EP1919529A2 - Method of removing medical adhesive - Google Patents

Method of removing medical adhesive

Info

Publication number
EP1919529A2
EP1919529A2 EP06824803A EP06824803A EP1919529A2 EP 1919529 A2 EP1919529 A2 EP 1919529A2 EP 06824803 A EP06824803 A EP 06824803A EP 06824803 A EP06824803 A EP 06824803A EP 1919529 A2 EP1919529 A2 EP 1919529A2
Authority
EP
European Patent Office
Prior art keywords
skin
remover
adhesive
providing
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06824803A
Other languages
German (de)
French (fr)
Other versions
EP1919529B1 (en
Inventor
Ian Nigel Askill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
Original Assignee
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Worldwide Inc, Kimberly Clark Corp filed Critical Kimberly Clark Worldwide Inc
Publication of EP1919529A2 publication Critical patent/EP1919529A2/en
Application granted granted Critical
Publication of EP1919529B1 publication Critical patent/EP1919529B1/en
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/11—Methods of delaminating, per se; i.e., separating at bonding face
    • Y10T156/1111—Using solvent during delaminating [e.g., water dissolving adhesive at bonding face during delamination, etc.]
    • Y10T156/1116—Using specified organic delamination solvent

Definitions

  • the present invention relates generally to the removal of medical adhesives from mammalian tissues such as hair and skin.
  • Medical adhesives have many uses, including securing wound dressings, surgical drapes, tapes, sensors and the like, as well as skin sealant and liquid sutures etc.
  • Medical adhesives in the form of surgical skin sealant are applied to the skin prior to, for example, surgery, in order to reduce the risk of infection by gluing in place any microbes, germs, dead skin and the like, so that they cannot move i into the surgical site.
  • Medical adhesives may also be used to hold together the sides of a wound or surgical incision to encourage healing, much like a butterfly bandage or stitches might do.
  • the medical adhesive is normally allowed to slough off the skin naturally with time. It may be removed from the skin, however, in the case of surgery for example, when the surgery is completed.
  • Acetone is currently used to remove medical adhesives but is somewhat limited in applicability, especially in a surgical environment, because of concerns about flammability and irritation of the skin.
  • Mineral oil and soap and water are also used but suffer from a lack of efficacy.
  • Removers for the adhesive should be able to remove the adhesive without damaging the skin, without strong smells, and without being flammable.
  • the present invention provides a method for removing medical adhesive from surfaces safely and effectively.
  • Medical adhesive may be removed by applying a solution including tetrahydrofurfuryl acetate (THFA) to the surface upon which is located the adhesive and rubbing the surface to facilitate removal of the adhesive.
  • THFA tetrahydrofurfuryl acetate
  • the solution may be applied to a wipe before application to the surface and the wipe may be used to rub the surface.
  • the surface may be living or dead human or animal skin, hair, organs and other tissues, hard surfaces and medical instruments.
  • Various additional ingredients may be added to the solution, like perfumes, emollients and other commonly known skin products.
  • Medical adhesives may also be used to aid in wound closure by holding together opposite sides of a wound or incision site and so allowing the skin to heal more quickly than it would without the adhesive.
  • THFA tetrahydrofurfuryl acetate
  • diluents like perfumes, emollients and other additives common to skin products, and diluents common to plastics and adhesives technology may be added in an amount up to about 20 weight percent without significantly interfering with the solvent properties of the THFA.
  • Potential diluents include, but are not limited to, vegetable oils like, for example soy oil, corn oil and safflower oil, vitamin E, citrates, and phthalate plasticizers, fatty acid esters, triacetin and the like.
  • the THFA solution may be applied to the skin by the use of wipers or by direct application to the skin in liquid form followed by rubbing or abrasion by a wiper.
  • the THFA solution may be sterile or non-sterile and can have a range of coverage areas depending on the amount of solution and abrasiveness of the wiper. Wipers that may be used in conjunction with the THFA solution include, but are not limited to, those taught in US patents 4,659,609, 4,775,582, 4,833,003 and 4,853,281.
  • the method of using the THFA solution includes the steps of providing the solution and adhesive coated surface to which the solution will be applied, applying the solution to the surface, and rubbing or abrading the surface to facilitate the removal of the adhesive.
  • the THFA may be applied to a wiper before application to the surface and the wiper may be used to rub the surface.
  • Also provided is system for teaching a method of using an adhesive remover having the steps of providing a container within which is the remover, labeling the container with steps for using the remover where the steps are; applyiffg'tHe remover to a surface and rubbing the remover on the surface in order to enhance removal.
  • compositions for removing adhesive include tetrahydrofurfuryl acetate and ingredients such as perfumes, emollients, dyes, colorants, vegetable oils, vitamin E, citrates, phthalate plasticizers, fatty acid esters, triacetin and mixtures thereof .
  • the remover may be used on any surface on which is located a medical adhesive.
  • the remover may be used to remove adhesive from living or dead human or animal skin, hair, organs and other tissues, hard surfaces, e.g. c ⁇ untertops, upon which adhesive may have been inadvertently applied, or from medical instruments, for example.
  • Tetrahydrofurfuryl acetate has a CAS registry number of 637-64-9. It has a molecular formula of C 7 H 1 2O 3 , a weight of 144.17, and a boiling point of about 194 0 C at 753 mmHg. Synonyms for THFA include tetrahydro-2-furyl methyl acetate, 2-(acetoxymethyl) tetrahydrofuran, 2-acetoxymethyl oxolane and tetrahydro-2- furan methanol acetate. THFA is non-flammable and is used currently as a flavoring or perfume ingredient.
  • Exemplary solutions of THFA include: a. 100% THFA which rapidly removes polyoctyl cyanoacrylate from skin after application of BAND-AIDTM Liquid Bandage, Skin Crack Gel,

