EP1799244A4 - Furin inhibitors - Google Patents

Furin inhibitors

Info

Publication number
EP1799244A4
EP1799244A4 EP05858535A EP05858535A EP1799244A4 EP 1799244 A4 EP1799244 A4 EP 1799244A4 EP 05858535 A EP05858535 A EP 05858535A EP 05858535 A EP05858535 A EP 05858535A EP 1799244 A4 EP1799244 A4 EP 1799244A4
Authority
EP
European Patent Office
Prior art keywords
furin inhibitors
furin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05858535A
Other languages
German (de)
French (fr)
Other versions
EP1799244A1 (en
Inventor
Robert E Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1799244A1 publication Critical patent/EP1799244A1/en
Publication of EP1799244A4 publication Critical patent/EP1799244A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP05858535A 2004-07-23 2005-07-22 Furin inhibitors Withdrawn EP1799244A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59057704P 2004-07-23 2004-07-23
PCT/US2005/026086 WO2007046781A1 (en) 2004-07-23 2005-07-22 Furin inhibitors

Publications (2)

Publication Number Publication Date
EP1799244A1 EP1799244A1 (en) 2007-06-27
EP1799244A4 true EP1799244A4 (en) 2010-06-09

Family

ID=37846313

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05858535A Withdrawn EP1799244A4 (en) 2004-07-23 2005-07-22 Furin inhibitors

Country Status (5)

Country Link
US (1) US8263563B2 (en)
EP (1) EP1799244A4 (en)
AU (1) AU2005334458B9 (en)
CA (1) CA2586086A1 (en)
WO (1) WO2007046781A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865865B2 (en) 2008-10-29 2014-10-21 Philipps-Universitat Marburg N-terminally modified tetrapeptide derivatives having a C-terminal arginine mimetic
JP5537144B2 (en) * 2009-12-16 2014-07-02 ＡｖａｎＳｔｒａｔｅ株式会社 Glass composition and glass substrate for flat panel display using the same
WO2012050673A1 (en) * 2010-10-14 2012-04-19 Wisconsin Alumni Research Foundation Methods for the treatment of x-linked hypophosphatemia and related disorders
CN103743909B (en) * 2013-11-29 2015-11-25 漯河医学高等专科学校 The influence research method that furin inhibitor grows lung adenocarcinoma cell and shifts
PE20171335A1 (en) 2014-10-06 2017-09-13 Cortexyme Inc LYSINE GINGIPAINE INHIBITORS
JP6877424B2 (en) 2015-11-09 2021-05-26 コーテクシーミー， インコーポレイテッド Inhibitor of arginine gingipain
BR112019004864A8 (en) 2016-09-16 2023-03-07 Cortexyme Inc LYSINE KETONE INHIBITORS GINGIPAIN
WO2019215341A1 (en) * 2018-05-11 2019-11-14 Glaxosmithkline Intellectual Property Development Limited Furin inhibitors
WO2020048942A1 (en) 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
WO2022235567A1 (en) * 2021-05-03 2022-11-10 nference, inc. Compositions and methods for treating sars-cov-2 infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274365A (en) * 1988-10-26 1993-12-28 Sun Microsystems, Inc. Method and apparatus for minimizing the visual degradation of digital typefaces-character analysis
US5935815A (en) 1989-10-25 1999-08-10 Katholieke Universiteit Leuven Process for micro biological production of proteins
US5151347A (en) 1989-11-27 1992-09-29 Martek Corporation Closed photobioreactor and method of use
US5604201A (en) * 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease
AT404838B (en) * 1995-11-24 1999-03-25 Immuno Ag PRODUCTION OF PROTEINS FROM PRO-PROTEINS BY FUSION PROTEINS DERIVED FROM FURIN OR FURINANALOGS
US6180356B1 (en) * 1998-03-06 2001-01-30 The Research Foundation Of State University Of Ny Membrane pore inhibiting agents for treating infection
FI4069U1 (en) * 1998-06-22 1999-07-23 Polar Electro Oy Heart rate monitor connector and electrode belt
US6596526B1 (en) * 2000-06-09 2003-07-22 Baxter Aktiengesellschaft Furin polypeptides with improved characteristics
US7033991B2 (en) * 2001-07-16 2006-04-25 Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College Inhibiting furin with polybasic peptides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CAMERON A ET AL: "Polyarginines Are Potent Furin Inhibitors", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.M003848200, vol. 275, no. 47, 24 November 2000 (2000-11-24), pages 36741 - 36749, XP002251991, ISSN: 0021-9258 *
HALLENBERGER S ET AL: "INHIBITION OF FURIN-MEDIATED CLEAVAGE ACTIVATION OF HIV-1 GLYCOPROTEIN GP160", NATURE, NATURE PUBLISHING GROUP, LONDON, GB LNKD- DOI:10.1038/360358A0, vol. 360, 26 November 1992 (1992-11-26), pages 358 - 361, XP000606696, ISSN: 0028-0836 *
HATANAKA Y ET AL: "INTERACTIONS OF DERIVATIVES OF GUANIDINOPHENYLALANINE AND GUANIDINOPHENYLGLYCINE WITH STREPTOMYCES GRISEUS TRYPSIN", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM; NL LNKD- DOI:10.1016/0167-4838(85)90260-2, vol. 832, no. 3, 20 December 1985 (1985-12-20), pages 274 - 279, XP000617791, ISSN: 0167-4838 *
JEAN F ET AL: "Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 18 AUG 1995 LNKD- PUBMED:7642593, vol. 270, no. 33, 18 August 1995 (1995-08-18), pages 19225 - 19231, XP002113498, ISSN: 0021-9258 *
See also references of WO2007046781A1 *
STIENEKE-GROEBER A ET AL: "INFLUENZA VIRUS HEMAGGLUTININ WITH MULTIBASIC CLEAVAGE SITE IS ACTIVATED BY FURIN, A SUBTILLISIN-LIKE ENDOPROTEASE", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 11, no. 7, 1 January 1992 (1992-01-01), pages 2407 - 2414, XP002925564, ISSN: 0261-4189 *
THOMAS GARY: "Furin at the cutting edge: from protein traffic to embryogenesis and disease.", NATURE REVIEWS. MOLECULAR CELL BIOLOGY OCT 2002 LNKD- PUBMED:12360192, vol. 3, no. 10, October 2002 (2002-10-01), pages 753 - 766, XP009131959, ISSN: 1471-0072 *

Also Published As

Publication number Publication date
US20090131328A1 (en) 2009-05-21
AU2005334458A8 (en) 2008-08-07
CA2586086A1 (en) 2006-01-23
EP1799244A1 (en) 2007-06-27
AU2005334458A1 (en) 2007-03-01
US8263563B2 (en) 2012-09-11
WO2007046781A1 (en) 2007-04-26
AU2005334458B9 (en) 2012-06-07
AU2005334458B2 (en) 2012-02-02
WO2007046781A8 (en) 2007-07-26

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