EP2240153A1 - Régime de soins buccaux - Google Patents

Régime de soins buccaux

Info

Publication number
EP2240153A1
EP2240153A1 EP08769086A EP08769086A EP2240153A1 EP 2240153 A1 EP2240153 A1 EP 2240153A1 EP 08769086 A EP08769086 A EP 08769086A EP 08769086 A EP08769086 A EP 08769086A EP 2240153 A1 EP2240153 A1 EP 2240153A1
Authority
EP
European Patent Office
Prior art keywords
oral care
agent
composition
periodic
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08769086A
Other languages
German (de)
English (en)
Inventor
Richard Scott Robinson
Richard J. Sullivan
Michael Prencipe
Isabelle Van Rycke
Richard Lovell
Rajnish Kohli
Sergio Leite
Eric A. Simon
Ralph Peter Santarpia, Iii
Diane Cummins
Sarita V. Mello
Suman K. Chopra
Karen Depierro
Lynette Zaidel
Constantina Christopoulou
Ravi Subramanyam
Donghui Wu
Andre M. Morgan
Qin Wang
Gary Edward Tambs
Virginia Monsul Barnes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Colgate Palmolive Co
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/028,782 external-priority patent/US20080274065A1/en
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of EP2240153A1 publication Critical patent/EP2240153A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly. The invention optionally further comprises contacting the oral surface with a periodic oral care cleaning composition at least once monthly.
  • the periodic oral care maintenance compositions suitable for use in the method comprise a basic amino acid in free or salt form.
  • the periodic oral care cleaning compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100.000 revolutions.
  • the ratio of the first abrasive to the second abrasive is about 1 : 1.6 to about 1.6: 1.
  • the periodic oral care cleaning compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
  • the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cnvVlOOg and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions.
  • the ratio of the first abrasive to the second abrasive may be about 1 : 1.6 to about 1.6: 1.
  • the total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
  • the present invention provides a periodic oral care maintenance composition comprising a basic amino acid, in free or salt form, for use in the therapeutic treatment of an oral surface, which treatment comprises a. contacting the oral surface with a primary oral care composition at least once daily, and b. contacting the oral surface with the periodic oral care maintenance composition at least once monthly.
  • the present invention further provides a combined preparation comprising a periodic oral care maintenance composition and a primary oral care composition for the manufacture of a combined preparation for simultaneous, sequential or separate administration to a subject in the therapeutic treatment of an oral surface, wherein the oral surface is: a. contacted with the primary oral care composition at least once daily, and b. contacted the with the periodic oral care maintenance composition at least once monthly; and wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form.
  • the present invention further provides the use of a basic amino acid, in free or salt form, for the manufacture of a periodic oral care maintenance composition for the therapeutic treatment of an oral surface, which treatment comprises a. contacting the oral surface with a primary oral care composition at least once daily, and b. contacting the oral surface with the periodic oral care maintenance composition at least once monthly.
  • the present invention further provides the use of a periodic oral care maintenance composition and a primary oral care composition for the manufacture of a combined preparation for simultaneous, sequential or separate administration to a subject in the therapeutic treatment of an oral surface, wherein the oral surface is: a. contacted with the primary oral care composition at least once daily, and b. contacted the with the periodic oral care maintenance composition at least once monthly; and wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form.
  • the present invention further provides a method comprising: a. contacting an oral surface with a primary oral care composition at least once daily, and b. contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form.
  • the invention provides a regimen method of cleaning an oral surface to remove, for example, bacteria, food particles, biofilm, plaque, and/or other agents that may result in or contribute to various oral conditions, such as bad breath, poor oral health, gingivitis, gum inflammation, or periodontitis.
  • the regimen method of the invention also provides the user with a smooth, polished feel and appearance to the tooth surfaces that may be perceived as comparable to the "clean feel" experienced after a professional cleaning. Methods of maintaining oral health and/or increasing oral health are also provided.
  • the Compositions of the Invention are useful for treating oral conditions in the mouth, and to clean the oral cavity and provide improved methods of promoting oral health.
  • Enhancing oral health also provides benefits in systemic health, as the oral tissues can be gateways for systemic infections.
  • Good oral health is associated with systemic health, including cardiovascular health.
  • the compositions and methods of the invention provide particular benefits because basic amino acids, especially arginine. are sources of nitrogen which supply NO synthesis pathways and thus enhance microcirculation in the oral tissues. Providing a less acidic oral environment is also helpful in reducing gastric distress and creates an environment less favorable to Heliobactcr, which is associated with gastric ulcers.
