EP1802199A4 - Isolated lineage negative hematopoietic stem cells and methods of treatment therewith - Google Patents

Isolated lineage negative hematopoietic stem cells and methods of treatment therewith

Info

Publication number
EP1802199A4
EP1802199A4 EP05814042A EP05814042A EP1802199A4 EP 1802199 A4 EP1802199 A4 EP 1802199A4 EP 05814042 A EP05814042 A EP 05814042A EP 05814042 A EP05814042 A EP 05814042A EP 1802199 A4 EP1802199 A4 EP 1802199A4
Authority
EP
European Patent Office
Prior art keywords
methods
stem cells
hematopoietic stem
lineage negative
treatment therewith
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05814042A
Other languages
German (de)
French (fr)
Other versions
EP1802199A2 (en
Inventor
Martin Friedlander
Atsushi Otani
Silva Karen Da
Stacey Hanekamp Moreno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/933,634 external-priority patent/US20050129665A1/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Priority claimed from PCT/US2005/031304 external-priority patent/WO2006031467A2/en
Publication of EP1802199A2 publication Critical patent/EP1802199A2/en
Publication of EP1802199A4 publication Critical patent/EP1802199A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
EP05814042A 2004-09-03 2005-09-02 Isolated lineage negative hematopoietic stem cells and methods of treatment therewith Withdrawn EP1802199A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/933,634 US20050129665A1 (en) 2002-07-25 2004-09-03 Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
PCT/US2005/031304 WO2006031467A2 (en) 2002-07-25 2005-09-02 Isolated lineage negative hematopoietic stem cells and methods of treatment therewith

Publications (2)

Publication Number Publication Date
EP1802199A2 EP1802199A2 (en) 2007-07-04
EP1802199A4 true EP1802199A4 (en) 2008-08-27

Family

ID=37903853

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05814042A Withdrawn EP1802199A4 (en) 2004-09-03 2005-09-02 Isolated lineage negative hematopoietic stem cells and methods of treatment therewith

Country Status (8)

Country Link
EP (1) EP1802199A4 (en)
JP (1) JP2008512376A (en)
KR (1) KR101309500B1 (en)
CN (1) CN101052305B (en)
AU (1) AU2005285246B2 (en)
CA (1) CA2579292A1 (en)
MX (1) MX2007002639A (en)
ZA (1) ZA200702607B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2554662A1 (en) * 2011-08-05 2013-02-06 M Maria Pia Cosma Methods of treatment of retinal degeneration diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010959A2 (en) * 2002-07-25 2004-02-05 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928638A (en) * 1996-06-17 1999-07-27 Systemix, Inc. Methods for gene transfer
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US6939378B2 (en) * 2001-06-01 2005-09-06 The Board Of Trustees Of The Leland Stanford Junior University Microfabricated tissue as a substrate for pigment epithelium transplantation
DE60223556T2 (en) * 2001-08-10 2008-09-18 Imclone Systems, Inc. MEDICAL USE OF STEM CELLS EXPRESSING VEGFR-1
KR20050042046A (en) * 2001-10-30 2005-05-04 다이이찌 세이야꾸 가부시기가이샤 Method of amplifying hematopoietic stem cells
CN1194086C (en) * 2002-02-01 2005-03-23 北京科宇联合干细胞生物技术有限公司 Neural stem cell preparation, preparing method thereof and use of same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010959A2 (en) * 2002-07-25 2004-02-05 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
WO2004098499A2 (en) * 2002-07-25 2004-11-18 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
OTANI A ET AL: "Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 8, no. 9, 1 September 2002 (2002-09-01), pages 1004 - 1010, XP002988691, ISSN: 1078-8956 *
OTANI ATSUSHI ET AL: "Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 114, no. 6, 15 September 2004 (2004-09-15), pages 765 - 774, XP002413476, ISSN: 0021-9738 *
SMITH L E H: "Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 114, no. 6, 15 September 2004 (2004-09-15), pages 755 - 757, XP003001779, ISSN: 0021-9738 *
WATANABE M ET AL: "Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina", NEUROSCIENCE, NEW YORK, NY, US, vol. 116, no. 3, 1 January 2003 (2003-01-01), pages 733 - 742, XP002413475, ISSN: 0306-4522 *
YIN A H ET AL: "AC133, a novel marker for human hematopoietic stem and progenitor cells", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, vol. 90, no. 12, 15 December 1997 (1997-12-15), pages 5002 - 5012, XP002264586, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
AU2005285246B2 (en) 2011-07-21
EP1802199A2 (en) 2007-07-04
CN101052305B (en) 2012-10-10
MX2007002639A (en) 2007-08-06
KR101309500B1 (en) 2013-09-24
KR20070104512A (en) 2007-10-26
CN101052305A (en) 2007-10-10
JP2008512376A (en) 2008-04-24
CA2579292A1 (en) 2006-03-23
AU2005285246A1 (en) 2006-03-23
ZA200702607B (en) 2008-08-27

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20070403

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20080730

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 27/02 20060101AFI20080724BHEP

Ipc: A61K 35/14 20060101ALI20080724BHEP

Ipc: C12N 5/06 20060101ALN20080724BHEP

Ipc: C12N 5/10 20060101ALN20080724BHEP

Ipc: C12N 5/00 20060101ALN20080724BHEP

17Q First examination report despatched

Effective date: 20081104

STAA Information on the status of an ep patent application or granted ep patent

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18W Application withdrawn

Effective date: 20111102