EP2126064A4 - Mek ligands and polynucleotides encoding mek ligands - Google Patents

Mek ligands and polynucleotides encoding mek ligands

Info

Publication number
EP2126064A4
EP2126064A4 EP08744516A EP08744516A EP2126064A4 EP 2126064 A4 EP2126064 A4 EP 2126064A4 EP 08744516 A EP08744516 A EP 08744516A EP 08744516 A EP08744516 A EP 08744516A EP 2126064 A4 EP2126064 A4 EP 2126064A4
Authority
EP
European Patent Office
Prior art keywords
ligands
mek
mek ligands
polynucleotides encoding
polynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08744516A
Other languages
German (de)
French (fr)
Other versions
EP2126064A2 (en
EP2126064B1 (en
Inventor
David Bachinsky
Jonathan Carson
Amy Atzel
Thomas Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precigen Inc
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Priority to EP12170618.8A priority Critical patent/EP2537924B1/en
Publication of EP2126064A2 publication Critical patent/EP2126064A2/en
Publication of EP2126064A4 publication Critical patent/EP2126064A4/en
Application granted granted Critical
Publication of EP2126064B1 publication Critical patent/EP2126064B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/12—Dual-specificity kinases (2.7.12)
    • C12Y207/12002—Mitogen-activated protein kinase kinase (2.7.12.2), i.e. MAPKK or MEK1 or MEK2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP08744516A 2007-03-27 2008-03-27 Mek ligands and polynucleotides encoding mek ligands Not-in-force EP2126064B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12170618.8A EP2537924B1 (en) 2007-03-27 2008-03-27 MEK ligands and polynucleotides encoding mek ligands

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90823107P 2007-03-27 2007-03-27
PCT/US2008/058531 WO2008119058A2 (en) 2007-03-27 2008-03-27 Mek ligands and polynucleotides encoding mek ligands

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP12170618.8A Division EP2537924B1 (en) 2007-03-27 2008-03-27 MEK ligands and polynucleotides encoding mek ligands

Publications (3)

Publication Number Publication Date
EP2126064A2 EP2126064A2 (en) 2009-12-02
EP2126064A4 true EP2126064A4 (en) 2010-06-23
EP2126064B1 EP2126064B1 (en) 2012-06-06

Family

ID=39789285

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12170618.8A Ceased EP2537924B1 (en) 2007-03-27 2008-03-27 MEK ligands and polynucleotides encoding mek ligands
EP08744516A Not-in-force EP2126064B1 (en) 2007-03-27 2008-03-27 Mek ligands and polynucleotides encoding mek ligands

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP12170618.8A Ceased EP2537924B1 (en) 2007-03-27 2008-03-27 MEK ligands and polynucleotides encoding mek ligands

Country Status (11)

Country Link
US (2) US8575304B2 (en)
EP (2) EP2537924B1 (en)
JP (1) JP5611814B2 (en)
KR (1) KR101557167B1 (en)
CN (1) CN101679956A (en)
AU (1) AU2008230711B9 (en)
CA (1) CA2680837C (en)
DK (1) DK2126064T3 (en)
ES (1) ES2390156T3 (en)
IL (1) IL201192A (en)
WO (1) WO2008119058A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153598B2 (en) 2005-10-19 2012-04-10 Intrexon Corporation PKD ligands and polynucleotides encoding PKD ligands
US7943732B2 (en) 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8283445B2 (en) 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US8729225B2 (en) 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US7705122B2 (en) 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
CN101679956A (en) 2007-03-27 2010-03-24 英特拉克森公司 mek ligands and polynucleotides encoding mek ligands
JP5675345B2 (en) 2007-05-02 2015-02-25 イントレキソン コーポレーション PP1 ligand
WO2009089059A2 (en) 2008-01-09 2009-07-16 Intrexon Corporation Therapeutic inhibitors of pai-1 function methods of their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051993A1 (en) * 2000-12-22 2002-07-04 The University Of Newcastle Research Associates Limited MAP kinase integrin-binding domain