  • Arginine in particular is required for high expression of specific immune cell receptors, for example T-cell receptors, so that arginine can enhance an effective immune response.
  • the compositions and methods of the invention are thus useful to enhance systemic health, including cardiovascular health.
  • the primary and the periodic oral care compositions may be effective upon application to the oral cavity, e.g., with brushing, to (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit pre-carious lesions of the enamel, e.g..
  • QLF quantitative light-induced fluorescence
  • ECM electrical caries measurement
  • the invention is an oral care regimen that includes contacting an oral surface with at least two oral care compositions at differing time increments.
  • the oral surface to be treated includes any within the oral cavity. Exemplary surfaces include hard tissues (e.g., teeth) and soft surfaces (e.g., gingiva and tongue).
  • the primary oral care composition may be any known or to be developed in the art and can take any form.
  • the primary oral care composition may be in the form of a rinse, paste, gel. fluid, suspension, film, patch, gum. lozenge, confectionary, or semi-solid pates or stick.
  • the primary oral care composition may be a conventional toothpaste, such as those sold under the COLGATE® trademark (Colgate- Palmolive Company, New York. New York) or under the CREST® trademark (Procter & Gamble Corporation. Cincinnati, Ohio).
  • the primary oral care composition may be any of those described in, e.g., United States Patent Nos.
  • the primary oral care composition may contain one or more agents such as humectants, solvents, thickeners, surfactants, abrasives, flavorants. colorants, viscosity and/or rheology modifiers, gums, polymers, sweeteners, etc.
  • agents such as humectants, solvents, thickeners, surfactants, abrasives, flavorants. colorants, viscosity and/or rheology modifiers, gums, polymers, sweeteners, etc.
  • agents that may be present in the primary oral care composition include an antibacterial agent, a plaque dispersion agent, an antiadhesion agent, an anticaries agent, a desensitizing agent, a flavorant, a colorant, a stannous ion agent, triclosan, triclosan monophosphate, chlorhexidine, alexidine, hexetidine, sanguinarine, benzalkonium chloride, salicylanilide, domiphen bromide, cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-e ⁇ hylpyridinium chloride, oclenidine, delmopinol, octapinol, nisin, zinc ion agent, copper ion agent, essential oils, furanones, bacteriocins, ethyl lauroyl arginate.
  • the primary oral care composition may be applied or contacted to the oral surface at least once daily. In some embodiments, the application of the primary oral care composition may be carried out two, three, four, five, six, seven times daily, or up to fifteen times daily.
  • the oral surface may be contacted to the primary oral care composition using any means known or to be developed in the art; such means may vary depending on the form of the primary oral care composition.
  • Exemplary means of contacting the primary oral care composition to the oral surface include application using an implement (such as a brush, toothbrush, stick, sponge, cotton swab), lavage, chewing, adjacent placement, and dissolution of confectionary.
  • the oral care maintenance composition is generally applied by the consumer.
  • the oral care maintenance composition is in a form selected from a mouthrinse, a toothpaste, a tooth gel, a tooth powder, a non-abrasive gel. a mousse, a foam, a mouth spray, a lozenge, an oral tablet, a varnish, or a sealant.
  • the periodic oral care maintenance composition comprises an effective amount of a basic amino acid, in free or salt form, e.g., arginine.
  • composition may further comprise an effective amount of an antibacterial agent, e.g., triclosan and /Or Zn + " ion source, e.g., zinc citrate; an effective amount of a fluoride source, e.g., a soluble fluoride salt; and/or a polymer.
  • an antibacterial agent e.g., triclosan and /Or Zn + " ion source, e.g., zinc citrate
  • a fluoride source e.g., a soluble fluoride salt
  • the antibacterial agent may be selected from halogcnated diphenyl ether (e.g. triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol. geraniol, carvacrol. citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin.
  • halogcnated diphenyl ether e.g. triclosan
  • herbal extracts and essential oils e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol. geraniol, carvacrol. citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin.
  • gallic acid miswak extract, sea- buckthorn extract
  • bisguanide antiseptics e.g., chlorhexidine, alexidine or octenidine
  • quaternary ammonium compounds e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylpyridini ⁇ m chloride (TDEPC)
  • phenolic antiseptics hexetidine.
  • octenidine e.g., sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (e.g., zinc salts, for example, zinc citrate, stannous salts, copper salts, iron salts), sanguinarine, propolis and oxygenating agents (e.g., hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phlhalic acid and its salts, monoperthalic acid and its salts and esters, ascorbyl stearate, oleoyl sarcosine, alkyl sulfate, dioctyl sulfosuccinate, salicylanilide, domiphen bromide, delmopinol, octapinol and other piperidino derivatives, irrigationn preparations, chlorite salts; and mixtures of any of the foregoing.
