EP2686016A4 - Antibody recognizing n-domain of midkine - Google Patents

Antibody recognizing n-domain of midkine

Info

Publication number
EP2686016A4
EP2686016A4 EP12757658.5A EP12757658A EP2686016A4 EP 2686016 A4 EP2686016 A4 EP 2686016A4 EP 12757658 A EP12757658 A EP 12757658A EP 2686016 A4 EP2686016 A4 EP 2686016A4
Authority
EP
European Patent Office
Prior art keywords
midkine
domain
antibody recognizing
recognizing
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP12757658.5A
Other languages
German (de)
French (fr)
Other versions
EP2686016A1 (en
Inventor
Sadatosi Sakuma
Maria Halasz
Darren Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Therapies Ltd
Original Assignee
Medical Therapies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201161452337P priority Critical
Application filed by Medical Therapies Ltd filed Critical Medical Therapies Ltd
Priority to PCT/AU2012/000251 priority patent/WO2012122590A1/en
Publication of EP2686016A1 publication Critical patent/EP2686016A1/en
Publication of EP2686016A4 publication Critical patent/EP2686016A4/en
Application status is Pending legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
EP12757658.5A 2011-03-14 2012-03-13 Antibody recognizing n-domain of midkine Pending EP2686016A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201161452337P true 2011-03-14 2011-03-14
PCT/AU2012/000251 WO2012122590A1 (en) 2011-03-14 2012-03-13 Antibody recognizing n-domain of midkine

Publications (2)

Publication Number Publication Date
EP2686016A1 EP2686016A1 (en) 2014-01-22
EP2686016A4 true EP2686016A4 (en) 2014-09-03

Family

ID=46829949

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12757658.5A Pending EP2686016A4 (en) 2011-03-14 2012-03-13 Antibody recognizing n-domain of midkine

Country Status (3)

Country Link
US (1) US9624294B2 (en)
EP (1) EP2686016A4 (en)
WO (1) WO2012122590A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9659437B2 (en) * 2012-09-28 2017-05-23 Bally Gaming, Inc. System and method for cross platform persistent gaming sessions using a mobile device
AU2015333590A1 (en) * 2014-10-14 2017-04-20 Cellmid Limited Improved midkine antibody
KR20180130507A (en) * 2016-03-01 2018-12-07 셀미드 리미티드 Bone diseases, disorders, and / or how to treat injuries and treatment reagents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1607102A1 (en) * 2003-03-06 2005-12-21 Muramatsu, Takashi Preventive for adhesion following abdominal surgery
EP2088159A1 (en) * 2006-11-14 2009-08-12 Medical Therapies Limited Antibody recognizing c-domain of midkine
WO2010074218A1 (en) * 2008-12-25 2010-07-01 株式会社イーベック Anti-human midkine antibody

