EP1792972A1 - Verwendung von multifunktionellen Tensiden zur Reinigung von Kontaktlinsen - Google Patents
Verwendung von multifunktionellen Tensiden zur Reinigung von Kontaktlinsen Download PDFInfo
- Publication number
- EP1792972A1 EP1792972A1 EP07005666A EP07005666A EP1792972A1 EP 1792972 A1 EP1792972 A1 EP 1792972A1 EP 07005666 A EP07005666 A EP 07005666A EP 07005666 A EP07005666 A EP 07005666A EP 1792972 A1 EP1792972 A1 EP 1792972A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- contact lenses
- cleaning
- lens
- multifunctional
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 0 *C(CC*=C)NC(*)=O Chemical compound *C(CC*=C)NC(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/10—Amino carboxylic acids; Imino carboxylic acids; Fatty acid condensates thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
Definitions
- the present invention relates to aqueous compositions for cleaning contact lenses, particularly soft contact lenses.
- Deposits such as proteins, lipids and calcium are formed on contact lenses when these lenses are worn on the eye. Proteins adsorb to almost all surfaces and the minimization or elimination of protein adsorption has been the subject of numerous studies and technologies. The removal of proteins from a contact lens is required due to the irritation and discomfort that result from the buildup of deposits on the surface of the lens.
- compositions and methods have been utilized to clean contact lenses prior to the present invention.
- the prior compositions and methods have included cleaning agents such as surfactants, chelating agents and proteolytic enzymes.
- the present invention is particularly directed to the removal of protein deposits from contact lenses. The principal component of such deposits is lysozyme.
- Lysozyme is one of the major proteinaceous components in human tears. It is an enzyme that acts as an antimicrobial agent by degrading glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine units of the microbial cell wall. Thus, the presence of lysozyme in human tears is a natural defense mechanism against ocular infections. Unfortunately, when contact lenses are placed on the eye, prolonged bathing of the lenses by the tears leads to deposits of lysozyme on the lenses. Lysozyme is a protein, and the deposits of lysozyme on contact lenses are typically composed of a mixture of proteins, lipids and other materials. These deposits become bound to the lenses, and consequently are very difficult to remove.
- proteolytic enzymes e.g., pancreatin
- the use of proteolytic enzymes to remove protein deposits from contact lenses has been fairly effective.
- the treatment of contact lenses with cleaning compositions containing proteolytic enzymes is considered by some contact lens wearers to be undesirable, in view of cost, convenience and other factors. Consequently, the use of proteolytic enzyme products to remove protein deposits from contact lenses has declined greatly over the past decade.
- the enzyme products have largely been replaced by complexing agents contained in "multi-purpose" solutions that are used to clean and disinfect contact lenses on a daily basis.
- U.S. Patent No. 5,858,937 (Richard, et al. ) describes the use of phosphonates in multi-purpose solutions to remove protein deposits.
- multi-purpose solutions containing such complexing agents have been commercially successful, there is a need for improved solutions, particularly solutions that are more effective in preventing and removing protein deposits.
- the present invention addresses this need.
- the present invention is based on the finding that certain types of anionic surfactants are particularly useful in removing deposits from contact lenses.
- the anionic surfactants utilized in the present invention have both surface active and chelating properties, and are therefore referred to as being "multifunctional".
- hydrophobic and sequestering properties makes the multifunctional anionic surfactants described herein particularly effective for removing insoluble proteinaceous material, inorganic calcium salts and lipids from contact lenses.
- the multifunctional agents described herein provide superior cleaning properties relative to common surfactants and chelating agents (e.g., non-ionic block copolymer surfactants, such as the poloxamines sold under the trade name “Tetronic ® " and the poloxamers sold under the trade name “Pluronic ® , and chelating agents, such as EDTA, 1-hydroxyethylidene-1,1-diphosphonic acid, and sodium citrate).
- the multifunctional agents preferably have sufficient hydrophobicity to confer anti-microbial properties to the molecule.
- the multifunctional cleaning agents described herein may be contained in various types of compositions for treating contact lenses, such as wetting solutions, soaking solutions, cleaning solutions, comfort solutions, and multi-purpose solutions.
- the primary function of the multifunctional anionic surfactants in the compositions of the present invention is to facilitate cleaning of contact lenses, but these agents may also serve to enhance the antimicrobial activity of the compositions, prevent or reduce the uptake of biocides by the lenses, and improve the wettability of the lenses.
- the enhanced antimicrobial activity may be useful in preventing microbial contamination of the compositions described herein (i.e., an antimicrobial preservative function), or to kill microorganisms found on contact lenses (i.e., a disinfection function).