  • metal ions e.g., zinc salts, for example
  • the application of the oral care maintenance composition may be carried out daily, every other day. weekly, monthly or any other interval based on the oral care maintenance composition delivery form and desired end benefit.
  • the oral care delivery form is a toothpaste the use is e.g., at least daily
  • the oral care delivery form is a varnish the use is e.g., weekly or monthly.
  • the periodic oral care cleaning composition typically has a Pellicle Cleaning Ratio ("PCR") of greater than about 100, while having a Radiotracer Dentin Abrasion ("RDA") of less than about 200.
  • PCR Pellicle Cleaning Ratio
  • RDA Radiotracer Dentin Abrasion
  • the RDA is less than or equal to about 175. while still having a PCR that exceeds about 100.
  • the RDA is less than about 165.
  • the periodic oral care cleaning composition may include a first abrasive and a second abrasive; such abrasives are described in United States Publication No. 2007/0140986, the contents of which are incorporated herein by reference.
  • the periodic oral composition comprises a first abrasive having an Einlehncr hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einleliner hardness of less than about 5 mg loss per 100,000 revolutions.
  • the first particle having an Einlehner hardness of greater than about 5 mg loss per 100.000 revolutions has a primary a polishing function when it is contacted with an oral surface.
  • the second particle having an Einlehner hardness of less than about 5 mg loss per 100.000 revolutions has a primary cleaning function, as it is a softer particle.
  • the second particle has a hardness of greater than about 10 mg loss per 100.000 revolutions, and in other embodiments, greater than about 15 mg loss per 100,000 revolutions.
  • the first abrasive of the periodic oral care cleaning composition may be of a cleaning abrasive that has a hardness of less than or equal to the oral surface to be treated, and the second abrasive is a polishing abrasive that has a hardness of greater than or equal to the oral surface to be treated.
  • Each of the first abrasive and second abrasive of the periodic oral care cleaning composition has a particle size.
  • the first particle size is less than the second particle size.
  • Mean particle size can be measured, e.g., using a Malvcm Particle Size Analyzer. Model Mastersizer S. Malvem Instruments, Inc. of Southborough, Massachusetts. U.S.A.
  • the first abrasive has a mean particle size of less than about 1 1 ⁇ m, e.g., less than about 10 ⁇ m.
  • suitable abrasives have mean particle sizes ranging from about 7 ⁇ m to about 11 ⁇ m.
  • Some abrasives have particle sizes of less than about 5 ⁇ m.
  • the second abrasive has a mean particle size of greater than about 8 ⁇ m, e.g., greater than about 10 ⁇ m.
  • the second abrasive can have a mean particle size of about 8 ⁇ m to about 14 ⁇ m.
  • Suitable abrasives include without limitation, silica, silicate, silicon, alumina (including calcined aluminum oxide), aluminosilicates. such as bentonite. zeolite, kaolin, and mica, siliceous or diatomaceous earth, pumice, calcium carbonate, cuttlebone.
  • insoluble phosphates composite resins, such as melamine resin, phenolic resin, and urea-formaldehyde resin, polycarbonate, silicon carbide, boron carbide, microcrystalline wax, microcrystallinc cellulose, including combinations of colloidal microcrystalline cellulose and carboxymethylcellulose, commercially available under the trade name AVICEL® from FMC Biopolymer of Philadelphia, Pennsylvania, U. S. A, and combinations and derivatives of all of the above.
  • AVICEL® FMC Biopolymer of Philadelphia, Pennsylvania, U. S. A, and combinations and derivatives of all of the above.
  • mica it is meant any one of a group of hydrous aluminum silicate minerals with plate morphology and perfect basal (micaceous) cleavage.
  • Mica can be, for example, sheet mica, scrap mica or flake mica, as exemplified by muscovite, biotite or phlogopite type micas.
  • insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates.
  • Illustrative examples are dicalcium orthophosphate dihydrate. dicalcium phosphate dihydrate. calcium hydrogen phosphate, calcium pyrophosphate, ⁇ - calcium pyrophosphate, tricalcium phosphate, calcium metaphosphate, potassium metaphosphate, and sodium metaphosphate.
  • Synthetic silicas include both silica gels and precipitated silicas which may be prepared, for example, by the neutralization of aqueous silicate solutions with a strong mineral acid.
  • a silica hydrogel is formed which is then typically washed to low salt content.
  • the washed hydrogel may be milled to the desired size, or otherwise dried, ultimately to the point where its structure no longer changes as a result of shrinkage.
  • the objective is to obtain abrasives which provide maximal cleaning (i.e., removal of stained pellicle) with minimal damage to the tooth enamel and other oral tissue.
  • Useful abrasive materials for preparing the periodic oral compositions include high cleaning, low structure silica abrasives, such as those marketed under the trade designation SYLODENT® XWA or SYLODENT® 783 by Davison Chemical Division of W. R. Grace & Co. of Baltimore, MD.
  • SYLODENT® XWA 650 is a silica hydrogel composed of particles of colloidal silica.
  • Exemplary silica hydrogels comprise colloidal particles of silica having an average particle size of about 3 ⁇ m to about 12 ⁇ m, and e.g., between about 5 ⁇ m to about 10 ⁇ m.
