EP2396002A4 - (2.2.2) bicyclic derivatives and methods of use - Google Patents

(2.2.2) bicyclic derivatives and methods of use

Info

Publication number
EP2396002A4
EP2396002A4 EP09833871A EP09833871A EP2396002A4 EP 2396002 A4 EP2396002 A4 EP 2396002A4 EP 09833871 A EP09833871 A EP 09833871A EP 09833871 A EP09833871 A EP 09833871A EP 2396002 A4 EP2396002 A4 EP 2396002A4
Authority
EP
European Patent Office
Prior art keywords
methods
bicyclic derivatives
bicyclic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09833871A
Other languages
German (de)
French (fr)
Other versions
EP2396002A2 (en
EP2396002B1 (en
Inventor
Susanna A Saakian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASE PHARMACEUTICALS LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2396002A2 publication Critical patent/EP2396002A2/en
Publication of EP2396002A4 publication Critical patent/EP2396002A4/en
Application granted granted Critical
Publication of EP2396002B1 publication Critical patent/EP2396002B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP09833871.8A 2008-12-20 2009-12-21 (2.2.2) bicyclic derivatives and methods of use Active EP2396002B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13956208P 2008-12-20 2008-12-20
PCT/US2009/068920 WO2010071872A2 (en) 2008-12-20 2009-12-21 [2.2.2] bicyclic derivatives and methods of use

Publications (3)

Publication Number Publication Date
EP2396002A2 EP2396002A2 (en) 2011-12-21
EP2396002A4 true EP2396002A4 (en) 2012-09-05
EP2396002B1 EP2396002B1 (en) 2020-07-29

Family

ID=42269293

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09833871.8A Active EP2396002B1 (en) 2008-12-20 2009-12-21 (2.2.2) bicyclic derivatives and methods of use

Country Status (11)

Country Link
US (4) US20110313037A1 (en)
EP (1) EP2396002B1 (en)
JP (1) JP6108423B2 (en)
KR (2) KR20110116135A (en)
CN (2) CN102300573A (en)
AU (1) AU2009327316B2 (en)
CA (2) CA2747803C (en)
IL (2) IL213609A (en)
MX (1) MX341241B (en)
RU (2) RU2691406C2 (en)
WO (1) WO2010071872A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2091366C1 (en) * 1992-06-16 1997-09-27 Инесса Ивановна Крицкая Bicyclo (2,2,2) octane-2-carboxylic acid sodium salt having anticonvulsion activity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
DE4231085A1 (en) * 1992-09-12 1994-03-17 Desitin Arzneimittel Gmbh VPA-like anti-epileptics
AU6425498A (en) * 1997-11-05 1999-05-24 Inessa Ivanovna Kritskaya New anticonvulsant drugs
RU2183454C1 (en) * 2000-12-18 2002-06-20 Чухрова Марина Геннадьевна Preparation to interrupt narcotic abstinent syndrome
DE10224170A1 (en) * 2002-05-31 2003-12-11 Desitin Arzneimittel Gmbh Retarded release pharmaceutical composition, obtained without use of organic solvents or water by densifying mixture of active agent and retarding polymer in heated rollers
RU2210360C1 (en) * 2002-09-19 2003-08-20 Общество С Ограниченной Ответственностью "Консорциум-Пик" Psychotropic agent
JP2008126189A (en) * 2006-11-24 2008-06-05 Hiroyuki Hoshino Electrostatic field type hydrogen ion reduction apparatus
RU2347523C2 (en) * 2007-10-29 2009-02-27 Государственное учреждение здравоохранения "Свердловская областная клиническая больница N 1" (СОКБ N1) Method for assessment of focal tick-borne encephalitis patient condition severity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2091366C1 (en) * 1992-06-16 1997-09-27 Инесса Ивановна Крицкая Bicyclo (2,2,2) octane-2-carboxylic acid sodium salt having anticonvulsion activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEPURNOV S A ET AL: "Sacricin - new antiepileptic drug", EPILEPSIA, RAVEN PRESS LTD, NEW YORK, US, vol. 40, no. Suppl.2, 1 February 1999 (1999-02-01), pages 127, XP009161496, ISSN: 0013-9580 *
See also references of WO2010071872A2 *

Also Published As

Publication number Publication date
IL213609A (en) 2016-08-31
CN102300573A (en) 2011-12-28
MX2011006576A (en) 2011-11-04
US9943493B2 (en) 2018-04-17
KR20170043678A (en) 2017-04-21
WO2010071872A3 (en) 2010-11-25
KR101840178B1 (en) 2018-03-19
KR20110116135A (en) 2011-10-25
JP6108423B2 (en) 2017-04-05
RU2015103607A (en) 2015-06-20
IL213609A0 (en) 2011-07-31
CN106309418A (en) 2017-01-11
US20110313037A1 (en) 2011-12-22
RU2011127331A (en) 2013-01-27
RU2015103607A3 (en) 2018-10-01
CA2747803A1 (en) 2010-06-24
IL246841A0 (en) 2016-08-31
AU2009327316A1 (en) 2011-07-07
AU2009327316B2 (en) 2015-06-04
EP2396002A2 (en) 2011-12-21
MX341241B (en) 2016-08-08
WO2010071872A2 (en) 2010-06-24
US20180200211A1 (en) 2018-07-19
EP2396002B1 (en) 2020-07-29
RU2691406C2 (en) 2019-06-13
US20170000750A1 (en) 2017-01-05
IL246841B (en) 2020-04-30
CA3075760C (en) 2021-09-07
US10966944B2 (en) 2021-04-06
JP2012512913A (en) 2012-06-07
US10751307B2 (en) 2020-08-25
RU2545876C2 (en) 2015-04-10
US20200215008A1 (en) 2020-07-09
CA2747803C (en) 2020-05-05
CA3075760A1 (en) 2010-06-24

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