EP1885855A4 - Cytokine receptor modulators and uses thereof - Google Patents
Cytokine receptor modulators and uses thereofInfo
- Publication number
- EP1885855A4 EP1885855A4 EP06795318A EP06795318A EP1885855A4 EP 1885855 A4 EP1885855 A4 EP 1885855A4 EP 06795318 A EP06795318 A EP 06795318A EP 06795318 A EP06795318 A EP 06795318A EP 1885855 A4 EP1885855 A4 EP 1885855A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor modulators
- cytokine receptor
- cytokine
- modulators
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11001894A EP2366786A3 (en) | 2005-05-05 | 2006-05-05 | Cytokine receptor modulators and uses thereof |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CA2005/000691 WO2005105830A1 (en) | 2004-05-05 | 2005-05-05 | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US75136005P | 2005-12-16 | 2005-12-16 | |
PCT/IB2006/002298 WO2007004060A2 (en) | 2005-05-05 | 2006-05-05 | Cytokine receptor modulators and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1885855A2 EP1885855A2 (en) | 2008-02-13 |
EP1885855A4 true EP1885855A4 (en) | 2009-03-04 |
Family
ID=37604843
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11001894A Withdrawn EP2366786A3 (en) | 2005-05-05 | 2006-05-05 | Cytokine receptor modulators and uses thereof |
EP06795318A Withdrawn EP1885855A4 (en) | 2005-05-05 | 2006-05-05 | Cytokine receptor modulators and uses thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11001894A Withdrawn EP2366786A3 (en) | 2005-05-05 | 2006-05-05 | Cytokine receptor modulators and uses thereof |
Country Status (6)
Country | Link |
---|---|
US (2) | US20090048161A1 (en) |
EP (2) | EP2366786A3 (en) |
JP (1) | JP2008542685A (en) |
AU (1) | AU2006264567A1 (en) |
CA (1) | CA2650656A1 (en) |
WO (1) | WO2007004060A2 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
ES2402823T3 (en) | 2006-06-01 | 2013-05-09 | Institut De Cardiologie De Montreal | Compound for use in the treatment of valve stenosis |
MX2009013269A (en) | 2007-06-05 | 2010-04-21 | Univ Yale | Inhibitors of receptor tyrosine kinases and methods of use thereof. |
EP2288621A4 (en) * | 2007-07-06 | 2012-01-04 | Valorisation Hsj Soc En Commandite | Il-23 receptor antagonists and uses thereof |
US20110135661A1 (en) * | 2008-02-19 | 2011-06-09 | Universite De Montreal | Treatment and prevention of dry age-related macular degeneration by activating cd36 |
WO2009120903A2 (en) * | 2008-03-26 | 2009-10-01 | Cellerant Therapeutics, Inc. | Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof |
RU2532222C2 (en) | 2009-02-16 | 2014-10-27 | Серенис Терапьютикс Холдинг С.А, | A-i apolipoprotein mimetics |
AU2014268255B2 (en) * | 2009-02-16 | 2016-04-21 | Cerenis Therapeutics Holding Sa | Apolipoprotein a-i mimics |
DK2403935T3 (en) | 2009-03-04 | 2017-09-11 | Univ Pennsylvania | COMPOSITIONS CONTAINING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF |
WO2010106441A2 (en) * | 2009-03-20 | 2010-09-23 | Centre Hospitalier Universitaire Sainte-Justine | Peptidomimetics for modulating interleukin-1 receptor |
WO2010124262A1 (en) * | 2009-04-24 | 2010-10-28 | Allostera Pharma Inc. | Methods of identification of allosteramers and uses thereof |
EP2668210B1 (en) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
WO2012106556A2 (en) | 2011-02-02 | 2012-08-09 | Amgen Inc. | Methods and compositons relating to inhibition of igf-1r |
AU2012228769B2 (en) | 2011-03-14 | 2016-09-08 | Phlogo Aps | Antagonists of the interleukin- 1 receptor |
WO2013071056A2 (en) | 2011-11-11 | 2013-05-16 | Duke University | Combination drug therapy for the treatment of solid tumors |
US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
SG11201500489YA (en) | 2012-07-25 | 2015-02-27 | Kolltan Pharmaceuticals Inc | Anti-kit antibodies and uses thereof |
WO2014100772A1 (en) * | 2012-12-21 | 2014-06-26 | Cellerant Therapeutics, Inc. | Antibodies that bind membrane-bound il1rap |
CN113908269A (en) | 2014-05-23 | 2022-01-11 | 塞尔德克斯医疗公司 | Treatment of eosinophil or mast cell related disorders |
WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
CN107328943B (en) * | 2017-07-28 | 2019-04-16 | 东曜药业有限公司 | A kind of detection method and application of vascular endothelial growth factor biological activity |
WO2019051494A1 (en) | 2017-09-11 | 2019-03-14 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
WO2019233605A1 (en) * | 2018-06-08 | 2019-12-12 | BioNTech SE | Compositions and methods for diagnosis and treatment of cancer |
TW202021618A (en) | 2018-08-17 | 2020-06-16 | 美商23與我有限公司 | Anti-il1rap antibodies and methods of use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005105830A1 (en) * | 2004-05-05 | 2005-11-10 | Valorisation-Recherche, Societe En Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US20060094663A1 (en) * | 2004-05-05 | 2006-05-04 | Sylvain Chemtob | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US20070037210A1 (en) * | 2002-10-24 | 2007-02-15 | Sylvain Chemtob | Cytokine receptor modulators, method of identifying same, and method of modulating cytokine receptors activity with same |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3645090A (en) | 1969-06-19 | 1972-02-29 | Citizen Watch Co Ltd | Day-date quick-adjuster for calender timepiece |