  • the particles of the XWA 650 contain about 10 % to about 35% by weight water, have a mean particle size of about 5 ⁇ m to about 12 ⁇ m, an Einlehner hardness of from greater than or equal to about 5 to about 20 mg loss per 100.000 revolutions, an oil absorption of less than about 90 cm 3 /100 g, for example from between about 40 cm 3 /100 g to about 90 cm 3 /100 g.
  • the abrasives have a Brunauer, Emmett and Teller (BET) surface area from about 100 to about 700 m 2 /g.
  • XWA 650 has a brightness of about 96.8 technidyne. Such abrasives are disclosed in. e.g., United States Patent No. 6.290,933, which is incorporated herein by reference in its entirety. [0030
  • the XWA 300 abrasive has an oil absorption of less than about 90 cm 3 /100 g silica; and a pH. in a 5% by weight suspension in boiled (CO 2 free) demineralized water, equal to or greater than about 8.5.
  • Such abrasives are disclosed in United States Patent No. 5,939.051, which is incorporated herein by reference in its entirety.
  • Another suitable high cleaning silica that can be included in the periodic composition comprises a silica product, where the particles are about 5 % to about 35% by weight water, having a mean particle size of about 7 ⁇ m to about 1 1 ⁇ m, an Einlehner hardness of from about 12 to about 19, an oil absorption value of about 50 cm 3 /100 g to about 65 cnrVlOO g.
  • a BET surface area is about 100 to about 700 m 2 /g of silica.
  • the brightness is generally reported to be greater than about 95 technidyne.
  • Such a silica product is commercially available as ZEODENT® 105 from J. M. Ruber of Havre de Grace. Maryland, U.S.A.
  • abrasives that can be used include typical cleaning silica abrasives, such as precipitated silicas having a mean particle size of up to about 20 ⁇ m, typically at about 8 to about 14 ⁇ m, with an oil absorption structure of greater than about 90 to about 1 10 cm 3 /100 g. such as ZEODENT®1 15. marketed by J. M. Huber. that has a pH at 5% of the particles of about 6.5 - about 7.5 and an Einlehner hardness of about 2 to about 4 nig loss per 100.000 revolutions. The brightness of such a silica particle is greater than about 95.
  • Such cleaning abrasives comprise the second abrasive of the oral composition in certain embodiments.
  • the silica abrasive polishing materials useful herein, as well as the other abrasives generally have an average particle size ranging between about 0. 1 and about 30 microns, about between 5 and about 15 microns.
  • the silica abrasives can be from precipitated silica or silica gels, such as the silica xerogels described in U.S. Pat. No. 3.538,230. to Pader et al. and U.S. Pat. No. 3,862,307, to Digiulio, both incorporated herein by reference. Particular silica xerogels are marketed under the trade name Syloid* by the W. R. Grace & Co.. Davison Chemical Division.
  • the precipitated silica materials include those marketed by the J. M. Huber Corp. under the trade name Zeodent , including the silica carrying the designation Zeodent 115 and 119. These silica abrasives are described in U.S. Pat. No. 4.340,583, to Wason, incorporated herein by reference.
  • abrasive materials useful in the practice of the oral care compositions in accordance with the invention include silica gels and precipitated amorphous silica having an oil absorption value of about less than 100 cc/100 g silica and in the range of about 45 cc/100 g to about 70 cc/100 g silica. Oil absorption values arc measured using the ASTA Rub-Out Method D281.
  • the silicas are colloidal particles having an average particle size of about 3 microns to about 12 microns, and about 5 to about 10 microns.
  • the particulate or abrasive materials comprise a large fraction of very small particles, e.g., having a d50 less than about 5 microns, for example small particle silica (SPS) having a d50 of about 3 to about 4 microns, for example Sorbosil AC43® (Ineos).
  • SPS small particle silica
  • Sorbosil AC43® Sorbosil AC43®
  • the formulation comprises about 3 to about 8% SPS and about 25 to about 45% of a conventional abrasive.
  • Low oil absorption silica abrasives particularly useful in the practice of the invention are marketed under the trade designation Sylodent XWA ® by Davison Chemical Division of W.R. Grace & Co., Baltimore, Md. 21203.
  • Sylodent 650 XWA ® a silica hydrogel composed of particles of colloidal silica having a water content of about 29% by weight averaging about 7 to about 10 microns in diameter, and an oil absorption of less than about 70 cc/100 g of silica is an example of a low oil absorption silica abrasive useful in the practice of the present invention.
  • the abrasive is present in the oral care composition of the present invention at a concentration of about 10 to about 60% by weight, in other embodiment about 20 to about 45% by weight, and in another embodiment about 30 to about 50% by weight.
  • an abrasive of colloidal silica such as those sold under the trademark SYLO1D® as SYLOID® 72 and SYLOID® 74 or under the trademark SANTOCEL® 100 alkali metal alumina-silicate complexes are particularly useful, since they have refractive indices close to the refractive indices of gelling agent-liquid (including water and/or humectant) systems commonly used in dentifrices.
  • a first and a second abrasive are combined in the periodic composition to provide cleaning capability, mildness (relatively low abrasivity), and aesthetically acceptable periodic care compositions.
