EP2391420A1 - Système pour moduler une perfusion dans la microcirculation sanguine - Google Patents

Système pour moduler une perfusion dans la microcirculation sanguine

Info

Publication number
EP2391420A1
EP2391420A1 EP10701028A EP10701028A EP2391420A1 EP 2391420 A1 EP2391420 A1 EP 2391420A1 EP 10701028 A EP10701028 A EP 10701028A EP 10701028 A EP10701028 A EP 10701028A EP 2391420 A1 EP2391420 A1 EP 2391420A1
Authority
EP
European Patent Office
Prior art keywords
pulse
pulses
infrared
seconds
massage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP10701028A
Other languages
German (de)
English (en)
Inventor
Peter Gleim
Rainer Klopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP10701028A priority Critical patent/EP2391420A1/fr
Publication of EP2391420A1 publication Critical patent/EP2391420A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0078—Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01—Constructive details
    • A61H2201/0119—Support for the device
    • A61H2201/0138—Support for the device incorporated in furniture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2203/00—Additional characteristics concerning the patient
    • A61H2203/04—Position of the patient
    • A61H2203/0443—Position of the patient substantially horizontal
    • A61H2203/0456—Supine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2203/00—Additional characteristics concerning the patient
    • A61H2203/04—Position of the patient
    • A61H2203/0443—Position of the patient substantially horizontal
    • A61H2203/0468—Prone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared