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
IL89989D0 (en) 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human interleukin-2 in methylotrophic yeasts
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE69233745D1 (en) 1991-12-02 2008-10-23 Cambridge Antibody Tech Production of autoantibodies on phage surfaces starting from antibody segment libraries
ES2136092T3 (en) 1991-09-23 1999-11-16 Medical Res Council Procedures for the production of humanized antibodies.
AU3691093A (en) 1992-04-14 1993-10-21 Hybritech Incorporated Methods of inhibiting the growth of multidrug resistant tumors
EP1621554B2 (en) 1992-08-21 2012-08-29 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
DE69334287D1 (en) 1992-09-25 2009-07-09 Avipep Pty Ltd Target molecules binding polypeptides of an Ig-like domain VL VH to an Ig-like domain consisting bound
JPH0739889A (en) 1993-07-29 1995-02-10 Meidensha Corp Treatment of high concentration ammonia waste liquid
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
DK0859841T3 (en) 1995-08-18 2002-09-09 Morphosys Ag Protein / (poly) peptide libraries
DK0937140T3 (en) 1996-06-27 2008-01-28 Vlaams Interuniv Inst Biotech Antibody molecules that specifically interact with a target molecule active site or cleft
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
WO1999003493A1 (en) 1997-07-14 1999-01-28 Meiji Milk Products Co., Ltd. Drugs containing as the active ingredient midkine or inhibitors thereof
IL139035D0 (en) 1998-05-06 2001-11-25 Genentech Inc Protein purification by ion exchange chromatography
WO2000010608A1 (en) 1998-08-24 2000-03-02 Meiji Milk Products Co., Ltd. Preventives/remedies for arteriosclerosis and post-ptca reangiostenosis
ES2278463T3 (en) 1998-12-08 2007-08-01 Biovation Limited Method to reduce immunogenicity of proteins.
JP3887154B2 (en) 2000-09-07 2007-02-28 喬 村松 Monoclonal antibodies against human mk
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7501494B2 (en) 2003-01-15 2009-03-10 United Biomedical, Inc. Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection
EP1658095A4 (en) 2003-06-02 2006-06-14 Alexion Pharma Inc De-immunized anti-cd3 antibody
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
US7977071B2 (en) 2004-06-02 2011-07-12 Adalta Pty Ltd. Binding moieties based on shark ignar domains
US20070135620A1 (en) 2004-11-12 2007-06-14 Xencor, Inc. Fc variants with altered binding to FcRn
US20060263367A1 (en) 2005-05-23 2006-11-23 Fey Georg H Bispecific antibody devoid of Fc region and method of treatment using same
EP1964574B1 (en) * 2005-11-14 2016-09-07 Cellmid Limited Method for treatment or prevention of disease associated with functional disorder of regulatory t cell

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1607102A1 (en) * 2003-03-06 2005-12-21 Muramatsu, Takashi Preventive for adhesion following abdominal surgery
EP2088159A1 (en) * 2006-11-14 2009-08-12 Medical Therapies Limited Antibody recognizing c-domain of midkine
WO2010074218A1 (en) * 2008-12-25 2010-07-01 株式会社イーベック Anti-human midkine antibody

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HIROTA YASUSHI ET AL: "The presence of midkine and its possible implication in human ovarian follicles", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 58, no. 4, October 2007 (2007-10-01), pages 367 - 373, XP055132022, ISSN: 1046-7408 *
INOH K ET AL: "Doxorubicin-Conjugated Anti-Midkine Monoclonal Antibody as a Ponential Anti-Tumor Drug", JAPANESE JOURNAL OF CLINICAL ONCOLOGY, TOKYO, JP, vol. 36, no. 4, 1 April 2006 (2006-04-01), pages 207 - 211, XP003022646, ISSN: 0368-2811, DOI: 10.1093/JJCO/HYL004 *
See also references of WO2012122590A1 *
XING YAO ET AL: "Preparation and Preliminary Characterization of Rabbit Monoclonal Antibodies Against Human Midkine", HYBRIDOMA, vol. 30, no. 1, 1 February 2011 (2011-02-01), pages 87 - 93, XP055131992, ISSN: 1554-0014, DOI: 10.1089/hyb.2010.0076 *

Also Published As

Publication number Publication date
EP2686016A1 (en) 2014-01-22
US20140170144A1 (en) 2014-06-19
WO2012122590A1 (en) 2012-09-20
US9624294B2 (en) 2017-04-18

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Legal Events

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Effective date: 20131010

AK Designated contracting states:

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (to any country) deleted
A4 Despatch of supplementary search report

Effective date: 20140806

RIC1 Classification (correction)

Ipc: C07K 16/22 20060101ALI20140731BHEP

Ipc: A61K 39/395 20060101AFI20140731BHEP

Ipc: A61P 25/28 20060101ALI20140731BHEP

Ipc: A61P 37/00 20060101ALI20140731BHEP

17Q First examination report

Effective date: 20160308

INTG Announcement of intention to grant

Effective date: 20181001

RIN1 Inventor (correction)

Inventor name: JONES, DARREN

Inventor name: HALASZ, MARIA

Inventor name: SAKUMA, SADATOSI