  • an amount of the first abrasive to the second abrasive can be expressed by a ratio of the first abrasive to the second abrasive ranging from about 1 : 1.6 to about 1.6: 1.
  • a ratio of the first abrasive to the second abrasive is about 1 : 1.
  • the respective amounts of the first abrasive and the second abrasive present in an oral composition may be about 13 to about 21% by weight of the oral composition.
  • the amount of the first abrasive is about 15% to about 19%, and the amount of the second abrasive is about 15% to about 19% by weight of the oral composition.
  • the first abrasive is present at about 17% by weight and the second abrasive is present at about 17% by weight of the oral composition.
  • the total amount of abrasive in the periodic oral care cleaning composition, including the first and second abrasive is e.g., greater than about 25%, greater than about 30%. and in some embodiments, greater than about 35% by total weight of the periodic oral care cleaning composition.
  • the periodic oral composition comprises a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions.
  • a ratio of the first abrasive to the second abrasive ranges from about 1 : 1.6 to about 1.6: 1.
  • the periodic oral composition has a PCR of greater than about 100 and an RDA of less than about 200. In certain embodiments, the RDA is less than about 175.
  • the first abrasive has an oil of absorption of less than about 90 cm /10Og
  • the second abrasive has an oil of absorption of greater than about 90 cm 3 /100g.
  • the ratio of the first abrasive to the second abrasive is about 1 : 1.
  • the total amount of the abrasives, including both the first and the second abrasives, is greater than about 30%.
  • the first abrasive and the second abrasive are optionally present at about 17% each, respectively.
  • the first and second abrasives are respectively present in an amount of about 15% to about 19% by weight of the total periodic oral care cleaning composition.
  • the first and second abrasives optionally comprise silica.
  • the periodic oral composition comprises a first abrasive comprising silica, having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions, and an oil of absorption of less than about 90 cm 3 /100g.
  • the periodic oral composition further comprises a second abrasive comprising silica having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions, and an oil of absorption of greater than about 90 cm 3 /100g.
  • the first abrasive is present at an amount of about 13% to about 21% by weight, likewise, the second abrasive is present in an amount of about 13% to about 21% by weight of the composition.
  • the first abrasive and the second abrasive are respectively present at about 15 % to about 19% by weight of the periodic oral composition. In certain embodiments, the first and second abrasives are respectively present in an amount of about 17% by weight of the oral composition.
  • the PCR is e.g., greater than about 100 and the RDA is e.g., less than about 200, and in certain embodiments, less than about 175.
  • a total amount of the first and second abrasive present in the oral composition are e.g., greater than about 25% or e.g., greater than about 30%.
  • the periodic oral composition comprises a first abrasive comprising silica and having an oil of absorption of less than about 90 cm 3 /100g and an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions.
  • the periodic oral composition further comprises a second abrasive comprising silica and having an oil of absorption of greater than about 90 cm 3 /100g and an Einlehner hardness of less than about 5 mg loss per 100.000 revolutions.
  • a ratio of the first abrasive to the second abrasive is about 1 : 1.6 to about 1.6: 1.
  • a total amount of the first and second abrasives present in the oral composition is greater than about 25% by weight of the composition.
  • the periodic oral composition has a ratio of the first abrasive to the second abrasive that ranges from about 1 : 1.6 to about 1.6: 1.
  • the active ingredient comprises a non-ionic antibacterial ingredient, such as a halogenated diphenyl ether like triclosan. which will be discussed in more detail below.
  • the first abrasive has an oil of absorption of less than about 90 cm 3 /100g and an Einlehner hardness of greater than about 5 mg loss per 100.000 revolutions
  • the second abrasive has an oil of absorption of greater than about 90 cm 3 /100g and an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions.
  • the periodic oral care cleaning compositions described herein may comprise an orally acceptable carrier.
  • Conventional ingredients that can be used to form the earners for oral care compositions are well known to the skilled artisan.
  • the earner can be a liquid, semi-solid, or solid phase.
  • Oral compositions can be in the form of a dentifrice (including toothpastes, toothpowders. and prophylaxis pastes), confectionaries (including gums, beads and chews), film, paint-on gels, or any other form known to one of skill in the art where abrasives are employed. Selection of specific carrier components is dependant on the desired product form.
  • the composition(s) are independently in the form of a dentifrice, where an exemplary carrier is substantially semi-solid or solid.
  • the carrier can be aqueous, in which case the carrier e.g., comprises about 5% to about 95% water. In other embodiments, the carrier is substantially non-aqueous.
