EP2736536A4 - Templated islet cells and small islet cell clusters for diabetes treatment - Google Patents

Templated islet cells and small islet cell clusters for diabetes treatment

Info

Publication number
EP2736536A4
EP2736536A4 EP12818108.8A EP12818108A EP2736536A4 EP 2736536 A4 EP2736536 A4 EP 2736536A4 EP 12818108 A EP12818108 A EP 12818108A EP 2736536 A4 EP2736536 A4 EP 2736536A4
Authority
EP
European Patent Office
Prior art keywords
templated
islet
cell clusters
diabetes treatment
small
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP12818108.8A
Other languages
German (de)
French (fr)
Other versions
EP2736536A2 (en
Inventor
Lisa A Stehno-Bittel
Karthik Ramachandran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas filed Critical University of Kansas
Priority to EP18186206.1A priority Critical patent/EP3498300A1/en
Publication of EP2736536A2 publication Critical patent/EP2736536A2/en
Publication of EP2736536A4 publication Critical patent/EP2736536A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/507—Pancreatic cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/12—Glass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/72—Chitin, chitosan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP12818108.8A 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment Ceased EP2736536A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18186206.1A EP3498300A1 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161512303P 2011-07-27 2011-07-27
US201213482671A 2012-05-29 2012-05-29
PCT/US2012/048352 WO2013016544A2 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18186206.1A Division EP3498300A1 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment

Publications (2)

Publication Number Publication Date
EP2736536A2 EP2736536A2 (en) 2014-06-04
EP2736536A4 true EP2736536A4 (en) 2015-03-11

Family

ID=46275980

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12818108.8A Ceased EP2736536A4 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment
EP18186206.1A Withdrawn EP3498300A1 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18186206.1A Withdrawn EP3498300A1 (en) 2011-07-27 2012-07-26 Templated islet cells and small islet cell clusters for diabetes treatment

Country Status (4)

Country Link
EP (2) EP2736536A4 (en)
JP (1) JP2014521335A (en)
CA (1) CA2842695C (en)
WO (1) WO2013016544A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102278652B1 (en) 2013-03-15 2021-07-19 미로매트릭스 메디칼 인크. Use of perfusion decellularized liver for islet cell recellularization
JP6405752B2 (en) * 2014-07-01 2018-10-17 大日本印刷株式会社 Cell culture vessel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087402A2 (en) * 2006-01-24 2007-08-02 Brown University Cell aggregation and encapsulation device and method
EP2286822A1 (en) * 2009-08-17 2011-02-23 Universiteit Twente Diabetes treatment
WO2011126921A2 (en) * 2010-04-06 2011-10-13 University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK402984D0 (en) 1984-08-23 1984-08-23 Nordisk Insulinlab PROCEDURE FOR PROMOTING INSULIN-PRODUCING CELLS
EP0363125A3 (en) 1988-10-03 1990-08-16 Hana Biologics Inc. Proliferated pancreatic endocrine cell product and process
US5164000A (en) 1991-06-27 1992-11-17 Gamblin Rodger L Lithographic printing fountain solution
US5280038A (en) 1992-03-13 1994-01-18 Virginia Commonwealth University Histidine as a protective agent in cardiac surgery and myocardial ischemic syndrome
US5696109A (en) 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US5670545A (en) 1996-02-09 1997-09-23 Board Of Regents Of The University Of Colorado Method for the treatment of ischemic disease and reperfusion injury and the prevention of the adverse effects of reactive oxygen species
US6783954B2 (en) 1999-03-05 2004-08-31 Compugen Ltd. VEGF nucleic acid and amino acid sequences
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US20070122904A1 (en) * 2000-09-29 2007-05-31 Unisearch Limited Method and apparatus for culturing cells
US7786257B2 (en) 2000-12-18 2010-08-31 University Of Kansas Signal-1/signal-2 bifunctional peptide inhibitors
EP2132302B1 (en) * 2007-03-12 2016-01-27 Technion Research & Development Foundation Ltd. Vascularized islets and methods of producing same
JP5932206B2 (en) * 2008-02-06 2016-06-08 公立大学法人横浜市立大学 Cell culture method and screening method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087402A2 (en) * 2006-01-24 2007-08-02 Brown University Cell aggregation and encapsulation device and method
EP2286822A1 (en) * 2009-08-17 2011-02-23 Universiteit Twente Diabetes treatment
WO2011126921A2 (en) * 2010-04-06 2011-10-13 University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALDERT H. PIERSMA: "Alternative Methods for Developmental Toxicity Testing", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol. 98, no. 5, 1 May 2006 (2006-05-01), pages 427 - 431, XP055164713, ISSN: 1742-7835, DOI: 10.1111/j.1742-7843.2006.pto_373.x *
CHOI Y Y ET AL: "Controlled-size embryoid body formation in concave microwell arrays", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 15, 1 May 2010 (2010-05-01), pages 4296 - 4303, XP026971506, ISSN: 0142-9612, [retrieved on 20100305] *
HWANG JIN WOOK ET AL: "Optimal size control of pancreatic islet cell clusters using concave-bottomed microwells.", JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY 30 NOV 2011, vol. 152 Suppl 1, 30 November 2011 (2011-11-30), pages e218 - e219, XP002734971, ISSN: 1873-4995 *
JIN WOOK HWANG ET AL: "Functional clustering of pancreatic islet cells using concave microwell array", MACROMOLECULAR RESEARCH, vol. 19, no. 12, 3 November 2011 (2011-11-03), pages 1320 - 1326, XP055164708, ISSN: 1598-5032, DOI: 10.1007/s13233-012-1202-4 *
KARTHIK RAMACHANDRAN ET AL: "Engineering Islets for Improved Performance by Optimized Reaggregation in a Micromold", TISSUE ENGINEERING PART A, vol. 19, no. 5-6, 1 March 2013 (2013-03-01), pages 604 - 612, XP055164716, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2012.0553 *
KUNZ-SCHUGHART L A ET AL: "The use of 3-D cultures for high-throughput screening: The multicellular spheroid model", JOURNAL OF BIOMOLECULAR SCREENING, SAGE; LIEBERT, US, vol. 9, no. 4, 1 June 2004 (2004-06-01), pages 273 - 285, XP002694233, ISSN: 1087-0571, DOI: 10.1177/1087057104265040 *

Also Published As

Publication number Publication date
CA2842695C (en) 2021-01-12
WO2013016544A3 (en) 2013-04-25
WO2013016544A2 (en) 2013-01-31
JP2014521335A (en) 2014-08-28
EP3498300A1 (en) 2019-06-19
CA2842695A1 (en) 2013-01-31
WO2013016544A4 (en) 2013-06-13
EP2736536A2 (en) 2014-06-04

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