US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
US4305872A (en) | 1979-10-19 | 1981-12-15 | Kenneth Wingrove | Polypeptide derivatives |
US4316891A (en) | 1980-06-14 | 1982-02-23 | The Salk Institute For Biological Studies | Extended N-terminal somatostatin |
US5227466A (en) * | 1988-06-30 | 1993-07-13 | City Of Hope | Insulin receptor binding site |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5126249A (en) | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
GB9017008D0 (en) | 1990-08-02 | 1990-09-19 | Erba Carlo Spa | Process for the enzymatic preparation of basic fibroblast growth factor |
US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US6184205B1 (en) * | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
PE64396A1 (en) * | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | INTERLEUKIN 1 RECEIVER ACCESSORY PROTEIN |
EP0861267A4 (en) * | 1995-11-14 | 2000-02-02 | Univ Jefferson | Inducing resistance to tumor growth with soluble igf-1 receptor |
US5854221A (en) | 1996-12-12 | 1998-12-29 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and method of use |
ATE296446T1 (en) * | 1997-01-15 | 2005-06-15 | Telik Inc | MODULATORS OF INSULIN RECEPTOR ACTIVITY |
EP1034188B1 (en) * | 1997-11-27 | 2006-06-07 | Commonwealth Scientific And Industrial Research Organisation | Method of designing agonists and antagonists to igf receptor (1-462) |
US6280955B1 (en) * | 1997-12-16 | 2001-08-28 | Tularik Inc. | Interleukin-1 receptor accessory proteins, nucleic acids and methods |
US20030190740A1 (en) * | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
EP1159289A1 (en) * | 1999-03-11 | 2001-12-05 | Gryphon Sciences | Chemical synthesis and use of soluble membrane protein receptor domains |
NZ515964A (en) | 1999-06-21 | 2004-03-26 | Murdoch Childrens Res Inst | A method for the prophylaxis and/or treatment of medical disorders |
CA2402780A1 (en) * | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
DE16192152T1 (en) * | 2000-05-26 | 2020-08-06 | Immunex Corporation | USE OF INTERLEUKIN-4 RECEPTOR (IL-4R) ANTIBODIES AND COMPOSITIONS THEREOF |
EP1450837A4 (en) * | 2001-08-07 | 2006-01-04 | Immunex Corp | Interleukin-1 receptors in the treatment of diseases |
GB0125338D0 (en) * | 2001-10-22 | 2001-12-12 | Isis Innovation | Process for reducing immunogenic reactions using selective TH1 cell binding antibodies |
US20030125518A1 (en) * | 2001-12-01 | 2003-07-03 | Crevecoeur Harry F. | Surface simulation synthetic peptides useful in the treatment of hyper-variable viral pathogens |
-
2006
- 2006-05-05 EP EP11001894A patent/EP2366786A3/en not_active Withdrawn
- 2006-05-05 EP EP06795318A patent/EP1885855A4/en not_active Withdrawn
- 2006-05-05 CA CA002650656A patent/CA2650656A1/en not_active Abandoned
- 2006-05-05 JP JP2008509540A patent/JP2008542685A/en active Pending
- 2006-05-05 AU AU2006264567A patent/AU2006264567A1/en not_active Abandoned
- 2006-05-05 WO PCT/IB2006/002298 patent/WO2007004060A2/en active Application Filing
- 2006-05-05 US US11/919,941 patent/US20090048161A1/en not_active Abandoned
-
2010
- 2010-12-15 US US12/968,363 patent/US20110144014A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070037210A1 (en) * | 2002-10-24 | 2007-02-15 | Sylvain Chemtob | Cytokine receptor modulators, method of identifying same, and method of modulating cytokine receptors activity with same |
WO2005105830A1 (en) * | 2004-05-05 | 2005-11-10 | Valorisation-Recherche, Societe En Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
US20060094663A1 (en) * | 2004-05-05 | 2006-05-04 | Sylvain Chemtob | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
EP1751175A1 (en) * | 2004-05-05 | 2007-02-14 | Valorisation-Recherche, Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
Non-Patent Citations (3)
Title |
---|
BEREZOV A ET AL: "Disabling receptor ensembles with rationally designed interface peptidomimetics", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 277, no. 31, 2 August 2002 (2002-08-02), pages 28330 - 28339, XP002354466, ISSN: 0021-9258 * |
PERCHERANCIER YANN ET AL: "Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 11, March 2005 (2005-03-01), pages 9895 - 9903, XP002511383, ISSN: 0021-9258 * |
TAN D C W ET AL: "A small peptide derived from Flt-1 (VEGFR-1) functions as an angiogenic inhibitor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 494, no. 3, 13 April 2001 (2001-04-13), pages 150 - 156, XP004235061, ISSN: 0014-5793 * |
Also Published As
Publication number | Publication date |
---|---|
US20110144014A1 (en) | 2011-06-16 |
US20090048161A1 (en) | 2009-02-19 |
EP2366786A2 (en) | 2011-09-21 |
WO2007004060A3 (en) | 2007-04-26 |
JP2008542685A (en) | 2008-11-27 |
CA2650656A1 (en) | 2007-01-11 |
AU2006264567A1 (en) | 2007-01-11 |
WO2007004060A2 (en) | 2007-01-11 |
EP2366786A3 (en) | 2012-08-29 |
EP1885855A2 (en) | 2008-02-13 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Inventor name: BEAUCHAMP, MARTIN Inventor name: CHEMTOB, SYLVAIN Inventor name: QUINIOU, CHRISTIANE |
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