  • the carrier optionally comprises, for example, oral care active ingredients, surface active agents, such as surfactants, cmulsificrs, and foam modulators, viscosity modifiers and thickeners, humectants, diluents, fillers, additional pH modifying agents, colorants, preservatives, solvents, and combinations thereof.
  • the oral composition(s) optionally include other materials in addition to those components previously described, including for example, emollients, moisturizers, mouth feel agents and the like.
  • suitable carriers for oral compositions are disclosed in United States Patent Nos. 6,669,929, 6,379.654. and 4.894.220, the content of each of which are incorporated herein by reference.
  • the oral care active ingredients include for example, anti-bacterial active agents, anti-tartar agents, anti-caries agents, anti-inflammatory agents, anti-sensitivity agents, enzymes, nutrients, and the like. Active agents among those useful herein are also disclosed in United States Patent Nos. 6,290,933 and 6,685,921, the contents of each of which arc incorporated herein by reference.
  • the primary and/or periodic oral care compositions may further comprise an agent that interferes with or prevents bacterial attachment, e.g., solbrol or chitosan.
  • Any suitable fluoride ion source may be present in either or both of the oral composition(s), such as those recited in United States Patent No. 5,080,887, the contents of which are incorporated herein by reference. Sources of fluoride ions, acid phosphatases, and pyrophosphatase enzyme inhibitors, are well known in the art as anti-caries agents.
  • Examples of such sources are inorganic metal and7or ammonium fluoride salts and compounds, such as, for example: sodium fluoride, potassium fluoride, ammonium fluoride, amine fluoride, calcium fluoride; a copper fluoride, such as cuprous fluoride; zinc fluoride, barium fluoride; sodium silicafluoride, sodium fluorosilicate. ammonium fluorosilicate, sodium fluorozirconate; and sodium monofluorophosphate. aluminum mono- and di- fluorophosphate. and fluorinated sodium calcium pyrophosphate, and combinations thereof.
  • the fluoride source can also be an amine fluoride, such as olaflur
  • the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
  • the periodic and/or primary oral care compositions of the invention may also contain a source of fluoride ions or fluorine-providing ingredient in amounts sufficient to supply about 25 ppm to 25,000 ppm of fluoride ions, generally at least about 500 ppm, e.g., about 500 to about 2000 ppm, e.g., about 1000 to about 1600 ppm, e.g., about 1450 ppm.
  • the appropriate level of fluoride will depend on the particular application.
  • a mouthwash for example, would typically have about 100 to about 250 ppm fluoride.
  • a toothpaste for general consumer use would typically have about 1000 to about 1500 ppm, with pediatric toothpaste having somewhat less.
  • the periodic and/or primary oral care compositions of the invention may comprise a calcium phosphate abrasive, e.g.. tricalcium phosphate (Ca 3 (POi) 2 ), hydroxyapatite (CaIo(PCU) 6 (OH) 2 ), or dicalcium phosphate dihydrate (CaHPO 4 • 2H 2 O, also sometimes referred to herein as DiCaI) or calcium pyrophosphate.
  • a calcium phosphate abrasive e.g... tricalcium phosphate (Ca 3 (POi) 2 ), hydroxyapatite (CaIo(PCU) 6 (OH) 2 ), or dicalcium phosphate dihydrate (CaHPO 4 • 2H 2 O, also sometimes referred to herein as DiCaI) or calcium pyrophosphate.
  • Either or both oral composition(s) optionally comprise an anticalculus component, such as one or more of the anti-calculus components recited in United States Patent No. 5.292,526, the contents of which are incorporated herein by reference.
  • the anti-calculus component includes one or more polyphosphates.
  • the anti- calculus composition can include at least one wholly or partially neutralized alkali metal or ammonium tripolyphosphate or hexametaphosphate salt present in the oral composition at an effective anti-calculus amount.
  • the anti-calculus component can also include at least one water soluble, linear, molecularly dehydrated polyphosphate salt effective in an anticalculus amount.
  • the anti-calculus component can also include a mixture of potassium and sodium salts, at least one of which is present in an effective anti-calculus amount as a polyphosphate anti-calculus agent.
  • Other useful anticalculus agents include polycarboxylate polymers and polyvinyl methyl ethcr/maleic anhydride (PVM/MA) copolymers, such as GANTREZ ⁇ .
  • PVM/MA polyvinyl methyl ethcr/maleic anhydride copolymers
  • GANTREZ ⁇ GANTREZ ⁇
  • All other substances or molecules known to be useful in oral care compositions may be included in either or both of the daily or the periodic compositions.
  • additional molecules may include antibacterial agents, antiplaque agents, desensitizing agents, anti-inflammation agents, colorants, thickeners, flavorants.
  • compositions include a stannous ion agent; triclosan; triclosan monophosphate; chlorhexidine; alexidine: hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacteriocins, ethyl lauroyl arginate, extracts of magnolia, a metal ion source, arg
  • ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range.
  • all references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls. It is understood that when formulations are described, they may be described in terms of their ingredients, as is common in the art, notwithstanding that these ingredients may react with one another in the actual formulation as it is made, stored and used, and such products are intended to be covered by the formulations described.

