EP2535709A4 - Method for identifying modulators that modulate physiological functions of intracellular components within a cell - Google Patents

Method for identifying modulators that modulate physiological functions of intracellular components within a cell

Info

Publication number
EP2535709A4
EP2535709A4 EP11742422.6A EP11742422A EP2535709A4 EP 2535709 A4 EP2535709 A4 EP 2535709A4 EP 11742422 A EP11742422 A EP 11742422A EP 2535709 A4 EP2535709 A4 EP 2535709A4
Authority
EP
European Patent Office
Prior art keywords
cell
physiological functions
intracellular components
identifying modulators
modulate physiological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11742422.6A
Other languages
German (de)
French (fr)
Other versions
EP2535709A2 (en
Inventor
Dae Joong Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MEDISCOV Inc
Original Assignee
MEDISCOV Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MEDISCOV Inc filed Critical MEDISCOV Inc
Publication of EP2535709A2 publication Critical patent/EP2535709A2/en
Publication of EP2535709A4 publication Critical patent/EP2535709A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Geometry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP11742422.6A 2010-02-12 2011-02-08 Method for identifying modulators that modulate physiological functions of intracellular components within a cell Withdrawn EP2535709A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100013372A KR101028875B1 (en) 2010-02-12 2010-02-12 Methods for identifying modulators for biological activity of cellular components in cells
PCT/KR2011/000790 WO2011099730A2 (en) 2010-02-12 2011-02-08 Method for identifying modulators that modulate physiological functions of intracellular components within a cell

Publications (2)

Publication Number Publication Date
EP2535709A2 EP2535709A2 (en) 2012-12-19
EP2535709A4 true EP2535709A4 (en) 2013-07-10

Family

ID=44050030

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11742422.6A Withdrawn EP2535709A4 (en) 2010-02-12 2011-02-08 Method for identifying modulators that modulate physiological functions of intracellular components within a cell

Country Status (6)

Country Link
US (1) US20110201016A1 (en)
EP (1) EP2535709A4 (en)
JP (1) JP2013518581A (en)
KR (1) KR101028875B1 (en)
CN (1) CN102782494A (en)
WO (1) WO2011099730A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014122275A1 (en) * 2013-02-08 2014-08-14 Fundación Pública Andaluza Progreso Y Salud Method for the diagnosis and monitoring of autoinmune diseases
WO2016013541A1 (en) * 2014-07-23 2016-01-28 コニカミノルタ株式会社 Labeling reagent containing a molecularly targeted drug

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083382A2 (en) * 2004-12-02 2006-08-10 Vanderbilt University Measuring forster resonance energy transfer with polarized and depolarized light

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53130572A (en) 1977-04-05 1978-11-14 Tdk Electronics Co Ltd Highhgradient magnetic separator using amorphous magnetic alloy
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5491068A (en) * 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
AU2002320058A1 (en) 2001-06-06 2002-12-16 The General Hspital Corporation Magnetic-nanoparticle conjugates and methods of use
EP1644513B1 (en) 2003-06-20 2011-08-10 DiscoveRx Corporation Assay for detecting protein binding
JP4195478B2 (en) * 2003-06-30 2008-12-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 Magnetic cells and methods of use thereof
JP3889026B2 (en) * 2003-06-30 2007-03-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Magnetic cells and methods of use thereof
AU2006259153B2 (en) 2005-06-14 2012-04-12 Cellzome Gmbh Process for the identification of novel enzyme interacting compounds
KR100809866B1 (en) * 2006-06-16 2008-03-06 연세대학교 산학협력단 Method and apparatus for detecting or sorting apoptotic cells using microfulidic channel and magnetic field
KR100792594B1 (en) 2006-11-30 2008-01-09 씨지케이 주식회사 Apparatus for applying magnetic field
KR100823684B1 (en) * 2006-12-06 2008-04-21 한국전자통신연구원 Method for detecting a biological target material using barcode dna
KR100862368B1 (en) 2007-06-14 2008-10-13 씨지케이 주식회사 Apparatus for applying magnetic field, method for applying magnetic field and apparatus for increasing magnetic gradient therefor
KR20080111326A (en) 2007-06-18 2008-12-23 삼성전자주식회사 Method for cognitive radio base station and customer premises equipment operating ad-hoc mod

