate 70. It should be noted that the distance between the x-ray imaging sensor 70 and plate 74 is exaggerated in Fig. 8 in order to show the x-rays 76.
- the x-ray imaging sensor 70 can be of many types.
- An exemplary x-ray imaging sensor 70 comprises an x-ray scintillator connected to an array of photomultipliers or photodiodes.
- the scintillator comprises a material that, when exposed to ionizing radiation such as x-rays, emits luminescent light, i.e. re-emits the absorbed energy in the form of light.
- the array of photomultipliers or photodiodes detect the light and converts is to an electric signal that is used for creating the image of the dose rate and electron beam shape.
- the sensor device 56 is connected to processing means for processing the information from the x-ray imaging sensor 70 and generate an image of the dose control parameter of the electron beam 16.
- Different scintillator materials react on different energies of the electrons. This may be utilized in a sensor device 56 with several sensing areas on different levels, as described with reference to the fourth embodiment.
- CCD charge-coupled device
- CMOS complementary metal-oxide-semiconductor
- the thickness of the metal plate or film of the lid 74 is dependent on the electron energy and the lid material used in each application. In general the thickness of the plate or film of the lid 74 should be large enough to prevent electrons e " of the electron beam 16 to pass through it, but still as thin as possible such that the x-ray imaging sensor array 70 may be positioned as close as possible to the electron exit window 20 of the electron beam emitter 10.
- the box 72 has walls which function are to shield off and protect the x-ray imaging sensor array 70 from the surrounding environment.
- the box walls are made of metal, for example stainless steel. The thickness of the walls is large enough to shield off unwanted electrons and x-rays from outside.
- the at least one x-ray imaging sensor can be of the linear type or the surface type.
- the linear type measures along a line, and to create an image of the entire electron beam, several measurements at different electron beam emitter positions need to be sampled.
- the entire electron beam can be measured in one instance.
- the plate 74 may be made smaller in size in case of a linear type of x-ray imaging sensor.
- the invention also comprises a method, which to a large extent has already been described in relation to the description of the irradiation device 36.
- the method comprises the step of providing at least one electron beam emitter 10 having an electron exit window 20, and at least one sensor device 56 for measuring first dose control parameters of the electron beam 16. It further comprises providing a first position 35 and a second position 37.
- the method further comprises moving said electron beam emitter from first position 35 to the second position 37, and from the second position 37 to the first position35, and at least temporarily engaging said electron beam emitter with a packaging container 12 for irradiating said packaging container 12, between the first position 35 and the second position 37, and at least temporarily positioning the electron exit window 20
- the method further comprises processing the information from the sensor device in a dose processing module, and at least sending a feedback signal to a filling machine control module if any dose control parameter is not within an acceptable, pre-set dose control parameter range.
- the method further comprises the step of generating a 2D image or 2D matrix of the dose control parameters in the sensor device or the dose processing module, and comparing, using a digital image processing means or matrix processing means, the generated 2D image or 2D matrix with a pre-set 2D image or matrix for the purpose of detecting unacceptable discrepancies.
- dose processing module 60 and the sensor device 56 is interconnected.
- the sensor device is 56 placed inside a radiation shield.
- the emitters 10 need to be located within a radiation shield in order to prevent harmful radiation and x- rays to leak out of the irradiation device.
- a portion of the radiation shield is shown as wall 84 in Fig. 9.
- the dose processing module 60 is located on the outside of the radiation shield. Between the dose processing module 60 and the sensor device 56 there is provided a cable 86.
- the cable 86 extends through a hole 88 in the radiation shield.
- the hole 88 is illustrated as being straight, for simplicity, but it should be understood that it is in fact designed as a labyrinth. Any x-ray from the irradiation chamber should need to hit a wall of the radiation shield twice before being able to enter the
- the sensor device 56 and the dose processing module 60 can be easily and stably connected to each other.
- the exemplary carrier in the third embodiment is a circular wheel but it should of course be understood that the carrier could alternatively be an endless conveyor of any shape. Further, the carrier is rotated with a continuous movement. Alternatively, the carrier may instead rotate intermittently. The type and/or position of the sensor device need to be chosen accordingly. If the electron emitter is paused aligned with the sensor device, the sensor device is preferably of the surface type of sensor, i.e. a sensor device being able to measure the entire electron beam in one instant. If a line type of sensor is used one of the electron beam emitter or the sensor device needs to move in order to cover the entire electron beam. Preferably, the sensor device is then placed in a position slightly to the left of the sensor device position shown in Fig. 3a, to be able to measure the electron beam before the electron beam emitter is intermittently paused.
- the accelerating voltage is in the order of 95 kV.
- the invention should not be limited to an acceleration voltage in that order. It may be any voltage within the interval 50-300kV depending on the application, for example an acceleration voltage of 150kV is common in the PET bottling industry.
