EP2627353A4 - CAPSID PROTEIN OF NOROVIRUS AND ROTAVIRUS VP6 FOR USE AS A COMBINED VACCINE - Google Patents

CAPSID PROTEIN OF NOROVIRUS AND ROTAVIRUS VP6 FOR USE AS A COMBINED VACCINE

Info

Publication number
EP2627353A4
EP2627353A4 EP11832191.8A EP11832191A EP2627353A4 EP 2627353 A4 EP2627353 A4 EP 2627353A4 EP 11832191 A EP11832191 A EP 11832191A EP 2627353 A4 EP2627353 A4 EP 2627353A4
Authority
EP
European Patent Office
Prior art keywords
norovirus
rotavirus
capsid protein
combined vaccine
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11832191.8A
Other languages
German (de)
French (fr)
Other versions
EP2627353A1 (en
EP2627353B1 (en
Inventor
Timo Vesikari
Vesna Blazevic
Kirsi Nurminen
Leena Huhti
Suvi Lappalainen
Eeva Jokela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BLAZEVIC, VESNA
VESIKARI, TIMO
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2627353A1 publication Critical patent/EP2627353A1/en
Publication of EP2627353A4 publication Critical patent/EP2627353A4/en
Application granted granted Critical
Publication of EP2627353B1 publication Critical patent/EP2627353B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12323—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP11832191.8A 2010-10-14 2011-10-12 Norovirus capsid and rotavirus vp6 protein for use as combined vaccine Active EP2627353B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39308110P 2010-10-14 2010-10-14
FI20106067A FI122520B (en) 2010-10-15 2010-10-15 Norovirus capsid and rotavirus VP6 protein for use as a combination vaccine
PCT/FI2011/050880 WO2012049366A1 (en) 2010-10-14 2011-10-12 Norovirus capsid and rotavirus vp6 protein for use as combined vaccine

Publications (3)

Publication Number Publication Date
EP2627353A1 EP2627353A1 (en) 2013-08-21
EP2627353A4 true EP2627353A4 (en) 2014-06-18
EP2627353B1 EP2627353B1 (en) 2017-11-29

Family

ID=43064225

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11832191.8A Active EP2627353B1 (en) 2010-10-14 2011-10-12 Norovirus capsid and rotavirus vp6 protein for use as combined vaccine

Country Status (14)