Definitions

  • the invention relates to a device for Perfusionsmoduiation in the microcirculation of the blood.
  • WO 2008/025731 describes a device for generating a pulsed electromagnetic field with periodic pulses with rising and falling envelopes as a function of certain measurement data of the microcirculation of the blood.
  • the object of the invention is to provide a device which is suitable for significantly increasing the microcirculation of the blood.
  • a device for perfusion modulation in the microcirculation of the blood consists of a first device for generating a pulsating electromagnetic field, comprising at least one pulse generator and a magnetic coil, with a pulse train of at least two simultaneous or time-shifted pulse groups, wherein for the first pulse group, the pulse time 0 , 1 to 0.2 seconds is at a magnetic flux density of 35 to 100 ⁇ T, and for the second pulse group, the pulse time is 10 to 30 seconds at a magnetic flux density of 2 to 40 ⁇ T; a second device for conveying the lymph stream, are triggered by the massage impulses via a massage device, wherein the massage arrangement comprises a plurality of superimposed circles of horizontally juxtaposed compression chambers in which via a pulse generator and one or more connected thereto pump gradient-shaped pressure pulses for the Compression chambers in one half of the circle and gradient-shaped falling pressure pulses for the chambers in the other half of the circle are to be triggered; a third device for dispensing Infrared radiation emitting
  • the functional state of an organ is essentially determined by the functional state of its microcirculation. It is generally accepted today that most functional disorders or diseased states of the organs are determined by microcirculatory disturbances, if not even triggered, at least in their course. Microcirculatory disorders often arise in the wake of macrocirculatory disorders and can gradually develop their own dynamics, which, regardless of macrocirculatory events, significantly influence or even dominate the course of the disease. Without corresponding involvement of the microcirculation, i. the transport processes in the area of
  • Microvessels no functional enhancements, healing or restitution processes in the organs are possible. If at all, restrictive microcirculation can, at best, temporarily, to a small extent, affect interference or disease symptoms. The influence of microcirculation is therefore of particular importance.
  • the first device for generating a pulsating electromagnetic field consists of at least one pulse generator and at least one coil connected thereto.
  • the coil is advantageously a sheet-like structure, preferably a mat, for generating the electromagnetic field.
  • This assembly comprises a plurality of circular or rectangular coils arranged side by side or partially overlapping, through which the electromagnetic pulses or pulse groups are transmitted to a user's skin surface which is in close contact therewith.
  • the coil may also be placed in an intensive hand applicator, thus occupying a relatively small area of 20-150 cm 2 , to allow for localized applications.
  • "simultaneous pulse group” means a passing base signal of the second pulse group of, for example, 2 to 40 ⁇ T and a higher additional signal of 35 to 100 ⁇ T of the first pulse group superposed at intervals of 10 to 30 seconds, preferably 10 to 20 seconds the pulse time of the additional signal is only 0, 1 to 0.2 seconds
  • the additional signal is in any case at least 10 ⁇ T and at most 90 ⁇ T above the base signal.
  • Time-shifted pulse group 1 means a base signal of the second pulse group aborted after 10 to 30 seconds, an additional signal of 0.1 - 0.2 seconds of the first pulse group immediately following an immediate renewed basic signal, and then a renewed additional signal and repetitions of this sequences.
  • the pulse train of the first device consists of pulse groups, which are assigned a pulse time and a magnetic flux density.
  • the pulse rate of a first pulse group is preferably 0.1 to 0.2 seconds at a magnetic flux density of 40 to 90 ⁇ T.
  • This first pulse group preferably occurs alternately with a second pulse group.
  • the pulse time of the second pulse group is preferably 10 to 20 seconds, in particular 15 to 20 seconds.
  • the magnetic flux density of the second pulse group is preferably 5 to 34 ⁇ T.
  • the first pulse group occurs two to six times per minute, in particular two to four times, particularly preferably two to three times.
  • the pulse sequences consist of individual pulses whose amplitudes follow, for example, an exponential function.
  • the individual pulses then have a profile approximately as in FIG 995463 B1.
  • the individual impulses can also have non-exponential curves, in that they represent rising and falling curve curves with harmonic or anharmonic oscillation sequence, as in WO 2008/025731.
  • Aitemierende pulse groups with such waveforms are shown for example in Fig. 4c to 4f in WO 2008/025731. Pulse- Groups with single-cell pulses whose amplitude corresponds to an e-function are preferred for the present invention.
  • a particularly preferred embodiment of the invention is when the second pulse group with about 9 - 22 ⁇ T over a period of about 15 to 25 seconds occurs and alternately soificatimpuise for 0.1 - 0.2 seconds of a Impuisrios of 30 -. 45 ⁇ T occur and this alternating sequence is delivered for a total period of 4 to 20 minutes from the first device.