- the advantages of the multifunctional agents include superior chelation properties, effectiveness at low concentrations, an ability to remove all types of lens deposits (protein, calcium and lipid), and compatibility with the disinfection properties of the formulation.
- the multifunctional agents utilized in the present invention are anionic dissociating compounds that contain hydrophilic dissociating head groups.
- the head groups must be capable of dissociating at physiological pH levels.
- the compounds have a hydrocarbon chain length of C8 to C18.
- the anionic groups can be derived from acids, such as carboxylic, sulfonic or phosphonic. Examples of structures for multifunctional agents bearing acetate groups include:
- the preferred multifunctional agents are those wherein R is an alkyl group containing nine or ten carbon atoms (" C9 or C10").
- the most preferred class of multifunctional agents are the ethylene diaminetriacetates of formula (IV), above. These agents are referred to herein by the term "ED3A”.
- the most preferred ethylene diaminetriacetate is lauryl ethylene diaminetriacetate (also known as "LED3A”), which has the following formula:
- the multifunctional agents of formulas (I) - (IV) above are known and are commercially available.
- the ethylene diaminetriacetate LED3A is available from Hampshire Chemical Corporation under the name “Hampshire LED3A”
- the alkyl iminodiacetates disodium cocoamphodiacetate and disodium lauroamphodiacetate are available from Goldschmidt Chemical Corporation under the trade names "REWOTERIC® AM2C NM” (referred to below by means of the term “REW AM2C”) and REWOTERIC® AM2L, respectively.
- the amount of multifunctional agent contained in the compositions of the present invention will depend on the particular agent selected, the type of formulation in which the agent is contained, and the function or functions to be performed by the agents (i.e., cleaning, enhancement of antimicrobial activity and/or prevention of biocide uptake by contact lenses), and other factors that will be apparent to persons skilled in the art.
- the amount of multifunctional agent required to achieve cleaning of contact lenses is referred to herein as a "an amount effective to clean”.
- the amount of multifunctional agent required to enhance antimicrobial activity is referred to as "an amount effective to enhance antimicrobial activity”.
- the amount of multifunctional agent required to prevent uptake of biocides by contact lenses is referred to as "an amount effective to prevent biocide uptake”.
- compositions of the present invention will typically contain one or more multifunctional agents at a concentration in the range of 0.001 to about 1 weight/volume percent ("w/v%"), preferably about 0.05 to 0.5 w/v%, and more preferably between 0.1 to 0.2 w/v%.
- the multifunctional agents of the present invention may also be combined with other components commonly utilized in products for treating contact lenses, such as rheology modifiers, enzymes, antimicrobial agents, surfactants, chelating agents or combinations thereof.
- the preferred surfactants include anionic surfactants, such as RLM 100, or nonionic surfactants, such as poloxamines and poloxamers.
- a variety of buffering agents may be added, such as sodium borate, boric acid, sodium citrate, citric acid, sodium bicarbonate, phosphate buffers and combinations thereof.
- the pH of the solutions should be preferably about 7.0-8.0.
- sodium hydroxide can be used to increase the pH of the formulations
- other bases such as 2-amino-2-methyl-1-propanol ("AMP"), triethanolamine, 2-amino-butanol and Tris(hydroxymethyl) aminomethane may also be used.
- AMP 2-amino-2-methyl-1-propanol
- triethanolamine 2-amino-butanol
- Tris(hydroxymethyl) aminomethane may also be used.
- micellar and other surface active properties of ionic surfactants are dependant on various factors, such as the degree of binding of the counterion, and consequently the type of base used can be important.
- Counterion properties such as valence, polarizability and hydrophobicity are factors requiring consideration when choosing bases to adjust the pH of surfactants to physiological conditions.
- the ophthalmic compositions of the present invention may contain one or more ophthalmically acceptable antimicrobial agents in an amount effective to prevent microbial contamination of the compositions (referred to herein as "an amount effective to preserve"), or in an amount effective to disinfect contact lenses by substantially reducing the number of viable microorganisms present on the lenses (referred to herein as "an amount effective to disinfect”).
- the invention is not limited relative to the types of antimicrobial agents that may be utilized.
- the preferred biocides include: chlorhexidine, polyhexamethylene biguanide polymers ("PHMB”), polyquaternium-1, and the amino biguanides described in co-pending U.S. Patent Application Serial No. 09/581,952 and corresponding International (PCT) Publication No. WO 99/32158 , the entire contents of which are hereby incorporated in the present specification by reference.
