EP2005990A4 - Microneedle device and transdermal administration device provided with microneedles - Google Patents

Microneedle device and transdermal administration device provided with microneedles

Info

Publication number
EP2005990A4
EP2005990A4 EP07741173A EP07741173A EP2005990A4 EP 2005990 A4 EP2005990 A4 EP 2005990A4 EP 07741173 A EP07741173 A EP 07741173A EP 07741173 A EP07741173 A EP 07741173A EP 2005990 A4 EP2005990 A4 EP 2005990A4
Authority
EP
European Patent Office
Prior art keywords
microneedles
transdermal administration
microneedle
device provided
administration device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07741173A
Other languages
German (de)
French (fr)
Other versions
EP2005990B1 (en
EP2005990A9 (en
EP2005990A2 (en
Inventor
Seiji Tokumoto
Toshiyuki Matsudo
Tetsuji Kuwahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of EP2005990A2 publication Critical patent/EP2005990A2/en
Publication of EP2005990A9 publication Critical patent/EP2005990A9/en
Publication of EP2005990A4 publication Critical patent/EP2005990A4/en
Application granted granted Critical
Publication of EP2005990B1 publication Critical patent/EP2005990B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
EP07741173.4A 2006-04-07 2007-04-06 Microneedle device and transdermal administration device provided with microneedles Active EP2005990B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006106995 2006-04-07
PCT/JP2007/057737 WO2007116959A1 (en) 2006-04-07 2007-04-06 Microneedle device and transdermal administration device provided with microneedles

Publications (4)

Publication Number Publication Date
EP2005990A2 EP2005990A2 (en) 2008-12-24
EP2005990A9 EP2005990A9 (en) 2009-07-29
EP2005990A4 true EP2005990A4 (en) 2011-04-27
EP2005990B1 EP2005990B1 (en) 2013-08-28

Family

ID=38581239

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07741173.4A Active EP2005990B1 (en) 2006-04-07 2007-04-06 Microneedle device and transdermal administration device provided with microneedles

Country Status (4)

