EP2453921A4 - DIFFERENTIATION OF MESENCHYMAL STEM CELLS - Google Patents

DIFFERENTIATION OF MESENCHYMAL STEM CELLS

Info

Publication number
EP2453921A4
EP2453921A4 EP10800425A EP10800425A EP2453921A4 EP 2453921 A4 EP2453921 A4 EP 2453921A4 EP 10800425 A EP10800425 A EP 10800425A EP 10800425 A EP10800425 A EP 10800425A EP 2453921 A4 EP2453921 A4 EP 2453921A4
Authority
EP
European Patent Office
Prior art keywords
differentiation
stem cells
mesenchymal stem
mesenchymal
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10800425A
Other languages
German (de)
French (fr)
Other versions
EP2453921A2 (en
EP2453921B1 (en
Inventor
Kristen Johnson
Lori Jennings
Peter Schultz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Scripps Research Institute
Original Assignee
IRM LLC
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43450138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2453921(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by IRM LLC, Scripps Research Institute filed Critical IRM LLC
Priority to PL10800425T priority Critical patent/PL2453921T3/en
Publication of EP2453921A2 publication Critical patent/EP2453921A2/en
Publication of EP2453921A4 publication Critical patent/EP2453921A4/en
Application granted granted Critical
Publication of EP2453921B1 publication Critical patent/EP2453921B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP10800425.0A 2009-07-14 2010-07-13 Mesenchymal stem cell differentiation Active EP2453921B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL10800425T PL2453921T3 (en) 2009-07-14 2010-07-13 Mesenchymal stem cell differentiation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22529309P 2009-07-14 2009-07-14
PCT/US2010/041850 WO2011008773A2 (en) 2009-07-14 2010-07-13 Mesenchymal stem cell differentiation

Publications (3)

Publication Number Publication Date
EP2453921A2 EP2453921A2 (en) 2012-05-23
EP2453921A4 true EP2453921A4 (en) 2012-12-19
EP2453921B1 EP2453921B1 (en) 2015-05-27

Family

ID=43450138

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10800425.0A Active EP2453921B1 (en) 2009-07-14 2010-07-13 Mesenchymal stem cell differentiation

Country Status (30)

Country Link
US (4) US9139633B2 (en)
EP (1) EP2453921B1 (en)
JP (1) JP5602850B2 (en)
KR (3) KR101590834B1 (en)
CN (2) CN105601728B (en)
AU (1) AU2010273570B2 (en)
BR (1) BR112012000914B8 (en)
CA (1) CA2767826C (en)
CL (1) CL2012000091A1 (en)
CO (1) CO6491059A2 (en)
CR (1) CR20120024A (en)
CU (1) CU24042B1 (en)
EA (1) EA023073B1 (en)
EC (1) ECSP12011604A (en)
ES (1) ES2541217T3 (en)
GT (1) GT201200011A (en)
IL (2) IL217383A (en)
IN (1) IN2012DN00572A (en)
MA (1) MA33423B1 (en)
MX (1) MX2012000707A (en)
MY (1) MY160951A (en)
NZ (1) NZ597306A (en)
PE (2) PE20120570A1 (en)
PL (1) PL2453921T3 (en)
PT (1) PT2453921E (en)
SG (1) SG177318A1 (en)
TN (1) TN2011000655A1 (en)
UA (1) UA104031C2 (en)
WO (1) WO2011008773A2 (en)
ZA (1) ZA201200078B (en)

Families Citing this family (19)

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KR101590834B1 (en) * 2009-07-14 2016-02-12 더 스크립스 리서치 인스티튜트 Mesenchymal stem cell differentiation
AR087329A1 (en) 2011-06-17 2014-03-19 Regeneron Pharma HUMAN ANTIBODIES AGAINST PROTEIN 3 OF HUMAN ANGIOPOIETIN TYPE
EP4009640A1 (en) 2011-11-08 2022-06-08 Electronics and Telecommunications Research Institute Method and device for sharing a candidate list
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
ES2651113T3 (en) 2012-06-25 2018-01-24 The Brigham And Women's Hospital, Inc. Targeted therapeutic treatments
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
UY35368A (en) * 2013-03-08 2014-10-31 Irm Llc PEPTIDES AND COMPOSITIONS FOR THE TREATMENT OF ARTICULAR DAMAGE
KR102283996B1 (en) 2013-03-15 2021-07-29 더 스크립스 리서치 인스티튜트 Compounds and methods for inducing chondrogenesis
HRP20241236T1 (en) 2014-05-13 2024-12-06 Novartis Ag COMPOUNDS AND PREPARATIONS FOR INDUCING CHONDROGENESIS
CN104840486A (en) * 2015-04-30 2015-08-19 北京益诺勤生物技术有限公司 Composition, application thereof and preparation
EA201891979A1 (en) 2016-03-03 2019-01-31 Ридженерон Фармасьютикалз, Инк. METHODS OF TREATMENT OF PATIENTS WITH HYPERLIPIDEMIA INTRODUCTION OF PCSK9 INHIBITOR IN COMBINATION WITH ANGPTL3 INHIBITOR
CA3043667A1 (en) * 2016-11-14 2018-05-17 Novartis Ag Methods and compositions for treatment of cartilage damage and arthritis
JOP20190245A1 (en) 2017-04-20 2019-10-15 Novartis Ag Sustained release delivery systems comprising traceless linkers
JOP20190282A1 (en) 2017-06-09 2019-12-05 Novartis Ag Compounds and compositions for inducing chondrogenesis
AR116566A1 (en) 2018-10-03 2021-05-19 Novartis Ag SUSTAINED ADMINISTRATION OF ANGIOPOYETIN-SIMILAR POLIPEPTIDES 3
JP7427665B2 (en) 2018-12-06 2024-02-05 ノバルティス アーゲー 6-Hydroxy-8-oxatricyclo[3.2.1.02,4]octane-2-carboxamide derivatives for inducing cartilage formation for treating joint injuries
ES2963508T3 (en) 2018-12-06 2024-03-27 Novartis Ag 5-Hydroxy-7-oxabicyclo[2.2.1]heptane-2-carboxamide derivatives to induce chondrogenesis for the treatment of joint damage
CN109432128A (en) * 2018-12-07 2019-03-08 卡替（上海）生物技术股份有限公司 Application of the dental pulp mescenchymal stem cell in curing psoriasis
KR102246582B1 (en) * 2019-04-03 2021-04-30 이화여자대학교 산학협력단 Method for inducing differentiation stem cells into chondrocytes using oligopeptides

