EP2635696A4 - Gardnerella vaginalis assay - Google Patents

Gardnerella vaginalis assay

Info

Publication number
EP2635696A4
EP2635696A4 EP11838580.6A EP11838580A EP2635696A4 EP 2635696 A4 EP2635696 A4 EP 2635696A4 EP 11838580 A EP11838580 A EP 11838580A EP 2635696 A4 EP2635696 A4 EP 2635696A4
Authority
EP
European Patent Office
Prior art keywords
gardnerella vaginalis
vaginalis assay
assay
gardnerella
vaginalis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11838580.6A
Other languages
German (de)
French (fr)
Other versions
EP2635696A2 (en
EP2635696B1 (en
Inventor
Jason P Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of EP2635696A2 publication Critical patent/EP2635696A2/en
Publication of EP2635696A4 publication Critical patent/EP2635696A4/en
Application granted granted Critical
Publication of EP2635696B1 publication Critical patent/EP2635696B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
EP11838580.6A 2010-11-01 2011-10-28 Gardnerella vaginalis assay Active EP2635696B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40884010P 2010-11-01 2010-11-01
PCT/US2011/058255 WO2012061225A2 (en) 2010-11-01 2011-10-28 Gardnerella vaginalis assay

Publications (3)

Publication Number Publication Date
EP2635696A2 EP2635696A2 (en) 2013-09-11
EP2635696A4 true EP2635696A4 (en) 2014-05-14
EP2635696B1 EP2635696B1 (en) 2017-11-29

Family

ID=46025032

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11838580.6A Active EP2635696B1 (en) 2010-11-01 2011-10-28 Gardnerella vaginalis assay

Country Status (8)

Country Link
US (2) US9410211B2 (en)
EP (1) EP2635696B1 (en)
JP (1) JP6081916B2 (en)
CN (2) CN103282511A (en)
BR (1) BR112013010856B1 (en)
CA (1) CA2816311C (en)
ES (1) ES2659543T3 (en)
WO (1) WO2012061225A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525504D0 (en) 2005-12-14 2006-01-25 Bristol Myers Squibb Co Antimicrobial composition
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
AU2013366038A1 (en) 2012-12-20 2015-07-16 Convatec Technologies Inc. Processing of chemically modified cellulosic fibres
CA2982467C (en) * 2015-04-24 2024-02-13 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis
GB201608099D0 (en) 2016-05-09 2016-06-22 Convatec Technologies Inc Negative pressure wound dressing
CN110542674B (en) * 2019-09-19 2021-10-22 济南大学 Biosensor for detecting glutathione and preparation method thereof
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
GB202001214D0 (en) 2020-01-29 2020-03-11 Convatec Ltd A pump assembly and a wound therapy apparatus
GB202002339D0 (en) 2020-02-20 2020-04-08 Convatec Ltd A wound dressing and a wound therapy apparatus
GB202002338D0 (en) 2020-02-20 2020-04-08 Convatec Ltd A method and control system for a wound therapy apparatus
GB202004055D0 (en) 2020-03-20 2020-05-06 Convatec Ltd Debridement Composition
GB202110650D0 (en) 2021-07-23 2021-09-08 Convatec Ltd Port with piercing means
GB202110652D0 (en) 2021-07-23 2021-09-08 Convatec Ltd A selectively configurable wound dressing
GB202110649D0 (en) 2021-07-23 2021-09-08 Convatec Ltd A selectively configurable wound dressing
GB202110648D0 (en) 2021-07-23 2021-09-08 Convatec Ltd A selectively configurable wound dressing
GB202110651D0 (en) 2021-07-23 2021-09-08 Convatec Ltd Kit for use with a selectively configurable wound dressing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095917A1 (en) * 2009-02-23 2010-08-26 Biotechnologijos Institutas Monoclonal antibodies against vaginolysin