Country Link
US (1) US20090099502A1 (en)
EP (1) EP2005990B1 (en)
JP (1) JP5049268B2 (en)
WO (1) WO2007116959A1 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006209421A1 (en) * 2005-01-31 2006-08-03 Bioserentach Co., Ltd. Transdermal absorption preparation, sheet holding transdermal absorption preparation and transdermal absorption preparation holder
WO2009021048A2 (en) 2007-08-06 2009-02-12 Transderm, Inc. Microneedle arrays formed from polymer films
US8591481B2 (en) * 2008-03-21 2013-11-26 Ut-Battelle, Llc Microfabricated instruments and methods to treat recurrent corneal erosion
CA2729404C (en) * 2008-06-30 2016-09-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and method for enhancing the efficacy of influenza vaccine using microneedle device
JP5744517B2 (en) * 2008-07-30 2015-07-08 久光製薬株式会社 Microneedle device and method for increasing the efficacy of Japanese encephalitis virus antigen by microneedle device
JP5063544B2 (en) * 2008-09-22 2012-10-31 富士フイルム株式会社 Transdermal absorption sheet and method for producing the same
JP5902390B2 (en) * 2008-12-26 2016-04-13 久光製薬株式会社 Microneedle device
KR101759354B1 (en) 2009-06-10 2017-07-18 히사미쓰 세이야꾸 가부시키가이샤 Microneedle device
EP2450079B1 (en) * 2009-07-01 2015-02-25 Toppan Printing Co., Ltd. Needle-like material
ES2826882T3 (en) 2009-07-23 2021-05-19 Hisamitsu Pharmaceutical Co Microneedle array
JPWO2011105496A1 (en) 2010-02-24 2013-06-20 久光製薬株式会社 Microneedle device
JP5615899B2 (en) * 2010-02-24 2014-10-29 久光製薬株式会社 Transdermal absorption preparation
JP5860032B2 (en) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド Device for the delivery of rheumatoid arthritis drugs
EP2563451B1 (en) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
CN102958555A (en) 2010-04-28 2013-03-06 金伯利-克拉克环球有限公司 Injection molded microneedle array and method for forming the microneedle array
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
EP2578264B1 (en) 2010-05-28 2019-01-23 Hisamitsu Pharmaceutical Co., Inc. Device having array provided with fine protrusions
DE102010029942A1 (en) * 2010-06-10 2011-12-15 Robert Bosch Gmbh injection needle
GB2483505B (en) * 2010-09-13 2012-10-10 Ndm Technologies Ltd Devices for transdermal drug delivery
US20120143119A1 (en) * 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of Serotonin Receptor Antagonists By Microinjection Systems
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
BR112013022949A2 (en) * 2011-03-07 2016-12-06 3M Innovative Properties Co microneedle device and methods
CN104667420B (en) * 2011-09-13 2017-09-08 Ndm科技有限公司 Transdermal drug delivery device
US9474685B2 (en) * 2011-09-28 2016-10-25 Sure-Shot Medical Device Inc. Apparatus for localized dermatological treatment
US9498611B2 (en) 2011-10-06 2016-11-22 Hisamitsu Pharmaceutical Co., Inc. Applicator
ES2908653T3 (en) 2011-10-27 2022-05-03 Sorrento Therapeutics Inc Implantable devices for the administration of bioactive agents
KR20220051429A (en) 2011-10-27 2022-04-26 소렌토 쎄라퓨틱스, 인코포레이티드 Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
JP2013153959A (en) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd Structure of needle shape body
AU2013280769A1 (en) * 2012-06-29 2015-01-22 Elc Management Llc Dissolvable microneedles comprising one or more encapsulated cosmetic ingredients
CN105073102B (en) 2012-10-01 2018-06-19 香港科技大学 Transdermal label apparatus
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
US9182368B2 (en) 2013-03-14 2015-11-10 Sano Intelligence, Inc. Method of manufacturing a sensor for sensing analytes
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
MX2016013200A (en) * 2014-04-30 2017-01-16 Kimberly Clark Co Draped microneedle array.
EP3135334A4 (en) 2014-06-13 2017-06-21 Toppan Printing Co., Ltd. Needle-shaped body manufacturing method and needle-shaped body
WO2016072060A1 (en) * 2014-11-05 2016-05-12 凸版印刷株式会社 Microneedle set
TWI564035B (en) * 2015-05-04 2017-01-01 國立屏東科技大學 Microneedle patch containing porcine vaccine
BR112019012924A2 (en) * 2016-12-22 2019-12-10 Ohio State Innovation Foundation nanochannel-based interpenetrating charge-release microstructures
KR102401856B1 (en) 2017-02-17 2022-05-26 알레간 인코포레이티드 Microneedle Array with Active Ingredient
EP3681584B1 (en) * 2017-09-12 2021-10-27 LTS Lohmann Therapie-Systeme AG Iontophoretic microneedle device
US10980448B2 (en) * 2018-05-16 2021-04-20 International Business Machines Corporation Electrically functional polymer microneedle array
CN109771812B (en) * 2019-01-21 2021-03-26 北京化工大学 Method for preparing hollow microneedle by using ultraviolet curing process with soluble fiber as core material
CN113133991B (en) * 2020-01-19 2023-06-13 南京大学 Colchicine soluble microneedle patch and preparation method thereof
KR102409490B1 (en) * 2020-07-03 2022-06-16 한남대학교 산학협력단 Microneedle for topical skin and manufacturing method thereof
DE102020122557A1 (en) * 2020-08-28 2022-03-03 Lts Lohmann Therapie-Systeme Ag mucosal perforation
CN112315896A (en) * 2020-11-04 2021-02-05 深圳前海鹰岗生物科技有限公司 Polymer microneedle for treating acute gout attack and preparation method thereof
US11766549B2 (en) * 2021-08-16 2023-09-26 Mirza Faizan Wearable device for managing alcohol-driven violence
DE102021130954A1 (en) 2021-11-25 2023-05-25 Lts Lohmann Therapie-Systeme Ag. Oral microneedle patch
DE102021130950A1 (en) * 2021-11-25 2023-05-25 Lts Lohmann Therapie-Systeme Ag. application help