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Paints Or Removers (AREA)

Abstract

Medical adhesive may be removed by applying a solution including tetrahydrofurfuryl acetate (THFA) to the surface upon which is located the adhesive and rubbing the surface to facilitate removal of the adhesive. The solution may be applied to a wipe before application to the surface and the wipe may be used to rub the surface. The surface may be living or dead human or animal skin, hard surfaces and medical instruments. Various additional ingredients may be added to the solution, like perfumes, emollients and other commonly known skin products and polymer diluents.

Description

METROD OF REMOVING MEDICALADHESIVE
The present invention relates generally to the removal of medical adhesives from mammalian tissues such as hair and skin. Medical adhesives have many uses, including securing wound dressings, surgical drapes, tapes, sensors and the like, as well as skin sealant and liquid sutures etc.
Medical adhesives in the form of surgical skin sealant are applied to the skin prior to, for example, surgery, in order to reduce the risk of infection by gluing in place any microbes, germs, dead skin and the like, so that they cannot move i into the surgical site.
Medical adhesives may also be used to hold together the sides of a wound or surgical incision to encourage healing, much like a butterfly bandage or stitches might do. The medical adhesive is normally allowed to slough off the skin naturally with time. It may be removed from the skin, however, in the case of surgery for example, when the surgery is completed. Acetone is currently used to remove medical adhesives but is somewhat limited in applicability, especially in a surgical environment, because of concerns about flammability and irritation of the skin. Mineral oil and soap and water are also used but suffer from a lack of efficacy.
Removers for the adhesive should be able to remove the adhesive without damaging the skin, without strong smells, and without being flammable. SUMMARY
The present invention provides a method for removing medical adhesive from surfaces safely and effectively. Medical adhesive may be removed by applying a solution including tetrahydrofurfuryl acetate (THFA) to the surface upon which is located the adhesive and rubbing the surface to facilitate removal of the adhesive. The solution may be applied to a wipe before application to the surface and the wipe may be used to rub the surface. The surface may be living or dead human or animal skin, hair, organs and other tissues, hard surfaces and medical instruments. Various additional ingredients may be added to the solution, like perfumes, emollients and other commonly known skin products.
DETAILED DESCRIPTION
Medical adhesives are often used in surgical environments to reduce the possibility that extraneous materials will enter the incision site. Loose skin cells and other potential contaminates on the skin can be immobilized by the application of an adhesive that coats the skin and thus holds these materials in place.
Medical adhesives may also be used to aid in wound closure by holding together opposite sides of a wound or incision site and so allowing the skin to heal more quickly than it would without the adhesive.