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
EP0461155B1 (en) 1989-03-03 1994-07-27 Genentech, Inc. Improved methods for in vitro dna amplification and genomic cloning and mapping
DE3929030A1 (en) 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh METHOD FOR PROPELLING NUCLEIC ACIDS
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5102784A (en) 1990-05-04 1992-04-07 Oncor, Inc. Restriction amplification assay
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
CA2122203C (en) 1993-05-11 2001-12-18 Melinda S. Fraiser Decontamination of nucleic acid amplification reactions
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5814490A (en) 1996-06-11 1998-09-29 Becton, Dickinson And Company Amplification and detection of chlamydia trachomatis nucleic acids
US5928869A (en) 1997-05-30 1999-07-27 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US5962273A (en) 1997-11-04 1999-10-05 Becton Dickinson And Company Detection of Neisseria gonorrhoeae by amplification and detection of its nucleic acid
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
US6379888B1 (en) 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
CA2905326C (en) * 1999-09-28 2016-09-27 Geneohm Sciences Canada Inc. Nucleic acids and methods for the detection of klebsiella
US6893671B2 (en) 2000-12-15 2005-05-17 Mars, Incorporated Chocolate confectionery having high resolution printed images on an edible image-substrate coating
US7732664B2 (en) 2006-03-08 2010-06-08 Universidade De Sao Paulo - Usp. Genes associated to sucrose content
FR2909099B1 (en) * 2006-11-24 2012-10-19 Univ Aix Marseille Ii METHOD FOR DIAGNOSING AND MONITORING BACTERIAL VAGINOSIS BY MOLECULAR QUANTIFICATION
ITTO20070097A1 (en) 2007-02-09 2008-08-10 Dominic & Star Company S R L PROCEDURE FOR THE REALIZATION OF CHOCOLATE PRODUCTS WITH PRINTED IMAGES
US20090081341A1 (en) 2007-09-25 2009-03-26 Isar Mandelboum Method and device for printing color images on chocolate products
US8802112B2 (en) 2008-03-15 2014-08-12 The Trustees Of Columbia University In The City Of New York Treatment and prevention of Gardnerella vaginalis infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095917A1 (en) * 2009-02-23 2010-08-26 Biotechnologijos Institutas Monoclonal antibodies against vaginolysin

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 28 June 2011 (2011-06-28), "JP 2006507841-A/1108135: Functional and Hyperfunctional siRNA.", XP002722533, retrieved from EBI accession no. EM_PAT:GB545726 Database accession no. GB545726 *
DATABASE EMBL [online] 28 June 2011 (2011-06-28), "JP 2006507841-A/1497073: Functional and Hyperfunctional siRNA.", XP002722537, retrieved from EBI accession no. EM_PAT:GB934664 Database accession no. GB934664 *
DATABASE Geneseq [online] 15 October 1997 (1997-10-15), "Fibrillin 1 Fbn1 gene primer B2.", XP002722538, retrieved from EBI accession no. GSN:AAT51773 Database accession no. AAT51773 *
DATABASE Geneseq [online] 19 August 2010 (2010-08-19), "Sugarcane assembled sequence specific real-time PCR primer, SEQ ID 400.", XP002722536, retrieved from EBI accession no. GSN:AYD77201 Database accession no. AYD77201 *
DATABASE Geneseq [online] 21 February 2008 (2008-02-21), "Saccharum stree related gene RT-PCR primer, SEQ ID 400.", XP002722535, retrieved from EBI accession no. GSN:AOF47809 Database accession no. AOF47809 *
DATABASE Geneseq [online] 26 January 1996 (1996-01-26), "Self splicing intron amplification primer oligo-4445.", XP002722539, retrieved from EBI accession no. GSN:AAQ94927 Database accession no. AAQ94927 *
DATABASE Geneseq [online] 8 March 2007 (2007-03-08), "Bovine FABP 4 gene, SNP at 7516 #1.", XP002722534, retrieved from EBI accession no. GSN:AEN60405 Database accession no. AEN60405 *
DATABASE Geneseq [online] 9 July 2009 (2009-07-09), "Human LOC643997 gene short interfering RNA target sequence.", XP002722540, retrieved from EBI accession no. GSN:AWW33851 Database accession no. AWW33851 *
G ROTTINI ET AL: "Identification and partial characterization of a cytolytic toxin produced by Gardnerella vaginalis", INFECTION AND IMMUNITY, 1 November 1990 (1990-11-01), UNITED STATES, pages 3751 - 3758, XP055111082, Retrieved from the Internet <URL:http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=313724&tool=pmcentrez&rendertype=abstract> *
RANDIS TARA M ET AL: "Antibody-Based Detection and Inhibition of Vaginolysin, the Gardnerella vaginalis Cytolysin", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 4, no. 4, 16 April 2009 (2009-04-16), pages e5207, XP009128317, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0005207 *
See also references of WO2012061225A2 *

Also Published As

Publication number Publication date
EP2635696A2 (en) 2013-09-11
JP2013544515A (en) 2013-12-19
BR112013010856A2 (en) 2018-03-06
CN108486261A (en) 2018-09-04
WO2012061225A2 (en) 2012-05-10
US9976190B2 (en) 2018-05-22
BR112013010856B1 (en) 2020-12-22
ES2659543T3 (en) 2018-03-16
CA2816311A1 (en) 2012-05-10
JP6081916B2 (en) 2017-02-15
US20160244814A1 (en) 2016-08-25
CA2816311C (en) 2018-07-17
US20140030710A1 (en) 2014-01-30
EP2635696B1 (en) 2017-11-29
US9410211B2 (en) 2016-08-09
WO2012061225A3 (en) 2012-07-05
CN103282511A (en) 2013-09-04

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