EP1965650A4 - Compositions and methods for attenuating mitochondria-mediated cell injury - Google Patents

Compositions and methods for attenuating mitochondria-mediated cell injury

Info

Publication number
EP1965650A4
EP1965650A4 EP06846653A EP06846653A EP1965650A4 EP 1965650 A4 EP1965650 A4 EP 1965650A4 EP 06846653 A EP06846653 A EP 06846653A EP 06846653 A EP06846653 A EP 06846653A EP 1965650 A4 EP1965650 A4 EP 1965650A4
Authority
EP
European Patent Office
Prior art keywords
mitochondria
attenuating
compositions
methods
mediated cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06846653A
Other languages
German (de)
French (fr)
Other versions
EP1965650A2 (en
Inventor
Paul S Brookes
Shey-Shing Sheu
Marion W Anders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of EP1965650A2 publication Critical patent/EP1965650A2/en
Publication of EP1965650A4 publication Critical patent/EP1965650A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP06846653A 2005-12-20 2006-12-18 Compositions and methods for attenuating mitochondria-mediated cell injury Withdrawn EP1965650A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/316,618 US20060122267A1 (en) 2003-11-25 2005-12-20 Compositions and methods for attenuating mitochondria-mediated cell injury
PCT/US2006/062229 WO2007076322A2 (en) 2005-12-20 2006-12-18 Compositions and methods for attenuating mitochondria-mediated cell injury

Publications (2)

Publication Number Publication Date
EP1965650A2 EP1965650A2 (en) 2008-09-10
EP1965650A4 true EP1965650A4 (en) 2010-02-17

Family

ID=38218790

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06846653A Withdrawn EP1965650A4 (en) 2005-12-20 2006-12-18 Compositions and methods for attenuating mitochondria-mediated cell injury

Country Status (5)

Country Link
US (1) US20060122267A1 (en)
EP (1) EP1965650A4 (en)
AU (1) AU2006330654A1 (en)
CA (1) CA2633361A1 (en)
WO (1) WO2007076322A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039085A1 (en) * 2006-09-28 2008-04-03 University Of Otago Triphenylphosphonium thionitrite nitric oxide donors
US9045505B2 (en) * 2006-09-28 2015-06-02 University Of Otago Nitric oxide donors
US20080171710A1 (en) * 2007-01-17 2008-07-17 University Of Rochester The Redox/Fyn/c-Cbl Pathway
US9078902B2 (en) 2009-06-09 2015-07-14 Nantbioscience, Inc. Triazine derivatives and their therapeutical applications
WO2010144586A1 (en) 2009-06-09 2010-12-16 Abraxis Bioscience, Llc Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
JP2012529517A (en) 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー Benzyl-substituted triazine derivatives and their therapeutic applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081642A1 (en) * 1999-10-29 2004-04-29 Joseph Loscalzo Methods of treating vascular diseases characterized by nitric oxide insufficiency related applications
WO2005051978A2 (en) * 2003-11-25 2005-06-09 University Of Rochester Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464825A (en) * 1991-03-14 1995-11-07 Cornell Research Foundation, Inc. Raising glutathione equivalent levels using N-acyl glutathione monoesters
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
US20060160748A1 (en) * 2003-11-25 2006-07-20 Shey-Shing Sheu Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081642A1 (en) * 1999-10-29 2004-04-29 Joseph Loscalzo Methods of treating vascular diseases characterized by nitric oxide insufficiency related applications
WO2005051978A2 (en) * 2003-11-25 2005-06-09 University Of Rochester Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BELL ROBERT M ET AL: "The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart.", CARDIOVASCULAR RESEARCH, vol. 57, no. 2, February 2003 (2003-02-01), pages 405 - 415, XP002559652, ISSN: 0008-6363 *
BUTLER A R ET AL: "SYNTHESIS, DECOMPOSITION, AND VASODILATOR ACTION OF SOME NEW S-NITROSATED DIPEPTIDES", NITRIC OXIDE: BIOLOGY AND CHEMISTRY, ACADEMIC PRESS, vol. 2, no. 3, 1 January 1998 (1998-01-01), pages 193 - 202, XP001033859, ISSN: 1089-8603 *
KONOREV EUGENE A ET AL: "The mechanism of cardioprotection by S-nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest", BRITISH JOURNAL OF PHARMACOLOGY, vol. 119, no. 3, 1996, pages 511 - 518, XP002559651, ISSN: 0007-1188 *
NADTOCHIY ET AL: "Cardioprotection and mitochondrial S-nitrosation: Effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB, vol. 42, no. 4, 5 April 2007 (2007-04-05), pages 812 - 825, XP022020013, ISSN: 0022-2828 *
NADTOCHIY S M ET AL: "In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB, vol. 46, no. 6, 1 June 2009 (2009-06-01), pages 960 - 968, XP026104984, ISSN: 0022-2828, [retrieved on 20090203] *
PRIME TRACY A ET AL: "A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, no. 26, June 2009 (2009-06-01), pages 10764 - 10769, XP002559653, ISSN: 0027-8424 *
TULLETT JAYNE M ET AL: "Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides", BIOCHEMICAL PHARMACOLOGY, vol. 62, no. 9, 1 November 2001 (2001-11-01), pages 1239 - 1247, XP002559650, ISSN: 0006-2952 *
WANG K ET AL: "N NMR and electronic properties of S-nitrosothiols", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 9, no. 19, 4 October 1999 (1999-10-04), pages 2897 - 2902, XP004179186, ISSN: 0960-894X *

Also Published As

Publication number Publication date
AU2006330654A1 (en) 2007-07-05
EP1965650A2 (en) 2008-09-10
US20060122267A1 (en) 2006-06-08
WO2007076322A3 (en) 2007-11-22
WO2007076322A8 (en) 2008-08-07
CA2633361A1 (en) 2007-07-05
WO2007076322A2 (en) 2007-07-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080721

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

A4 Supplementary search report drawn up and despatched

Effective date: 20100120

RIC1 Information provided on ipc code assigned before grant

Ipc: A01N 65/00 20090101AFI20080707BHEP

Ipc: A61P 9/00 20060101ALI20100111BHEP

Ipc: A61K 31/21 20060101ALI20100111BHEP

Ipc: A01N 57/00 20060101ALI20100111BHEP

17Q First examination report despatched

Effective date: 20100629

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110111