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050031676A1 (en) * 2003-08-04 2005-02-10 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
WO2005044366A2 (en) * 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
WO2006016647A1 (en) * 2004-08-12 2006-02-16 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus with microneedle
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647528A (en) * 1970-01-07 1972-03-07 Du Pont Polyvinyl alcohol coating colors
EP0398960B1 (en) 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
JPH03242233A (en) * 1990-02-20 1991-10-29 Nok Corp Molecular valve film
US6402314B1 (en) * 1994-01-19 2002-06-11 Seiko Instruments Inc. Inkjet recording apparatus
EP0914178B1 (en) 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
JP2001316215A (en) * 1999-06-21 2001-11-13 Taimei Chemicals Co Ltd Alum aqueous solution and method for producing the same, viscous alum aqueous solution and method for producing the same, gelled composition and method for producing the same
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
CN101129327A (en) 2001-04-20 2008-02-27 阿尔扎公司 Micro-projection array having a beneficial agent containing coating
DE60210441T2 (en) * 2001-04-23 2006-11-16 Nucryst Pharmaceuticals Corp., Fort Saskatchewan MEDICAMENT OR PLASTER CONTAINS A METAL SUCH AS SILVER, GOLD, PLATINUM OR PALLADIUM AS AN ANTIMICROBIAL ACTIVE INGREDIENT AND ITS USE IN THE TREATMENT OF SKIN INFUSION
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
JP4647863B2 (en) 2001-09-26 2011-03-09 テルモ株式会社 Drug administration device and drug administration device
JP4090018B2 (en) 2002-02-18 2008-05-28 For Head株式会社 Functional micropile and manufacturing method thereof
US7047070B2 (en) 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
JP2004065775A (en) 2002-08-08 2004-03-04 Sanwa Kagaku Kenkyusho Co Ltd Device equipped with needle-like structure element
US8050918B2 (en) * 2003-12-11 2011-11-01 Nuance Communications, Inc. Quality evaluation tool for dynamic voice portals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050031676A1 (en) * 2003-08-04 2005-02-10 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
WO2005044366A2 (en) * 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
WO2006016647A1 (en) * 2004-08-12 2006-02-16 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus with microneedle
EP1790375A1 (en) * 2004-08-12 2007-05-30 Hisamitsu Pharmaceutical Co. Inc. Transdermal drug administration apparatus with microneedle
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAN LAI WAH ET AL: "Evaluation of permeability and mechanical properties of composite polyvinyl alcohol films", CHEMICAL AND PHARMACEUTICAL BULLETIN (TOKYO), vol. 47, no. 10, October 1999 (1999-10-01), pages 1412 - 1416, XP002626065, ISSN: 0009-2363 *
PÉRENN GBP ES F ET AL: "Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol; Sharp beveled tip hollow microneedle arrays", JOURNAL OF MICROMECHANICS & MICROENGINEERING, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 16, no. 3, 1 March 2006 (2006-03-01), pages 473 - 479, XP020104929, ISSN: 0960-1317, DOI: 10.1088/0960-1317/16/3/001 *
See also references of WO2007116959A1 *

Also Published As

Publication number Publication date
JP5049268B2 (en) 2012-10-17
EP2005990B1 (en) 2013-08-28
US20090099502A1 (en) 2009-04-16
EP2005990A9 (en) 2009-07-29
EP2005990A2 (en) 2008-12-24
JPWO2007116959A1 (en) 2009-08-20
WO2007116959A1 (en) 2007-10-18

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