EP2340245A4 - A novel betaine cocrystal of epalrestat - Google Patents

A novel betaine cocrystal of epalrestat

Info

Publication number
EP2340245A4
EP2340245A4 EP09801070A EP09801070A EP2340245A4 EP 2340245 A4 EP2340245 A4 EP 2340245A4 EP 09801070 A EP09801070 A EP 09801070A EP 09801070 A EP09801070 A EP 09801070A EP 2340245 A4 EP2340245 A4 EP 2340245A4
Authority
EP
European Patent Office
Prior art keywords
epalrestat
novel betaine
betaine cocrystal
cocrystal
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09801070A
Other languages
German (de)
French (fr)
Other versions
EP2340245A2 (en
Inventor
Isabel Kalofonos
Patrick G Stahly
William Martin-Doyle
Dimitris Kalofonos
Jeffrey S Stults
Travis L Houston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bionevia Pharmaceuticals Inc
Original Assignee
Bionevia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionevia Pharmaceuticals Inc filed Critical Bionevia Pharmaceuticals Inc
Publication of EP2340245A2 publication Critical patent/EP2340245A2/en
Publication of EP2340245A4 publication Critical patent/EP2340245A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
EP09801070A 2008-07-25 2009-07-24 A novel betaine cocrystal of epalrestat Withdrawn EP2340245A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8361908P 2008-07-25 2008-07-25
PCT/US2009/051693 WO2010011926A2 (en) 2008-07-25 2009-07-24 A novel betaine cocrystal of epalrestat

Publications (2)

Publication Number Publication Date
EP2340245A2 EP2340245A2 (en) 2011-07-06
EP2340245A4 true EP2340245A4 (en) 2011-09-28

Family

ID=41570882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09801070A Withdrawn EP2340245A4 (en) 2008-07-25 2009-07-24 A novel betaine cocrystal of epalrestat

Country Status (3)

Country Link
EP (1) EP2340245A4 (en)
EA (1) EA018905B1 (en)
WO (1) WO2010011926A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697735B2 (en) 2008-07-25 2014-04-15 Bionevia Pharmaceuticals, Inc. Solid forms of epalrestat
PL2326632T3 (en) 2008-09-06 2017-10-31 Bionevia Pharmaceuticals Inc Novel choline cocrystal of epalrestat
WO2012100208A1 (en) 2011-01-20 2012-07-26 Bionevia Pharmaceuticals Inc. Modified release compositions of epalrestat or a derivative thereof and methods for using the same
ITMI20120586A1 (en) 2012-04-11 2013-10-12 Milano Politecnico CO-CRYSTALS OF 3-IODIOPROPINYL BUTYCARBAMMATE
CN113336718B (en) * 2021-06-01 2023-02-28 天津大学 Epalrestat-metformin salt and preparation method and application thereof
CN113277962B (en) * 2021-06-01 2023-02-07 天津大学 Epalrestat-metformin salt hydrate and preparation method and application thereof
CN115925650B (en) * 2022-12-13 2023-08-01 山东达因海洋生物制药股份有限公司 Epalrestat eutectic and preparation method and application thereof
CN115947699B (en) * 2023-01-16 2024-01-19 威海海洋职业学院 Epalrestat eutectic crystal taking nicotinamide as precursor and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078161A1 (en) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2007099680A (en) * 2005-10-04 2007-04-19 Konica Minolta Chemical Co Ltd Method for producing epalrestat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
JP2007516259A (en) * 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー Method for preparing mixed phase co-crystal with activator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078161A1 (en) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2007099680A (en) * 2005-10-04 2007-04-19 Konica Minolta Chemical Co Ltd Method for producing epalrestat

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTHEW L. PETERSON ET AL: "Expanding the Scope of Crystal Form Evaluation in Pharmaceu tical Science", J PHARM PHARMACEUT SCI, 1 January 2006 (2006-01-01), pages 317 - 326, XP055020303, Retrieved from the Internet <URL:http://www.ualberta.ca/~csps/JPPS9_3/Peterson/676_Final.pdf> [retrieved on 20120224] *

Also Published As

Publication number Publication date
WO2010011926A2 (en) 2010-01-28
EA018905B1 (en) 2013-11-29
EA201100246A1 (en) 2011-10-31
EP2340245A2 (en) 2011-07-06
WO2010011926A3 (en) 2010-05-27

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