EP2226390A4 - Melting curve analyzing method and melting curve analyzing device - Google Patents
Melting curve analyzing method and melting curve analyzing deviceInfo
- Publication number
- EP2226390A4 EP2226390A4 EP08863847.3A EP08863847A EP2226390A4 EP 2226390 A4 EP2226390 A4 EP 2226390A4 EP 08863847 A EP08863847 A EP 08863847A EP 2226390 A4 EP2226390 A4 EP 2226390A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- melting curve
- curve analyzing
- analyzing device
- analyzing method
- melting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002844 melting Methods 0.000 title 2
- 230000008018 melting Effects 0.000 title 2
- 238000000034 method Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/02—Investigating or analyzing materials by the use of thermal means by investigating changes of state or changes of phase; by investigating sintering
- G01N25/04—Investigating or analyzing materials by the use of thermal means by investigating changes of state or changes of phase; by investigating sintering of melting point; of freezing point; of softening point
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/107—Temperature of melting, i.e. Tm
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007334975 | 2007-12-26 | ||
PCT/JP2008/073535 WO2009081965A1 (en) | 2007-12-26 | 2008-12-25 | Melting curve analyzing method and melting curve analyzing device |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2226390A1 EP2226390A1 (en) | 2010-09-08 |
EP2226390A4 true EP2226390A4 (en) | 2013-05-01 |
EP2226390B1 EP2226390B1 (en) | 2018-08-29 |
Family
ID=40801265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08863847.3A Active EP2226390B1 (en) | 2007-12-26 | 2008-12-25 | Melting curve analyzing method and melting curve analyzing device |
Country Status (6)
Country | Link |
---|---|
US (1) | US8364415B2 (en) |
EP (1) | EP2226390B1 (en) |
JP (1) | JP5542438B2 (en) |
KR (1) | KR101251177B1 (en) |
CN (1) | CN101663408B (en) |
WO (1) | WO2009081965A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5843501B2 (en) | 2010-07-07 | 2016-01-13 | アークレイ株式会社 | Nucleic acid abundance ratio measuring apparatus, nucleic acid abundance ratio measuring method, nucleic acid abundance ratio measuring program, determination method, and nucleic acid abundance ratio measuring kit |
EP2766711B1 (en) | 2011-10-14 | 2017-12-13 | Becton, Dickinson and Company | Square wave thermal cycling |
KR101483576B1 (en) | 2011-10-31 | 2015-01-21 | 아크레이 가부시키가이샤 | Method for measuring abundance of genes |
CN102559868B (en) * | 2011-11-28 | 2014-11-05 | 厦门大学 | Method for qualitative and quantitative detection of multiple target nucleotide sequences with single tube |
AU2015221851B2 (en) * | 2014-02-25 | 2019-05-09 | C.Y. O'connor Erade Village Foundation Inc. | Methods and systems for measuring melting temperatures |
US20210005286A1 (en) | 2018-01-23 | 2021-01-07 | Biocartis Nv | Methods for the analysis of dissociation melt curve data |
BR112020019755A2 (en) | 2018-04-20 | 2021-01-26 | Seegene, Inc. | method and apparatus for detecting a plurality of target nucleic acid sequences in the sample |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174670B1 (en) * | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
US6506568B2 (en) * | 2000-02-10 | 2003-01-14 | The Penn State Research Foundation | Method of analyzing single nucleotide polymorphisms using melting curve and restriction endonuclease digestion |
US20050233335A1 (en) * | 2004-04-20 | 2005-10-20 | University Of Utah Research Foundation | Nucleic and melting analysis with saturation dyes |
US20060172324A1 (en) * | 2005-01-28 | 2006-08-03 | Roche Molecular Systems, Inc. | Methods of genotyping using differences in melting temperature |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3071085B2 (en) | 1993-03-15 | 2000-07-31 | 株式会社日立製作所 | Chromatogram analysis display method and apparatus |
EP1499745B1 (en) * | 2002-04-26 | 2016-11-23 | University of Utah Research Foundation | Characterization of single stranded nucleic acids by melting analysis of secondary structure using double strand-specific nucleic acid dye |
JP4454265B2 (en) | 2003-08-13 | 2010-04-21 | アークレイ株式会社 | Melting curve analysis method |
JP4355281B2 (en) * | 2004-12-13 | 2009-10-28 | 株式会社インテックシステム研究所 | Peak extraction method and peak extraction apparatus |
JP2007282512A (en) | 2006-04-12 | 2007-11-01 | Arkray Inc | Method for inhibiting self-annealing formation and use thereof |
-
2008
- 2008-12-25 CN CN2008800128455A patent/CN101663408B/en active Active
- 2008-12-25 EP EP08863847.3A patent/EP2226390B1/en active Active
- 2008-12-25 KR KR1020097020954A patent/KR101251177B1/en active IP Right Grant
- 2008-12-25 WO PCT/JP2008/073535 patent/WO2009081965A1/en active Application Filing
- 2008-12-25 US US12/810,250 patent/US8364415B2/en active Active
- 2008-12-25 JP JP2009522262A patent/JP5542438B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174670B1 (en) * | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
US6506568B2 (en) * | 2000-02-10 | 2003-01-14 | The Penn State Research Foundation | Method of analyzing single nucleotide polymorphisms using melting curve and restriction endonuclease digestion |
US20050233335A1 (en) * | 2004-04-20 | 2005-10-20 | University Of Utah Research Foundation | Nucleic and melting analysis with saturation dyes |
US20060172324A1 (en) * | 2005-01-28 | 2006-08-03 | Roche Molecular Systems, Inc. | Methods of genotyping using differences in melting temperature |
Non-Patent Citations (4)
Title |
---|
BRANDFASS CHRISTOPH ET AL: "Simultaneous detection of Fusarium culmorum and F. graminearum in plant material by duplex PCR with melting curve analysis", BMC MICROBIOLOGY, BIOMED CENTRAL LTD, GB, vol. 6, no. 1, 23 January 2006 (2006-01-23), pages 1 - 10, XP021014869, ISSN: 1471-2180, DOI: 10.1186/1471-2180-6-4 * |
KURTZ D I ET AL: "Multiple peaks in the derivative melting curve of chromatin from animals of varying age", MECHANISMS OF AGEING AND DEVELOPMENT, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 3, 1 January 1974 (1974-01-01), pages 37 - 49, XP025423520, ISSN: 0047-6374, [retrieved on 19740101], DOI: 10.1016/0047-6374(74)90004-9 * |
L. ZHOU ET AL: "Closed-Tube Genotyping with Unlabeled Oligonucleotide Probes and a Saturating DNA Dye", CLINICAL CHEMISTRY, vol. 50, no. 8, 1 August 2004 (2004-08-01), pages 1328 - 1335, XP055041287, ISSN: 0009-9147, DOI: 10.1373/clinchem.2004.034322 * |
See also references of WO2009081965A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20100280789A1 (en) | 2010-11-04 |
KR20090130287A (en) | 2009-12-22 |
KR101251177B1 (en) | 2013-04-08 |
CN101663408B (en) | 2012-11-28 |
EP2226390A1 (en) | 2010-09-08 |
EP2226390B1 (en) | 2018-08-29 |
JPWO2009081965A1 (en) | 2011-05-06 |
JP5542438B2 (en) | 2014-07-09 |
CN101663408A (en) | 2010-03-03 |
WO2009081965A1 (en) | 2009-07-02 |
US8364415B2 (en) | 2013-01-29 |
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