EP1989319A4 - Variants in complement regulatory genes predict age-related macular degeneration - Google Patents
Variants in complement regulatory genes predict age-related macular degenerationInfo
- Publication number
- EP1989319A4 EP1989319A4 EP07750527A EP07750527A EP1989319A4 EP 1989319 A4 EP1989319 A4 EP 1989319A4 EP 07750527 A EP07750527 A EP 07750527A EP 07750527 A EP07750527 A EP 07750527A EP 1989319 A4 EP1989319 A4 EP 1989319A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- variants
- macular degeneration
- related macular
- regulatory genes
- complement regulatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108700005075 Regulator Genes Proteins 0.000 title 1
- 206010064930 age-related macular degeneration Diseases 0.000 title 1
- 230000000295 complement effect Effects 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77298906P | 2006-02-13 | 2006-02-13 | |
PCT/US2007/003696 WO2007095185A2 (en) | 2006-02-13 | 2007-02-13 | Variants in complement regulatory genes predict age-related macular degeneration |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1989319A2 EP1989319A2 (en) | 2008-11-12 |
EP1989319A4 true EP1989319A4 (en) | 2009-11-11 |
Family
ID=38372062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07750527A Withdrawn EP1989319A4 (en) | 2006-02-13 | 2007-02-13 | Variants in complement regulatory genes predict age-related macular degeneration |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1989319A4 (en) |
JP (1) | JP5290772B2 (en) |
CN (1) | CN101421409A (en) |
AU (1) | AU2007215218B2 (en) |
CA (1) | CA2638916A1 (en) |
IL (1) | IL193396A (en) |
NZ (1) | NZ570431A (en) |
WO (1) | WO2007095185A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
US20120141994A1 (en) * | 2009-04-29 | 2012-06-07 | Deangelis Margaret M | Methods and compositions for prognosing and detecting age-related macular degeneration |
EP2963128A1 (en) | 2009-07-10 | 2016-01-06 | The Regents of the University of Michigan | Compositions and methods for diagnosing and treating macular degeneration |
WO2011053774A1 (en) * | 2009-10-30 | 2011-05-05 | Alcon Research, Ltd. | Single nucleotide polymorphisms and genes associated with age-related macular degeneration |
US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
CN102707068B (en) * | 2012-05-31 | 2015-03-18 | 北京大学 | Application of complement factor H (CFH) to genetic expression products of methamphetamine (METH) addiction patient |
WO2014143638A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases |
JP2016535042A (en) | 2013-10-30 | 2016-11-10 | ノバルティス アーゲー | 2-Benzyl-benzimidazole complement factor B inhibitor and uses thereof |
WO2015120130A1 (en) * | 2014-02-07 | 2015-08-13 | Novartis Ag | Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy |
EP3233115B1 (en) * | 2014-12-19 | 2021-02-17 | Children's Hospital Medical Center | Methods and compositions related to transplant-associated thrombotic microangiopathy |
CN109082460B (en) * | 2018-09-27 | 2021-07-13 | 领航基因科技(杭州)有限公司 | Non-competitive probe design method, detection method and application applied to SNP typing |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006062716A2 (en) * | 2004-11-18 | 2006-06-15 | Yale University | Methods and compositions for treating ocular disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985001051A1 (en) | 1983-09-02 | 1985-03-14 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
EP0758403B1 (en) | 1994-05-05 | 1998-06-24 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
US5985567A (en) | 1997-08-15 | 1999-11-16 | Beckman Coulter, Inc. | Hybridization detection by pretreating bound single-stranded probes |
US6013789A (en) | 1998-02-20 | 2000-01-11 | Beckman Coulter, Inc. | Covalent attachment of biomolecules to derivatized polypropylene supports |
-
2007
- 2007-02-13 JP JP2008554415A patent/JP5290772B2/en not_active Expired - Fee Related
- 2007-02-13 AU AU2007215218A patent/AU2007215218B2/en not_active Ceased
- 2007-02-13 WO PCT/US2007/003696 patent/WO2007095185A2/en active Application Filing
- 2007-02-13 CA CA002638916A patent/CA2638916A1/en not_active Abandoned
- 2007-02-13 NZ NZ570431A patent/NZ570431A/en not_active IP Right Cessation
- 2007-02-13 CN CN200780012906.3A patent/CN101421409A/en active Pending
- 2007-02-13 EP EP07750527A patent/EP1989319A4/en not_active Withdrawn
-
2008
- 2008-08-12 IL IL193396A patent/IL193396A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006062716A2 (en) * | 2004-11-18 | 2006-06-15 | Yale University | Methods and compositions for treating ocular disorders |
Non-Patent Citations (23)
Title |
---|
"Homo sapiens bead probe urn: LSID:sanger.hapmap.org:Assay:1730462:1 for variation rs4151667", Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/probe/?term=pr501784&report=fullreport> * |