  • the pulses are delivered via a pulse generator with connected Spulena ⁇ owski in the form of a mat and are controlled by the control unit.
  • the person to be treated lies on the mat with a small distance of 5 - 20 mm to the coil arrangements.
  • the pulses of the second pulse group may be two to three times and thus at 6 - 70 ⁇ T, in particular 30 - 68 ⁇ T during the additional pulses of the first pulse group are 60-95 ⁇ T, in particular 80-95 ⁇ T, and the latter are at least 10 ⁇ T difference over that of the second impuis group.
  • the coil arrangement may be realized in such a way that one or more flat
  • Coils which may be circular or rectangular, are distributed in a planar element, such as a mat next to each other or partially overlapping. Such a mat or cuff is then brought into contact with a part of the human body.
  • the coil arrangement can also be designed as a small-area manual or intensive applicator, which is guided over the skin surface.
  • the frequency is preferably in the range of 8-40 Hz.
  • the second device relates to the transport of the lymph stream.
  • the microcirculation is closely linked to the initial lymphatic flow with its transcapillary fluid exchange in the capillary flow area.
  • lymphatic flow is a "one-way street.”
  • a preferred second device of the invention is therefore in massage arrangements within a body-fitted cuff, e.g. for one leg.
  • the massage arrangements are e.g. individual compression chambers, which are arranged horizontally next to each other and vertically (from bottom to top) one above the other in circular planes.
  • the chambers are connected in series and are operated by compressed air or a liquid pressure system.
  • the adjacent chambers form a circle, eg a circle of 7 chambers.
  • the pressure can be increased by means of a pulse generator and one or more connected pumps from chamber 1 to chamber 7, or it can be built in one half of the circle from chamber 1 to chamber 4 (overrun phase) and from chamber 5 to 7 again be degraded (relaxation phase), ie the chambers are controlled one after the other with different pressures via a control unit.
  • This first circle is at the end of the cuff at the ankle.
  • the next circle above in the direction of the knee / thigh again has several chambers next to each other. Further circles in the cuff follow eg to the end of the thigh.
  • the pressure is applied successively from the first circle to the last circle from distal to proximal and always within the circle with gradient-shaped pushing and Entspa ⁇ ungsphase, the pressure for each
  • Massage circle can be individually controlled stronger or weaker, as a rule, the pressure in the massage circles is successively increased from one circle level to the next from distal to proximal.
  • each circuit is assigned a pump.
  • the same pumps can then take over the action phase in the next circle.
  • it can also be provided for each chamber, a special pump and then controlled by the pulse generator.
  • the function of the second device for the conveyance of lymphatic flow takes place over a period of 5 to 20 minutes.
  • the force exerted via the pressure chambers generally corresponds to the force that is also used in manual lymphatic drainage.
  • the force is in the range of 2 to 65 N, based on the skin surface.
  • the force is in the pressure chambers, which come into contact with the lower extremities, at 2 to 35 N in the relaxation phase and 10 to 65 N in the overrun phase.
  • the force is preferably 2 to 20 N in the relaxation phase and 5 to 35 N in the shear phase. This is based on a skin area of about 18 x 18 cm each.
  • the chambers are to be designed according to the force absorption.
  • the clock for the pressure build-up achieved by pumping is adapted to the rate of vasomotion. Therefore, 2-4 push / relax phases are performed per minute.
  • the control of the pressures in the form of thrust and relaxation phase in the sequence of chambers within a circular level and the design of different pressures (strength) in the upper and lower extremities is a completely new principle of action and is a manual lymph drainage and so far on the market clearly superior to equipment for intermittent compression (AIK).
  • the invention therefore also relates to a Massagevorrichtu ⁇ g for the transport of the lymph stream, which is characterized in that in a flat structure massage arrangements, for example, 21; 22; 23; 24 horizontally next to each other and vertika!
  • a pulse generator and a pump control device 35 are arranged one above the other in several circular planes, in which via a pulse generator and a pump control device 35 a plurality of pumps connected thereto, for example 31; 33 gradient-shaped rising pressure pulses for the chambers 21; 23 in one half of the circle and over the pumps for example 32; 34 gradient-shaped falling pressure pulses for the chambers 22; 24 in the other half of the circle are triggered.
  • the function of the second device as well as the first and third takes place
  • the evaluation of the stimulation of the (initial) lymph stream is carried out by recognized criteria for characterizing the microcirculation of the blood such as number of blood cell perfu ⁇ d striv nodes in the defined microvessel network (nNP), changes in venular flow ( ⁇ Qven), venolen learnede oxygen exhaustion (ApO 2 ) and about the flow of the initial lymph ( ⁇ QL).
