EP2007379A4 - Nanoelectronic detection of biomolecules employing analyte amplification and reporters - Google Patents

Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Info

Publication number
EP2007379A4
EP2007379A4 EP07754869A EP07754869A EP2007379A4 EP 2007379 A4 EP2007379 A4 EP 2007379A4 EP 07754869 A EP07754869 A EP 07754869A EP 07754869 A EP07754869 A EP 07754869A EP 2007379 A4 EP2007379 A4 EP 2007379A4
Authority
EP
European Patent Office
Prior art keywords
nanoelectronic
reporters
biomolecules
detection
analyte amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07754869A
Other languages
German (de)
French (fr)
Other versions
EP2007379A2 (en
Inventor
Eugene Tu
Christian Valcke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanomix Inc
Original Assignee
Nanomix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/488,465 external-priority patent/US20070045756A1/en
Priority claimed from US11/588,845 external-priority patent/US20080021339A1/en
Application filed by Nanomix Inc filed Critical Nanomix Inc
Publication of EP2007379A2 publication Critical patent/EP2007379A2/en
Publication of EP2007379A4 publication Critical patent/EP2007379A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
EP07754869A 2006-04-04 2007-04-03 Nanoelectronic detection of biomolecules employing analyte amplification and reporters Withdrawn EP2007379A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78902206P 2006-04-04 2006-04-04
US11/488,465 US20070045756A1 (en) 2002-09-04 2006-07-18 Nanoelectronic sensor with integral suspended micro-heater
US85021706P 2006-10-06 2006-10-06
US11/588,845 US20080021339A1 (en) 2005-10-27 2006-10-26 Anesthesia monitor, capacitance nanosensors and dynamic sensor sampling method
US90153807P 2007-02-14 2007-02-14
PCT/US2007/008422 WO2007114931A2 (en) 2006-04-04 2007-04-03 Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Publications (2)

Publication Number Publication Date
EP2007379A2 EP2007379A2 (en) 2008-12-31
EP2007379A4 true EP2007379A4 (en) 2009-12-09

Family

ID=38564139

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07754869A Withdrawn EP2007379A4 (en) 2006-04-04 2007-04-03 Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Country Status (3)

Country Link
EP (1) EP2007379A4 (en)
JP (1) JP2009532064A (en)
WO (1) WO2007114931A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8152991B2 (en) 2005-10-27 2012-04-10 Nanomix, Inc. Ammonia nanosensors, and environmental control system
US8154093B2 (en) 2002-01-16 2012-04-10 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US7522040B2 (en) 2004-04-20 2009-04-21 Nanomix, Inc. Remotely communicating, battery-powered nanostructure sensor devices
US7714398B2 (en) 2002-09-05 2010-05-11 Nanomix, Inc. Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide
US7948041B2 (en) 2005-05-19 2011-05-24 Nanomix, Inc. Sensor having a thin-film inhibition layer
EP2462051A4 (en) 2009-08-07 2013-06-26 Nanomix Inc Magnetic carbon nanotube based biodetection
ES2877551T3 (en) 2013-04-24 2021-11-17 Fresenius Kabi Deutschland Gmbh Operating procedure of a control device to control an infusion device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036065A1 (en) * 2001-08-17 2003-02-20 Robert Gellibolian Method and system for array signal generation and amplification
US20040214176A1 (en) * 2003-04-22 2004-10-28 Osborne James C. Multiplexed DNA assays using structure-specific endonucleases
US20050003355A1 (en) * 2002-04-22 2005-01-06 Manchun Lu Single nucleotide polymorphism analysis using surface invasive cleavage reactions
WO2005047468A2 (en) * 2003-11-06 2005-05-26 University Of Nevada, Reno Improved methods for detecting and measuring specific nucleic acid sequences
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
WO2006071895A2 (en) * 2004-12-28 2006-07-06 Nanomix, Inc. Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430665T2 (en) * 1993-01-15 2002-11-21 New York Health Res Inst SENSITIVE NUCLEIC ACID SANDWICH HYBRIDIZATION ASSAY AND KITS
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
WO1998026095A1 (en) * 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US7118860B2 (en) * 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036065A1 (en) * 2001-08-17 2003-02-20 Robert Gellibolian Method and system for array signal generation and amplification
US20050003355A1 (en) * 2002-04-22 2005-01-06 Manchun Lu Single nucleotide polymorphism analysis using surface invasive cleavage reactions
US20040214176A1 (en) * 2003-04-22 2004-10-28 Osborne James C. Multiplexed DNA assays using structure-specific endonucleases
WO2005047468A2 (en) * 2003-11-06 2005-05-26 University Of Nevada, Reno Improved methods for detecting and measuring specific nucleic acid sequences
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
WO2006071895A2 (en) * 2004-12-28 2006-07-06 Nanomix, Inc. Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAEUMNER A J ET AL: "A Universal Nucleic Acid Sequence Biosensor with Nanomolar Detection Limits", ANALYTICAL CHEMISTRY 20040215 AMERICAN CHEMICAL SOCIETY US, vol. 76, no. 4, 1 January 2004 (2004-01-01), pages 888 - 894, XP002551933 *
DUCK ET AL: "PROBE AMPLIFIER SYSTEM BASED ON CHIMERIC CYCLING OLIGONUCLEOTIDES", BIOTECHNIQUES, NATICK, MA, US, vol. 9, no. 2, 1 January 1990 (1990-01-01), pages - 147, XP000406092 *
GOODRICH TERRY T ET AL: "Direct detection of genomic DNA by enzymatically amplified SPR imaging measurements of RNA microarrays", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 13, 7 April 2004 (2004-04-07), pages 4086 - 4087, XP002551932, ISSN: 0002-7863 *
LEE H J ET AL: "Enzymatically amplified surface plasmon resonance imaging detection of DNA by exonuclease III digestion of DNA microarrays", ANALYTICAL CHEMISTRY 20050815 AMERICAN CHEMICAL SOCIETY US, vol. 77, no. 16, 15 August 2005 (2005-08-15), pages 5096 - 5100, XP002551931 *

Also Published As

Publication number Publication date
WO2007114931A2 (en) 2007-10-11
WO2007114931A3 (en) 2008-12-24
EP2007379A2 (en) 2008-12-31
JP2009532064A (en) 2009-09-10

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