Country Link
US (1) US8895015B2 (en)
EP (1) EP2627353B1 (en)
JP (1) JP5902181B2 (en)
KR (1) KR101847472B1 (en)
CN (1) CN103260645B (en)
AU (1) AU2011315405B2 (en)
BR (1) BR112013009164A2 (en)
CA (1) CA2814175C (en)
FI (1) FI122520B (en)
MX (1) MX352478B (en)
RU (1) RU2013121815A (en)
SG (1) SG189398A1 (en)
TW (1) TWI479022B (en)
WO (1) WO2012049366A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE028605T2 (en) 2007-03-14 2016-12-28 Takeda Vaccines Inc Virus like particle purification
CN104024419A (en) 2011-10-24 2014-09-03 丰田自动车株式会社 Method for producing ethanol using recombinant yeast
JOP20130186B1 (en) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc Purification of virus like particles
CN103667199B (en) * 2012-09-20 2019-01-22 厦门大学 Method for preparing rotavirus bilayer virus-like particles in vitro
ES2762631T3 (en) 2013-03-14 2020-05-25 Harvard College Compositions based on nanoparticles
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
JP2015015931A (en) * 2013-07-12 2015-01-29 株式会社Ｕｍｎファーマ Method for producing culture comprising virus-like particles
US20160194625A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
KR20160067219A (en) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 Polynucleotides encoding low density lipoprotein receptor
JP2018078806A (en) * 2016-11-14 2018-05-24 東ソー株式会社 Methods for detecting noroviral rna
WO2018182983A1 (en) * 2017-03-28 2018-10-04 Children's Hospital Medical Center Norovirus s particle based vaccines and methods of making and using same
US11421011B2 (en) 2017-05-18 2022-08-23 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
JP6879111B2 (en) 2017-08-02 2021-06-02 トヨタ自動車株式会社 Recombinant yeast and method for producing ethanol using it
KR102038364B1 (en) 2018-03-15 2019-10-30 전남대학교 산학협력단 Mixed live attenuated vaccine composition for protecting bovine rotavirus infection
WO2021140524A1 (en) 2020-01-08 2021-07-15 Bharat Biotech International Limited Viral vaccine compositions and methods of preparations thereof
CN111265660B (en) * 2020-01-19 2022-11-15 青岛明勤生物科技有限公司 Universal vaccine immunopotentiator
CN114316009B (en) * 2020-09-29 2023-04-25 上海交通大学 Protein capable of combining multiple viruses and application thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298244A (en) * 1990-10-25 1994-03-29 University Of Saskatchewan Assembled viral particles and their use in a vaccine to rotaviral disease
IE920366A1 (en) 1991-02-04 1992-08-12 Univ Saskatchewan Vp6 encapsulated drug delivery
US6673355B1 (en) 1995-06-14 2004-01-06 Baylor College Of Medicine Rotavirus enterotoxin NSP4 and methods of using same
JP2000139473A (en) * 1998-11-16 2000-05-23 Hokkaido Green Bio Kenkyusho:Kk Transgenic plant into which rotavirus gene has been introduced, rotavirus protein derived from the transgenic plant, and antibody against the rotavirus protein
US20030166139A1 (en) 2001-07-20 2003-09-04 Choi Anthony H. Rotavirus VP6 subunit
WO2006138514A2 (en) * 2005-06-16 2006-12-28 Children's Hospital Medical Center Novel norovirus particle for use as an antiviral or vaccine
US8168202B2 (en) 2005-07-07 2012-05-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hexavalent bovine rotavirus reassortant composition designed for use in developing countries
AU2006335256B2 (en) * 2005-11-22 2012-10-18 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
HUE028605T2 (en) * 2007-03-14 2016-12-28 Takeda Vaccines Inc Virus like particle purification
SG10201601660YA (en) * 2007-09-18 2016-04-28 Takeda Vaccines Inc Method of conferring a protective immune response to norovirus
WO2009127519A1 (en) * 2008-04-18 2009-10-22 Unilever Nv Compositions comprising antibodies or antibody fragments
WO2010006326A2 (en) * 2008-07-11 2010-01-14 Tufts University Methods and compositions for spore-based vaccines
JP5894528B2 (en) * 2009-06-09 2016-03-30 チルドレンズ ホスピタル メディカル センター Antigen-norovirus P domain monomers and dimers, antigen-norovirus P particle molecules, and their production and use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KOO HOONMO L ET AL: "Noroviruses: The leading cause of foodborne disease worldwide.", July 2010 (2010-07-01), pages 1 - 16, XP002723203, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150746/pdf/nihms294945.pdf> [retrieved on 20140428] *
MING TAN ET AL: "Norovirus P Particle, a Novel Platform for Vaccine Development and Antibody Production", JOURNAL OF VIROLOGY, vol. 85, no. 2, 1 January 2011 (2011-01-01), THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, pages 753 - 764, XP002669772, ISSN: 0022-538X, [retrieved on 20101110], DOI: 10.1128/JVI.01835-10 *
See also references of WO2012049366A1 *
TAMMINEN KIRSI ET AL: "A comparison of immunogenicity of norovirus GII-4 virus-like particles and P-particles.", IMMUNOLOGY, vol. 135, no. 1, January 2012 (2012-01-01), pages 89 - 99, XP002723204, ISSN: 1365-2567 *
TAMMINEN KIRSI ET AL: "Trivalent combination vaccine induces broad heterologous immune responses to norovirus and rotavirus in mice.", PLOS ONE, vol. 8, no. 7, E70409, 26 July 2013 (2013-07-26), pages 1 - 14, XP002723205, ISSN: 1932-6203 *

Also Published As

Publication number Publication date
US20120093884A1 (en) 2012-04-19
TWI479022B (en) 2015-04-01
EP2627353A1 (en) 2013-08-21
JP5902181B2 (en) 2016-04-13
KR20140030100A (en) 2014-03-11
CA2814175A1 (en) 2012-04-19
CN103260645A (en) 2013-08-21
WO2012049366A1 (en) 2012-04-19
RU2013121815A (en) 2014-11-20
CN103260645B (en) 2016-03-16
BR112013009164A2 (en) 2019-09-24
KR101847472B1 (en) 2018-04-11
FI122520B (en) 2012-03-15
TW201217530A (en) 2012-05-01
AU2011315405B2 (en) 2016-09-22
AU2011315405A1 (en) 2013-05-23
EP2627353B1 (en) 2017-11-29
US8895015B2 (en) 2014-11-25
SG189398A1 (en) 2013-05-31
JP2013540773A (en) 2013-11-07
FI20106067A0 (en) 2010-10-15
MX352478B (en) 2017-11-27
CA2814175C (en) 2019-11-05
MX2013004159A (en) 2013-11-04

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