- Amidoamines and amino alcohols may also be utilized to enhance the antimicrobial activity of the compositions described herein.
- the preferred amidoamines are myristamidopropyl dimethylamine ("MAPDA") and related compounds described in U.S. Patent No. 5,631,005 (Dassanayake, et al.).
- the preferred amino alcohols are 2-amino-2-methyl-1-propanol ("AMP") and other amino alcohols described in U.S. Patent No. 6,319,464 .
- AMP 2-amino-2-methyl-1-propanol
- the most preferred antimicrobial agents for use in multi-purpose solutions for treating contact lenses are polyquaternium-1 and MAPDA.
- the ophthalmic compositions of the present invention will generally be formulated as sterile aqueous solutions.
- the compositions must be formulated so as to be compatible with ophthalmic tissues and contact lens materials.
- the compositions will generally have an osmolality of from about 200 to about 400 milliosmoles/kilogram water (“mOsm/kg”) and a physiologically compatible pH.
- compositions of the present invention and the ability of these compositions to clean contact lenses are further illustrated in the following examples.
- PBS Phosphate Buffered Saline
- the materials and methods utilized in the evaluation were as follows: 1.311 g of monobasic sodium phosphate (monohydrate), 5.74 g of dibasic sodium phosphate (anhydrous), and 9.0 g of sodium chloride were dissolved in deionized water and the volume was brought to 1000 mL with deionized water after completely dissolving the solutes and adjusting pH (if needed). The final concentrations of sodium phosphate and sodium chloride were 0.05 M and 0.9 w/v %, respectively. The final pH was 7.4.
- a 1.0-mg/mL lysozyme solution was prepared by dissolving 500 mg of lysozyme in 500-mL of phosphate buffered saline.
- a lens extraction solution was prepared by mixing 1.0 mL of trifluoroacetic acid with 500-mL of acetonitrile and 500 mL of deionized water.
- the pH of the solution ranged from 1.5 to 2.0.
- Each lens was immersed with 5 mL of lysozyme solution in a Wheaton glass sample vial.
- the vial was closed with a plastic snap cap and incubated in a constant temperature water bath at 37°C for 24 hours.
- the deposited lens was removed from the vial and rinsed by dipping into three consecutive beakers containing 50 mL of deionized water to remove any excess of the deposition solution.
- the lens was then blotted gently with a laboratory towel (Kaydry EX-L, from Kimberly-Clark). These lenses were used as a soiled lenses for the evaluation of cleaning efficacy of the test solutions.
- the lens was immersed in a Wheaton glass sample vial containing 5 mL of UNISOL ® 4 saline solution.
- the vial was closed with a plastic snap cap held secure with a metal clasp to prevent the cap from popping off during the thermal treatment.
- the vial was then heated in a professional contact lens aseptor at 90°C for 15 minutes. After cooling down to room temperature, the lens was removed from the vial and rinsed by dipping one time into a 50 mL fresh UNISOL ® 4 solution and blotted gently with a laboratory towel (Kaydry EX-L). These lenses were adopted as the soiled lenses of physiological/thermal combination model for the cleaning efficacy evaluation.
- Each soiled lens was soaked and shaken with 5 mL of the test solution in a scintillation vial at room temperature for 12 hours. After the soaking period, the lenses were removed from their respective test solutions and rinsed by dipping into three consecutive beakers containing 20 mL of UNISOL ® 4 solution. No mechanical rubbing was applied to the cleaning regimen. The clean lenses were then subjected to the extraction procedure described below, and the amount of lysozyme present in the soaking solutions was measured with a fluorescence spectrophotometer.
- the clean lenses were extracted with 5 ml of ACN/TFA extraction solution in a screw-capped glass scintillation vial.
- the extraction was conducted by shaking the vial with a rotary shaker (Red Rotor) at room temperature for at least 2 hours (usually overnight).
- a quantitative determination of the amount of lysozyme in the lens extract solution and lens soaking solutions was carried out by a fluorescence spectrophotometer interfaced with an autosampler and a computer.
- the fluorescence intensity of a 2 mL aliquot from each sample solution was measured by setting the excitation/emission wavelength at 280 nm /346 nm with excitation/emission slits of 2.5 nm /10 nm, respectively, and the sensitivity of the photomultiplier was set at 950 volts.
- a lysozyme standard curve was established by diluting the lysozyme stock solution to concentrations ranging from 0 to 60 ⁇ g/ml with either ACN/TFA solution or OPTI-FREE ® Rinsing, Disinfecting and Storage Solution (Alcon Laboratories, Inc.) and measuring the fluorescence intensity using the same instrumental settings as those used for the lens extracts and lens soaking solutions.