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9904395D0 (en) 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US20050089932A1 (en) * 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding
AU2002348791A1 (en) * 2001-12-21 2003-07-09 Warner-Lambert Company Llc Modified mek1 and mek2, crystal of a peptide: ligand: cofactor complex containing such modified mek1 or mek2, and methods of use thereof
AU2003245627A1 (en) * 2002-06-21 2004-01-06 Incyte Corporation Kinases and phosphatases
US20080050808A1 (en) * 2002-10-09 2008-02-28 Reed Thomas D DNA modular cloning vector plasmids and methods for their use
US7785871B2 (en) 2002-10-09 2010-08-31 Intrexon Corporation DNA cloning vector plasmids and methods for their use
US7071295B2 (en) 2002-12-02 2006-07-04 Intrexon Corporation Signal for targeting molecules to the sarco(endo)plasmic reticulum
US20080220497A1 (en) * 2003-12-24 2008-09-11 Flynn Daniel L Modulation of protein functionalities
WO2005113812A2 (en) * 2004-04-23 2005-12-01 Invitrogen Corporation Collections of matched biological reagents and methods for identifying matched reagents
AU2005248371B2 (en) 2004-05-18 2011-12-15 Intrexon Corporation Methods for dynamic vector assembly of DNA cloning vector plasmids
US20080227128A1 (en) * 2004-10-01 2008-09-18 Mount Sinai School Of Medicine Of New York University Resonance Energy Transfer System and Method
WO2007048103A2 (en) 2006-10-18 2007-04-26 Intrexon Corporation Pkd ligands and polynucleotides encoding pkd ligands
US8153598B2 (en) 2005-10-19 2012-04-10 Intrexon Corporation PKD ligands and polynucleotides encoding PKD ligands
US7943732B2 (en) * 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) * 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) * 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8283445B2 (en) * 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US8729225B2 (en) * 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US7705122B2 (en) * 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
CN101679956A (en) 2007-03-27 2010-03-24 英特拉克森公司 mek ligands and polynucleotides encoding mek ligands
US7927987B2 (en) 2007-03-27 2011-04-19 Texas Instruments Incorporated Method of reducing channeling of ion implants using a sacrificial scattering layer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051993A1 (en) * 2000-12-22 2002-07-04 The University Of Newcastle Research Associates Limited MAP kinase integrin-binding domain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE UniProt [online] 1 January 1998 (1998-01-01), "SubName: Full=ERK2;", XP002581682, retrieved from EBI accession no. UNIPROT:O35558 Database accession no. O35558 *
DATABASE UniProt [online] 1 October 2003 (2003-10-01), "SubName: Full=Putative uncharacterized protein DKFZp686O0215; Flags: Fragment;", XP002581683, retrieved from EBI accession no. UNIPROT:Q7Z3H5 Database accession no. Q7Z3H5 *
See also references of WO2008119058A2 *

Also Published As

Publication number Publication date
IL201192A (en) 2014-11-30
CA2680837A1 (en) 2008-10-02
CA2680837C (en) 2017-06-06
CN101679956A (en) 2010-03-24
EP2126064A2 (en) 2009-12-02
US9006390B2 (en) 2015-04-14
US20140073028A1 (en) 2014-03-13
JP2010522568A (en) 2010-07-08
US8575304B2 (en) 2013-11-05
US20100279378A1 (en) 2010-11-04
AU2008230711B2 (en) 2014-03-27
DK2126064T3 (en) 2012-09-10
EP2537924B1 (en) 2015-03-18
KR20100015944A (en) 2010-02-12
WO2008119058A9 (en) 2008-12-24
EP2537924A2 (en) 2012-12-26
EP2126064B1 (en) 2012-06-06
WO2008119058A3 (en) 2009-02-12
WO2008119058A2 (en) 2008-10-02
EP2537924A3 (en) 2013-04-10
KR101557167B1 (en) 2015-10-02
HK1138876A1 (en) 2010-09-03
IL201192A0 (en) 2011-08-01
ES2390156T3 (en) 2012-11-07
JP5611814B2 (en) 2014-10-22
AU2008230711A1 (en) 2008-10-02
AU2008230711B9 (en) 2014-08-21

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