In the case of surgical applications of medical adhesives, once the surgery is complete it may be desired to remove the adhesive. Acetone is often chosen for adhesive removal but is flammable, irritates the skin, and has an unpleasant odor. THe inventor Has found that tetrahydrofurfuryl acetate (THFA) can dissolve medical adhesive common in the surgical suite. The inventor has further found that diluents like perfumes, emollients and other additives common to skin products, and diluents common to plastics and adhesives technology may be added in an amount up to about 20 weight percent without significantly interfering with the solvent properties of the THFA. Potential diluents include, but are not limited to, vegetable oils like, for example soy oil, corn oil and safflower oil, vitamin E, citrates, and phthalate plasticizers, fatty acid esters, triacetin and the like.
The THFA solution may be applied to the skin by the use of wipers or by direct application to the skin in liquid form followed by rubbing or abrasion by a wiper. The THFA solution may be sterile or non-sterile and can have a range of coverage areas depending on the amount of solution and abrasiveness of the wiper. Wipers that may be used in conjunction with the THFA solution include, but are not limited to, those taught in US patents 4,659,609, 4,775,582, 4,833,003 and 4,853,281.
The method of using the THFA solution includes the steps of providing the solution and adhesive coated surface to which the solution will be applied, applying the solution to the surface, and rubbing or abrading the surface to facilitate the removal of the adhesive. As noted above, the THFA may be applied to a wiper before application to the surface and the wiper may be used to rub the surface.
Also provided is system for teaching a method of using an adhesive remover having the steps of providing a container within which is the remover, labeling the container with steps for using the remover where the steps are; applyiffg'tHe remover to a surface and rubbing the remover on the surface in order to enhance removal.
A composition for removing adhesive is also provided where the composition includes tetrahydrofurfuryl acetate and ingredients such as perfumes, emollients, dyes, colorants, vegetable oils, vitamin E, citrates, phthalate plasticizers, fatty acid esters, triacetin and mixtures thereof .
It should be noted that the remover may be used on any surface on which is located a medical adhesive. Thus the remover may be used to remove adhesive from living or dead human or animal skin, hair, organs and other tissues, hard surfaces, e.g. cσuntertops, upon which adhesive may have been inadvertently applied, or from medical instruments, for example.
Tetrahydrofurfuryl acetate has a CAS registry number of 637-64-9. It has a molecular formula of C7H12O3, a weight of 144.17, and a boiling point of about 194 0C at 753 mmHg. Synonyms for THFA include tetrahydro-2-furyl methyl acetate, 2-(acetoxymethyl) tetrahydrofuran, 2-acetoxymethyl oxolane and tetrahydro-2- furan methanol acetate. THFA is non-flammable and is used currently as a flavoring or perfume ingredient.
Exemplary solutions of THFA include: a. 100% THFA which rapidly removes polyoctyl cyanoacrylate from skin after application of BAND-AID™ Liquid Bandage, Skin Crack Gel,
(Johnson &Johnson Skillman, NJ) However the skin after removal appears slightly white and dusty and may have been de-fatted. b. 80% THFA, 20% triacetin, which readily removes polybutyl cyanoacrylate from skin after application of Nexcare™ Liquid Bandage V3lf ti$nsumer Health Care, St Paul, MN) c. 90% THFA, 9% safflower oil and 1% vitamin E, which readily removes adhesive residue from loBan™ antimicrobial surgical drape (3M Healthcare, St Paul MN)
It should be appreciated by those skilled in the art that various modifications and variations can be made to the embodiments of the present invention described and illustrated herein without departing from the scope and spirit of the invention. The invention includes such modifications and variations coming within the meaning and range of equivalency of the appended claims.