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WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
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WO2003044172A2 (en) * 2001-11-16 2003-05-30 Genentech, Inc. Composition comprising and method of using angiopoietin-like protein 3 angptl3

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UY35368A (en) 2013-03-08 2014-10-31 Irm Llc PEPTIDES AND COMPOSITIONS FOR THE TREATMENT OF ARTICULAR DAMAGE

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WO1999058660A1 (en) * 1998-05-12 1999-11-18 Human Genome Sciences, Inc. 97 human secreted proteins
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
WO2001005972A1 (en) * 1999-07-20 2001-01-25 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2003044172A2 (en) * 2001-11-16 2003-05-30 Genentech, Inc. Composition comprising and method of using angiopoietin-like protein 3 angptl3

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HATO ET AL: "The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism", TRENDS IN CARDIOVASCULAR MEDICINE, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 18, no. 1, 16 January 2008 (2008-01-16), pages 6 - 14, XP022423503, ISSN: 1050-1738, DOI: 10.1016/J.TCM.2007.10.003 *
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Also Published As

Publication number Publication date
CN102625830A (en) 2012-08-01
BR112012000914A2 (en) 2017-08-08
CN105601728B (en) 2020-01-10
EP2453921A2 (en) 2012-05-23
PT2453921E (en) 2015-09-25
KR20120029472A (en) 2012-03-26
MY160951A (en) 2017-03-31
PE20120570A1 (en) 2012-05-19
CA2767826C (en) 2015-11-24
GT201200011A (en) 2013-12-10
BR112012000914B8 (en) 2021-05-25
PL2453921T3 (en) 2015-11-30
CO6491059A2 (en) 2012-07-31
US20120177644A1 (en) 2012-07-12
AU2010273570A1 (en) 2012-02-02
US10555990B2 (en) 2020-02-11
NZ597306A (en) 2014-03-28
CA2767826A1 (en) 2011-01-20
KR20180000337A (en) 2018-01-02
US10064918B2 (en) 2018-09-04
HK1164169A1 (en) 2012-09-21
MA33423B1 (en) 2012-07-03
JP2012533549A (en) 2012-12-27
AU2010273570B2 (en) 2014-07-03
US20200108122A1 (en) 2020-04-09
US20160213748A1 (en) 2016-07-28
KR101590834B1 (en) 2016-02-12
BR112012000914A8 (en) 2017-12-19
IL217383A0 (en) 2012-02-29
MX2012000707A (en) 2012-03-21
IL217383A (en) 2016-08-31
PE20160507A1 (en) 2016-05-20
CN102625830B (en) 2016-03-02
CU24042B1 (en) 2014-11-27
CL2012000091A1 (en) 2012-10-26
US11241482B2 (en) 2022-02-08
EA201200118A1 (en) 2012-09-28
UA104031C2 (en) 2013-12-25
ES2541217T3 (en) 2015-07-16
BR112012000914B1 (en) 2021-04-06
CR20120024A (en) 2012-06-11
IL247310B (en) 2018-04-30
CN105601728A (en) 2016-05-25
WO2011008773A2 (en) 2011-01-20
TN2011000655A1 (en) 2013-05-24
ECSP12011604A (en) 2012-06-29
KR20160015403A (en) 2016-02-12
IN2012DN00572A (en) 2015-06-12
US9139633B2 (en) 2015-09-22
WO2011008773A3 (en) 2011-08-25
ZA201200078B (en) 2013-01-30
EP2453921B1 (en) 2015-05-27
SG177318A1 (en) 2012-03-29
US20190000922A1 (en) 2019-01-03
EA023073B1 (en) 2016-04-29
JP5602850B2 (en) 2014-10-08
CU20120007A7 (en) 2013-02-26

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