- a suitable sensor device 56 is chosen.
- the sensor device 56 is stationary positioned, whilst the electron beam emitter is adapted to be moved past the sensor device 56 so that the measurement can be performed.
- the sensor device 56 is also made movable. The sensor device 56 may be moved synchronously, and in alignment, with the electron beam emitter during at least a portion of the electron beam dose
- the electron beam emitter and the sensor device are stationary in the vertical direction, i.e. none of them is adapted to be movable in the vertical direction, i.e. in relation to each other.
- at least one of the sensor device 56 and the electron beam emitter is movable in relation to each other in the vertical direction to provide them in a position suitable for dose parameter measurement. Either one of them is movable in relation to the other, or both are movable a distance each.
- a relative movement in the vertical direction is necessary if the design of the irradiation device, for some reason, does not otherwise provide for a gap between the electron exit window 20 and the sensing area 58 in the range of approximately 1-10 mm.
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Toxicology (AREA)
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- Apparatus For Disinfection Or Sterilisation (AREA)
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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EP13805800.3A EP2926166A2 (de) | 2012-12-03 | 2013-11-29 | Vorrichtung zur überwachung eines elektronenstrahls über bremsstrahlungsbildgebung |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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EP20120195285 EP2737909A1 (de) | 2012-12-03 | 2012-12-03 | Vorrichtung und Verfahren zur Bestrahlung von Verpackungsbehältern mit einem Elektronenstrahl |
EP13150854.1A EP2755052A1 (de) | 2013-01-10 | 2013-01-10 | Vorrichtung zur Überwachung eines Elektronenstrahls durch Abbildung von Bremsstrahlung |
EP13805800.3A EP2926166A2 (de) | 2012-12-03 | 2013-11-29 | Vorrichtung zur überwachung eines elektronenstrahls über bremsstrahlungsbildgebung |
PCT/EP2013/075083 WO2014086675A2 (en) | 2012-12-03 | 2013-11-29 | Device and method for irradiating packaging containers with electron beam |
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EP2926166A2 true EP2926166A2 (de) | 2015-10-07 |
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JP6157312B2 (ja) * | 2013-10-24 | 2017-07-05 | 日立造船株式会社 | 容器滅菌方法および容器滅菌設備 |
EP3009362A1 (de) * | 2014-10-17 | 2016-04-20 | Tetra Laval Holdings & Finance S.A. | Erkennungsvorrichtung zum Nachweis von UV-Strahlung |
JP6893879B2 (ja) * | 2014-11-18 | 2021-06-23 | テトラ ラバル ホールディングス アンド ファイナンス エス エイ | 低電圧電子ビームの線量計装置及び方法 |
CN106772528B (zh) * | 2016-11-28 | 2020-04-14 | 江苏省农业科学院 | 一种产品辐照剂量分布及其不均匀度的测定方法 |
KR101871608B1 (ko) * | 2016-12-23 | 2018-06-28 | 가톨릭대학교 산학협력단 | 전자선 치료시 신틸레이션 가스를 이용한 실시간 선량 모니터링 장치 및 방법 |
WO2020114824A1 (en) * | 2018-12-04 | 2020-06-11 | Tetra Laval Holdings & Finance S.A. | A method, device and system for sterilising packaging material of packages |
DE102019109210A1 (de) * | 2019-04-08 | 2020-10-08 | B.Braun Avitum Ag | Vorrichtung und Verfahren zur Sterilisation von Medizinprodukten mittels Röntgenstrahlung |
JP7377730B2 (ja) * | 2020-02-07 | 2023-11-10 | 日立造船株式会社 | ノズル式電子線出射装置の交換時期決定方法 |
CN116615671A (zh) * | 2020-12-21 | 2023-08-18 | 赛多利斯史泰迪Fmt简易股份公司 | 在产品级别测量辐照剂量的方法 |
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JPH05100040A (ja) * | 1991-10-04 | 1993-04-23 | Mitsubishi Electric Corp | ビーム・スクレーパ装置 |
US6221216B1 (en) * | 1997-03-26 | 2001-04-24 | Electron Processing Systems, Inc. | Technique for interior electron sterilization of an open mouthed container |
JP3809627B2 (ja) * | 1997-10-08 | 2006-08-16 | アサヒ飲料株式会社 | プラスチック空容器の電子線殺菌装置および殺菌方法 |
US7375345B2 (en) * | 2005-10-26 | 2008-05-20 | Tetra Laval Holdings & Finance S.A. | Exposed conductor system and method for sensing an electron beam |
US20110012030A1 (en) * | 2009-04-30 | 2011-01-20 | Michael Lawrence Bufano | Ebeam sterilization apparatus |
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2013
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WO2014086675A2 (en) | 2014-06-12 |
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