- the lysozyme concentrations for all the samples were calculated based on the slope developed from the linear lysozyme standard curve.
- the percent cleaning efficacy of the test solutions was calculated by dividing the amount of lysozyme present in the soaking solution by the sum of the amounts present in the lens extract solution and the soaking solution, and multiplying the resulting quotient by 100.
- Table 1 The cleaning efficacy of the formulations described in Table 1 below was evaluated based on the above-described procedures. Table 1 shows the cleaning efficacy results using a sorbitol/boric acid/sodium chloride buffer vehicle.
- the cleaning efficacy of the control vehicle (formulation E) was 14.3%, whereas the cleaning efficacies of solutions containing the multifunctional agents described herein ranged from 39.4% to 67.1%.
- Formulation A was utilized as a control solution. It contained the sorbitol/boric acid/sodium chloride vehicle utilized in all of the compositions tested, but without any cleaning agent. The percent cleaning efficacy ("%CE") of formulation A was 7.6%. Formulation B was utilized as a second control solution. It was identical to formulation A, except for the addition of EDTA at a concentration of 0.2 w/v%.
- EDTA is widely used in contact lens care products.
- the multifunctional surfactant LED3A is similar to EDTA, except for the substitution of the acetic acid group for an acyl group (i.e., a C 12 chain in the case of LED3A).
- a comparison of the results obtained with the EDTA solution (i.e., formulation B) to the results obtained with the LED3A solutions (see Table 1 - Formulations A and B) shows that the cleaning efficacy using EDTA at a concentration of 0.2% was 19.4%, while the cleaning efficacies of the LED3A solutions at concentrations of 0.1 and 0.2% were 39.4% and 67.1%, respectively.
- Formulation G contained one of the preferred surfactants of the present invention, REWAM2C, while formulation F (Table 2) contained a related surfactant that does not fall within the scope of the present invention, (i.e., REW AMC).
- REW AMC has a similar structure to REW AM2C, except that one of its carboxymethyl groups is replaced with a proton (bonded to the nitrogen atom).
- the results in Table 2 show that cleaning efficacy increased from 15.4% (formulation F) to 52.3% (formulation G) when the number of carboxymethyl groups on the head group increased from one to two.
- the data in Table 3 show the dose response of adding LED3A to a borate buffered vehicle containing 0.6% sodium citrate.
- the vehicle containing citrate without LED3A has a cleaning efficacy of 22%.
- the addition of LED3A at concentrations of 0.03 and 0.075% increased the cleaning efficacy of the formulations to 29.5% and 47.5%, respectively.
- Increasing the concentration of the LED3A to 0.1% and 0.2% further enhanced the cleaning levels to 56.0 and 60.2%, respectively.
- Table 6 below shows that the lens uptake after 2 cycles using 4 ppm AL-8496 can be reduced using C9-ED3A.
- the control solutions i.e., 9979-65H and 9979-651 gave lens uptakes of 17.4 ⁇ g/Lens and 14.0 ⁇ g/Lens, respectively.
- Table 7 below shows that the lens uptake after 2 cycles using 4 ppm AL-8496 can be reduced using the multifunctional surfactant C10-ED3A.
- the control solutions i.e., 9979-65G and 9979-65H
- Increasing the C10-ED3A concentration from 0.05% to 0.1% led to significant lens uptake reductions relative to these controls.