  • recognized criteria for characterizing the microcirculation of the blood such as number of blood cell perfu ⁇ d striving nodes in the defined microvessel network (nNP), changes in venular flow ( ⁇ Qven), venolen learnede oxygen exhaustion (ApO 2 ) and about the flow of the initial lymph ( ⁇ QL).
  • the absolute difference in oxygen saturation of hemoglobin in the afferent arterioles and efferent venules of the network of a selected tissue target is determined.
  • the target is tissue sections of the skin or intestine, which have the targeted blood vessel networks of the organism and are further among the immunologically active organs, and which are further easily accessible for non-invasive measurements selected.
  • nNP The number of blood cell-perfused nodal points in the defined microvascular network, nNP, is the number of blood cell-perfused branching sites in this network used as a measure of the distribution state of the blood.
  • the venular flow flow Qven and the arteriolar flow flow Qart is the particle flow (blood cell flow) in defined venules or arterioles. It is stated in ⁇ m 3 / s. In a lymphatic drainage according to the invention over 15 minutes, for example, there is an increase in nNP of 15% after about 20 minutes, which then slowly drops again. ApO 2 and ⁇ Qven increase to about 10% in 10 minutes and then decrease again.
  • the percent increase with the first device alone is about 1%, with the second device alone about 15% and with both about 22%.
  • the percent increase with only the first device is about 5%, with the second device alone about 10% and with both about 18%.
  • the percent increase with the first device alone is about 2.5%, with the second device being about 11% and with both about 20%.
  • the percentage increase with the first device alone is about 9%, with the second device alone about 10% and with both about 31%.
  • the third device in the context of the device according to the invention relates to a device for emitting infrared radiation.
  • Thermal radiation in the narrower sense refers to that part of the spectrum of electromagnetic waves that is outside the range of visible light in the longer-wave infrared. Electromagnetic waves with wavelengths ⁇ > 780 Na ⁇ ometer are referred to as infrared rays. The essence of the emission of thermal radiation is a conversion of thermal energy into radiant energy.
  • the wavelengths of the temperature radiation of a solid form a continuous spectrum (eg solar spectrum). The focus of radiation is on low temperatures in the range of long wavelengths (infrared), at higher temperatures in the range of shorter wavelengths.
  • infrared A wavelength 800-1400 nm, penetration depth into the skin up to 6 mm
  • Infrared B wavelength 1400 - 3000 ⁇ m, penetration into the skin up to 2 mm
  • Infrared C wavelength 3000 - 10 000 nm, penetration into the skin up to 1 mm.
  • absorption in which some of the incident radiation enters the tissue and is absorbed
  • Reflection in which a part of the incident radiation is reflected from the surface in accordance with the law of reflection.
  • reaction rate temperature rule For the course of biochemical reactions, a relationship between temperature and metabolic activity has long been known as the "reaction rate temperature rule, RGT rule.” Thereafter, the rate of biochemical reactions increases (Intensity of metabolism) at a temperature increase of 10 D C to 2 to 3 times. In detail, however, the manifold networked metabolic processes in heat supply are not yet sufficiently researched.
  • Red blood cell desaggregation as a result of increased flow rates Improves blood flow properties in dermal tissue for more favorable microhemodynamic conditions for an unimpeded first immune response (influx and distribution of white blood cells in the skin microvascular networks, rolling phenomena and adhesions on the skin)
  • a suitable third device for emitting infrared radiation is one which emits heat pulses whose spectrum corresponds to that of natural sunlight after passing through the air envelope of the earth. This infrared spectrum consists of about 80% infrared A 1 19% infrared B and about 1% infrared C. Industrial area radiators with only about 5% proportion of infrared A are not suitable.
  • a third device whose spectrum consists essentially of 90% infrared A, 9% infrared B and 1% infrared C, in particular 100% infrared A.
  • a preferred wavelength is 940 nm.
  • the energy input into the skin tissue must be homogeneous, in order to avoid unwanted mutual influences of the closely networked microvessels in the skin tissue and thus local "irritation" of the warm receptors in the skin.
  • the operation of the third apparatus is therefore greatly influenced by the ambient conditions, especially from site temperature aiigemei ⁇ in the range of 18 - 25 should be C ⁇ to generate a comfortable temperature for the patient.
  • a stimulation of the microcirculation by an increased venular effluent with simultaneous extended distribution of the blood in the capillary networks can only be achieved if the interaction of local and nervous controls of the skin circulation can be physiologically favorably influenced.
  • the third device it is necessary for the third device to emit a heat radiation pulse at a distance of 0.15-0.40 m from the irradiated skin tissue, which irradiates an increase in the mean temperature of the radiation at a radiation duration of 10 to 30 minutes
  • Skin field reaches 2 to 5 0 C. This can be done with a hand-held applicator with a