Claims

What is claimed is:
1. A method of removing adhesive from a surface comprising the steps of: providing a surface upon which is an adhesive; providing an adhesive remover; applying said remover to the surface; rubbing the remover on the surface in order to enhance removal; wherein said remover comprises tetrahydrofurfuryl acetate.
2. The method of claims 1 wherein said surface is skin.
3. The method of claim 2 wherein said skin is living human skin.
4. The method of claim 2 wherein said skin is dead human skin.
5. The method of claim 2 wherein said skin is animal skin.
6. The method of claim 1 wherein said surface is tissue.
7. The method of claim 1 wherein said remover further comprises ingredients selected from the group consisting of perfumes, emollients, dyes, colorants, vegetable oils, vitamin E, citrates, phthalate plasticizers, fatty acid esters, triacetin and mixtures thereof.
8. A method of removing adhesive from a surface comprising the steps of: providing a surface upon which is an adhesive; providing an adhesive remover; applying said remover to a wipe; rubbing said wipe on the surface in order to enhance removal; wherein said remover comprises tetrahydrofurfuryl acetate.
9. The method of claim 8 wherein said surface is skin.
10. The method of claim 9 wherein said skin is living human skin.
11. The method of claim 8 wherein said skin is dead human skin.
12. The method of claim 8 wherein said skin is animal skin.
13. The method of claim 8 wherein said surface is tissue.
14. The method of claim 8 wherein said remover further comprises ingredients selected from the group consisting of perfumes, emollients, dyes, colorants, vegetable oils, vitamin E, citrates, phthalate plasticizers, fatty acid esters, triacetin and mixtures thereof.
15. A composition for the removal of adhesive comprising tetrahydrofurfuryl acetate and ingredients selected from the group consisting of perfumes, emollients, dyes, colorants, vegetable oils, vitamin E, citrates, phthalate plasticizers, fatty acid esters, triacetin and mixtures thereof .
16. A system for teaching a method of using an adhesive remover comprising providing a container within which is said remover, labeling said container with steps for using said remover comprising: applying said remover to a surface; rubbing the remover on the surface in order to enhance removal; wherein said remover comprises tetrahydrofurfuryl acetate.
EP06824803A 2005-08-31 2006-08-04 Method of removing medical adhesive Active EP1919529B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/216,701 US7354889B2 (en) 2005-08-31 2005-08-31 Method of removing medical adhesive with a remover comprising tetrahydrofurfuryl acetate
PCT/US2006/030615 WO2007027371A2 (en) 2005-08-31 2006-08-04 Method of removing medical adhesive

Publications (2)

Publication Number Publication Date
EP1919529A2 true EP1919529A2 (en) 2008-05-14
EP1919529B1 EP1919529B1 (en) 2012-04-25

Family

ID=37697823

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06824803A Active EP1919529B1 (en) 2005-08-31 2006-08-04 Method of removing medical adhesive

Country Status (5)

Country Link
US (1) US7354889B2 (en)
EP (1) EP1919529B1 (en)
JP (1) JP4970455B2 (en)
CA (1) CA2619460C (en)
WO (1) WO2007027371A2 (en)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
US8957277B2 (en) 2009-04-27 2015-02-17 Avery Dennison Corporation Disruptable adhesive layer for fluid activated debonding
KR101733021B1 (en) 2009-04-27 2017-05-08 애버리 데니슨 코포레이션 Systems, methods and materials for delivery and debonding on demand
US7780795B1 (en) 2009-12-08 2010-08-24 Universal Beauty, Inc. Adhesive removal indicator system and method of use
DK2773304T3 (en) 2011-10-31 2016-05-02 Avery Dennison Corp Adhesive layers, which can be torn apart, to the fluid-activated solution.
GB201119198D0 (en) * 2011-11-07 2011-12-21 Jack Amanda Removal of surgical casts
ES2677469T3 (en) 2012-07-24 2018-08-02 Avery Dennison Corporation Hybrid silicone / acrylic adhesives
EP2909270A1 (en) 2012-10-22 2015-08-26 Avery Dennison Corporation Hybrid material of crosslinked microgel particles dispersed in an adhesive
US11851637B2 (en) 2013-08-23 2023-12-26 Ecolab Usa Inc. Adhesive remover compositions and methods of use

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Also Published As

Publication number Publication date
CA2619460C (en) 2014-04-29
US7354889B2 (en) 2008-04-08
JP4970455B2 (en) 2012-07-04
EP1919529B1 (en) 2012-04-25
US20070054821A1 (en) 2007-03-08
JP2009506190A (en) 2009-02-12
CA2619460A1 (en) 2007-03-08
WO2007027371A3 (en) 2008-03-27
WO2007027371A2 (en) 2007-03-08

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