EP2792295A4 - Laser scanning method for measuring in vivo amount of specific substance - Google Patents

Laser scanning method for measuring in vivo amount of specific substance

Info

Publication number
EP2792295A4
EP2792295A4 EP12858271.5A EP12858271A EP2792295A4 EP 2792295 A4 EP2792295 A4 EP 2792295A4 EP 12858271 A EP12858271 A EP 12858271A EP 2792295 A4 EP2792295 A4 EP 2792295A4
Authority
EP
European Patent Office
Prior art keywords
measuring
laser scanning
specific substance
vivo amount
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12858271.5A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2792295A1 (en
Inventor
Satoshi Wada
Kazuo Tsubota
Atsushi Shinjo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
Original Assignee
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2011276295A priority Critical patent/JP2013126443A/ja
Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Priority to PCT/JP2012/008035 priority patent/WO2013088746A1/ja
Publication of EP2792295A1 publication Critical patent/EP2792295A1/en
Publication of EP2792295A4 publication Critical patent/EP2792295A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1025Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0068Confocal scanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • G01N21/5907Densitometers
    • G01N2021/5957Densitometers using an image detector type detector, e.g. CCD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/061Sources
    • G01N2201/06113Coherent sources; lasers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/10Scanning
    • G01N2201/105Purely optical scan
EP12858271.5A 2011-12-16 2012-12-17 Laser scanning method for measuring in vivo amount of specific substance Withdrawn EP2792295A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2011276295A JP2013126443A (ja) 2011-12-16 2011-12-16 レーザー走査型生体内特定物質量計測方法
PCT/JP2012/008035 WO2013088746A1 (ja) 2011-12-16 2012-12-17 レーザー走査型生体内特定物質量計測方法

Publications (2)

Publication Number Publication Date
EP2792295A1 EP2792295A1 (en) 2014-10-22
EP2792295A4 true EP2792295A4 (en) 2015-09-09

Family

ID=48612217

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12858271.5A Withdrawn EP2792295A4 (en) 2011-12-16 2012-12-17 Laser scanning method for measuring in vivo amount of specific substance

Country Status (4)

Country Link
US (1) US20140357969A1 (ja)
EP (1) EP2792295A4 (ja)
JP (1) JP2013126443A (ja)
WO (1) WO2013088746A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016157156A1 (en) 2015-04-02 2016-10-06 Livspek Medical Technologies Inc. Method and apparatus for a spectral detector for noninvasive detection and monitoring of a variety of biomarkers and other blood constituents in the conjunctiva

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210952A1 (en) * 2008-05-02 2010-08-19 Olympus Corporation Optical inspection device, electromagnetic wave detection method, electromagnetic wave detection device, organism observation method, microscope, endoscope, and optical tomographic image generation device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5873831A (en) * 1997-03-13 1999-02-23 The University Of Utah Technology Transfer Office Method and system for measurement of macular carotenoid levels
US6181957B1 (en) * 1998-07-13 2001-01-30 California Institute Of Technology Non-invasive glucose monitor
JP2001275976A (ja) 2000-03-31 2001-10-09 Canon Inc 眼底検査装置
US7039452B2 (en) * 2002-12-19 2006-05-02 The University Of Utah Research Foundation Method and apparatus for Raman imaging of macular pigments
US20060134004A1 (en) * 2004-12-21 2006-06-22 The University Of Utah Methods and apparatus for detection of carotenoids in macular tissue
JP4618341B2 (ja) * 2008-06-26 2011-01-26 ソニー株式会社 コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210952A1 (en) * 2008-05-02 2010-08-19 Olympus Corporation Optical inspection device, electromagnetic wave detection method, electromagnetic wave detection device, organism observation method, microscope, endoscope, and optical tomographic image generation device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CONOR L. EVANS ET AL: "Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine", ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, vol. 1, no. 1, 1 July 2008 (2008-07-01), pages 883 - 909, XP055006229, ISSN: 1936-1327, DOI: 10.1146/annurev.anchem.1.031207.112754 *
See also references of WO2013088746A1 *
STEPHEN A. BOPPART ET AL: "Optical probes and techniques for molecular contrast enhancement in coherence imaging", JOURNAL OF BIOMEDICAL OPTICS, vol. 10, no. 4, 041208, 15 August 2005 (2005-08-15), XP040213645 *

Also Published As

Publication number Publication date
JP2013126443A (ja) 2013-06-27
WO2013088746A1 (ja) 2013-06-20
US20140357969A1 (en) 2014-12-04
EP2792295A1 (en) 2014-10-22

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Effective date: 20150806

RIC1 Classification (correction)

Ipc: A61B 3/10 20060101AFI20150731BHEP

Ipc: A61B 3/12 20060101ALI20150731BHEP

Ipc: G01N 21/65 20060101ALI20150731BHEP

Ipc: A61B 5/00 20060101ALI20150731BHEP

18D Deemed to be withdrawn

Effective date: 20180703