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083382A2 (en) * 2004-12-02 2006-08-10 Vanderbilt University Measuring forster resonance energy transfer with polarized and depolarized light

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DAE-JOONG KIM ET AL: "In Situ Monitoring of Bindings between Dasatinib and Its Target Protein Kinases Using Magnetic Nanoparticles in Live Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 49, 10 December 2008 (2008-12-10), pages 16466 - 16467, XP055064833, ISSN: 0002-7863, DOI: 10.1021/ja8063843 *
DAE-JOONG KIM ET AL: "Supportive information for In Situ Monitoring of Bindings between Dasatinib and Its Target Protein Kinases Using Magnetic Nanoparticles in Live Cells", JACS, 1 June 2008 (2008-06-01), pages S1 - S6, XP055065259, Retrieved from the Internet <URL:http://pubs.acs.org/doi/suppl/10.1021/ja8063843/suppl_file/ja8063843_si_001.pdf> [retrieved on 20130604] *
KIM J E ET AL: "MO08-11: FRET -BASED ASSAY DEVELOPMENT FOR MODULATOR SCREENING BETWEEN GAMMA SECRETASE AND APP INTERACTION IN LIVE CELL", JOURNAL OF NEUROCHEMISTRY; 22ND BIENNIAL MEETING OF THE INTERNATIONAL-SOCIETY-OF-NEUROCHEMISTRY / ASIAN-PACIFIC-SOCIETY-FOR-NEURO, WILEY INTERSCIENCE, NEW YORK, NY, US; BUSAN, SOUTH KOREA, vol. 110, no. Suppl. 2, 1 September 2009 (2009-09-01), pages 60, XP008162676, ISSN: 0022-3042, [retrieved on 20090729], DOI: 10.1111/J.1471-4159.2009.06238.X *
PIEHLER J: "New methodologies for measuring protein interactions in vivo and in vitro", CURRENT OPINION IN STRUCTURAL BIOLOGY, ELSEVIER LTD, GB, vol. 15, no. 1, 1 February 2005 (2005-02-01), pages 4 - 14, XP004755659, ISSN: 0959-440X, DOI: 10.1016/J.SBI.2005.01.008 *
SALAKLANG JATUPORN ET AL: "Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context", ANGEWANDTE CHEMIE (INTERNATIONAL EDITION), WILEY - VCH VERLAG GMBH & CO, DE, vol. 47, no. 41, 1 January 2008 (2008-01-01), pages 7857 - 7860, XP002586198, ISSN: 1521-3773, DOI: 10.1002/ANIE.200800357 *
See also references of WO2011099730A2 *
TOM K. KERPPOLA: "Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells", ANNUAL REVIEW OF BIOPHYSICS, vol. 37, no. 1, 1 June 2008 (2008-06-01), pages 465 - 487, XP055065255, ISSN: 1936-122X, DOI: 10.1146/annurev.biophys.37.032807.125842 *
WON J ET AL: "A magnetic nanoprobe technology for detecting molecular interactions in live cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 309, no. 5731, 1 July 2005 (2005-07-01), pages 121 - 125, XP003014064, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1112869 *

Also Published As

Publication number Publication date
JP2013518581A (en) 2013-05-23
US20110201016A1 (en) 2011-08-18
CN102782494A (en) 2012-11-14
WO2011099730A3 (en) 2012-01-12
EP2535709A2 (en) 2012-12-19
WO2011099730A2 (en) 2011-08-18
KR101028875B1 (en) 2011-04-12

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