  • Radiating surface of 50 x 50 mm which is filled with about 40 infrared A diodes and achieves a radiated power of 0.6 W.
  • a surface applicator with a radiation area of 109 ⁇ 270 mm, which is filled with infrared A diodes at approximately the same density as the hand applicator, and which achieves a radiated power of 5.3 W .
  • Several surface applicators can be combined with each other. In order to achieve a homogeneous energy input to the skin tissue, the distances to the skin surface must be observed in accordance with the radiation set. Since the energy per area decreases with the square of the distance from the radiation source, inhomogeneous fields can form on skin surfaces with small radii of curvature.
  • a semicircular curved realization of the third device with a length which corresponds approximately to the length of a human body (100 - 200 cm).
  • Another embodiment relates to plate-shaped third devices, in which a
  • Plate is arranged horizontally and e.g. two plates are arranged on the left and right of the horizontal plate at an angle of 30-60 ° inclined to the tissue surface to be irradiated.
  • 120-200 diodes may be arranged per panel (luminescent area), preferably 150-170 diodes, such that the three pivotable panels have a total of preferably 450-510 diodes.
  • the modulation of the heat pulse in the form of the luminance in candela (cd) is preferably carried out with a digitally processed signal of the first device for generating a pulsating electromagnetic field and thus according to the pulse sequences as in this first device.
  • a digitally processed signal of the first device for generating a pulsating electromagnetic field and thus according to the pulse sequences as in this first device.
  • the percent increase with only the first device is about 7% for another subject group, about 14% for the third device alone, and about 25% for both.
  • the percent increase with the first device alone is about 5%, with the third device alone about 13% and with both about 22%.
  • the percent increase with only the first device is about 5%, with the third device alone about 12% and with both about 28%.
  • ApO 2 is about 28% for a combination of the first and third devices as stated above.
  • the second device alone results in about 3% improvement. All three devices together give about 37% for ⁇ pO 2
  • the tests particularly those made with a combination of the first and second devices and the first, second and third devices, show that macrocirculatory changes are also achievable due to a physiologically favorable influence of the venous return flow in the right atrium clues.
  • the pressure difference between the right atrium and the vena cava is about 5% for the combination in a panel of volunteers, while the individual devices in total remain below 4%.
  • the flat structure is preferably a leg cuff with compression chambers as massage arrangements. Further advantageous embodiments are described in the above-mentioned second device.
  • FIG. 1 Schematic representation of the applications of the device on
  • FIG. 2 Schematic representation of a device for conveying the lymph stream in cuff form
  • FIG. 3 Presentation of the pressure in the massage circle
  • Fig. 4b device for infrared radiation (plates)
  • Fig. 5 Diagram showing venous side acid release from apO 2 after treatment with first and second device.
  • Fig. 6 Diagram for changing the flow flow of the initial lymph ⁇ Q L after
  • FIG. 7 Diagram for venous side oxygen utilization ApO 3 after treatment with first and third device.
  • Fig. 8 Diagram for venous side oxygen utilization ApO 2 after treatment with first, second and third device
  • FIG. 1 the individual devices in the device for perfusion modulation of the microcirculation of the blood are shown schematically.
  • the device for generating a pulsating electromagnetic field is shown as a mat 1.
  • one or more coils are arranged, which are connected to a pulse generator (not shown).
  • Reference numeral 2 indicates the range for the action of the lymph flow transport device.
  • the device itself is e.g. realized in the form of a Bei ⁇ manschette, which can reach to the hip of the patient.
  • Also indicated by reference numeral 3 is an area, namely the area for the action of the device for emitting infrared radiation.
  • the device itself is e.g. realized according to Fig. 4a or Fig. 4b.
  • the three devices are coordinated via a control unit 4 which controls different combinations of the devices with each other and optionally the pulses emitted by each device to the body surface of a patient.
  • FIG. 2 shows the second device for conveying the lymph stream in the form of a collagen.
  • Several horizontal juxtaposed massage arrangements in the form of chambers are controlled by a pump control unit 35 of the pumps 31 and 32 to successively with different pressures (on and off according to the intended clock sequence descending). Thereafter, the further proximal chambers 23 and 24 (and the other chambers in this county level) are acted upon by rising and falling pressures, so that there is a push phase and a relaxation phase in the circular plane.
  • the total pressure increases from distal to proximal, i. each circle level starts with a slightly higher pressure than the previous circle level.
  • Fig. 3 the course of the pressure in a massage circle is shown schematically.