- Table 8 The formulation shown in Table 8 below is a further example of a preferred multi-purpose solution for cleaning, rinsing, disinfecting and storing contact lenses: Table 8 Component Concentration (% w/v) Polyquaternium-1 0.001 MAPDA 0.0005 C9-ED3A 0.1 Sorbitol 1.2 Boric Acid 0.6 Sodium Citrate 0.65 Sodium Chloride 0.1 Poloxamine 1304 0.1 EDTA 0.05 AMP (95%) 0.45 Purified Water QS PH 7.8
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43616302P | 2002-12-23 | 2002-12-23 | |
EP03814179A EP1576081B1 (de) | 2002-12-23 | 2003-12-17 | Verwendung von multifunktionellen tensidenzur reinigung von kontaktlinsen |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03814179A Division EP1576081B1 (de) | 2002-12-23 | 2003-12-17 | Verwendung von multifunktionellen tensidenzur reinigung von kontaktlinsen |
Publications (1)
Publication Number | Publication Date |
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EP1792972A1 true EP1792972A1 (de) | 2007-06-06 |
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ID=38009381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07005666A Withdrawn EP1792972A1 (de) | 2002-12-23 | 2003-12-17 | Verwendung von multifunktionellen Tensiden zur Reinigung von Kontaktlinsen |
Country Status (2)
Country | Link |
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EP (1) | EP1792972A1 (de) |
SI (1) | SI1576081T1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018185788A1 (en) * | 2017-04-07 | 2018-10-11 | Sun Pharma Advanced Research Company Limited | Ophthalmic solution of bimatoprost |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4013576A (en) * | 1973-11-21 | 1977-03-22 | Wesley-Jessen Inc. | Contact lens treating composition |
US4046706A (en) * | 1976-04-06 | 1977-09-06 | Flow Pharmaceuticals, Inc. | Contact lens cleaning composition |
US4738790A (en) * | 1984-08-21 | 1988-04-19 | Toyo Contact Lens Co., Ltd. | Method for cleaning contact lenses with composition containing amidoamine surfactant, thiourea and reducing agent |
WO1992005234A1 (en) * | 1990-09-21 | 1992-04-02 | The Procter & Gamble Company | Cleansing compositions |
US5801139A (en) * | 1997-06-05 | 1998-09-01 | Lever Brothers Company, Division Of Conopco, Inc. | Process for making bar compositions comprising novel chelating surfactants |
WO1999019449A1 (en) * | 1997-10-14 | 1999-04-22 | The Procter & Gamble Company | Hard surface cleaning compositions comprising mid-chain branched surfactants |
EP0976392A1 (de) * | 1998-07-29 | 2000-02-02 | Unilever Plc | Flüssige Zusammensetzungen, die Antioxydantien und von ED3A-abgeleitete, chelatierende Tenside als Stabilisierungsmittel enthalten |
US6057277A (en) * | 1996-04-25 | 2000-05-02 | Hampshire Chemical Corp. | N-acyl ethylenediaminetriacetic acid surfactants as enzyme compatible surfactants, stabilizers and activators |
US6242411B1 (en) * | 2001-01-09 | 2001-06-05 | Colgate-Palmolive Co. | Grease cutting light duty liquid detergent comprising lauryol ethylene diamine triacetate |
-
2003
- 2003-12-17 SI SI200330928T patent/SI1576081T1/sl unknown
- 2003-12-17 EP EP07005666A patent/EP1792972A1/de not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4013576A (en) * | 1973-11-21 | 1977-03-22 | Wesley-Jessen Inc. | Contact lens treating composition |
US4046706A (en) * | 1976-04-06 | 1977-09-06 | Flow Pharmaceuticals, Inc. | Contact lens cleaning composition |
US4738790A (en) * | 1984-08-21 | 1988-04-19 | Toyo Contact Lens Co., Ltd. | Method for cleaning contact lenses with composition containing amidoamine surfactant, thiourea and reducing agent |
WO1992005234A1 (en) * | 1990-09-21 | 1992-04-02 | The Procter & Gamble Company | Cleansing compositions |
US6057277A (en) * | 1996-04-25 | 2000-05-02 | Hampshire Chemical Corp. | N-acyl ethylenediaminetriacetic acid surfactants as enzyme compatible surfactants, stabilizers and activators |
US5801139A (en) * | 1997-06-05 | 1998-09-01 | Lever Brothers Company, Division Of Conopco, Inc. | Process for making bar compositions comprising novel chelating surfactants |
WO1999019449A1 (en) * | 1997-10-14 | 1999-04-22 | The Procter & Gamble Company | Hard surface cleaning compositions comprising mid-chain branched surfactants |
EP0976392A1 (de) * | 1998-07-29 | 2000-02-02 | Unilever Plc | Flüssige Zusammensetzungen, die Antioxydantien und von ED3A-abgeleitete, chelatierende Tenside als Stabilisierungsmittel enthalten |
US6242411B1 (en) * | 2001-01-09 | 2001-06-05 | Colgate-Palmolive Co. | Grease cutting light duty liquid detergent comprising lauryol ethylene diamine triacetate |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018185788A1 (en) * | 2017-04-07 | 2018-10-11 | Sun Pharma Advanced Research Company Limited | Ophthalmic solution of bimatoprost |
US11241443B2 (en) | 2017-04-07 | 2022-02-08 | Sun Pharma Advanced Research Company Ltd. | Ophthalmic solution of bimatoprost |
Also Published As
Publication number | Publication date |
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SI1576081T1 (sl) | 2007-12-31 |
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