EP1791562A4 - Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine - Google Patents

Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Info

Publication number
EP1791562A4
EP1791562A4 EP05812510A EP05812510A EP1791562A4 EP 1791562 A4 EP1791562 A4 EP 1791562A4 EP 05812510 A EP05812510 A EP 05812510A EP 05812510 A EP05812510 A EP 05812510A EP 1791562 A4 EP1791562 A4 EP 1791562A4
Authority
EP
European Patent Office
Prior art keywords
vaccine
protein conjugates
derivatized polysaccharide
multivalent meningococcal
meningococcal derivatized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05812510A
Other languages
German (de)
French (fr)
Other versions
EP1791562A2 (en
Inventor
Robert P Ryall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Inc
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Priority to EP10189369A priority Critical patent/EP2345422A1/en
Publication of EP1791562A2 publication Critical patent/EP1791562A2/en
Publication of EP1791562A4 publication Critical patent/EP1791562A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EP05812510A 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine Withdrawn EP1791562A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10189369A EP2345422A1 (en) 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61212304P 2004-09-21 2004-09-21
PCT/US2005/033761 WO2006034320A2 (en) 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Publications (2)

Publication Number Publication Date
EP1791562A2 EP1791562A2 (en) 2007-06-06
EP1791562A4 true EP1791562A4 (en) 2008-07-09

Family

ID=36090637

Family Applications (2)

Application Number Title Priority Date Filing Date
EP05812510A Withdrawn EP1791562A4 (en) 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
EP10189369A Withdrawn EP2345422A1 (en) 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10189369A Withdrawn EP2345422A1 (en) 2004-09-21 2005-09-21 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Country Status (10)

Country Link
EP (2) EP1791562A4 (en)
JP (2) JP2008513541A (en)
KR (1) KR20070095868A (en)
CN (1) CN101072586A (en)
AU (1) AU2005286798A1 (en)
BR (1) BRPI0516770A (en)
CA (1) CA2580693A1 (en)
IL (1) IL181951A0 (en)
MX (1) MX2007003292A (en)
WO (1) WO2006034320A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101934077A (en) * 2004-08-30 2011-01-05 圣诺菲·帕斯图尔公司 Multivalent meningococcal derivatized polysaccharide-proteinconjugates and vaccine
GB2468803B (en) * 2005-05-19 2011-01-19 Exocyte Ltd Screening methods for bacterial killing
MX2012001312A (en) * 2009-07-31 2012-06-01 Nat Research Council H. pylori lipopolysaccharide outer core epitope.
ES2744471T3 (en) * 2010-09-04 2020-02-25 Glaxosmithkline Biologicals Sa Bactericidal antibody assays to assess immunogenesis and potency of meningococcal capsular saccharide vaccines
CN102462839B (en) * 2010-11-12 2016-03-30 北京生物制品研究所 polysaccharide conjugate vaccine and preparation method thereof
JP2015517089A (en) 2012-03-08 2015-06-18 ノバルティス アーゲー In vitro efficacy assay for protein-based meningococcal vaccines
CN104902931A (en) * 2012-09-10 2015-09-09 格林考瓦因有限公司 Bioconjugates comprising modified antigens and uses thereof
CN106046127A (en) * 2016-08-10 2016-10-26 成都生物制品研究所有限责任公司 Preparation method of diphtheria toxoid
CA3033364A1 (en) 2016-09-02 2018-03-08 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine
CN106397537B (en) * 2016-10-13 2020-01-07 李红臣 Efficient and rapid purification and analysis method for polysaccharide-protein conjugate vaccine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965714A (en) * 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
WO2002058737A2 (en) * 2001-01-23 2002-08-01 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
WO2003007985A2 (en) * 2001-06-20 2003-01-30 Chiron Srl. Capsular polysaccharide solubilisation and combination vaccines
WO2004103400A2 (en) * 2003-05-07 2004-12-02 Aventis Pasteur,Inc. Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4619828A (en) 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
US5422427A (en) 1991-09-17 1995-06-06 The United States Of America As Represented By The United States Department Of Health And Human Services Pneumococcal fimbrial protein A
US5445817A (en) 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
US6146902A (en) * 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
AU2002309706A1 (en) * 2001-05-11 2002-11-25 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
EP1777236B8 (en) * 2002-03-26 2017-02-22 GlaxoSmithKline Biologicals SA Modified saccharides having improved stability in water for use as a medicament
CN101934077A (en) * 2004-08-30 2011-01-05 圣诺菲·帕斯图尔公司 Multivalent meningococcal derivatized polysaccharide-proteinconjugates and vaccine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965714A (en) * 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
WO2002058737A2 (en) * 2001-01-23 2002-08-01 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
WO2003007985A2 (en) * 2001-06-20 2003-01-30 Chiron Srl. Capsular polysaccharide solubilisation and combination vaccines
WO2004103400A2 (en) * 2003-05-07 2004-12-02 Aventis Pasteur,Inc. Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"DOSE ESCALATION, SAFETY AND IMMUNOGENICITY STUDY OF A TETRAVALENT MENINGOCOCCAL POLYSACCHARIDE DIPHTHERIA CONJUGATE VACCINE IN TODDLERS", PEDIATRIC INFECTIOUS DISEASE JOURNAL, WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 21, no. 10, 1 October 2002 (2002-10-01), pages 978/979, XP008015582, ISSN: 0891-3668 *
CAMPAGNE G ET AL: "SAFETY AND IMMUNOGENICITY OF THREE DOSES OF A NEISSERIA MENINGITIDIS A + C DIPHTHERIA CONJUGATE VACCINE IN INFANTS FROM NIGER", PEDIATRIC INFECTIOUS DISEASE JOURNAL, WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 19, no. 2, 1 February 2000 (2000-02-01), pages 144 - 150, XP008015581, ISSN: 0891-3668 *
CHIPPAUX J-P ET AL: "Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 25-26, 3 September 2004 (2004-09-03), pages 3303 - 3311, XP004526904, ISSN: 0264-410X *

Also Published As

Publication number Publication date
EP1791562A2 (en) 2007-06-06
IL181951A0 (en) 2007-07-04
AU2005286798A1 (en) 2006-03-30
JP2008513541A (en) 2008-05-01
CN101072586A (en) 2007-11-14
WO2006034320A3 (en) 2006-09-28
BRPI0516770A (en) 2008-09-23
WO2006034320A2 (en) 2006-03-30
MX2007003292A (en) 2007-09-07
EP2345422A1 (en) 2011-07-20
CA2580693A1 (en) 2006-03-30
JP2012140457A (en) 2012-07-26
KR20070095868A (en) 2007-10-01

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