  • the massage arrangement here consists of 16 chambers in which the massage pressure is increased in the left half of the circle with the chambers 1 to 8 and in the chambers of the right half of the circle corresponding to the shortened arrows in the chambers 9 to 16, the massage pressure is designed slowly sloping.
  • the leg cuff according to the invention encloses the lower extremities and can be controlled in these two parts with different forces, as stated above.
  • Test 1 Use of the first device (BEMER 3000 plus, manufactured by Innomed AG, Liechtenstein) with pulse groups of 12 ⁇ T for 20 seconds alternately with pulse groups of 35 ⁇ T for 0.12 seconds on a body-sized mat on which the subjects were lying prone. Test time 10 minutes; Frequency 33 Hz.
  • Test 2 Use of the second device as two leg cuffs, each with 5 massage circles arranged one above the other. Each circle contains 7 - 9 chambers. Control of pressure pulses (air) in 3 phases per minute. The on the Skin surface force is 2 - 35 N in the relaxation phase and 10 - 65 N in the shear phase; Test time 15 minutes.
  • Test 3 use of both devices immediately one after the other with 0.5 min break between them.
  • microcirculation values are measured on the subcutis (thigh, flexor side) at intervals of 10 minutes for an observation time of 120 minutes.
  • Additional pulse of the first pulse group 0.15 seconds at 45 ⁇ T.
  • Example 3 Basic pulse of the second pulse group at 33 ⁇ T for 18 seconds;
  • Fig. 4a shows a preferred variant of the third device for emitting infrared radiation.
  • the device may be formed as a semicircle or as a smaller pitch circle be.
  • the inside of the semicircle is fitted with a series of infrared A-diodes, which allow for an overall increase in skin temperature of up to 8 D C at an average distance of 20 cm from the body surface of a subject.
  • Test 1 Use of the first device (BEMER 3000 plus, manufactured by Innomed AG, Liechtenstein) with pulse groups of 12 ⁇ T for 20 seconds alternating with pulse groups of 44 ⁇ T for 0.12 seconds on a body-sized mat on which the subjects were lying prone Test time 10 minutes, frequency 33 Hz.
  • Test 2 Use of the third device with predominantly infrared A radiation for a period of 10 minutes on the thigh (flexor side) while lying in prone position.
  • Test 3 Use of both devices simultaneously.
  • microcirculation values are measured on the subcutis (thigh, flexor side) at 5 minute intervals.
  • Example 5 In a manner similar to Example 4, Test 1 was carried out with the following changes: Example 5
  • Test 1 Use of the first device (device BEMER 3000 plus, manufacturer Innomed AG, Liechtenstein) with pulse groups of 12 ⁇ T for 20 seconds alternating with
  • Test 2 Use of the third device with predominantly infrared A radiation for a period of 10 minutes on the thigh (flexor side) while lying in
  • Test 3 Use of both devices simultaneously.
  • Test 4 Use of the second device as two Beinmanschette ⁇ each with 5 superposed massage circles. Each circle contains 7 - 9 chambers. Control of pressure pulses (air) in 3 phases per minute. The force acting on the skin surface is 2 - 35 N in the relaxation phase and 10 - 65 N in the shear phase; Test time 15 minutes.
  • Test 5 Use of the first and third devices simultaneously and the second
  • microcirculation values are measured on the subcutis (thigh, flexor side) at intervals of 5 minutes.
  • Example 8 The procedure was as in Example 7, whereby all three devices gave impulses simultaneously in test 5. ⁇ pO 2 was about 40%.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rehabilitation Therapy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Massaging Devices (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L'invention concerne un système pour moduler une perfusion dans la microcirculation sanguine. Ce système comprend un premier dispositif conçu pour générer un champ électromagnétique pulsé comportant une série d'impulsions spécifiques synchrones ou asynchrones d'un champ électromagnétique périodique, qui comprend un premier groupe d'impulsions d'une durée d'impulsion comprise entre 0,1 et 0,2 secondes pour 35-100 µT et un deuxième groupe d'impulsions d'une durée d'impulsion comprise entre 10 et 20 secondes pour 2-40 µT, un deuxième dispositif conçu pour stimuler la circulation lymphatique et qui sert à créer des impulsions de massage par des pressions d'intensité croissante et décroissante, par l'intermédiaire de plusieurs dispositifs de massage juxtaposés, ainsi qu'un troisième dispositif destiné à appliquer un rayonnement infrarouge et qui émet au moins une impulsion thermique, et une unité de commande conçue pour commander les impulsions des trois dispositifs de manière que deux ou trois dispositifs émettent des impulsions simultanément. Le système selon l'invention permet d'améliorer de manière significative des paramètres de la microcirculation et de la macrocirculation sanguines.
EP10701028A 2009-01-29 2010-01-26 Système pour moduler une perfusion dans la microcirculation sanguine Ceased EP2391420A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10701028A EP2391420A1 (fr) 2009-01-29 2010-01-26 Système pour moduler une perfusion dans la microcirculation sanguine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09151615 2009-01-29
EP10701028A EP2391420A1 (fr) 2009-01-29 2010-01-26 Système pour moduler une perfusion dans la microcirculation sanguine
PCT/EP2010/050852 WO2010086301A1 (fr) 2009-01-29 2010-01-26 Système pour moduler une perfusion dans la microcirculation sanguine