Abstract

L'invention concerne des procédés de nettoyage d'une surface buccale, d'entretien et/ou d’amélioration de la santé buccale. De tels procédés consistent à mettre, au moins une fois par jour, la surface buccale en contact avec une composition pour soins buccaux de base ; à mettre, au moins une fois par mois, la surface buccale en contact avec une composition d'entretien de soins buccaux périodiques renfermant un acide aminé basique, sous forme libre ou de sel ; et, facultativement, à mettre, au moins une fois par mois, la surface buccale en contact avec une composition de nettoyage pour soins buccaux renfermant un système abrasif.
EP08769086A 2008-02-08 2008-03-28 Régime de soins buccaux Withdrawn EP2240153A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2742008P 2008-02-08 2008-02-08
US2743108P 2008-02-08 2008-02-08
US2743508P 2008-02-08 2008-02-08
US2743208P 2008-02-08 2008-02-08
US12/028,782 US20080274065A1 (en) 2006-05-09 2008-02-08 Oral Care Regimen
PCT/US2008/058650 WO2009099450A1 (fr) 2008-02-08 2008-03-28 Régime de soins buccaux

Publications (1)

Publication Number Publication Date
EP2240153A1 true EP2240153A1 (fr) 2010-10-20

Family

ID=40122498

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08769086A Withdrawn EP2240153A1 (fr) 2008-02-08 2008-03-28 Régime de soins buccaux

Country Status (17)

Country Link
EP (1) EP2240153A1 (fr)
JP (1) JP2011510981A (fr)
CN (1) CN101938979B (fr)
AR (1) AR065888A1 (fr)
AU (1) AU2008349845C1 (fr)
BR (1) BRPI0821857A2 (fr)
CA (1) CA2706481C (fr)
CL (1) CL2008000896A1 (fr)
CO (1) CO6280462A2 (fr)
MX (1) MX2010004708A (fr)
MY (1) MY155709A (fr)
PA (1) PA8774301A1 (fr)
PE (1) PE20091442A1 (fr)
RU (1) RU2012121147A (fr)
TW (1) TWI459970B (fr)
WO (1) WO2009099450A1 (fr)
ZA (1) ZA201003676B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501161B2 (en) 2006-05-09 2013-08-06 Colgate-Palmolive Company Oral care regimen
MY155568A (en) 2008-02-08 2015-10-30 Colgate Palmolive Co Oral care methods and systems
CA2711414C (fr) 2008-02-08 2013-11-19 Colgate-Palmolive Company Produit de soins oraux et leurs methodes d'utilisation et procedes de fabrication
RU2563990C2 (ru) * 2010-11-12 2015-09-27 Колгейт-Палмолив Компани Продукт для ухода за полостью рта и способы его применения и получения
EP2637633B1 (fr) * 2010-11-12 2018-07-11 Colgate-Palmolive Company Produit pour soins buccaux, et ses procédés d'utilisation et de fabrication
CN103476386B (zh) 2011-02-18 2016-10-26 加巴国际控股有限公司 洁齿剂组合物
JP6038567B2 (ja) * 2012-09-21 2016-12-07 花王株式会社 口腔用組成物
WO2014088573A1 (fr) * 2012-12-05 2014-06-12 Colgate-Palmolive Company Compositions contenant du phosphate de zinc
CN105916486B (zh) * 2013-12-27 2020-01-14 高露洁-棕榄公司 含有羧酸的益生元口腔护理组合物
BR112016023498B1 (pt) * 2014-04-10 2020-10-06 Basf Se Composição para higiene bucal, combinação, métodos para inibir placa bacteriana, para retardar ou prevenir a produção de ácido das bactérias, para desfazer uma biopelícula, para reduzir a sensibilidade dental, para edulcorar ou engrossar uma composição e usos do polímero formado e de uma composição
US20170266091A1 (en) * 2014-08-18 2017-09-21 Colgate-Palmolive Company Mouthwash Composition Comprising a Peroxide Source and an N-Acyl-L-Arginine Alkyl Ester Salt
JP2016006102A (ja) * 2015-08-14 2016-01-14 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 口腔ケア製品およびその使用方法および製造方法
EP3347005B1 (fr) * 2015-09-11 2021-07-07 Wm. Wrigley Jr. Company Effets antibactérien synergiques d'un extrait d'écorce de magnolia et d'ester éthylique de n-alpha-lauroyl-l-arginine, sur un biofilm de plaque dentaire
RU2727969C1 (ru) * 2016-11-08 2020-07-28 Колгейт-Палмолив Компани Композиции для ухода за полостью рта
WO2018089394A1 (fr) * 2016-11-08 2018-05-17 Colgate-Palmolive Company Compositions de soins bucco-dentaires
RU2750199C2 (ru) * 2017-06-14 2021-06-23 Колгейт-Палмолив Компани Композиции, содержащие фосфат цинка
MX2020006254A (es) 2017-12-18 2020-09-07 Gaba Int Holding Gmbh Composiciones para el cuidado bucal.
US11642199B2 (en) * 2018-09-24 2023-05-09 3M Innovative Properties Company Dental appliance with cosmetic therapeutic aqueous solution
CA3134598A1 (fr) * 2019-03-29 2020-10-08 Colgate-Palmolive Company Produit de soin buccal