"Homo sapiens bead probe urn:LSID:sanger.hapmap.org:Assay:1727808:1 for variation rs641153", Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/probe/503071?report=fullreport> * |
"Homo sapiens SSO probe urn:lsid:perlegen.hapmap.org:Assay:25175.4056446:1 for variation rs547154", Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/probe/3131349> * |
CHARBEL ISSA P ET AL: "The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)", OPHTHALMOLOGE 2005 GERMANY, vol. 102, no. 11, 2005, pages 1036 - 1042, XP002452750, ISSN: 0941-293X * |
DATABASE HAPMAP PROJECT HOMPAGE [online] XP002452762, retrieved from HTTP://WWW.HAPMAP.ORG/DOWNLOADS/ASSAY-DESIGN_PROTOCOLS.HTML * |
DATABASE PROBE [online] 16 September 2005 (2005-09-16), XP002452757, retrieved from NCBI Database accession no. Pr503071 * |
DATABASE PROBE [online] 16 September 2005 (2005-09-16), XP002452758, retrieved from NCBI Database accession no. Pr501784 * |
DATABASE PROBE [online] 24 January 2006 (2006-01-24), XP002452761, retrieved from NCBI Database accession no. Pr003249825 * |
DATABASE PROBE [online] 25 January 2006 (2006-01-25), XP002452759, retrieved from NCBI Database accession no. Pr003131349 * |
DATABASE PROBE [online] 5 October 2005 (2005-10-05), XP002452760, retrieved from NCBI Database accession no. Pr001347746 * |
DATABASE SNP [online] 3 December 2002 (2002-12-03), XP002550606, retrieved from NCBI Database accession no. rs641153 * |
DATABASE SNP [online] 3 December 2002 (2002-12-03), XP002550607, retrieved from NCBI Database accession no. rs4151667 * |
DATABASE SNP [online] 3 December 2002 (2002-12-03), XP002550609, retrieved from NCBI Database accession no. rs1048709 * |
DATABASE SNP [online] 3 September 2003 (2003-09-03), XP002550605, retrieved from NCBI Database accession no. rs9332739 * |
DATABASE SNP [online] 3 September 2003 (2003-09-03), XP002550608, retrieved from NCBI Database accession no. rs547154 * |
FAN BAO JIAN ET AL: "Molecular diagnostics of genetic eye diseases", CLINICAL BIOCHEMISTRY, vol. 39, no. 3, January 2006 (2006-01-01), pages 231 - 239, XP002452749, ISSN: 0009-9120 * |
GOLD BERT ET AL: "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration", NATURE GENETICS, vol. 38, no. 4, April 2006 (2006-04-01), pages 458 - 462, XP002452747, ISSN: 1061-4036 * |
GUNDERSON KEVIN L ET AL: "A genome-wide scalable SNP genotyping assay using microarray technology", NATURE GENETICS, vol. 37, no. 5, May 2005 (2005-05-01), pages 549 - 554, XP002452745, ISSN: 1061-4036 * |
HAGEMAN GREGORY S ET AL: "A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 20, May 2005 (2005-05-01), pages 7227 - 7232, XP002391909, ISSN: 0027-8424 * |
MALLER JULIAN ET AL: "Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration", NATURE GENETICS, vol. 38, no. 9, September 2006 (2006-09-01), pages 1055 - 1059, XP002452748, ISSN: 1061-4036 * |
MATSUZAKI HAJIME ET AL: "GENOTYPING OVER 100,000 SNPS ON A PAIR OF OLIGONUCLEOTIDE ARRAYS", NATURE METHODS, vol. 1, no. 2, 1 November 2004 (2004-11-01), NATURE PUBLISHING GROUP, GB, pages 109 - 111, XP009082656, ISSN: 1548-7091, DOI: 10.1038/NMETH718 * |
See also references of WO2007095185A2 * |
ZIPFEL P F ET AL: "Complement and diseases: Defective alternative pathway control results in kidney and eye diseases", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 43, no. 1-2, 1 January 2006 (2006-01-01), pages 97 - 106, XP025037099, ISSN: 0161-5890, [retrieved on 20060101] * |
Also Published As
Publication number | Publication date |
---|---|
CA2638916A1 (en) | 2007-08-23 |
AU2007215218A1 (en) | 2007-08-23 |
WO2007095185A3 (en) | 2008-09-25 |
AU2007215218B2 (en) | 2013-09-19 |
NZ570431A (en) | 2011-12-22 |
WO2007095185A2 (en) | 2007-08-23 |
JP2009526524A (en) | 2009-07-23 |
CN101421409A (en) | 2009-04-29 |
EP1989319A2 (en) | 2008-11-12 |
IL193396A (en) | 2013-03-24 |
JP5290772B2 (en) | 2013-09-18 |
IL193396A0 (en) | 2009-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20080826 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: UNIVERSITY OF IOWA RESEARCH FOUNDATION Owner name: NATIONAL INSTITUTES OF HEALTH, DHHS Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: UNIVERSITY OF IOWA RESEARCH FOUNDATION Owner name: NATIONAL INSTITUTES OF HEALTH Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20091008 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20060101AFI20091002BHEP |
|
17Q | First examination report despatched |
Effective date: 20100127 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: NATIONAL INSTITUTES OF HEALTH Owner name: UNIVERSITY OF IOWA RESEARCH FOUNDATION Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF |
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GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
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INTG | Intention to grant announced |
Effective date: 20160308 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20160719 |