Publications (1)

Publication Number Publication Date
EP2391420A1 true EP2391420A1 (fr) 2011-12-07

Family

ID=40668253

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10701028A Ceased EP2391420A1 (fr) 2009-01-29 2010-01-26 Système pour moduler une perfusion dans la microcirculation sanguine

Country Status (10)

Country Link
US (1) US20110313235A1 (fr)
EP (1) EP2391420A1 (fr)
JP (1) JP2012516170A (fr)
KR (1) KR20110110820A (fr)
CN (1) CN102438699A (fr)
AU (1) AU2010209776A1 (fr)
BR (1) BRPI1007512A2 (fr)
CA (1) CA2750468A1 (fr)
WO (1) WO2010086301A1 (fr)
ZA (1) ZA201104908B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013017586A1 (de) 2013-10-17 2015-05-07 Turbolite Vertriebs Gmbh BEHANDLUNGSGERÄT für magnetfeldunterstützte BESTRAHLUNGSTHERAPIEN

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11794040B2 (en) 2010-01-19 2023-10-24 The Board Of Regents Of The University Of Texas System Apparatuses and systems for generating high-frequency shockwaves, and methods of use
JP5752436B2 (ja) * 2011-02-21 2015-07-22 ファミリー・サービス・エイコー株式会社 磁気治療器
AR087170A1 (es) 2011-07-15 2014-02-26 Univ Texas Aparato para generar ondas de choque terapeuticas y sus aplicaciones
CA2965866A1 (fr) * 2013-12-05 2015-06-11 Veriskin, Inc. Dispositif de surveillance d'une perfusion cutanee
JP6383945B2 (ja) 2014-11-11 2018-09-05 株式会社テクノリンク 生体刺激装置
WO2016187136A1 (fr) * 2015-05-15 2016-11-24 Veriskin, Inc. Dispositif de surveillance de flux sanguin cutané
TWI742110B (zh) 2016-07-21 2021-10-11 美商席利通公司 具備改良電極壽命之快速脈波電動液壓脈衝產生裝置及使用該裝置生成壓縮聲波之方法
KR102587035B1 (ko) 2017-02-19 2023-10-10 솔리톤, 인코포레이티드 생물학적 매체 내의 선택적 레이저 유도 광학 파괴
DE202018002413U1 (de) * 2018-05-17 2018-08-23 Booster Germany GmbH i. Gr. Therapie-Gerät mit kurzwelligen Infrarot und pulsierenden Magentfeldern
US11020603B2 (en) 2019-05-06 2021-06-01 Kamran Ansari Systems and methods of modulating electrical impulses in an animal brain using arrays of planar coils configured to generate pulsed electromagnetic fields and integrated into clothing
AU2020267399A1 (en) 2019-05-06 2021-12-02 Kamran Ansari Therapeutic arrays of planar coils configured to generate pulsed electromagnetic fields and integrated into clothing

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8532628U1 (de) * 1985-11-19 1986-04-17 Elec Elektronische Bauteile und Geräte GmbH, 6209 Heidenrod Kombiniertes Magnetfeld-Infrarot-Behandlungsgerät
US5282467A (en) * 1992-08-13 1994-02-01 Duke University Non-invasive method for detecting deep venous thrombosis in the human body
DE4431661A1 (de) * 1994-09-06 1996-03-07 Kaufmann Walter Magnetfeldunterbett mit Vibrationsmassage und Entstörung
US5788647A (en) * 1997-01-24 1998-08-04 Eggers; Philip E. Method, system and apparatus for evaluating hemodynamic parameters
DE29703132U1 (de) * 1997-02-21 1997-08-07 Schipke, Ulf, 93133 Burglengenfeld Vorrichtung
EP0995463B1 (fr) 1998-10-21 2001-08-16 Wolf. A. Prof. Kafka Appareil appliquant des signaux électriques ou électromagnétiques pour influencer des processus biologiques
DE10149418A1 (de) * 2001-10-02 2003-04-17 Norbert Egger Fitnessgerät
US8303511B2 (en) * 2002-09-26 2012-11-06 Pacesetter, Inc. Implantable pressure transducer system optimized for reduced thrombosis effect
DE202004002685U1 (de) * 2004-02-20 2004-05-06 Hörnstein, Karin Multifunktionales medizinisches elektrotechnisches Gerät
DE102006041365B4 (de) * 2006-08-28 2010-09-02 Peter Gleim Vorrichtung zur Erzeugung eines pulsierenden elektromagnetischen Feldes mit Impulssteuerung
US8147395B2 (en) * 2006-11-28 2012-04-03 Gregory S. Anderson Bone-activity stimulation apparatus and method
DE202006019324U1 (de) * 2006-12-22 2007-03-08 Biro, Stephan Vorrichtung zur therapeutischen und/oder kosmetischen Behandlung einer Körperzone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2010086301A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013017586A1 (de) 2013-10-17 2015-05-07 Turbolite Vertriebs Gmbh BEHANDLUNGSGERÄT für magnetfeldunterstützte BESTRAHLUNGSTHERAPIEN