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5370865A (en) * 1992-05-15 1994-12-06 Kao Corporation Composition for use in oral cavity
JP2627709B2 (ja) * 1992-05-15 1997-07-09 花王株式会社 口腔用組成物
JP3803695B2 (ja) * 1994-11-28 2006-08-02 サンスター株式会社 抗菌製剤
US5762911A (en) * 1996-03-05 1998-06-09 The Research Foundation Of State University Of New York Anti-caries oral compositions
US6436370B1 (en) * 1999-06-23 2002-08-20 The Research Foundation Of State University Of New York Dental anti-hypersensitivity composition and method
US8501161B2 (en) * 2006-05-09 2013-08-06 Colgate-Palmolive Company Oral care regimen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009099450A1 *

Also Published As

Publication number Publication date
RU2012121147A (ru) 2013-11-27
JP2011510981A (ja) 2011-04-07
CA2706481C (fr) 2015-06-16
ZA201003676B (en) 2014-11-26
CN101938979A (zh) 2011-01-05
TW200934519A (en) 2009-08-16
CO6280462A2 (es) 2011-05-20
CL2008000896A1 (es) 2009-08-14
PE20091442A1 (es) 2009-09-24
MX2010004708A (es) 2010-06-07
MY155709A (en) 2015-11-13
CA2706481A1 (fr) 2009-08-13
AU2008349845B2 (en) 2012-02-16
AU2008349845C1 (en) 2012-09-20
BRPI0821857A2 (pt) 2014-09-30
PA8774301A1 (es) 2009-09-17
CN101938979B (zh) 2014-11-26
TWI459970B (zh) 2014-11-11
WO2009099450A1 (fr) 2009-08-13
AR065888A1 (es) 2009-07-08
AU2008349845A1 (en) 2009-08-13

Similar Documents

Publication Publication Date Title
AU2008349845C1 (en) Oral care regimen
US8501161B2 (en) Oral care regimen
EP2249784B1 (fr) Produit pour soins buccaux, et ses procédés d'utilisation et de fabrication
AU2013364205B2 (en) Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine
EP2249787B1 (fr) Produit de soins oraux et leurs méthodes d'utilisation et procédés de fabrication
AU2009212319B2 (en) Oral care product and methods of use and manufacture thereof
WO2012057739A1 (fr) Composition d'hygiène buccale comprenant de l'arginine et du carbonate de calcium
US20080274065A1 (en) Oral Care Regimen
AU2009212335A1 (en) Compositions comprising basic amino acid and soluble carbonate salt
US20090202452A1 (en) Oral care regimen
AU2012204031B2 (en) Oral care product and methods of use and manufacture thereof
WO2020205238A1 (fr) Produit de soin buccal et procédés d'utilisation et de fabrication de celui-ci

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100803

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1147935

Country of ref document: HK

17Q First examination report despatched

Effective date: 20150225

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20150708

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1147935

Country of ref document: HK