Also Published As

Publication number Publication date
KR20110110820A (ko) 2011-10-07
CA2750468A1 (fr) 2010-08-05
ZA201104908B (en) 2012-03-28
US20110313235A1 (en) 2011-12-22
BRPI1007512A2 (pt) 2016-02-23
JP2012516170A (ja) 2012-07-19
WO2010086301A1 (fr) 2010-08-05
AU2010209776A1 (en) 2011-07-28
CN102438699A (zh) 2012-05-02

Similar Documents

Publication Publication Date Title
EP2391420A1 (fr) Système pour moduler une perfusion dans la microcirculation sanguine
EP3513836B1 (fr) Applicateur de champ magnétique à une allure de signal des courants de bobine utilisés en forme de rampe
DE69434666T2 (de) Vorrichtung zur elektrischen nervenstimulation
DE60111388T2 (de) Vorrichtung zur behandlung von vaskulären und orthopädischen krankheiten mittels abgabe von elektrischen impulsen auf die haut zur modulierung des neurovegetativen systems
DE102012005030B4 (de) Vorrichtung und Verfahren zur Stimulation mit Thermoreizen
EP2470265B1 (fr) Dispositif de stimulation de mécanismes autorégulateurs locaux et supérieurs de l'homéostasie de l'organisme
DE69924494T2 (de) Verfahren und vorrichtung zum stimulieren des immunsystems und zum generieren des heilprozesses auf zellenniveau
EP2676700A2 (fr) Procédé et dispositif pour la rééducation du plancher pelvien assistée par une machine
DE69227814T2 (de) Vorrichtung zur Regelung und Verbesserung des Entwicklungs- und Lebenserhaltungszustands lebender Organismen
EP2470266B1 (fr) Dispositif de stimulation de mécanismes autorégulateurs de l'homéostasie de l'organisme
EP3946576A1 (fr) Dispositif de luminothérapie de biostimulation
DE1239089B (de) Verfahren zur Erhoehung der Absorptionsfaehigkeit von Kollagenerzeugnissen im lebenden Koerper
DE102006001598A1 (de) Resorbierbare Akupunkturnadel
Skorykh et al. Using biophysical methods in sheep breading
DE102018104515A1 (de) Vorrichtung zur transkraniellen Magnetstimulation
WO2019121622A1 (fr) Dispositif et procédé pour stimuler la régulation locale de la microcirculation
AT510790B1 (de) Verfahren zur kosmetischen behandlung
DE102004024655A1 (de) Arbeitsverfahren zum Betreiben einer Vorrichtung zur Probanden-Stimulation mittels zeitveränderlicher Mikroströme und/oder Magnetfelder und/oder Licht sowie zugehörige Vorrichtung
DE19914979A1 (de) Vorrichtung und Verfahren zur Reduzierung von Fettgewebe
Dae-Kyoo The Effect of Simultaneous treatment with acupuncture, herb medication and non-invasive laser irradiation of blood vessel on headache
DE69821235T2 (de) Vorrichtung zur ehf punktion (oder therapie mit millimetrischen wellenlängen)
Dobšák Neuro-muscular Electrical Stimulation (NMES) in Rehabilitation of Chronic Diseases
DE19904383C2 (de) Verfahren zum Reizen einer einem Pathologiegebiet zugeordneten Reflexzone sowie Vorrichtung zum Durchführen des Verfahrens
DE202018002313U1 (de) Vorrichtung für die kosmetische Ultraschallbehandlung
DE2828097B1 (de) Moebel zum Entspannen des menschlichen Koerpers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110829

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20121105

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20121223